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Article ; Online: Helicobacter pylori Eradication Treatment in Older Patients.

Jonaitis, Paulius / Kupcinskas, Juozas / Gisbert, Javier P / Jonaitis, Laimas

2024 Volume 41, Issue 2, Page(s) 141–151

Abstract: Helicobacter pylori is the main etiopathogenetic factor of chronic gastritis, peptic ulcer disease and gastric cancer. The world's population is shifting towards older people, who have the highest prevalence of H. pylori. Aging-related peculiarities ... ...

Abstract	Helicobacter pylori is the main etiopathogenetic factor of chronic gastritis, peptic ulcer disease and gastric cancer. The world's population is shifting towards older people, who have the highest prevalence of H. pylori. Aging-related peculiarities could have an impact on the treatment of H. pylori and there is still a lack of research data in the older population. The aim of this review was to summarize the findings of the most recent information, publications and studies on the issues relating to H. pylori infection in older patients. H. pylori eradication offers gastrointestinal and extra gastrointestinal benefits in older patients. Based on the main guidelines, H. pylori should be eradicated independent of the patient's age, only reconsidering cases with terminal illness and low life expectancy. Proton pump inhibitors are generally safe and well tolerated. Some antibiotics require dose adjustment only in advanced renal insufficiency and the risk of hepatotoxicity is very low. Special precautions should be taken in patients with polypharmacy and those taking aspirin or non-steroidal anti-inflammatory drugs. In older patients, H. pylori eradication treatment frequently causes only mild and short-term adverse events; however, treatment compliance is usually still very good. H. pylori treatment in older patients does not increase the risk of Clostridium difficile infection. Optimal eradication effectiveness (> 90%) is mostly achieved with bismuth- and non-bismuth-based quadruple therapies. Susceptibility-guided treatment of H. pylori can contribute to increasing the effectiveness of eradication regimens in older adults. To achieve optimal H. pylori eradication effectiveness in older patients, the same guidelines, which are applied to adults, also apply to this population: avoiding repetitive treatment prescriptions, choosing quadruple therapies, prescribing longer treatment duration and administering high-dose proton pump inhibitors twice daily.
MeSH term(s)	Humans ; Aged ; Helicobacter pylori ; Proton Pump Inhibitors/adverse effects ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/chemically induced ; Anti-Bacterial Agents/adverse effects ; Bismuth/adverse effects ; Drug Therapy, Combination ; Treatment Outcome
Chemical Substances	Proton Pump Inhibitors ; Anti-Bacterial Agents ; Bismuth (U015TT5I8H)
Language	English
Publishing date	2024-02-10
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1075770-3
ISSN	1179-1969 ; 1170-229X
ISSN (online)	1179-1969
ISSN	1170-229X
DOI	10.1007/s40266-023-01090-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Defluorinative Asymmetric Allylic Alkylations

Rodríguez, Paula / Duran, Jordi / Gisbert, Martí / Companyó, Xavier

Synlett

2023

Abstract: The introduction of allyl fluorides as alternative electrophiles in asymmetric allylic alkylation reactions has recently attracted significant interest. Despite the intrinsic thermodynamically demanding C–F bond-cleavage event, the fluorophilic nature of ...

Abstract	The introduction of allyl fluorides as alternative electrophiles in asymmetric allylic alkylation reactions has recently attracted significant interest. Despite the intrinsic thermodynamically demanding C–F bond-cleavage event, the fluorophilic nature of the silicon atom is key in assisting the activation and cleavage of the allylic C–F bond. Thus, the use of silylated compounds as unconventional nucleophiles, together with the Lewis basicity of fluorine when acting as a leaving group, enables the development of innovative chemical transformations within mild and selective catalytic schemes. This Synpacts article summarizes the diverse defluorinative asymmetric allylic alkylations with allyl fluorides reported to date under both chiral Lewis base and transition-metal catalysis.
Keywords	C–F bond activation ; defluorination ; asymmetric catalysis ; allylic alkylation ; Lewis base catalysis ; transition-metal catalysis
Language	English
Publishing date	2023-11-15
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2211-6538
Database	Thieme publisher's database

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Article ; Online: Emulsion Nanofibres as a Composite for a Textile Touch Sensor.

Mínguez-García, David / Díaz-García, Pablo / Gisbert-Payá, Jaime / Bonet-Aracil, Marilés

Polymers

2023 Volume 15, Issue 19

Abstract: The combination of a nanofibre net and textile support represents an interesting composite capable of conferring various properties. Nanofibres are so thin that they can be easily damaged by human touch. In this study, we hypothesised that dyeing ... ...

Abstract	The combination of a nanofibre net and textile support represents an interesting composite capable of conferring various properties. Nanofibres are so thin that they can be easily damaged by human touch. In this study, we hypothesised that dyeing nanofibres with different colours from their textile supports would result in a colour difference upon their degradation, providing evidence that the composite has been touched and acting as a touch sensor. Two different methods were studied: directly inserting the dye into the polymer via electrospinning or creating a coloured liquid emulsion encapsulated by the polymer via electrospinning. Two black dyes were studied. Colour index (CI) Acid Black 194 was added directly to polyvinyl alcohol (PVA) as the polymer. Sage oil was used for CI Solvent Black 3. The nanofibre nets were conveniently electrospun on a white polyester fabric; the fabrics were then characterised by colour coordinate analysis, FTIR, and SEM. The results showed that the dyed solution in oil was encapsulated, and the black colour could only be observed when rubbed, whereas the dyed polymer showed a black colour that was removed when rubbed. Therefore, the hypothesis was confirmed, and both samples demonstrated the desired touch sensor behaviour.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15193903
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Article ; Online: PVA Nanofibers as an Insoluble pH Sensor.

Mínguez-García, David / Montava, Ignacio / Bonet-Aracil, Marilés / Gisbert-Payá, Jaime / Díaz-García, Pablo

Polymers

2023 Volume 15, Issue 23

Abstract: Turmeric has been widely studied as a color indicator for pH variations due to its halochromic properties. It has been tested in solution or included in some polymeric matrices. Some studies have demonstrated that its change in color is due to the ... ...

Abstract	Turmeric has been widely studied as a color indicator for pH variations due to its halochromic properties. It has been tested in solution or included in some polymeric matrices. Some studies have demonstrated that its change in color is due to the tautomeric species of curcumin, and this property can be observed even if turmeric is assimilated in a film or nanofiber. Chitosan/polyethylene oxide (PEO) polymers have been tested in previous studies. Polyvinyl alcohol (PVA) nanofibers are used as potential carriers of drugs once they are insolubilized. The aim of this work is to cross-link PVA with citric acid (CA) to insolubilize the nanofibers and determine the effect on turmeric's halochromic properties. The nanofibers were treated with a sodium hydroxide (NaOH) solution, and a chromatic study was undertaken to determine color change. The change in color was assessed by eye (subjective) and by spectroscopy (objective). The nanofibers were characterized, in addition to the colorimetric study, by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) as well. The results demonstrate how thermal treatment induces cross-linking between the nanofibers, allowing them to keep their shape once the NaOH solution is applied to them. The opposite effect (solubilization) can be observed for non-cross-linked (NCL) samples. Although the final color varied, the cross-linked (CL) nanofibers' halochromic behavior was maintained. It was demonstrated that during cross-linking, ester groups are formed from the free carboxyl group in the cross-linked CA and the ketones present in the curcumin under acid conditions. So, CA acts as an acid catalyst to bond turmeric to the cross-linked PVA nanofibers.
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15234480
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Article: Efficacy of tofacitinib treatment in ulcerative colitis.

Panés, Julián / Gisbert, Javier P

Gastroenterologia y hepatologia

2019 Volume 42, Issue 6, Page(s) 403–412

Abstract: Tofacitinib is an oral synthetic small-molecule inhibitor of Janus kinases, which are involved in the pathogenesis of various inflammatory diseases, representing a new therapeutic option for ulcerative colitis. The efficacy and safety of tofacitinib have ...

Title translation	Eficacia de tofacitinib en el tratamiento de la colitis ulcerosa.
Abstract	Tofacitinib is an oral synthetic small-molecule inhibitor of Janus kinases, which are involved in the pathogenesis of various inflammatory diseases, representing a new therapeutic option for ulcerative colitis. The efficacy and safety of tofacitinib have been demonstrated in clinical trials in patients with moderate to severe ulcerative colitis, and it has recently been approved by the European Medicines Agency to treat this disease. This article reviews the most relevant characteristics of tofacitinib, its main differences from biological agents, the studies which demonstrate its efficacy in patients with ulcerative colitis, and its optimal use in different clinical situations.
MeSH term(s)	Adalimumab/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Colitis, Ulcerative/drug therapy ; Gastrointestinal Agents/therapeutic use ; Humans ; Infliximab/therapeutic use ; Janus Kinases/antagonists & inhibitors ; Maintenance Chemotherapy ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/therapeutic use ; Pyrroles/therapeutic use ; Quality of Life ; Remission Induction ; Retreatment
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Gastrointestinal Agents ; Piperidines ; Protein Kinase Inhibitors ; Pyrimidines ; Pyrroles ; tofacitinib (87LA6FU830) ; golimumab (91X1KLU43E) ; vedolizumab (9RV78Q2002) ; Infliximab (B72HH48FLU) ; Janus Kinases (EC 2.7.10.2) ; Adalimumab (FYS6T7F842)
Language	Spanish
Publishing date	2019-05-14
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2019.03.002
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Article ; Online: Editorial: accumulating data about ustekinumab in refractory Crohn's disease in real world experience.

Khorrami, S / Gisbert, J P

Alimentary pharmacology & therapeutics

2017 Volume 45, Issue 10, Page(s) 1374–1375

Language	English
Publishing date	2017-05
Publishing country	England
Document type	Editorial
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.14053
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Article ; Online: Letter: the ethics of using inferior regimens in H. pylori randomised trials - invited comment.

Gisbert, J P

Alimentary pharmacology & therapeutics

2012 Volume 35, Issue 7, Page(s) 856–7; discussion 858

MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Female ; Helicobacter Infections/drug therapy ; Humans ; Male ; Proton Pump Inhibitors/administration & dosage
Chemical Substances	Anti-Bacterial Agents ; Proton Pump Inhibitors
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/j.1365-2036.2011.04985.x
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Article ; Online: Letter: third-line rescue therapy with levofloxacin after failure of two treatments to eradicate Helicobacter pylori infection.

Gisbert, J P

Alimentary pharmacology & therapeutics

2012 Volume 35, Issue 12, Page(s) 1484–5; author reply 1486

MeSH term(s)	Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Helicobacter Infections/drug therapy ; Helicobacter pylori/isolation & purification ; Humans ; Levofloxacin ; Ofloxacin/therapeutic use ; Proton Pump Inhibitors/therapeutic use ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Proton Pump Inhibitors ; Levofloxacin (6GNT3Y5LMF) ; Amoxicillin (804826J2HU) ; Ofloxacin (A4P49JAZ9H)
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/j.1365-2036.2012.05117.x
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Article: Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis.

Rojo, Eukene / Casanova, María José / P Gisbert, Javier

Gastroenterologia y hepatologia

2020 Volume 44, Issue 10, Page(s) 671–679

Abstract: ... in both subtypes, although patients with collagenous colitis had a chronic course more frequently (48% vs. 29%, p ...

Title translation	Características epidemiológicas, clínicas y respuesta al tratamiento en 113 pacientes con colitis microscópica.
Abstract	Objective: To study the epidemiological and clinical characteristics, and response to treatment in patients with microscopic colitis. Patients and method: Epidemiological, clinical, blood test and endoscopic data were retrospectively collected from 113 patients with microscopic colitis. Response to treatment was analyzed in 104 of them. Efficacy and relapse after treatment with budesonide were assessed using survival curves (Kaplan-Meier). Results: 78% of the patients were women, with a mean age of 65 ± 16 years. In smokers, the mean age was 10 years younger. 48% of them had some concomitant autoimmune disease; 60% suffered a single outbreak of the disease. The clinical presentation was similar in both subtypes, although patients with collagenous colitis had a chronic course more frequently (48% vs. 29%, p = 0.047). The remission rate with budesonide was 93% (95% CI 82-98). The cumulative incidence of relapse, after a median follow-up of 21 months, was 39% (95% CI 26-54%): 19% at one year, 32% at two years, and 46% at three years of follow-up. There were no differences in clinical response to budesonide based on smoking habit or microscopic colitis subtype. Conclusions: Microscopic colitis is more frequent in elderly women. Smoking was associated with earlier onset of the disease, although it did not influence the clinical course or response to treatment. The majority (> 90%) of patients treated with budesonide achieved remission, although nearly half subsequently relapsed.
MeSH term(s)	Adult ; Aged ; Anti-Inflammatory Agents/therapeutic use ; Budesonide/therapeutic use ; Colitis, Collagenous/complications ; Colitis, Collagenous/drug therapy ; Colitis, Collagenous/epidemiology ; Colitis, Collagenous/mortality ; Colitis, Lymphocytic/complications ; Colitis, Lymphocytic/drug therapy ; Colitis, Lymphocytic/epidemiology ; Colitis, Lymphocytic/mortality ; Colitis, Microscopic/complications ; Colitis, Microscopic/drug therapy ; Colitis, Microscopic/epidemiology ; Colitis, Microscopic/mortality ; Colonoscopy ; Ex-Smokers ; Female ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Recurrence ; Retrospective Studies ; Smokers ; Smoking/adverse effects ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents ; Budesonide (51333-22-3)
Language	Spanish
Publishing date	2020-11-25
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2020.11.007
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Article ; Online: Letter: switching from one to another anti-tumour necrosis factor alpha agent, and the risks of an overlap of exposure--authors' reply.

Gisbert, J P / Chaparro, M

Alimentary pharmacology & therapeutics

2016 Volume 43, Issue 9, Page(s) 1020

MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Immunoglobulin Fab Fragments/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Polyethylene Glycols/therapeutic use ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Immunoglobulin Fab Fragments ; Immunosuppressive Agents ; Tumor Necrosis Factor-alpha ; Polyethylene Glycols (30IQX730WE)
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.13579
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