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  1. Article ; Online: Sequential analysis for identification of byproduct from

    Verma, Ekta / Patil, Shailendra / Gajbhiye, Asmita

    RSC advances

    2023  Volume 13, Issue 37, Page(s) 25904–25911

    Abstract: A very common reaction, ...

    Abstract A very common reaction,
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03720g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Isolated bone marrow candidiasis in an immunocompetent elderly.

    Dubey, Deval B / Jain, Mili / Verma, Shailendra P / Agarwal, Preeti

    Indian journal of pathology & microbiology

    2024  Volume 67, Issue 1, Page(s) 149–150

    MeSH term(s) Humans ; Aged ; Bone Marrow ; Candidiasis/diagnosis
    Language English
    Publishing date 2024-02-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_918_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Safety, Tolerability, and Immunogenicity of COVID-19 Bivalent Vaccination.

    Saxena, Divyasha / Batra, Lalit / Verma, Shailendra Kumar

    Vaccines

    2023  Volume 11, Issue 6

    Abstract: The COVID-19 pandemic has triggered unparalleled global disruption [ ... ]. ...

    Abstract The COVID-19 pandemic has triggered unparalleled global disruption [...].
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11061040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Safety, Tolerability, and Immunogenicity of COVID-19 Bivalent Vaccination

    Divyasha Saxena / Lalit Batra / Shailendra Kumar Verma

    Vaccines, Vol 11, Iss 1040, p

    2023  Volume 1040

    Abstract: The COVID-19 pandemic has triggered unparalleled global disruption [.] ...

    Abstract The COVID-19 pandemic has triggered unparalleled global disruption [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Broad-Spectrum Antivirals against Multiple Human and Animal Coronaviruses Infection.

    Saxena, Divyasha / Batra, Lalit / Verma, Shailendra Kumar

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Among the seven coronaviruses that infect humans, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 usually cause mild and common cold symptoms; however, infection with three coronaviruses, namely severe acute respiratory syndrome coronavirus [SARS-CoV], ... ...

    Abstract Among the seven coronaviruses that infect humans, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 usually cause mild and common cold symptoms; however, infection with three coronaviruses, namely severe acute respiratory syndrome coronavirus [SARS-CoV], Middle East respiratory syndrome coronavirus [MERS-CoV], and the newly identified severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], often results in respiratory distress, cytokine storm and multiorgan failure [...].
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Broad-Spectrum Antivirals against Multiple Human and Animal Coronaviruses Infection

    Divyasha Saxena / Lalit Batra / Shailendra Kumar Verma

    Pathogens, Vol 12, Iss 823, p

    2023  Volume 823

    Abstract: Among the seven coronaviruses that infect humans, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 usually cause mild and common cold symptoms; however, infection with three coronaviruses, namely severe acute respiratory syndrome coronavirus [SARS-CoV], ... ...

    Abstract Among the seven coronaviruses that infect humans, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 usually cause mild and common cold symptoms; however, infection with three coronaviruses, namely severe acute respiratory syndrome coronavirus [SARS-CoV], Middle East respiratory syndrome coronavirus [MERS-CoV], and the newly identified severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], often results in respiratory distress, cytokine storm and multiorgan failure [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Convenient Novel Method to Access

    Verma, Ekta / Patil, Shailendra / Gajbhiye, Asmita

    ACS omega

    2021  Volume 6, Issue 12, Page(s) 8346–8355

    Abstract: Sodium hydride, potassium carbonate, and other bases are commonly used ... ...

    Abstract Sodium hydride, potassium carbonate, and other bases are commonly used for
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c00061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploration of quinazoline-tethered hydroxamic acid derivatives as HDAC inhibitors for anticancer activity

    Shweta Mishra / Ekta Verma / Shailendra Patil / Dhanji P. Rajani / Asmita Gajbhiye

    Results in Chemistry, Vol 7, Iss , Pp 101253- (2024)

    Design, synthesis, molecular docking, and biological evaluation

    1481  

    Abstract: In the past two decades, targeted cancer therapy has emerged as a novel class of anticancer therapeutics, besides traditional chemotherapy, surgery, and radiotherapy. Inhibition of HDACs represents a promising avenue for cancer therapeutics and initial ... ...

    Abstract In the past two decades, targeted cancer therapy has emerged as a novel class of anticancer therapeutics, besides traditional chemotherapy, surgery, and radiotherapy. Inhibition of HDACs represents a promising avenue for cancer therapeutics and initial success in treating select T-cell lymphomas has led to the FDA approval of four HDAC-targeted agents. The majority of currently available HDAC inhibitors have weak anticancer activity, with significant side effects. To address these drawbacks, in the present work we have designed and synthesized a novel series of histone deacetylase inhibitors combining 2-(4-substituted phenyl) quinazoline bioactive fragment as cap group and N-hydroxycinnamamide/ N-hydroxybenzamide as linker group, and evaluated for their cytotoxic activity against the three cancer cell lines (HeLa, MCF-7 and HCT-116) and HDAC inhibitory activity. All three cancer cell lines were most sensitive to the N-hydroxyacrylamide derivatives (5a-f) as compared to N-hydroxybenzamides (7a-f) derivatives. In particular, compound 5a (0.39, 0.26, 0.41 µM respectively) and 5b (0.27, 0.57, 0.32 µM respectively) were found to be the most potent derivatives among all tested cell lines. For HDAC inhibitory activity, it was found that compounds 5a, 5b, and 5d possessed comparable, even better HDAC inhibitory activity as compared to SAHA. These compounds also tested in vitro heamolytic activity, most of the compounds found biocompatible with human erythrocytes thereby evidencing the lack of haemolytic toxicity of anticancer drugs. In silico ADMET and molecular docking studies further corroborated with the experimental results. Overall, the new synthesized compounds exhibited significant HDAC and cytotoxic activity. Also, the different substituents and unsaturated bond influenced both HDAC inhibitory and cytotoxic activity. The outcome of the current work is that several potential HDAC inhibitors have emerged for further design of more potent HDAC inhibitors with better cytotoxicity.
    Keywords Histone deacetylases inhibitors ; HDAC ; 2-(4-substitutedphenyl) quinazoline ; Anticancer ; Cytotoxicity ; Heamolytic activity ; Chemistry ; QD1-999
    Subject code 540 ; 500
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Pyopneumothorax Secondary to Pulmonary Tuberculosis Superadded by Congenital Factor XIII Deficiency: A Case Report.

    Bajpai, Jyoti / Tewari, Jay / Roy, Shubhajeet / Verma, Ajay K / Verma, Shailendra P / Kant, Surya

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47350

    Abstract: Pyopneumothorax is a rare complication of pulmonary tuberculosis, contributing significantly to morbidity and mortality. Additionally, factor XIII deficiency, a rare bleeding disorder, may pose a diagnostic challenge due to normal results in routine ... ...

    Abstract Pyopneumothorax is a rare complication of pulmonary tuberculosis, contributing significantly to morbidity and mortality. Additionally, factor XIII deficiency, a rare bleeding disorder, may pose a diagnostic challenge due to normal results in routine coagulation tests. We present the case of an 18-year-old boy who presented with a history of left-sided pyopneumothorax secondary to drug-sensitive
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Role of G-Proteins and GPCRs in Cardiovascular Pathologies.

    Kaur, Geetika / Verma, Shailendra Kumar / Singh, Deepak / Singh, Nikhlesh K

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 1

    Abstract: Cell signaling is a fundamental process that enables cells to survive under various ecological and environmental contexts and imparts tolerance towards stressful conditions. The basic machinery for cell signaling includes a receptor molecule that senses ... ...

    Abstract Cell signaling is a fundamental process that enables cells to survive under various ecological and environmental contexts and imparts tolerance towards stressful conditions. The basic machinery for cell signaling includes a receptor molecule that senses and receives the signal. The primary form of the signal might be a hormone, light, an antigen, an odorant, a neurotransmitter, etc. Similarly, heterotrimeric G-proteins principally provide communication from the plasma membrane G-protein-coupled receptors (GPCRs) to the inner compartments of the cells to control various biochemical activities. G-protein-coupled signaling regulates different physiological functions in the targeted cell types. This review article discusses G-proteins' signaling and regulation functions and their physiological relevance. In addition, we also elaborate on the role of G-proteins in several cardiovascular diseases, such as myocardial ischemia, hypertension, atherosclerosis, restenosis, stroke, and peripheral artery disease.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10010076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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