Result 1 - 10 of total 6747
The Chicago medical journal
2023 Volume 25, Issue 2, Page(s) 60–61
| Language | English |
|---|---|
| Publishing date | 2023-07-06 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2011 Volume 4, Issue 170, Page(s) er2
Abstract: The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumetinib ( ... ...
| Abstract | The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumetinib (AZD6244) in colorectal cancer cell lines harboring mutations in BRAF (COLO205 and HT29 lines) or KRAS (HCT116 and LoVo lines). AZD6244-resistant derivatives were refractory to AZD6244-induced cell cycle arrest and death and exhibited a marked increase in ERK1/2 (extracellular signal–regulated kinases 1 and 2) pathway signaling and cyclin D1 abundance when assessed in the absence of inhibitor. Genomic sequencing revealed no acquired mutations in MEK1 or MEK2, the primary target of AZD6244. Rather, resistant lines showed a marked up-regulation of their respective driving oncogenes, BRAF600E or KRAS13D, due to intrachromosomal amplification. Inhibition of BRAF reversed resistance to AZD6244 in COLO205 cells, which suggested that combined inhibition of MEK1/2 and BRAF may reduce the likelihood of acquired resistance in tumors with BRAF600E. Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B; however, the combined inhibition of ERK1/2 and phosphatidylinositol 3-kinase signaling had little effect on AZD6244 resistance, suggesting that additional KRAS effector pathways contribute to this process. Microarray analysis identified increased expression of an 18-gene signature previously identified as reflecting MEK1/2 pathway output in resistant cells. Thus, amplification of the driving oncogene (BRAF600E or KRAS13D) can drive acquired resistance to MEK1/2 inhibitors by increasing signaling through the ERK1/2 pathway. However, up-regulation of KRAS13D leads to activation of multiple KRAS effector pathways, underlining the therapeutic challenge posed by KRAS mutations. These results may have implications for the use of combination therapies. |
|---|---|
| MeSH term(s) | Benzimidazoles ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; Gene Amplification ; Genes, ras ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras) ; Up-Regulation ; ras Proteins/genetics |
| Chemical Substances | AZD 6244 ; Benzimidazoles ; KRAS protein, human ; Proto-Oncogene Proteins ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2) |
| Language | English |
| Publishing date | 2011-06-10 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Corrected and Republished Article |
| ZDB-ID | 2417226-1 |
| ISSN | 1937-9145 ; 1945-0877 |
| ISSN (online) | 1937-9145 |
| ISSN | 1945-0877 |
| DOI | 10.1126/scisignal.4170er2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2024 Volume 134, Issue 9, Page(s) 1197–1217
Abstract: Ubiquitous environmental exposures increase cardiovascular disease risk via diverse mechanisms. This review examines personal strategies to minimize this risk. With regard to fine particulate air pollution exposure, evidence exists to recommend the use ... ...
| Abstract | Ubiquitous environmental exposures increase cardiovascular disease risk via diverse mechanisms. This review examines personal strategies to minimize this risk. With regard to fine particulate air pollution exposure, evidence exists to recommend the use of portable air cleaners and avoidance of outdoor activity during periods of poor air quality. Other evidence may support physical activity, dietary modification, omega-3 fatty acid supplementation, and indoor and in-vehicle air conditioning as viable strategies to minimize adverse health effects. There is currently insufficient data to recommend specific personal approaches to reduce the adverse cardiovascular effects of noise pollution. Public health advisories for periods of extreme heat or cold should be observed, with limited evidence supporting a warm ambient home temperature and physical activity as strategies to limit the cardiovascular harms of temperature extremes. Perfluoroalkyl and polyfluoroalkyl substance exposure can be reduced by avoiding contact with perfluoroalkyl and polyfluoroalkyl substance-containing materials; blood or plasma donation and cholestyramine may reduce total body stores of perfluoroalkyl and polyfluoroalkyl substances. However, the cardiovascular impact of these interventions has not been examined. Limited utilization of pesticides and safe handling during use should be encouraged. Finally, vasculotoxic metal exposure can be decreased by using portable air cleaners, home water filtration, and awareness of potential contaminants in ground spices. Chelation therapy reduces physiological stores of vasculotoxic metals and may be effective for the secondary prevention of cardiovascular disease. |
|---|---|
| MeSH term(s) | Humans ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/etiology ; Environmental Exposure/adverse effects ; Environmental Exposure/prevention & control ; Exercise ; Particulate Matter/adverse effects ; Air Pollutants/adverse effects ; Air Pollution/adverse effects |
| Chemical Substances | Particulate Matter ; Air Pollutants |
| Language | English |
| Publishing date | 2024-04-25 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 80100-8 |
| ISSN | 1524-4571 ; 0009-7330 ; 0931-6876 |
| ISSN (online) | 1524-4571 |
| ISSN | 0009-7330 ; 0931-6876 |
| DOI | 10.1161/CIRCRESAHA.123.323624 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui IV Zs.70: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Ui IV Zs.60: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Mentalis
1971 Volume 1, Issue 1, Page(s) 8–12
| MeSH term(s) | Dentists ; Research |
|---|---|
| Language | English |
| Publishing date | 1971 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 0360-7232 |
| ISSN | 0360-7232 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
making it happen
2012
| Author's details | J. Timothy Harrington ; Eric D. Newman eds |
|---|---|
| Language | English |
| Size | XII, 258 S. : Ill. |
| Publisher | Springer |
| Publishing place | New York u.a. |
| Publishing country | United States |
| Document type | Book |
| HBZ-ID | HT017092504 |
| ISBN | 978-1-4614-1197-0 ; 1-4614-1197-1 ; 9781461411987 ; 146141198X |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2012 A 216 | order for loan | Magazin |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Animals : an open access journal from MDPI
2024 Volume 14, Issue 3
Abstract: This review examines the visual systems of cervids in relation to their ability to meet their ecological needs and how their visual systems are specialized for particular tasks. Cervidae encompasses a diverse group of mammals that serve as important ... ...
| Abstract | This review examines the visual systems of cervids in relation to their ability to meet their ecological needs and how their visual systems are specialized for particular tasks. Cervidae encompasses a diverse group of mammals that serve as important ecological drivers within their ecosystems. Despite evidence of highly specialized visual systems, a large portion of cervid research ignores or fails to consider the realities of cervid vision as it relates to their ecology. Failure to account for an animal's visual ecology during research can lead to unintentional biases and uninformed conclusions regarding the decision making and behaviors for a species or population. Our review addresses core behaviors and their interrelationship with cervid visual characteristics. Historically, the study of cervid visual characteristics has been restricted to specific areas of inquiry such as color vision and contains limited integration into broader ecological and behavioral research. The purpose of our review is to bridge these gaps by offering a comprehensive review of cervid visual ecology that emphasizes the interplay between the visual adaptations of cervids and their interactions with habitats and other species. Ultimately, a better understanding of cervid visual ecology allows researchers to gain deeper insights into their behavior and ecology, providing critical information for conservation and management efforts. |
|---|---|
| Language | English |
| Publishing date | 2024-01-27 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2606558-7 |
| ISSN | 2076-2615 |
| ISSN | 2076-2615 |
| DOI | 10.3390/ani14030420 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
2024 Volume 49, Issue 2, Page(s) 33–43
Abstract: Purpose: The purpose of this study was to characterize the unmet needs and concerns of working-age caregivers of stroke survivors and to explore the relationships between these unmet needs and concerns and factors such as stroke survivor functional ... ...
| Abstract | Purpose: The purpose of this study was to characterize the unmet needs and concerns of working-age caregivers of stroke survivors and to explore the relationships between these unmet needs and concerns and factors such as stroke survivor functional independence, caregiver strain, caregiver self-efficacy, caregiver perceived social support, and caregiver quality of life (QoL). Design: Cross-sectional descriptive design was used in this study. Methods: Participants ( N = 103) completed an online survey. Descriptive statistics, bivariate Pearson correlation, and linear regression analysis was performed. Results: Negative correlations were found between caregiver needs and concerns and both stroke survivor functional independence and caregiver self-efficacy. Positive correlations were identified between caregiver needs and concerns and caregiver strain. In multiple regression models, stroke survivor functional independence, caregiver self-efficacy, race, and gender were statistically significantly associated with caregiver QoL. Clinical relevance to the practice of rehabilitation nursing: Results of this study can inform nurses as they collaborate with informal caregivers and researchers in optimizing the rehabilitation and discharge process and aiding in the support of caregiver QoL. Conclusion: Working-age caregivers of stroke survivors expressed many needs and concerns. These needs, along with other factors, can affect outcomes including QoL in caregivers and stroke survivors. |
|---|---|
| MeSH term(s) | Humans ; Quality of Life ; Caregivers ; Cross-Sectional Studies ; Stroke/complications ; Stroke Rehabilitation ; Survivors |
| Language | English |
| Publishing date | 2024-02-10 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 604872-9 |
| ISSN | 2048-7940 ; 0278-4807 ; 0248-7940 |
| ISSN (online) | 2048-7940 |
| ISSN | 0278-4807 ; 0248-7940 |
| DOI | 10.1097/RNJ.0000000000000447 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 2601: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2024 Volume 15, Page(s) 1321323
Abstract: The prevalence of diabetes is estimated to reach almost 630 million cases worldwide by the year 2045; of current and projected cases, over 90% are type 2 diabetes. Air pollution exposure has been implicated in the onset and progression of diabetes. ... ...
| Abstract | The prevalence of diabetes is estimated to reach almost 630 million cases worldwide by the year 2045; of current and projected cases, over 90% are type 2 diabetes. Air pollution exposure has been implicated in the onset and progression of diabetes. Increased exposure to fine particulate matter air pollution (PM |
|---|---|
| MeSH term(s) | Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/epidemiology ; Air Pollution/adverse effects ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Environmental Exposure/adverse effects ; Particulate Matter/adverse effects ; Air Pollutants/adverse effects ; Risk Factors ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Heart Disease Risk Factors ; Blood Glucose/metabolism |
| Chemical Substances | Particulate Matter ; Air Pollutants ; Blood Glucose |
| Language | English |
| Publishing date | 2024-04-11 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592084-4 |
| ISSN | 1664-2392 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2024.1321323 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2024 Volume 14, Issue 4, Page(s) e11168
Abstract: Avian nests are fundamental structures in avian reproduction and face strong selective forces. Climatic conditions are likely to have shaped the evolution of specific nest traits, but evidence is scarce at a macroevolutionary level. The Thraupidae family ...
| Abstract | Avian nests are fundamental structures in avian reproduction and face strong selective forces. Climatic conditions are likely to have shaped the evolution of specific nest traits, but evidence is scarce at a macroevolutionary level. The Thraupidae family (commonly known as tanagers) is an ideal clade to understand the link between nest architecture and climate because it presents wide variation in nest traits. To understand whether climatic variables have played a role in the diversification of nest traits among species in this family, we measured nests from 49 species using museum collections. We observed that dome-nesting species are present in dryer and hotter environments, in line with previous findings suggesting that domed nests are a specialisation for arid conditions. We also found evidence that nests with thicker walls are present in locations with lower precipitation and that solar radiation can influence the shape of domed nests; birds tend to build shorter and narrower domes in areas with high levels of solar radiation. Open nest architecture is also potentially influenced by wind speed, with longer and deeper nests in areas characterised by strong winds. Our results support the hypothesis that different climatic variables can drive the evolution of specific aspects of nest architecture and contribute to the diversity of nest shapes we currently observe. However, climatic variables account only for a small fraction of the observed structural variation, leaving a significant portion still unexplained. |
|---|---|
| Language | English |
| Publishing date | 2024-04-01 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2635675-2 |
| ISSN | 2045-7758 |
| ISSN | 2045-7758 |
| DOI | 10.1002/ece3.11168 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
American journal of primatology
2020 Volume 30, Issue 1, Page(s) 37–54
Abstract: Captive adult common marmosets (Callithrix jacchus) produce whistle-like "phee" calls in two contexts; in the home cage environment, phee calls may function as part of territorial marking behavior, and when animals are separated from social companions, ... ...
| Abstract | Captive adult common marmosets (Callithrix jacchus) produce whistle-like "phee" calls in two contexts; in the home cage environment, phee calls may function as part of territorial marking behavior, and when animals are separated from social companions, phee calls may serve to reunite the group. Isolation phee calls tend to have more syllables than calls produced in the home cage by the same animals, and as a result, are longer in duration. The durations of isolation call syllables are shorter than in home cage calls, and isolation calls have lower start and end frequencies, higher peak frequencies, and increased frequency range compared to phee calls produced by the same animals in their home cages. The modifications made to the general structure of the phee call by isolated animals result in more information that may indicate context or location of an isolated caller. When the vocalizations were analyzed by sex, between-sex differences in call structure appeared consistently in both contexts. Males tended to exhibit higher call frequencies and greater variability between syllables than females. Published 1993 Wiley-Liss, Inc. |
|---|---|
| Language | English |
| Publishing date | 2020-01-13 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1495834-X |
| ISSN | 1098-2345 ; 0275-2565 |
| ISSN (online) | 1098-2345 |
| ISSN | 0275-2565 |
| DOI | 10.1002/ajp.1350300104 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.