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  1. Article ; Online: Comment on "Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients".

    Ferreira, Miguel R / Andreyev, Jervoise N / Wedlake, Linda / Dearnaley, David P

    British journal of cancer

    2023  Volume 128, Issue 5, Page(s) 711–712

    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Dietary Fiber ; Gastrointestinal Tract ; Pelvis
    Chemical Substances Dietary Fiber
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-023-02163-8
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  2. Article ; Online: What do readers want? Results of an online survey to involve readers in updating the seventh edition of the Manual of dietetic practice.

    Wedlake, Linda / Mellor, Duane / Marriott, Tom / Maslin, Kate / Frost, Gary / Hickson, Mary

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

    2023  Volume 37, Issue 1, Page(s) 280–291

    Abstract: Background: The Manual of dietetic practice ('Manual') is the core textbook for qualified and student dietitians. A survey was conducted to explore views on the scope, content and presentation of the Manual to inform the forthcoming edition.: Methods!# ...

    Abstract Background: The Manual of dietetic practice ('Manual') is the core textbook for qualified and student dietitians. A survey was conducted to explore views on the scope, content and presentation of the Manual to inform the forthcoming edition.
    Methods: The survey comprised of questions on demographics, structure, content, access (print/digital), missing topics, strengths and weaknesses. It was distributed to members of the British Dietetic Association (BDA) and other relevant groups in August 2022. Responses are presented as frequencies and free text as themes.
    Results: Of 1179 responses, 91% were from professionals, of whom 72% were registered dietitians with a mean of 12.7 years (range: 1-44) in practice: 60% worked in the United Kingdom with 52% based in a clinical setting. The printed version was preferred: 59% professionals, 60% students, 94% professionals and 88% students were satisfied with the structure; however, 26% professionals and 22% students identified content that was lacking or outdated, including mental health and sustainability. The strengths were its comprehensive coverage and respected contributing authors. Weaknesses included the cost, size, lack of visual aids and currency. Professionals indicated the seventh edition should focus on more practical information required for clinical practice, whereas students wanted more emphasis on summarised information and visual formats.
    Conclusions: The survey proved a valuable method to engage with the readership to ensure the next edition reflected their requirements. Although nearly all respondents were satisfied with the scope and content, the results highlighted those topics lacking and/or outdated. Results also showed that the next edition should focus on practical information required for clinical practice, with more summarised and visual formats.
    MeSH term(s) Humans ; Dietetics/education ; Nutritionists/education ; Students ; Surveys and Questionnaires ; United Kingdom ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13254
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    Zs.A 2551: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Humor in rehabilitation professions: a scoping review.

    Kfrerer, Marisa L / Rudman, Debbie Laliberte / Aitken Schermer, Julie / Wedlake, Marnie / Murphy, Michelle / Marshall, Carrie Anne

    Disability and rehabilitation

    2022  Volume 45, Issue 5, Page(s) 911–926

    Abstract: Purpose: Studying humor in the rehabilitation professions is important given its positive effects on health and well-being. We conducted a scoping review to understand how the use of humor has been explored in the existing literature in four ... ...

    Abstract Purpose: Studying humor in the rehabilitation professions is important given its positive effects on health and well-being. We conducted a scoping review to understand how the use of humor has been explored in the existing literature in four rehabilitation professions. The rehabilitation professions included audiology, speech-language pathology, physical therapy, and occupational therapy.
    Materials and methods: The five-stage method identified by Arksey and O'Malley was used to conduct this review. Six databases were searched. We included 57 articles in our final review, summarized in a narrative synthesis.
    Results: We generated seven themes in our analysis: (1) humour as a management strategy in therapy; (2) humour as a power establisher vs. equalizer; (3) humour as a coping mechanism in rehabilitation; (4) conceptualizations of non-verbal humor cues in therapy; (5) Is humour trainable? (6) Humor used to foster group cohesion; and (7) Attitudes and beliefs surrounding humor practice.
    Conclusions: Our findings emphasize the importance of using humor in the rehabilitation professions, and the ways in which humor is conceptualized in a multitude of ways for both clinician and client. Future work is needed to further understand the presence and use of humor in rehabilitation professions.IMPLICATIONS FOR REHABILITATIONIn a scoping review of the literature, this study showed that humor was used mainly positively in rehabilitation by the included professions of audiology, speech-language pathology, physical therapy, and occupational therapy and contributed to a sense of belonging.Humor may be an effective way to improve management of client/clinician relations as well as improving group cohesion in rehabilitation settings.In the rehabilitation professions of audiology, speech-language pathology, physical therapy, and occupational therapy, non-verbal humor cues were used in instances where communication was difficult or impaired for clients.
    MeSH term(s) Humans ; Occupational Therapy ; Physical Therapy Modalities ; Speech-Language Pathology ; Communication
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2022.2048909
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    Zs.A 1569: Show issues Location:
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  4. Book: Kenpo Karate 201

    Wedlake, Lee

    die Grundlagen- und Übungsformen

    2012  

    Author's details Lee Wedlake
    Size 112 Seiten: Illustrationen
    Edition Dt. Ausg.
    Publisher Books on Demand; Norderstedt
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT017499131
    ISBN 978-3-8482-3123-2 ; 3-8482-3123-9
    Database Central Library of Sport Science of the German Sport University Cologne

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  5. Article: Curation of myeloma observational study MALIMAR using XNAT: solving the challenges posed by real-world data.

    Doran, Simon J / Barfoot, Theo / Wedlake, Linda / Winfield, Jessica M / Petts, James / Glocker, Ben / Li, Xingfeng / Leach, Martin / Kaiser, Martin / Barwick, Tara D / Chaidos, Aristeidis / Satchwell, Laura / Soneji, Neil / Elgendy, Khalil / Sheeka, Alexander / Wallitt, Kathryn / Koh, Dow-Mu / Messiou, Christina / Rockall, Andrea

    Insights into imaging

    2024  Volume 15, Issue 1, Page(s) 47

    Abstract: Objectives: MAchine Learning In MyelomA Response (MALIMAR) is an observational clinical study combining "real-world" and clinical trial data, both retrospective and prospective. Images were acquired on three MRI scanners over a 10-year window at two ... ...

    Abstract Objectives: MAchine Learning In MyelomA Response (MALIMAR) is an observational clinical study combining "real-world" and clinical trial data, both retrospective and prospective. Images were acquired on three MRI scanners over a 10-year window at two institutions, leading to a need for extensive curation.
    Methods: Curation involved image aggregation, pseudonymisation, allocation between project phases, data cleaning, upload to an XNAT repository visible from multiple sites, annotation, incorporation of machine learning research outputs and quality assurance using programmatic methods.
    Results: A total of 796 whole-body MR imaging sessions from 462 subjects were curated. A major change in scan protocol part way through the retrospective window meant that approximately 30% of available imaging sessions had properties that differed significantly from the remainder of the data. Issues were found with a vendor-supplied clinical algorithm for "composing" whole-body images from multiple imaging stations. Historic weaknesses in a digital video disk (DVD) research archive (already addressed by the mid-2010s) were highlighted by incomplete datasets, some of which could not be completely recovered. The final dataset contained 736 imaging sessions for 432 subjects. Software was written to clean and harmonise data. Implications for the subsequent machine learning activity are considered.
    Conclusions: MALIMAR exemplifies the vital role that curation plays in machine learning studies that use real-world data. A research repository such as XNAT facilitates day-to-day management, ensures robustness and consistency and enhances the value of the final dataset. The types of process described here will be vital for future large-scale multi-institutional and multi-national imaging projects.
    Critical relevance statement: This article showcases innovative data curation methods using a state-of-the-art image repository platform; such tools will be vital for managing the large multi-institutional datasets required to train and validate generalisable ML algorithms and future foundation models in medical imaging.
    Key points: • Heterogeneous data in the MALIMAR study required the development of novel curation strategies. • Correction of multiple problems affecting the real-world data was successful, but implications for machine learning are still being evaluated. • Modern image repositories have rich application programming interfaces enabling data enrichment and programmatic QA, making them much more than simple "image marts".
    Language English
    Publishing date 2024-02-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-023-01591-7
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  6. Article ; Online: Assessing the collection and reporting of patient-reported outcome data in interventional cancer trials: a single institution, retrospective systematic evaluation.

    Lidington, Emma / Hogan, Holly / Gandolfi, Ann / Lawrence, Jane / Younger, Eugenie / Cho, Helena / Peckitt, Clare / Mohammed, Kabir / Matharu, Sheila / Scerri, Lisa / Husson, Olga / Cruickshank, Susanne / Turner, Rachel / Wedlake, Linda

    Journal of patient-reported outcomes

    2022  Volume 6, Issue 1, Page(s) 128

    Abstract: Background: To understand our performance with respect to the collection and reporting of patient-reported outcome (PRO) measure (PROM) data, we examined the protocol content, data completeness and publication of PROs from interventional trials ... ...

    Abstract Background: To understand our performance with respect to the collection and reporting of patient-reported outcome (PRO) measure (PROM) data, we examined the protocol content, data completeness and publication of PROs from interventional trials conducted at the Royal Marsden NHS Foundation Trust (RM) and explored factors associated with data missingness and PRO publication.
    Design: From local records, we identified closed, intervention trials sponsored by RM that opened after 1995 and collected PROMs as primary, secondary or exploratory outcomes. Protocol data were extracted by two researchers and scored against the SPIRIT-PRO (PRO protocol content checklist; score 0-100, higher scores indicate better completeness). For studies with locally held datasets, the information team summarized for each study, PRO completion defined as the number of expected (as per protocol) PRO measurements versus the number of actual (i.e. completed) PRO measurements captured in the study data set. Relevant publications were identified by searching three online databases and chief investigator request. Data were extracted and each publication scored against the CONSORT-PRO (PRO manuscript content checklist; scored as SPIRIT-PRO above). Descriptive statistics are presented with exploratory comparisons of point estimates and 95% confidence intervals.
    Results: Twenty-six of 65 studies were included in the review. Nineteen studies had accessible datasets and 18 studies published at least one article. Fourteen studies published PRO results. Most studies had a clinical (rather than PRO) primary outcome (16/26). Across all studies, responses in respect of 35 of 69 PROMs were published. Trial protocols scored on average 46.7 (range 7.1-92.9) on the SPIRIT-PRO. Among studies with accessible data, half (10/19) had less than 25% missing measurements. Publications scored on average 80.9 (range 36-100%) on the CONSORT-PRO. Studies that published PRO results had somewhat fewer missing measurements (19% [7-32%] vs 60% [- 26 to 146%]). For individual PROMs within studies, missing measurements were lower for those that were published (17% [10-24%] vs 41% [18-63%]). Studies with higher SPIRIT-PRO scores and PROs as primary endpoints (13% [4-22%] vs 39% [10-58%]) had fewer missing measurements.
    Conclusions: Missing data may affect publication of PROs. Extent of inclusion of SPIRIT-PRO protocol items and PROs as primary endpoints may improve data completeness. Preliminary evidence from the study suggests a future larger study examining the relationship between PRO completion and publication is warranted.
    Language English
    Publishing date 2022-12-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-022-00529-9
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  7. Article ; Online: Intensity-modulated Radiotherapy and Anal Cancer: Clinical Outcome and Late Toxicity Assessment.

    De Francesco, I / Thomas, K / Wedlake, L / Tait, D

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2016  Volume 28, Issue 9, Page(s) 604–610

    Abstract: Aims: To assess the potential impact on long-term consequences of treatment (intensity-modulated radiotherapy with concomitant chemotherapy) in patients diagnosed with anal cancer.: Materials and methods: We identified 43 eligible patients treated ... ...

    Abstract Aims: To assess the potential impact on long-term consequences of treatment (intensity-modulated radiotherapy with concomitant chemotherapy) in patients diagnosed with anal cancer.
    Materials and methods: We identified 43 eligible patients treated with concomitant chemoradiotherapy (pelvic intensity-modulated radiotherapy) at the Royal Marsden Hospital between 2010 and 2013. We determined late genitalia and bowel side-effects using specific questionnaires [Pelvic Symptom Questionnaire, Vaizey Incontinence Questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ) and IBDQ-B]. Using descriptive statistics, we report clinical outcomes in all patients, by time, since the end of treatment (grouped as 1-1.5, 1.5-2.5 and 2.5-3.5 years).
    Results: Twenty-seven of 43 (63%) patients were identified as available for questionnaire follow-up. Reasons for unavailability were death (n = 3), lost to palliative care service (n = 1), referred to surgery (n = 4), lost to follow-up (n = 8). In the 27 patients studied, bowel toxicity was assessed by IBDQ, IBDQ-B and the Vaizey Incontinence Questionnaire. The median value was 208 for IBDQ, 38 for IBDQ-B and 3.0 for the Vaizey Incontinence Questionnaire, as assessed at 1 year or more post-completion of treatment. Treatment was reported to affect quality of life/sexual function in two of the female patients (n = 21) and three male patients (n = 6). No insufficiency fractures have been reported. Bone marrow function remained stable over the time of the follow-up.
    Conclusions: Although there are data supporting a reduction in acute effects using intensity-modulated radiotherapy in anal cancer, there is very little in the literature to establish the late toxicity profile. Our results indicate that there is an effect on bowel and sexual function, but it does not increase over the period observed. These data provide a benchmark against which to compare outcomes with future manipulation in treatment, and provide us with real information to give patients as to the expectation of their functional outcome after treatment.
    MeSH term(s) Adult ; Aged ; Anus Neoplasms/drug therapy ; Anus Neoplasms/radiotherapy ; Chemoradiotherapy/adverse effects ; Chemoradiotherapy/methods ; Female ; Humans ; Male ; Middle Aged ; Quality of Life ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Surveys and Questionnaires
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2016.04.039
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    Zs.A 2774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Attitudes towards and knowledge of nutrition support amongst health care professionals on London intensive care units.

    Lane, C / Wedlake, L J / Dougherty, L / Shaw, C

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

    2014  Volume 27 Suppl 2, Page(s) 339–351

    Abstract: Background: Nutrition support on intensive care units (ICUs) has gained a higher profile ever since the development of published guidelines (Clin. Nutr. 2006, 25, 210; J. Parenter. Enteral Nutr. 2009, 33, 277; http://www.nice.org.uk/Guidance/CG32; Clin. ...

    Abstract Background: Nutrition support on intensive care units (ICUs) has gained a higher profile ever since the development of published guidelines (Clin. Nutr. 2006, 25, 210; J. Parenter. Enteral Nutr. 2009, 33, 277; http://www.nice.org.uk/Guidance/CG32; Clin. Nutr. 2009, 28, 387). However, there are limited data available on knowledge and attitudes towards nutrition support specific to ICU.
    Methods: An online survey was sent to all healthcare professionals working on ICUs across London via an e-mail link. The aim of the study was to assess the knowledge base of and attitudes of staff towards nutrition support, within an ICU setting, and to understand their educational needs. The results were analysed using descriptive statistics.
    Results: Attitudes were in line with the evidence in current nutrition guidelines. The proportion of healthcare professionals who were regarded as demonstrating sufficient understanding of the evidence set out in the nutrition support guidelines were 44% of clinicians, 26% of nurses, 76% of dietitians and 67% of other staff. In total, 59% of staff wanted more education on a number of aspects related to nutrition support on ICU.
    Conclusions: The present study highlights the need for more prominent dissemination of the current guidelines and illustrates the preferred mode. Specific gaps in knowledge regarding energy intake and the use of parenteral feeding are highlighted. It is hoped that the present survey will help to guide education in this area.
    MeSH term(s) Adult ; Cohort Studies ; Electronic Mail ; Female ; Health Knowledge, Attitudes, Practice ; Health Personnel/psychology ; Health Surveys ; Humans ; Intensive Care Units ; London ; Male ; Middle Aged ; Nutritional Support/methods ; Pilot Projects ; Surveys and Questionnaires
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.12152
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    Zs.A 2551: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Development of machine learning support for reading whole body diffusion-weighted MRI (WB-MRI) in myeloma for the detection and quantification of the extent of disease before and after treatment (MALIMAR): protocol for a cross-sectional diagnostic test accuracy study.

    Satchwell, Laura / Wedlake, Linda / Greenlay, Emily / Li, Xingfeng / Messiou, Christina / Glocker, Ben / Barwick, Tara / Barfoot, Theodore / Doran, Simon / Leach, Martin O / Koh, Dow Mu / Kaiser, Martin / Winzeck, Stefan / Qaiser, Talha / Aboagye, Eric / Rockall, Andrea

    BMJ open

    2022  Volume 12, Issue 10, Page(s) e067140

    Abstract: Introduction: Whole-body MRI (WB-MRI) is recommended by the National Institute of Clinical Excellence as the first-line imaging tool for diagnosis of multiple myeloma. Reporting WB-MRI scans requires expertise to interpret and can be challenging for ... ...

    Abstract Introduction: Whole-body MRI (WB-MRI) is recommended by the National Institute of Clinical Excellence as the first-line imaging tool for diagnosis of multiple myeloma. Reporting WB-MRI scans requires expertise to interpret and can be challenging for radiologists who need to meet rapid turn-around requirements. Automated computational tools based on machine learning (ML) could assist the radiologist in terms of sensitivity and reading speed and would facilitate improved accuracy, productivity and cost-effectiveness. The MALIMAR study aims to develop and validate a ML algorithm to increase the diagnostic accuracy and reading speed of radiological interpretation of WB-MRI compared with standard methods.
    Methods and analysis: This phase II/III imaging trial will perform retrospective analysis of previously obtained clinical radiology MRI scans and scans from healthy volunteers obtained prospectively to implement training and validation of an ML algorithm. The study will comprise three project phases using approximately 633 scans to (1) train the ML algorithm to identify active disease, (2) clinically validate the ML algorithm and (3) determine change in disease status following treatment via a quantification of burden of disease in patients with myeloma. Phase 1 will primarily train the ML algorithm to detect active myeloma against an expert assessment ('reference standard'). Phase 2 will use the ML output in the setting of radiology reader study to assess the difference in sensitivity when using ML-assisted reading or human-alone reading. Phase 3 will assess the agreement between experienced readers (with and without ML) and the reference standard in scoring both overall burden of disease before and after treatment, and response.
    Ethics and dissemination: MALIMAR has ethical approval from South Central-Oxford C Research Ethics Committee (REC Reference: 17/SC/0630). IRAS Project ID: 233501. CPMS Portfolio adoption (CPMS ID: 36766). Participants gave informed consent to participate in the study before taking part. MALIMAR is funded by National Institute for Healthcare Research Efficacy and Mechanism Evaluation funding (NIHR EME Project ID: 16/68/34). Findings will be made available through peer-reviewed publications and conference dissemination.
    Trial registration number: NCT03574454.
    MeSH term(s) Chlorobenzenes ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Cross-Sectional Studies ; Diagnostic Tests, Routine ; Humans ; Machine Learning ; Magnetic Resonance Imaging/methods ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/therapy ; Retrospective Studies ; Sulfides ; Whole Body Imaging/methods
    Chemical Substances Chlorobenzenes ; Sulfides ; 4-chlorophenyl methyl sulfide (123-09-1)
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-067140
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  10. Article ; Online: Systematic review: the efficacy of nutritional interventions to counteract acute gastrointestinal toxicity during therapeutic pelvic radiotherapy.

    Wedlake, L J / Shaw, C / Whelan, K / Andreyev, H J N

    Alimentary pharmacology & therapeutics

    2013  Volume 37, Issue 11, Page(s) 1046–1056

    Abstract: Background: Radiotherapy-induced damage to noncancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary ... ...

    Abstract Background: Radiotherapy-induced damage to noncancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option for the prevention and management of symptoms.
    Aim: To synthesise the evidence for the use of elemental formula low- or modified-fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the gastrointestinal tract during pelvic radiotherapy.
    Methods: Four electronic databases were searched. Randomised controlled trials (RCT), controlled trials (CT) and case series in adult patients receiving radiotherapy for pelvic cancers employing nutritional interventions to reduce gastrointestinal toxicity were included. Methodological quality was assessed using a bespoke tool.
    Results: Twenty-two original studies (2446 patients) were identified. Study quality was highly variable with only 37% scoring ≥10 points (maximum 17: bespoke scale). Few studies assessed compliance with the intervention. End-points varied and included symptom scales (IBDQ, CTC, Bristol Stool and RTOG). Evidence from RCTs was weak for elemental, low- or modified-fat, fibre and low-lactose interventions with 1/4, 3/4, 1/2, 0/1 trials respectively reporting favourable outcomes. Evidence for probiotics as prophylactic interventions was more promising (4/5 favourable), but dose, strains and methodologies varied.
    Conclusions: There is insufficient high-grade evidence to recommend nutritional intervention during pelvic radiotherapy. Total replacement of diet with elemental formula may be appropriate in severe toxicity. Probiotics offer promise, but cannot be introduced into clinical practice without rigorous safety analysis, not least in immunocompromised patients. The methodological quality of nutritional intervention studies needs to be improved.
    MeSH term(s) Diet, Fat-Restricted ; Dietary Supplements ; Feeding Behavior ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/prevention & control ; Gastrointestinal Tract/radiation effects ; Humans ; Pelvic Neoplasms/radiotherapy ; Radiation Injuries/etiology ; Radiation Injuries/prevention & control ; Radiotherapy/adverse effects ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.12316
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