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  1. Article ; Online: Fourier-synthesis approach for static charge-density reconstruction from theoretical structure factors of CaB

    Bergner, Carina / Grin, Yuri / Wagner, Frank Richard

    Acta crystallographica. Section A, Foundations and advances

    2023  Volume 79, Issue Pt 3, Page(s) 246–272

    Abstract: In a pilot study, electron-density (ED) and ED Laplacian distributions were reconstructed for the challenging case of ... ...

    Abstract In a pilot study, electron-density (ED) and ED Laplacian distributions were reconstructed for the challenging case of CaB
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020844-3
    ISSN 2053-2733 ; 1600-5724 ; 0108-7673
    ISSN (online) 2053-2733 ; 1600-5724
    ISSN 0108-7673
    DOI 10.1107/S2053273323002644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Experience report of two living systematic Cochrane reviews on COVID-19.

    Wagner, Carina / Hirsch, Caroline / Siemens, Waldemar / Kapp, Philipp / Iannizzi, Claire

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2024  Volume 184, Page(s) 90–95

    Abstract: Introduction: Up-to-date systematic reviews (SRs) are essential for making evidence-based decisions. During the 2019 coronavirus (COVID-19) pandemic, there was a particular need for up-to-date evidence, making the living systematic review (LSR) approach ...

    Abstract Introduction: Up-to-date systematic reviews (SRs) are essential for making evidence-based decisions. During the 2019 coronavirus (COVID-19) pandemic, there was a particular need for up-to-date evidence, making the living systematic review (LSR) approach an appropriate review type. However, this approach poses certain challenges.
    Objective and outline: We aim to provide practice insights and report challenges that we faced while conducting two Cochrane LSRs on COVID-19 treatments with (i) convalescent plasma and (ii) systemic corticosteroids. We address our objective with an experience report and share challenges of the following components based on Iannizzi et al. (2022): study design, publication types, intervention/comparator, outcomes, search strategy, review updates and transparent reporting of differences between review updates.
    Results: Regarding the study design, the plasma LSR included different study designs because RCT data were not available at the beginning of the pandemic, whereas for the corticosteroids LSR, which started several months later, RCT data were already available. The challenges in both LSRs included the publication types (preprints were included with caution) and the intervention/comparator, for instance the unavailability of standard of care for either LSR, or SARS-CoV-2 variants occurrence. Further challenges in both LSRs occurred in the components "outcome sets" (which had to be adjusted) and "literature search". The decision criteria for updating were based on important studies and available resources in both LSRs and policy relevance in the plasma LSR. Transparent reporting of the differences between the various update versions were discussed for both LSRs.
    Discussion and conclusion: In summary, there are similarities and differences regarding challenges of review components for both LSRs. It is important to keep in mind that the two LSR examples presented here were conducted in the wake of the COVID-19 pandemic. Therefore, many of the challenges are attributable to the pandemic and are not specific to LSRs, such as constant adjustments of the outcome sets or changes in the database search. Nevertheless, we believe that some of these aspects are helpful for LSR authors and are applicable to other LSRs outside the pandemic context, particularly in areas where new evidence is rapidly emerging.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; COVID-19 Serotherapy ; Germany ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2023.11.004
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Conference proceedings: GRADE – Summary-of-Findings-Tabellen und Evidenzprofile richtig verstehen

    Wagner, Carina / Csenar, Mario / Hirsch, Caroline

    2023  , Page(s) 23ebmWS2–01

    Event/congress 24. Jahrestagung des Netzwerks Evidenzbasierte Medizin; Gesundheit und Klima – EbM für die Zukunft; Potsdam; Netzwerk Evidenzbasierte Medizin e.V.; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-03-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23ebm133
    Database German Medical Science

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  4. Article: KIAA1363-A Multifunctional Enzyme in Xenobiotic Detoxification and Lipid Ester Hydrolysis.

    Wagner, Carina / Hois, Victoria / Taschler, Ulrike / Schupp, Michael / Lass, Achim

    Metabolites

    2022  Volume 12, Issue 6

    Abstract: KIAA1363, annotated as neutral cholesterol ester hydrolase 1 (NCEH1), is a member of the arylacetamide deacetylase (AADAC) protein family. The name-giving enzyme, AADAC, is known to hydrolyze amide and ester bonds of a number of xenobiotic substances, as ...

    Abstract KIAA1363, annotated as neutral cholesterol ester hydrolase 1 (NCEH1), is a member of the arylacetamide deacetylase (AADAC) protein family. The name-giving enzyme, AADAC, is known to hydrolyze amide and ester bonds of a number of xenobiotic substances, as well as clinical drugs and of endogenous lipid substrates such as diglycerides, respectively. Similarly, KIAA1363, annotated as the first AADAC-like protein, exhibits enzymatic activities for a diverse substrate range including the xenobiotic insecticide chlorpyrifos oxon and endogenous substrates, acetyl monoalkylglycerol ether, cholesterol ester, and retinyl ester. Two independent knockout mouse models have been generated and characterized. However, apart from reduced acetyl monoalkylglycerol ether and cholesterol ester hydrolase activity in specific tissues and cell types, no gross-phenotype has been reported. This raises the question of its physiological role and whether it functions as drug detoxifying enzyme and/or as hydrolase/lipase of endogenous substrates. This review delineates the current knowledge about the structure, function and of the physiological role of KIAA1363, as evident from the phenotypical changes inflicted by pharmacological inhibition or by silencing as well as knockout of KIAA1363 gene expression in cells, as well as mouse models, respectively.
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12060516
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  5. Conference proceedings: GRADE – Summary-of-findings-Tabellen und Evidenzprofile richtig verstehen

    Csenar, Mario / Hirsch, Caroline / Goldkuhle, Marius / Töws, Ingrid / Wagner, Carina

    2022  , Page(s) 22ebmWS02

    Event/congress 23. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin; Evidenzbasierte Medizin für eine bedarfsgerechte Gesundheitsversorgung; Lübeck; Deutsches Netzwerk Evidenzbasierte Medizin e.V.; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22ebm171
    Database German Medical Science

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  6. Article: Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in

    Čiučiulkaitė, Ieva / Siffert, Winfried / Elsner, Carina / Dittmer, Ulf / Wichert, Marc / Wagner, Bernd / Volbracht, Lothar / Mosel, Frank / Möhlendick, Birte

    Vaccines

    2023  Volume 11, Issue 7

    Abstract: The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination ...

    Abstract The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination with the COVID-19 vaccines are variable within a population. Host genetic factors probably contribute to this variability. In this study, we investigated the effect of the single-nucleotide polymorphisms rs12252 and rs34481144 in the
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11071257
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  7. Conference proceedings: Verfügbarkeit, Preise und Finanzierbarkeit essentieller Krebsmedikamente (EML der WHO) in einkommensschwächeren Ländern: wirkungsvolle Implementierung von Cochrane-Evidenz?

    Wagner, Carina / Skoetz, Nicole / Piechotta, Vanessa

    2021  , Page(s) 21ebmPS–4–05

    Event/congress 22. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin; Who cares? – EbM und Transformation im Gesundheitswesen; sine loco [digital]; Deutsches Netzwerk Evidenzbasierte Medizin e.V.; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-02-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21ebm077
    Database German Medical Science

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  8. Article ; Online: Assessing the Impact of ESD

    Quentin Ssossé / Johanna Wagner / Carina Hopper

    Sustainability, Vol 13, Iss 5, p

    Methods, Challenges, Results

    2021  Volume 2854

    Abstract: Education for Sustainable Development (ESD; also often called Education for Sustainability (EfS)) is a key lever of the United Nations’ Sustainable Development Goals, which emphasize the need for everyone to have the knowledge and skills to meet the ... ...

    Abstract Education for Sustainable Development (ESD; also often called Education for Sustainability (EfS)) is a key lever of the United Nations’ Sustainable Development Goals, which emphasize the need for everyone to have the knowledge and skills to meet the challenges of creating a more sustainable world. However, while we can find examples of ESD across the globe, its potential to scale effectively and its impact on achieving the goals of sustainable development as compared with traditional curricula are often questioned. This literature review, at the crossroads of econometrics, educational sciences and psychology, aims to foster scaled ESD research and initiatives by offering a better understanding of the doubts that surround its potential impact. To that end, we (1) shed light on the methods and good practices for assessing this impact; (2) underline the specificity of the data to be collected in the context of these methods of assessment; and (3) outline the existing conclusions of impact studies dedicated to ESD that have served to highlight the limits and challenges for accurate measurement. These impact studies suggest that ESD will only achieve its objectives if pedagogical approaches are renewed. The inclusion of studies showing de facto poor results for ESD makes it possible to complete the picture of the endogenous and exogenous factors determining sustainable behavior that must be taken into account, both in the design of impact assessment tools and in the concrete implementation of ESD.
    Keywords education for sustainable development ; sustainability education ; environmental literacy ; competences for sustainable development ; sustainability citizens ; impact assessment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 306 ; 370
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: PUFA Changes in White Adipose Tissue during Hibernation in Common Hamsters.

    Siutz, Carina / Nemeth, Matthias / Quint, Ruth / Wagner, Karl-Heinz / Millesi, Eva

    Physiological and biochemical zoology : PBZ

    2022  Volume 95, Issue 6, Page(s) 525–535

    Abstract: AbstractHibernators save energy during winter by expressing torpor bouts characterized by strongly reduced body temperature and metabolic rate. Polyunsaturated fatty acids (PUFAs), specifically n-6 PUFAs, are known to positively affect hibernation ... ...

    Abstract AbstractHibernators save energy during winter by expressing torpor bouts characterized by strongly reduced body temperature and metabolic rate. Polyunsaturated fatty acids (PUFAs), specifically n-6 PUFAs, are known to positively affect hibernation performance and thereby energy savings predominantly in fat-storing hibernators. Accordingly, hibernators usually retain PUFAs and mobilize monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) during hibernation. In food-storing common hamsters (
    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Cricetinae ; Fatty Acids/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated/metabolism ; Hibernation
    Chemical Substances Fatty Acids ; Fatty Acids, Monounsaturated ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1473845-4
    ISSN 1537-5293 ; 1522-2152
    ISSN (online) 1537-5293
    ISSN 1522-2152
    DOI 10.1086/721444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prospective Study on the Influence of Occupational Hand Protection Products on the Efficacy of Hand Disinfection.

    Metzger, Magdalena / Manhartseder, Stefan / Krausgruber, Leonie / Wagner, Carina / Frank, Sara / Reisner, Rosmarie / Ehling-Schulz, Monika / Grillari, Johannes / Hosemann, Roswitha / Dungel, Peter

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 6

    Abstract: Background: To prevent occupational skin diseases, employees are instructed to periodically apply hand protection products as a barrier to protect their hands from water, cleaning agents or other irritants. The aim of this work was to investigate ... ...

    Abstract Background: To prevent occupational skin diseases, employees are instructed to periodically apply hand protection products as a barrier to protect their hands from water, cleaning agents or other irritants. The aim of this work was to investigate whether bacteria present on the skin at the time of protection product application are enclosed underneath this protective layer, if they can be transferred to other surfaces and if a standard isopropanol-based skin disinfectant can nonetheless reduce the bacterial burden.
    Methods: This prospective study was conducted in human volunteers based on the European Standard (EN 1500) to assess the burden of microorganisms before and after the application of various protection product formulations and subsequent hand disinfection.
    Results: All protection products, with the exception of alcohol-based gels, enclosed bacteria underneath a lipid layer which could be transferred onto other surfaces. Still, the hand disinfectant efficiently reduced the bacteria burden.
    Discussion: In occupations where proper hand hygiene is vital, alcohol-based gels might be the best option for the protection of the skin barrier as well as for reducing the contamination risk.
    Conclusion: An alcohol-based disinfection agent can dissolve the lipid film of protection products following the standard protocol for hygienic hand disinfection.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12060646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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