LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 205

Search options

  1. Article ; Online: Special Issue: "Innate Immune Sensing of Viruses and Viral Evasion".

    König, Renate / Münk, Carsten

    Viruses

    2021  Volume 13, Issue 4

    Abstract: In this Special Issue, a wide variety of original and review articles provide a timely overview of how viruses are recognized by and evade from cellular innate immunity, which represents the first line of defense against viruses [ ... ]. ...

    Abstract In this Special Issue, a wide variety of original and review articles provide a timely overview of how viruses are recognized by and evade from cellular innate immunity, which represents the first line of defense against viruses [...].
    MeSH term(s) Host-Pathogen Interactions/immunology ; Humans ; Immune Evasion ; Immunity, Innate ; Receptors, Pattern Recognition/immunology ; Virus Replication ; Viruses/immunology
    Chemical Substances Receptors, Pattern Recognition
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13040567
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online ; Thesis: Impact of USP18 and ISG15 on sensing of HIV-1 infection

    Lin, Chaohui [Verfasser] / Münk, Carsten [Gutachter] / Lang, Philipp [Gutachter]

    2023  

    Author's details Chaohui Lin ; Gutachter: Carsten Münk, Philipp Lang
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: HIV-1 restriction by SERINC5.

    Cano-Ortiz, Lucía / Luedde, Tom / Münk, Carsten

    Medical microbiology and immunology

    2022  Volume 212, Issue 2, Page(s) 133–140

    Abstract: Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a human immunodeficiency virus 1 (HIV-1) restriction factor capable of inhibiting HIV-1 that does not ... ...

    Abstract Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a human immunodeficiency virus 1 (HIV-1) restriction factor capable of inhibiting HIV-1 that does not express its accessory protein Nef (Δ Nef). SER5 incorporated into the viral membrane impairs the entry of HIV-1 by disrupting the fusion between the viral and the plasma membrane after envelope receptor interaction induced the first steps of the fusion process. The mechanisms of how SER5 prevents membrane fusion are not fully understood and viral envelope proteins were identified that escape the SER5-mediated restriction. Primate lentiviruses, such as HIV-1 and simian immunodeficiency viruses (SIVs), use their accessory protein Nef to downregulate SER5 from the plasma membrane by inducing an endocytic pathway. In addition to being directly antiviral, recent data suggest that SER5 is an important adapter protein in innate signaling pathways leading to the induction of inflammatory cytokines. This review discusses the current knowledge about HIV-1 restriction by SER5.
    MeSH term(s) Animals ; Humans ; HIV-1 ; nef Gene Products, Human Immunodeficiency Virus/metabolism ; Membrane Proteins/metabolism
    Chemical Substances nef Gene Products, Human Immunodeficiency Virus ; Membrane Proteins ; SERINC5 protein, human
    Language English
    Publishing date 2022-03-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 120933-4
    ISSN 1432-1831 ; 0300-8584
    ISSN (online) 1432-1831
    ISSN 0300-8584
    DOI 10.1007/s00430-022-00732-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.170: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Online ; Thesis: Determinanten für den klinischen Verlauf der Sepsis und prognostischer Wert von Sepsis-Scores in der Arsi Region von Äthiopien

    Hörner, Johannes [Verfasser] / Münk, Carsten [Gutachter] / MacKenzie, Colin R. [Gutachter]

    2023  

    Author's details Johannes Hörner ; Gutachter: Carsten Münk, Colin R. MacKenzie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: The cyclophilin A-binding loop of the capsid regulates the human TRIM5α sensitivity of nonpandemic HIV-1.

    Twizerimana, Augustin P / Becker, Daniel / Zhu, Shenglin / Luedde, Tom / Gohlke, Holger / Münk, Carsten

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 48, Page(s) e2306374120

    Abstract: The rather few cases of humans infected by HIV-1 N, O, or P raise the question of their incomplete adaptation to humans. We hypothesized that early postentry restrictions may be relevant for the impaired spread of these HIVs. One of the best- ... ...

    Abstract The rather few cases of humans infected by HIV-1 N, O, or P raise the question of their incomplete adaptation to humans. We hypothesized that early postentry restrictions may be relevant for the impaired spread of these HIVs. One of the best-characterized species-specific restriction factors is TRIM5α. HIV-1 M can escape human (hu) TRIM5α restriction by binding cyclophilin A (CYPA, also known as PPIA, peptidylprolyl isomerase A) to the so-called CYPA-binding loop of its capsid protein. How non-M HIV-1s interact with huTRIM5α is ill-defined. By testing full-length reporter viruses (Δ
    MeSH term(s) Humans ; Cyclophilin A/metabolism ; Capsid/metabolism ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; HIV-1/physiology ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; HIV Seropositivity ; HIV Infections/metabolism
    Chemical Substances Cyclophilin A (EC 5.2.1.-) ; Capsid Proteins ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2306374120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online ; Thesis: Untersuchungen zu viralen, zellulären und pharmakologischen Determinanten des Uncoatings von HIV-1 in vitro

    Tischler, Sebastian [Verfasser] / Münk, Carsten [Gutachter] / Schaal, Heiner [Gutachter]

    2021  

    Author's details Sebastian Tischler ; Gutachter: Carsten Münk, Heiner Schaal
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book ; Online ; Thesis: Zelluläre und virale Determinanten bei der Entstehung der AIDS-Pandemie: Untersuchung früher Replikationsschritte simianer Immundefizienzviren des Schimpansen (SIVcpz)

    Scheck, Rachel [Verfasser] / Münk, Carsten [Gutachter] / Schaal, Heiner [Gutachter]

    2021  

    Author's details Rachel Scheck ; Gutachter: Carsten Münk, Heiner Schaal
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book ; Online ; Thesis: Human host factors involved in HIV-1 replication

    Hain, Anika [Verfasser] / Münk, Carsten [Gutachter]

    2017  

    Author's details Anika Hain ; Gutachter: Carsten Münk
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.

    Balakrishnan, Kannan / Jaguva Vasudevan, Ananda Ayyappan / Mohareer, Krishnaveni / Luedde, Tom / Münk, Carsten / Banerjee, Sharmistha

    Viruses

    2021  Volume 13, Issue 12

    Abstract: Staufen, the RNA-binding family of proteins, affects various steps in the Human Immuno-Deficiency Virus (HIV-1) replication cycle. While our previous study established Staufen-2-HIV-1 Rev interaction and its role in augmenting nucleocytoplasmic export of ...

    Abstract Staufen, the RNA-binding family of proteins, affects various steps in the Human Immuno-Deficiency Virus (HIV-1) replication cycle. While our previous study established Staufen-2-HIV-1 Rev interaction and its role in augmenting nucleocytoplasmic export of RRE-containing viral RNA, viral incorporation of Staufen-2 and its effect on viral propagation were unknown. Here, we report that Staufen-2 interacts with HIV-1 Gag and is incorporated into virions and that encapsidated Staufen-2 boosted viral infectivity. Further, Staufen-2 gets co-packaged into virions, possibly by interacting with host factors Staufen-1 or antiviral protein APOBEC3G, which resulted in different outcomes on the infectivity of Staufen-2-encapsidated virions. These observations suggest that encapsidated host factors influence viral population dynamics and infectivity. With the explicit identification of the incorporation of Staufen proteins into HIV-1 and other retroviruses, such as Simian Immunodeficiency Virus (SIV), we propose that packaging of RNA binding proteins, such as Staufen, in budding virions of retroviruses is probably a general phenomenon that can drive or impact the viral population dynamics, infectivity, and evolution.
    MeSH term(s) Cell Line ; Gene Products, gag/genetics ; Gene Products, gag/metabolism ; HIV Infections/genetics ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/pathogenicity ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Protein Binding ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Viral Genome Packaging ; Virulence
    Chemical Substances Gene Products, gag ; Nerve Tissue Proteins ; RNA-Binding Proteins ; STAU2 protein, human
    Language English
    Publishing date 2021-12-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13122459
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Foamy Viruses, Bet, and APOBEC3 Restriction.

    Jaguva Vasudevan, Ananda Ayyappan / Becker, Daniel / Luedde, Tom / Gohlke, Holger / Münk, Carsten

    Viruses

    2021  Volume 13, Issue 3

    Abstract: Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called ... ...

    Abstract Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are occasionally detected in bushmeat hunters or zookeepers. Various FVs are endemic in numerous mammalian natural hosts, such as primates, felines, bovines, and equines, and other animals, but not in humans. They are apathogenic, and significant differences exist between the viral life cycles of FV and other retroviruses. Importantly, FVs replicate in the presence of many well-defined retroviral restriction factors such as TRIM5α, BST2 (Tetherin), MX2, and APOBEC3 (A3). While the interaction of A3s with HIV-1 is well studied, the escape mechanisms of FVs from restriction by A3 is much less explored. Here we review the current knowledge of FV biology, host restriction factors, and FV-host interactions with an emphasis on the consequences of FV regulatory protein Bet binding to A3s and outline crucial open questions for future studies.
    MeSH term(s) APOBEC Deaminases/metabolism ; Animals ; Cell Line ; Host Microbial Interactions ; Humans ; Mutation ; Primates/virology ; Retroviridae Infections/immunology ; Retroviridae Infections/virology ; Retroviridae Proteins/classification ; Retroviridae Proteins/genetics ; Retroviridae Proteins/metabolism ; Spumavirus/genetics ; Spumavirus/immunology ; Spumavirus/physiology
    Chemical Substances Retroviridae Proteins ; bet protein, human foamy virus ; APOBEC Deaminases (EC 3.5.4.5) ; APOBEC3 proteins, human (EC 3.5.4.5)
    Language English
    Publishing date 2021-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13030504
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top