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  1. Article ; Online: Isomer Differentiation of Trapped C

    Vinitha, M Viswanathan / Mundlapati, Venkateswara Rao / Marciniak, Alexandre / Carlos, Mickaël / Sabbah, Hassan / Bonnamy, Anthony / Noguès, Loïc / Murat, David / Coeur-Joly, Odile / Joblin, Christine

    The journal of physical chemistry. A

    2022  Volume 126, Issue 33, Page(s) 5632–5646

    Abstract: Polycyclic aromatic hydrocarbons are major species in astrophysical environments, and this motivates their study in samples of astrochemical interest such as meteorites and laboratory analogues of stardust. Molecular analyses of carbonaceous matter in ... ...

    Abstract Polycyclic aromatic hydrocarbons are major species in astrophysical environments, and this motivates their study in samples of astrochemical interest such as meteorites and laboratory analogues of stardust. Molecular analyses of carbonaceous matter in these samples show a dominant peak at
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c03304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Covalent Triazine Framework C

    Hammud, Hassan H / Yar, Muhammad / Bayach, Imene / Ayub, Khurshid

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: ... the electrochemical sensing potential of a C ...

    Abstract Industrial pollutants pose a serious threat to ecosystems. Hence, there is a need to search for new efficient sensor materials for the detection of pollutants. In the current study, we explored the electrochemical sensing potential of a C
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13061121
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  3. Article ; Online: HLA-C Genotyping Reveals Haplotype C*07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients.

    Benlabsir, Chaimaa / Riyad, Myriam / Saik, Imane El Idrissi / Ettayebi, Hanaa / Aazzane, Oussama / Nassar, Kawtar / Zaher, Soukaina / Bennani, Siham / Admou, Brahim / Housbane, Samy / Sadki, Khalid / Chiheb, Soumiya / Fellah, Hassan

    Current issues in molecular biology

    2023  Volume 45, Issue 2, Page(s) 1012–1023

    Abstract: ... Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess ... Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match ... it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy ...

    Abstract Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45020066
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    Zs.A 5122: Show issues Location:
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  4. Article: The Chemistry of Cosmic Dust Analogues from C, C

    Santoro, Gonzalo / Martínez, Lidia / Lauwaet, Koen / Accolla, Mario / Tajuelo-Castilla, Guillermo / Merino, Pablo / Sobrado, Jesús M / Peláez, Ramón J / Herrero, Víctor J / Tanarro, Isabel / Mayoral, Á Lvaro / Agúndez, Marcelino / Sabbah, Hassan / Joblin, Christine / Cernicharo, José / Martín-Gago, José Ángel

    The Astrophysical journal

    2020  Volume 895, Issue 2

    Abstract: Interstellar carbonaceous dust is mainly formed in the innermost regions of circumstellar envelopes around carbon-rich asymptotic giant branch (AGB) stars. In these highly chemically stratified regions, atomic and diatomic carbon, along with acetylene ... ...

    Abstract Interstellar carbonaceous dust is mainly formed in the innermost regions of circumstellar envelopes around carbon-rich asymptotic giant branch (AGB) stars. In these highly chemically stratified regions, atomic and diatomic carbon, along with acetylene are the most abundant species after H
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2960-9
    ISSN 0004-637X
    ISSN 0004-637X
    DOI 10.3847/1538-4357/ab9086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Homozygous mild beta-thalassaemia promoter transversion -71 C>T HBB:c.-121 C>T.

    Hassan, Suha Mustafa / Alrawas, Abdulhakim / Al Khanbashi, Laila / Wali, Yasser

    BMJ case reports

    2023  Volume 16, Issue 4

    Abstract: ... within the promoter region of the β-globin gene at position -71 (C>T). The patient was a female child, who was referred ...

    Abstract Beta-thalassaemia is one of the most common genetic disorders worldwide, which is caused by absent or decreased synthesis of beta-globin chain subunits. Beta-thalassaemias are diverse groups of disease with a wide spectrum of clinical phenotypes. The clinical phenotypes can include asymptomatic forms of beta-thalassaemia minor, intermediate and severe transfusion dependent beta-thalassaemia major. Clinical severity varies depending on the underlying β globin gene mutation. There are a number of mild β-thalassaemia gene defects that could be referred as a 'silent carrier'. Identifying the underlying molecular defect is essential to predict phenotype severity for optimal management, tailored treatment and improved quality of life.We report the first identification of a homozygous point mutation located within the promoter region of the β-globin gene at position -71 (C>T). The patient was a female child, who was referred to our clinic after she was found to have hypochromic microcytic anaemia with low haemoglobin (Hb) (67 g/L) and an Hb A
    MeSH term(s) Humans ; Female ; beta-Thalassemia/genetics ; beta-Thalassemia/diagnosis ; Quality of Life ; Thalassemia ; Promoter Regions, Genetic/genetics ; beta-Globins/genetics
    Chemical Substances beta-Globins
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254416
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  6. Article: HLA-C

    Biberg-Salum, Tânia Gisela / Veronese Rodrigues, Maria de Lourdes / Fernandes, Ana Paula Morais / Deghaide, Neifi Hassan Salum / de Paula, Jayter Silva / Castelli, Erick C / Mendes-Junior, Celso Teixeira / Donadi, Eduardo Antonio

    Journal of ophthalmology

    2018  Volume 2018, Page(s) 3830104

    Abstract: Purpose: Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and : Methods: Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR ( ... ...

    Abstract Purpose: Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and
    Methods: Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III).
    Results: The
    Conclusion: The
    Language English
    Publishing date 2018-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2018/3830104
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  7. Article ; Online: Biosystems Design to Accelerate C

    Yuan, Guoliang / Hassan, Md Mahmudul / Liu, Degao / Lim, Sung Don / Yim, Won Cheol / Cushman, John C / Markel, Kasey / Shih, Patrick M / Lu, Haiwei / Weston, David J / Chen, Jin-Gui / Tschaplinski, Timothy J / Tuskan, Gerald A / Yang, Xiaohan

    Biodesign research

    2020  Volume 2020, Page(s) 3686791

    Abstract: ... species have substantially higher WUE than species performing C ...

    Abstract Global demand for food and bioenergy production has increased rapidly, while the area of arable land has been declining for decades due to damage caused by erosion, pollution, sea level rise, urban development, soil salinization, and water scarcity driven by global climate change. In order to overcome this conflict, there is an urgent need to adapt conventional agriculture to water-limited and hotter conditions with plant crop systems that display higher water-use efficiency (WUE). Crassulacean acid metabolism (CAM) species have substantially higher WUE than species performing C
    Language English
    Publishing date 2020-10-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2693-1257
    ISSN (online) 2693-1257
    DOI 10.34133/2020/3686791
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  8. Article ; Online: Identification of the novel HLA-C allele, HLA-C*12:351Q, using next-generation sequencing.

    AlZahrani, Saber / Alharbi, Hassan / Bamrdouf, Rafah / Ajebi, Ali / Mohammed, Amani

    HLA

    2024  Volume 103, Issue 4, Page(s) e15493

    Abstract: The novel allele HLA-C*12:351Q differs from HLA-C*12:02:02:01 by a single nucleotide deletion ...

    Abstract The novel allele HLA-C*12:351Q differs from HLA-C*12:02:02:01 by a single nucleotide deletion in exon 5.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15493
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 661: Show issues Location:
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  9. Article ; Online: Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.

    Imhoff, Ryan D / Patel, Rishi / Safdar, Muhammad Hassan / Jones, Hannah B L / Pinto-Fernandez, Adan / Vendrell, Iolanda / Chen, Hao / Muli, Christine S / Krabill, Aaron D / Kessler, Benedikt M / Wendt, Michael K / Das, Chittaranjan / Flaherty, Daniel P

    Journal of medicinal chemistry

    2024  Volume 67, Issue 6, Page(s) 4496–4524

    Abstract: ... neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed ...

    Abstract Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the central nervous system under normal physiological conditions, however, is considered an oncogene in various cancers, including melanoma, lung, breast, and lymphoma. Thus, UCHL1 inhibitors could serve as a viable treatment strategy against these aggressive cancers. Herein, we describe a covalent fragment screen that identified the chloroacetohydrazide scaffold as a covalent UCHL1 inhibitor. Subsequent optimization provided an improved fragment with single-digit micromolar potency against UCHL1 and selectivity over the closely related UCHL3. The molecule demonstrated efficacy in cellular assays of metastasis. Additionally, we report a ligand-bound crystal structure of the most potent molecule in complex with UCHL1, providing insight into the binding mode and information for future optimization.
    MeSH term(s) Humans ; Ubiquitin Thiolesterase/chemistry ; Ubiquitin Thiolesterase/metabolism ; Ubiquitin/metabolism ; Breast ; Proteasome Endopeptidase Complex ; Neoplasms
    Chemical Substances Ubiquitin Thiolesterase (EC 3.4.19.12) ; Ubiquitin ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; UCHL3 protein, human (EC 3.4.19.12)
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01661
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  10. Article ; Online: MUC1-C: The Occam Razor of Osimertinib Resistance?

    Yalamanchali, Anirudh / Hassan, Khaled A

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 19, Issue 3, Page(s) 370–372

    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung ; Pyrimidines ; Acrylamides/pharmacology ; Aniline Compounds/pharmacology ; Drug Resistance, Neoplasm ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Cell Line, Tumor ; Mucin-1 ; Indoles
    Chemical Substances osimertinib (3C06JJ0Z2O) ; Pyrimidines ; Acrylamides ; Aniline Compounds ; Protein Kinase Inhibitors ; MUC1 protein, human ; Mucin-1 ; Indoles
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.12.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
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    Zs.MO 652: Show issues

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