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  1. Article ; Online: Cancer matters: Now more than ever!

    Ramalingam, Suresh S

    Cancer

    2021  Volume 127, Issue 13, Page(s) 2174–2176

    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Sensing of Quercetin With Cobalt-Doped Manganese Nanosystems by Electrochemical Method.

    Thalir, Sree / Celshia Susai, Sherin / Selvamani, Muthamizh / Suresh, Vasugi / Sethuraman, Sathya / Ramalingam, Karthikeyan

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56665

    Abstract: Background: The pressing need for precise, quick, and affordable detection of diverse biomolecules has led to notable developments in the realm of biosensors. Quercetin, a biomolecule rich in flavonoids predominantly found in our diet, is sensed by the ... ...

    Abstract Background: The pressing need for precise, quick, and affordable detection of diverse biomolecules has led to notable developments in the realm of biosensors. Quercetin, a biomolecule rich in flavonoids predominantly found in our diet, is sensed by the electrochemical method. The electrochemical properties show remarkable improvement when Mn
    Conclusion: The Co-doped MO exhibited enhanced conductivity, reactivity, and electrochemical performance. This tailored approach will help in the optimization of material properties toward specific biomolecule sensing applications.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neoadjuvant therapy gains FDA approval in non-small cell lung cancer.

    Leal, Ticiana A / Ramalingam, Suresh S

    Cell reports. Medicine

    2022  Volume 3, Issue 7, Page(s) 100691

    Abstract: Forde et al. ...

    Abstract Forde et al.
    MeSH term(s) Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Neoadjuvant Therapy ; Nivolumab/administration & dosage ; Progression-Free Survival
    Chemical Substances Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Targeted Drug Designing for Treating Masticatory Myofascial Pain Dysfunction Syndrome: An In Silico Simulation Study.

    Suresh, Ramya / Ramadoss, Ramya / Doble, Mukesh / Ramalingam, Karthikeyan / Sundar, Sandhya / Panneer Selvam, Suganya

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51661

    Abstract: Background Masticatory Myofascial Pain Dysfunction Syndrome (MMPDS) is a musculoligamentous disorder that shares similarities with temporomandibular joint pain and odontogenic pain. It manifests as dull or aching pain in masticatory muscles, influenced ... ...

    Abstract Background Masticatory Myofascial Pain Dysfunction Syndrome (MMPDS) is a musculoligamentous disorder that shares similarities with temporomandibular joint pain and odontogenic pain. It manifests as dull or aching pain in masticatory muscles, influenced by jaw movement. Computer-aided drug design (CADD) encompasses various theoretical and computational approaches used in modern drug discovery. Molecular docking is a prominent method in CADD that facilitates the understanding of drug-bimolecular interactions for rational drug design, mechanistic studies & the formation of stable complexes with increased specificity and potential efficacy. The docking technique provides valuable insights into binding energy, free energy, and complex stability predictions. Aim The aim of this study was to use the docking technique for myosin inhibitors. Materials and methods Four inhibitors of myosin were chosen from the literature. These compound structures were retrieved from the Zinc15 database. Myosin protein was chosen as the target and was optimized using the RCSB Protein Data Bank. After pharmacophore modeling, 20 novel compounds were found and the SwissDock was used to dock them with the target protein. We compared the binding energies of the newly discovered compounds to those of the previously published molecules with the target. Results The results indicated that among the 20 molecules ZINC035924607 and ZINC5110352 exhibited the highest binding energy and displayed superior properties compared to the other molecules. Conclusion The study concluded that ZINC035924607 and ZINC5110352 exhibited greater binding affinity than the reported inhibitors of myosin. Therefore, these two molecules can be used as a potential and promising lead for the treatment of MMPDS and could be employed in targeted drug therapy.
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The National Cancer Act of 1971: A seminal milestone in the fight against cancer.

    Ramalingam, Suresh S / Khuri, Fadlo R

    Cancer

    2021  Volume 127, Issue 24, Page(s) 4532–4533

    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34001
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  6. Article ; Online: Harnessing CD8 T cell responses using PD-1-IL-2 combination therapy.

    Hashimoto, Masao / Ramalingam, Suresh S / Ahmed, Rafi

    Trends in cancer

    2023  Volume 10, Issue 4, Page(s) 332–346

    Abstract: There is considerable interest in developing more effective programmed cell death (PD)-1 combination therapies against cancer. One major obstacle to these efforts is a dysfunctional/exhausted state of CD8 T cells, which PD-1 monotherapy is not able to ... ...

    Abstract There is considerable interest in developing more effective programmed cell death (PD)-1 combination therapies against cancer. One major obstacle to these efforts is a dysfunctional/exhausted state of CD8 T cells, which PD-1 monotherapy is not able to overcome. Recent studies have highlighted that PD-1
    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor/metabolism ; Interleukin-2/pharmacology ; Interleukin-2/therapeutic use ; Interleukin-2/metabolism ; CD8-Positive T-Lymphocytes ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Cell Differentiation
    Chemical Substances Programmed Cell Death 1 Receptor ; Interleukin-2
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Training community health workers to limit the transmission of monkeypox virus in India: an urgent need for action.

    Sekaran, Saravanan / Ramalingam, Gayatri Devi / Arumugasamy, Harini / R Sekar, Suresh Kumar

    International journal of surgery (London, England)

    2023  Volume 109, Issue 3, Page(s) 545–546

    MeSH term(s) Humans ; Monkeypox virus ; Community Health Workers/education ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks ; India
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lung-MAP: A Collaborative Roadmap to Improve Cancer Outcomes.

    Leal, Ticiana A / Dahlberg, Suzanne E / Ramalingam, Suresh S

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 21, Page(s) 2285–2287

    MeSH term(s) Humans ; Lung ; Neoplasms
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advances in Immunotherapy and Implications for Current Practice in Non-Small-Cell Lung Cancer.

    Steuer, Conor E / Ramalingam, Suresh S

    JCO oncology practice

    2021  Volume 17, Issue 11, Page(s) 662–668

    Abstract: Treatment options for patients with non-small-cell lung cancer (NSCLC) have improved dramatically in recent years. For decades, harnessing a person's own immune system to fight cancer has been a major area of research in oncology. Recently, these efforts ...

    Abstract Treatment options for patients with non-small-cell lung cancer (NSCLC) have improved dramatically in recent years. For decades, harnessing a person's own immune system to fight cancer has been a major area of research in oncology. Recently, these efforts have proven successful with the development of immune checkpoint inhibitors; these agents have now become part of the routine care of NSCLC. Presently, five programmed cell death-1 and programmed cell death-1 ligand 1 inhibitors and one anti-cytotoxic T-cell lymphocyte-4 inhibitor are US Food and Drug Administration-approved in the treatment of NSCLC. These drugs have made a dramatic difference in the lives of patients with NSCLC, although durable benefits are limited to a subset of patients. In this review, we highlight the trials that led to our current treatment practices, discuss areas of active research, and address common clinical issues that have risen as immune therapy has become a mainstay of treatment in NSCLC.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Immunotherapy ; Lung Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.21.00305
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    Zs.A 7198: Show issues Location:
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  10. Article: EGFR tyrosine kinase inhibitors (TKIs) for adjuvant therapy of early-stage non-small cell lung cancer (NSCLC): ready for the clinic?

    Steuer, Conor E / Ramalingam, Suresh S

    Translational lung cancer research

    2020  Volume 9, Issue 5, Page(s) 1720–1723

    Language English
    Publishing date 2020-11-04
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-2020-13
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