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Article: Growth and Migration Blocking Effect of Nanaomycin K, a Compound Produced by

Hirata, Yuto / Shigemura, Katsumi / Moriwaki, Michika / Iwatsuki, Masato / Kan, Yuki / Ooya, Tooru / Maeda, Koki / Yang, Youngmin / Nakashima, Takuji / Matsuo, Hirotaka / Nakanishi, Jun / Fujisawa, Masato

Cancers

2023 Volume 15, Issue 10

Abstract: ... In this study, we investigated the anti-tumor effects of nanaomycin K, derived from " ...

Abstract	Since castration-resistant prostate cancer (CRPC) acquires resistance to molecularly targeted drugs, discovering a class of drugs with different mechanisms of action is needed for more efficient treatment. In this study, we investigated the anti-tumor effects of nanaomycin K, derived from "
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15102684
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Article ; Online: Two-Dimensional Perovskite Oxynitride K

Oshima, Takayoshi / Ichibha, Tom / Oqmhula, Kenji / Hibino, Keisuke / Mogi, Hiroto / Yamashita, Shunsuke / Fujii, Kotaro / Miseki, Yugo / Hongo, Kenta / Lu, Daling / Maezono, Ryo / Sayama, Kazuhiro / Yashima, Masatomo / Kimoto, Koji / Kato, Hideki / Kakihana, Masato / Kageyama, Hiroshi / Maeda, Kazuhiko

Angewandte Chemie (International ed. in English)

2020 Volume 59, Issue 24, Page(s) 9736–9743

Abstract: Undoped layered oxynitrides have not been considered as promising ... ...

Abstract	Undoped layered oxynitrides have not been considered as promising H
Language	English
Publishing date	2020-04-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202002534
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Article ; Online: Synthesis of Three-Layer Perovskite Oxynitride K

Tang, Ya / Kato, Kosaku / Oshima, Takayoshi / Mogi, Hiroto / Miyoshi, Akinobu / Fujii, Kotaro / Yanagisawa, Kei-Ichi / Kimoto, Koji / Yamakata, Akira / Yashima, Masatomo / Maeda, Kazuhiko

Inorganic chemistry

2020 Volume 59, Issue 15, Page(s) 11122–11128

Abstract: Substitution of oxide anions ( ... ...

Abstract	Substitution of oxide anions (O
Language	English
Publishing date	2020-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.0c01607
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Article ; Online: Synthesis and photocatalytic activity of K

Oshima, Takayoshi / Yokoi, Toshiyuki / Eguchi, Miharu / Maeda, Kazuhiko

Dalton transactions (Cambridge, England : 2003)

2017 Volume 46, Issue 32, Page(s) 10594–10601

Abstract: A new three-layer perovskite oxide with the Ruddlesden-Popper (R-P) phase, K ...

Abstract	A new three-layer perovskite oxide with the Ruddlesden-Popper (R-P) phase, K
Language	English
Publishing date	2017-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c6dt04872b
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Article: A Japanese Dose of Prasugrel versus a Standard Dose of Clopidogrel in Patients with Acute Myocardial Infarction from the K-ACTIVE Registry.

Mori, Hiroyoshi / Mizukami, Takuya / Maeda, Atsuo / Fukui, Kazuki / Akashi, Yoshihiro / Ako, Junya / Ikari, Yuji / Ebina, Toshiaki / Tamura, Kouichi / Namiki, Atsuo / Michishita, Ichiro / Kimura, Kazuo / Suzuki, Hiroshi

Journal of clinical medicine

2022 Volume 11, Issue 7

Abstract: ... data regarding its efficacy and safety exist.: Methods: From the K-ACTIVE registry, based ...

Abstract	Background: Dual antiplatelet therapy (DAPT) with aspirin plus P2Y12 inhibitor is used as a standard therapy for patients with acute myocardial infarction (AMI) treated with drug-eluting stents (DESs). In Japan, clopidogrel was the major P2Y12 inhibitor used for a decade until the new P2Y12 inhibitor, prasugrel, was introduced. Based on clinical studies considering Japanese features, the set dose for prasugrel was reduced to 20 mg as a loading dose (LD) and 3.75 mg as a maintenance dose (MD); these values are 60 and 10 mg, respectively, globally. Despite this dose discrepancy, little real-world clinical data regarding its efficacy and safety exist. Methods: From the K-ACTIVE registry, based on the DAPT regimen, patients were divided into a prasugrel group and a clopidogrel group. The ischemic event was a composite of cardiovascular death, non-fatal MI, and non-fatal stroke. The bleeding event was type 3 or 5 bleeding based on the Bleeding Academic Research Consortium (BARC) criteria. Results: Substantially more patients were prescribed prasugrel ( Conclusion: A Japanese dose of prasugrel was commonly used in AMI patients in the real-world database. Both the prasugrel and clopidogrel groups showed comparable rates of 1 year ischemic and bleeding events.
Language	English
Publishing date	2022-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11072016
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Article ; Online: Impact of atrial fibrillation and the clinical outcomes in patients with acute myocardial infarction from the K-ACTIVE registry.

Mori, Hiroyoshi / Fukui, Kazuki / Maeda, Atsuo / Akashi, Yoshihiro / Ako, Junya / Ikari, Yuji / Ebina, Toshiaki / Tamura, Kouichi / Namiki, Atsuo / Michishita, Ichiro / Kimura, Kazuo / Suzuki, Hiroshi

Journal of cardiology

2022 Volume 79, Issue 6, Page(s) 768–775

Abstract: ... multicenter registry of acute myocardial infarction (K-ACTIVE: Kanagawa ACuTe cardIoVascular rEgistry ...

Abstract	Background: The clinical incidence and impact of atrial fibrillation (AF) in Japanese acute myocardial infarction (AMI) patients is not fully understood. Methods: To elucidate the clinical incidence and impact of AF on in-hospital mortality in AMI patients, we analyzed a Japanese observational prospective multicenter registry of acute myocardial infarction (K-ACTIVE: Kanagawa ACuTe cardIoVascular rEgistry), which spans 2015 to 2019. A major adverse cardiac event (MACE) was defined as cardiovascular death, non-fatal myocardial infarction (MI), and non-fatal stroke. For assessing bleeding events, Bleeding Academic Research Consortium (BARC) type 3 or 5 was used. MACE plus BARC type 3 or 5 bleeding were considered as composite events. The clinical outcomes were followed for 1 year. Results: The total of 5059 patients included 531 patients with AF (10.5%) and 4528 patients with sinus rhythm (SR; 89.5%). AF patients were significantly older and tended to have more comorbidities than SR patients. Oral anticoagulation therapy (OAC) was used in 44% of AF patients while single antiplatelet therapy was selected for 52% of patients with OAC. Crude in-hospital mortality was significantly greater in AF patients than in SR patients (10.4%, 5.0%, respectively, p < 0.01). The multivariate analysis was adjusted for age, sex, diabetes, hypertension, hemodialysis, smoking, previous MI, body mass index, Killip classification, out of hospital cardiac arrest, and OAC. In-hospital mortality was still significantly greater in AF patients than in SR patients in the logistic regression analysis [adjusted odds ratio 2.02 (1.31-3.14)]. AF was an independent risk factor for MACE and composite events in the Cox proportional hazards model [adjusted risk ratio (ARR) 1.91 (1.36-2.69), p < 0.01; ARR 1.72 (1.25-2.36), p < 0.01]. In contrast, AF was not an independent risk factor for bleeding [ARR 1.71 (0.79-3.71), p = 0.18]. Conclusion: In Japanese AMI patients, AF was often observed and was associated with worse MACE but not worse bleeding.
MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Fibrillation ; Hemorrhage/chemically induced ; Humans ; Myocardial Infarction ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Registries ; Risk Factors ; Stroke/complications ; Stroke/etiology ; Treatment Outcome
Chemical Substances	Anticoagulants ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2022-02-23
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2022.02.007
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Article ; Online: Search for K_{L}→π^{0}νν[over ¯] and K_{L}→π^{0}X^{0} Decays at the J-PARC KOTO Experiment.

Ahn, J K / Beckford, B / Beechert, J / Bryant, K / Campbell, M / Chen, S H / Comfort, J / Dona, K / Hara, N / Haraguchi, H / Hsiung, Y B / Hutcheson, M / Inagaki, T / Kamiji, I / Kawasaki, N / Kim, E J / Kim, J L / Kim, Y J / Ko, J W /

Komatsubara, T K / Kotera, K / Kurilin, A S / Lee, J W / Lim, G Y / Lin, C / Lin, Q / Luo, Y / Ma, J / Maeda, Y / Mari, T / Masuda, T / Matsumura, T / Mcfarland, D / McNeal, N / Micallef, J / Miyazaki, K / Murayama, R / Naito, D / Nakagiri, K / Nanjo, H / Nishimiya, H / Nomura, T / Ohsugi, M / Okuno, H / Sasaki, M / Sasao, N / Sato, K / Sato, T / Sato, Y / Schamis, H / Seki, S / Shimizu, N / Shimogawa, T / Shinkawa, T / Shinohara, S / Shiomi, K / Su, S / Sugiyama, Y / Suzuki, S / Tajima, Y / Taylor, M / Tecchio, M / Togawa, M / Tung, Y C / Wah, Y W / Watanabe, H / Woo, J K / Yamanaka, T / Yoshida, H Y

Physical review letters

2019 Volume 122, Issue 2, Page(s) 21802

Abstract: A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015 ... for the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level (C.L.), which improved the previous ... limit by almost an order of magnitude. An upper limit for K_{L}→π^{0}X^{0} was also set as 2.4×10^{-9 ...

Abstract	A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015, corresponding to 2.2×10^{19} protons on target, a single event sensitivity of (1.30±0.01_{stat}±0.14_{syst})×10^{-9} was achieved and no candidate events were observed. We set an upper limit of 3.0×10^{-9} for the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level (C.L.), which improved the previous limit by almost an order of magnitude. An upper limit for K_{L}→π^{0}X^{0} was also set as 2.4×10^{-9} at the 90% C.L., where X^{0} is an invisible boson with a mass of 135 MeV/c^{2}.
Language	English
Publishing date	2019-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.122.021802
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Article ; Online: Distribution of proteinase K-resistant anti-α-synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall.

Fukasawa, Nei / Maeda, Miku / Sugiyama, Yoshifumi / Fukuda, Takahiro / Shimoda, Masayuki

Pathology international

2023 Volume 74, Issue 1, Page(s) 1–12

Abstract: ... from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically ...

Abstract	Lewy body disease (LBD) is characterized by the appearance of Lewy neurites and Lewy bodies, which are predominantly composed of α-synuclein. Notably, the cardiac plexus (CP) is one of the main targets of LBD research. Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any part of the CP. Thus, we aimed to clarify the emergence and/or propagation of LBP in the CP. In this study, 263 consecutive autopsy cases of patients aged ≥50 years were included, with one region per case selected from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically stained with anti-α-synuclein antibodies to assess LBP. We stained all three MPAs in 17 cases with low-density LBP and observed the actual distribution of LBP. LBP were identified in the CP in 20.2% (53/263) of patients. Moreover, we found that LBP may appear in only one region of MPAs, mainly in the young-old group (35.3% (6/17) of patients). These findings suggest that it is possible to underestimate LBP in the CP, especially in the young-old group, by restricting the search to only one of the three MPAs.
MeSH term(s)	Humans ; alpha-Synuclein ; Endopeptidase K ; Lewy Body Disease/pathology ; Axons/pathology ; Lewy Bodies/pathology
Chemical Substances	alpha-Synuclein ; Endopeptidase K (EC 3.4.21.64)
Language	English
Publishing date	2023-12-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13389
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Article ; Online: Superconductivity at 38 K at an electrochemical interface between an ionic liquid and FeSe

Kouno, Shunsuke / Sato, Yohei / Katayama, Yumiko / Ichinose, Ataru / Asami, Daisuke / Nabeshima, Fuyuki / Imai, Yoshinori / Maeda, Atsutaka / Ueno, Kazunori

Scientific reports

2018 Volume 8, Issue 1, Page(s) 14731

Abstract: Superconducting ... ...

Abstract	Superconducting FeSe
Language	English
Publishing date	2018-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-33121-7
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Article ; Online: Radial versus femoral access in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: A propensity-matched analysis from real-world data of the K-ACTIVE registry.

Mori, Hiroyoshi / Sakurai, Kaoru / Ikari, Yuji / Fukui, Kazuki / Maeda, Atsuo / Akashi, Yoshihiro / Ako, Junya / Ebina, Toshiaki / Tamura, Kouichi / Namiki, Atsuo / Michishita, Ichiro / Kimura, Kazuo / Suzuki, Hiroshi

Journal of cardiology

2022 Volume 81, Issue 2, Page(s) 189–195

Abstract: ... of acute myocardial infarction (K-ACTIVE: Kanagawa ACuTe cardIoVascular rEgistry) in 2015 to 2021. Data ...

Abstract	Background: The access site for primary percutaneous coronary intervention (PCI) for patients with ST-elevation myocardial infarction (STEMI) recently shifted from femoral to radial. However, few real-world data on Japanese patients exist. Methods: To elucidate the clinical selection and impact of the access site in STEMI patients, we analyzed a Japanese observational prospective multicenter registry of acute myocardial infarction (K-ACTIVE: Kanagawa ACuTe cardIoVascular rEgistry) in 2015 to 2021. Data were analyzed in the entire population and a propensity score-matched population adjusted for confounding factors. Major adverse cardiac event (MACE) was defined as cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Bleeding Academic Research Consortium (BARC) type 3 or 5 was used to assess bleeding events. MACE plus BARC type 3 or 5 bleeding were considered composite events. Clinical outcomes were followed for 30 days. Results: The 6802 STEMI patients included 4786 patients with radial access (70.3 %) and 2016 with femoral access (29.7 %). Femoral access tended to be selected for more severe conditions than radial access. The median door-to-device time in the radial access group was significantly shorter than the femoral access group in the entire population (75 min versus 79 min, p < 0.01). After propensity score matching (each group, n = 1208), the incidence of MACE tended to be lower in the radial access group [risk ratio (RR) 0.83, 95 % confidence interval (CI) 0.63-1.09, p = 0.17]. The incidence of BARC 3 or 5 bleeding was significantly less in the radial access group (RR 0.47, 95%CI 0.23-0.97, p = 0.04). The incidence of composite events was significantly less in the radial access group (RR 0.74, 95%CI 0.57-0.96, p = 0.02). Conclusion: In STEMI patients undergoing primary PCI, in comparison to femoral access, radial access reduced composite events in the entire population and the matched population, through a reduction in MACE and BARC 3 or 5 bleeding.
MeSH term(s)	Humans ; ST Elevation Myocardial Infarction/surgery ; Percutaneous Coronary Intervention/adverse effects ; Radial Artery ; Prospective Studies ; Femoral Artery ; Myocardial Infarction/etiology ; Registries ; Hemorrhage/etiology ; Treatment Outcome
Language	English
Publishing date	2022-09-24
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2022.09.001
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