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  1. Article ; Online: Management of Patients With Crohn's Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic

    Rubin, D.T. / Abreu, M.T. / Rai, V. / Siegel, C.A. / Ahuja, V. / Allez, M. / Ananthakrishnan, A.N. / Bernstein, C.N. / Braun, J.G. / Chowers, Y. / Colombel, J.-F. / Danese, S. / D'Haens, G. / D'Hoore, A. / Dignass, A. / Dotan, I. / Dubinsky, M.C. / Ekbom, A. / Fleshner, P.R. /
    Gassull, M.A. / Gearry, R.B. / Ghosh, S. / Griffiths, A.M. / Halfvarson, J. / Hanauer, S.B. / Harpaz, N. / Hart, A. / Kamm, M.A. / Kaplan, G.G. / Koutroubakis, I. / Lakatos, P.L. / Levine, A. / Lewis, J.D. / Lindsay, J.O. / Loftus, E.V., Jr. / Louis, E. / Lukas, M. / Magro, F. / Mahadevan, U. / Mantzaris, G.J. / McGovern, D.P. / Moum, B.A. / Munkholm, P. / Neurath, M.F. / Ng, S.C. / O'Morain, C. / Panaccione, R. / Panes, J. / Peyrin-Biroulet, L. / Prantera, C. / Ran, Z. / Reinisch, W. / Remzi, F.H. / Sachar, D.B. / Sandborn, W.J. / Sartor, R.B. / Schoelmerich, J. / Schreiber, S. / Siegmund, B. / Silverberg, M.S. / Soederholm, J.D. / Stange, E.F. / Steinwurz, F. / Turner, D. / Vatn, M.H. / Vermeire, S. / Brenner, E.J. / Christensen, B. / D'Amico, F. / Griffiths, C.M. / Higgins, P.D. / Kappelman, M.D. / Lees, C. / Regueiro, M.D. / Rosh, J.R. / Ungaro, R. / International Organization for the Study of Inflammatory Bowel Disease

    Gastroenterology, 159(1)

    Results of an International Meeting

    2020  

    Abstract: The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is the only global organization devoted to the study of and management of the inflammatory bowel diseases (IBDs), namely, Crohn?s disease and ulcerative colitis. ... ...

    Abstract The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is the only global organization devoted to the study of and management of the inflammatory bowel diseases (IBDs), namely, Crohn?s disease and ulcerative colitis. Membership is composed of physician-scientists who have established expertise in these diseases. The organization hosts an annual meeting and a number of working groups addressing issues of the epidemiology of IBD, diet and nutrition, and the development and use of treatments for IBD. There are currently 89 members of IOIBD representing 26 different countries. The organization has taken particular interest in the coronavirus disease-2019 (COVID-19) pandemic and how it may affect the IBD patient population. This document summarizes the results of 2 recent virtual meetings of the group and subsequent expert guidance for patients and providers.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; health care organization ; Crohn disease ; practice guideline ; coronavirus disease 2019 ; pandemic ; inflammatory bowel disease ; ulcerative colitis ; immune response ; nonhuman ; human ; patient care ; methodology ; covid19
    Subject code 610
    Language English
    Publisher W.B. Saunders
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Die Rolle der Dünndarmendoskopie beim Management von Patienten mit chronischentzündlichen Darmerkrankungen: ein internationaler OMED-ECCO-Konsensus. Role of Small-Bowel Endoscopy in the Management of Patients with Inflammatory Bowel Disease: an International OMED-ECCO Consensus

    Bourreille, A. / Ignjatovic, A. / Aabakken, L. / Loftus, E. V. / Eliakim Jr., R. / Pennazio, M. / Bouhnik, Y. / Seidman, E. / Keuchel, M. / Albert, J. G. / Ardizzone, S. / Bar-Meir, S. / Bisschops, R. / Despott, E. J. / Fortun, P. F. / Heuschkel, R. / Kammermeier, J. / Leighton, J. A. / Mantzaris, G. J. /
    Moussata, D. / Lo, S. / Paulsen, V. / Panés, J. / Radford-Smith, G. / Reinisch, W. / Rondonotti, E. / Sanders, D. S. / Swoger, J. M. / Yamamoto, H. / Travis, S. / Colombel, J.-F. / Van Gossum, A.

    Endoskopie heute

    2009  Volume 22, Issue 4, Page(s) 201

    Language German
    Document type Article
    ZDB-ID 18679-x
    ISSN 0933-811X
    Database Current Contents Medicine

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  3. Article: Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

    Bourreille, A. / Ignjatovic, A. / Aabakken, L. / Loftus Jr, E. V. / Eliakim, R. / Pennazio, M. / Bouhnik, Y. / Seidman, E. / Keuchel, M. / Albert, J. G. / Ardizzone, S. / Bar-Meir, S. / Bisschops, R. / Despott, E. J. / Fortun, P. F. / Heuschkel, R. / Kammermeier, J. / Leighton, J. A. / Mantzaris, G. J. /
    Moussata, D. / Lo, S. / Paulsen, V. / Panés, J. / Radford-Smith, G. / Reinisch, W. / Rondonotti, E. / Sanders, D. S. / Swoger, J. M. / Yamamoto, H. / Travis, S. / Colombel, J.-F. / Van Gossum, A.

    Endoscopy

    2009  Volume 41, Issue 07, Page(s) 618–637

    Language English
    Publishing date 2009-07-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0029-1214790
    Database Thieme publisher's database

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  4. Article ; Online: Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.

    Feagan, Brian G / Sandborn, William J / Gasink, Christopher / Jacobstein, Douglas / Lang, Yinghua / Friedman, Joshua R / Blank, Marion A / Johanns, Jewel / Gao, Long-Long / Miao, Ye / Adedokun, Omoniyi J / Sands, Bruce E / Hanauer, Stephen B / Vermeire, Severine / Targan, Stephan / Ghosh, Subrata / de Villiers, Willem J / Colombel, Jean-Frédéric / Tulassay, Zsolt /
    Seidler, Ursula / Salzberg, Bruce A / Desreumaux, Pierre / Lee, Scott D / Loftus, Edward V / Dieleman, Levinus A / Katz, Seymour / Rutgeerts, Paul

    The New England journal of medicine

    2016  Volume 375, Issue 20, Page(s) 1946–1960

    Abstract: Background: Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn's disease. Ustekinumab was also ... ...

    Abstract Background: Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn's disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy.
    Methods: We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects. The UNITI-2 trial included 628 patients in whom conventional therapy failed or unacceptable side effects occurred. Patients who completed these induction trials then participated in IM-UNITI, in which the 397 patients who had a response to ustekinumab were randomly assigned to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 8 weeks or every 12 weeks) or placebo. The primary end point for the induction trials was a clinical response at week 6 (defined as a decrease from baseline in the Crohn's Disease Activity Index [CDAI] score of ≥100 points or a CDAI score <150). The primary end point for the maintenance trial was remission at week 44 (CDAI score <150).
    Results: The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, with P≤0.003 for both comparisons with placebo; in UNITI-2, 51.7%, 55.5%, and 28.7%, respectively, with P<0.001 for both doses). In the groups receiving maintenance doses of ustekinumab every 8 weeks or every 12 weeks, 53.1% and 48.8%, respectively, were in remission at week 44, as compared with 35.9% of those receiving placebo (P=0.005 and P=0.04, respectively). Within each trial, adverse-event rates were similar among treatment groups.
    Conclusions: Among patients with moderately to severely active Crohn's disease, those receiving intravenous ustekinumab had a significantly higher rate of response than did those receiving placebo. Subcutaneous ustekinumab maintained remission in patients who had a clinical response to induction therapy. (Funded by Janssen Research and Development; ClinicalTrials.gov numbers, NCT01369329 , NCT01369342 , and NCT01369355 .).
    MeSH term(s) Adult ; Crohn Disease/drug therapy ; Female ; Humans ; Induction Chemotherapy ; Infusions, Intravenous ; Maintenance Chemotherapy ; Male ; Middle Aged ; Remission Induction ; Ustekinumab/adverse effects ; Ustekinumab/immunology ; Ustekinumab/pharmacokinetics ; Ustekinumab/therapeutic use
    Chemical Substances Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2016-12-14
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1602773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

    Loftus, Brendan J / Fung, Eula / Roncaglia, Paola / Rowley, Don / Amedeo, Paolo / Bruno, Dan / Vamathevan, Jessica / Miranda, Molly / Anderson, Iain J / Fraser, James A / Allen, Jonathan E / Bosdet, Ian E / Brent, Michael R / Chiu, Readman / Doering, Tamara L / Donlin, Maureen J / D'Souza, Cletus A / Fox, Deborah S / Grinberg, Viktoriya /
    Fu, Jianmin / Fukushima, Marilyn / Haas, Brian J / Huang, James C / Janbon, Guilhem / Jones, Steven J M / Koo, Hean L / Krzywinski, Martin I / Kwon-Chung, June K / Lengeler, Klaus B / Maiti, Rama / Marra, Marco A / Marra, Robert E / Mathewson, Carrie A / Mitchell, Thomas G / Pertea, Mihaela / Riggs, Florenta R / Salzberg, Steven L / Schein, Jacqueline E / Shvartsbeyn, Alla / Shin, Heesun / Shumway, Martin / Specht, Charles A / Suh, Bernard B / Tenney, Aaron / Utterback, Terry R / Wickes, Brian L / Wortman, Jennifer R / Wye, Natasja H / Kronstad, James W / Lodge, Jennifer K / Heitman, Joseph / Davis, Ronald W / Fraser, Claire M / Hyman, Richard W

    Science (New York, N.Y.)

    2005  Volume 307, Issue 5713, Page(s) 1321–1324

    Abstract: Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains ... ...

    Abstract Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.
    MeSH term(s) Alternative Splicing ; Cell Wall/metabolism ; Chromosomes, Fungal/genetics ; Computational Biology ; Cryptococcus neoformans/genetics ; Cryptococcus neoformans/pathogenicity ; Cryptococcus neoformans/physiology ; DNA Transposable Elements ; Fungal Proteins/metabolism ; Gene Library ; Genes, Fungal ; Genome, Fungal ; Humans ; Introns ; Molecular Sequence Data ; Phenotype ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Polysaccharides/metabolism ; RNA, Antisense ; Sequence Analysis, DNA ; Transcription, Genetic ; Virulence ; Virulence Factors/metabolism
    Chemical Substances DNA Transposable Elements ; Fungal Proteins ; Polysaccharides ; RNA, Antisense ; Virulence Factors
    Language English
    Publishing date 2005-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1103773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genome sequence of Aedes aegypti, a major arbovirus vector.

    Nene, Vishvanath / Wortman, Jennifer R / Lawson, Daniel / Haas, Brian / Kodira, Chinnappa / Tu, Zhijian Jake / Loftus, Brendan / Xi, Zhiyong / Megy, Karyn / Grabherr, Manfred / Ren, Quinghu / Zdobnov, Evgeny M / Lobo, Neil F / Campbell, Kathryn S / Brown, Susan E / Bonaldo, Maria F / Zhu, Jingsong / Sinkins, Steven P / Hogenkamp, David G /
    Amedeo, Paolo / Arensburger, Peter / Atkinson, Peter W / Bidwell, Shelby / Biedler, Jim / Birney, Ewan / Bruggner, Robert V / Costas, Javier / Coy, Monique R / Crabtree, Jonathan / Crawford, Matt / Debruyn, Becky / Decaprio, David / Eiglmeier, Karin / Eisenstadt, Eric / El-Dorry, Hamza / Gelbart, William M / Gomes, Suely L / Hammond, Martin / Hannick, Linda I / Hogan, James R / Holmes, Michael H / Jaffe, David / Johnston, J Spencer / Kennedy, Ryan C / Koo, Hean / Kravitz, Saul / Kriventseva, Evgenia V / Kulp, David / Labutti, Kurt / Lee, Eduardo / Li, Song / Lovin, Diane D / Mao, Chunhong / Mauceli, Evan / Menck, Carlos F M / Miller, Jason R / Montgomery, Philip / Mori, Akio / Nascimento, Ana L / Naveira, Horacio F / Nusbaum, Chad / O'leary, Sinéad / Orvis, Joshua / Pertea, Mihaela / Quesneville, Hadi / Reidenbach, Kyanne R / Rogers, Yu-Hui / Roth, Charles W / Schneider, Jennifer R / Schatz, Michael / Shumway, Martin / Stanke, Mario / Stinson, Eric O / Tubio, Jose M C / Vanzee, Janice P / Verjovski-Almeida, Sergio / Werner, Doreen / White, Owen / Wyder, Stefan / Zeng, Qiandong / Zhao, Qi / Zhao, Yongmei / Hill, Catherine A / Raikhel, Alexander S / Soares, Marcelo B / Knudson, Dennis L / Lee, Norman H / Galagan, James / Salzberg, Steven L / Paulsen, Ian T / Dimopoulos, George / Collins, Frank H / Birren, Bruce / Fraser-Liggett, Claire M / Severson, David W

    Science (New York, N.Y.)

    2007  Volume 316, Issue 5832, Page(s) 1718–1723

    Abstract: We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% ... ...

    Abstract We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
    MeSH term(s) Aedes/genetics ; Aedes/metabolism ; Animals ; Anopheles/genetics ; Anopheles/metabolism ; Arboviruses ; Base Sequence ; DNA Transposable Elements ; Dengue/prevention & control ; Dengue/transmission ; Drosophila melanogaster/genetics ; Female ; Genes, Insect ; Genome, Insect ; Humans ; Insect Proteins/genetics ; Insect Vectors/genetics ; Insect Vectors/metabolism ; Male ; Membrane Transport Proteins/genetics ; Molecular Sequence Data ; Multigene Family ; Protein Structure, Tertiary/genetics ; Sequence Analysis, DNA ; Sex Characteristics ; Sex Determination Processes ; Species Specificity ; Synteny ; Transcription, Genetic ; Yellow Fever/prevention & control ; Yellow Fever/transmission
    Chemical Substances DNA Transposable Elements ; Insect Proteins ; Membrane Transport Proteins
    Language English
    Publishing date 2007-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1138878
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  7. Article ; Online: The genome sequence of the malaria mosquito Anopheles gambiae.

    Holt, Robert A / Subramanian, G Mani / Halpern, Aaron / Sutton, Granger G / Charlab, Rosane / Nusskern, Deborah R / Wincker, Patrick / Clark, Andrew G / Ribeiro, José M C / Wides, Ron / Salzberg, Steven L / Loftus, Brendan / Yandell, Mark / Majoros, William H / Rusch, Douglas B / Lai, Zhongwu / Kraft, Cheryl L / Abril, Josep F / Anthouard, Veronique /
    Arensburger, Peter / Atkinson, Peter W / Baden, Holly / de Berardinis, Veronique / Baldwin, Danita / Benes, Vladimir / Biedler, Jim / Blass, Claudia / Bolanos, Randall / Boscus, Didier / Barnstead, Mary / Cai, Shuang / Center, Angela / Chaturverdi, Kabir / Christophides, George K / Chrystal, Mathew A / Clamp, Michele / Cravchik, Anibal / Curwen, Val / Dana, Ali / Delcher, Art / Dew, Ian / Evans, Cheryl A / Flanigan, Michael / Grundschober-Freimoser, Anne / Friedli, Lisa / Gu, Zhiping / Guan, Ping / Guigo, Roderic / Hillenmeyer, Maureen E / Hladun, Susanne L / Hogan, James R / Hong, Young S / Hoover, Jeffrey / Jaillon, Olivier / Ke, Zhaoxi / Kodira, Chinnappa / Kokoza, Elena / Koutsos, Anastasios / Letunic, Ivica / Levitsky, Alex / Liang, Yong / Lin, Jhy-Jhu / Lobo, Neil F / Lopez, John R / Malek, Joel A / McIntosh, Tina C / Meister, Stephan / Miller, Jason / Mobarry, Clark / Mongin, Emmanuel / Murphy, Sean D / O'Brochta, David A / Pfannkoch, Cynthia / Qi, Rong / Regier, Megan A / Remington, Karin / Shao, Hongguang / Sharakhova, Maria V / Sitter, Cynthia D / Shetty, Jyoti / Smith, Thomas J / Strong, Renee / Sun, Jingtao / Thomasova, Dana / Ton, Lucas Q / Topalis, Pantelis / Tu, Zhijian / Unger, Maria F / Walenz, Brian / Wang, Aihui / Wang, Jian / Wang, Mei / Wang, Xuelan / Woodford, Kerry J / Wortman, Jennifer R / Wu, Martin / Yao, Alison / Zdobnov, Evgeny M / Zhang, Hongyu / Zhao, Qi / Zhao, Shaying / Zhu, Shiaoping C / Zhimulev, Igor / Coluzzi, Mario / della Torre, Alessandra / Roth, Charles W / Louis, Christos / Kalush, Francis / Mural, Richard J / Myers, Eugene W / Adams, Mark D / Smith, Hamilton O / Broder, Samuel / Gardner, Malcolm J / Fraser, Claire M / Birney, Ewan / Bork, Peer / Brey, Paul T / Venter, J Craig / Weissenbach, Jean / Kafatos, Fotis C / Collins, Frank H / Hoffman, Stephen L

    Science (New York, N.Y.)

    2002  Volume 298, Issue 5591, Page(s) 129–149

    Abstract: Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled ... ...

    Abstract Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence of two haplotypes of approximately equal frequency ("dual haplotypes") in a substantial fraction of the genome likely reflects the outbred nature of the PEST strain. The sequence produced a conservative inference of more than 400,000 single-nucleotide polymorphisms that showed a markedly bimodal density distribution. Analysis of the genome sequence revealed strong evidence for about 14,000 protein-encoding transcripts. Prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect.
    MeSH term(s) Animals ; Anopheles/classification ; Anopheles/genetics ; Anopheles/parasitology ; Anopheles/physiology ; Biological Evolution ; Blood ; Chromosome Inversion ; Chromosomes, Artificial, Bacterial ; Computational Biology ; DNA Transposable Elements ; Digestion ; Drosophila melanogaster/genetics ; Enzymes/chemistry ; Enzymes/genetics ; Enzymes/metabolism ; Expressed Sequence Tags ; Feeding Behavior ; Gene Expression Regulation ; Genes, Insect ; Genetic Variation ; Genome ; Haplotypes ; Humans ; Insect Proteins/chemistry ; Insect Proteins/genetics ; Insect Proteins/physiology ; Insect Vectors/genetics ; Insect Vectors/parasitology ; Insect Vectors/physiology ; Malaria, Falciparum/transmission ; Molecular Sequence Data ; Mosquito Control ; Physical Chromosome Mapping ; Plasmodium falciparum/growth & development ; Polymorphism, Single Nucleotide ; Proteome ; Sequence Analysis, DNA ; Species Specificity ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/physiology
    Chemical Substances DNA Transposable Elements ; Enzymes ; Insect Proteins ; Proteome ; Transcription Factors
    Language English
    Publishing date 2002-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1076181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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