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Book ; Online: Methane measurements during POLARSTERN cruise ARK-XXII/2, supplementary data to: Damm, Ellen; Helmke, Elisabeth; Thoms, Silke; Schauer, Ursula; Nöthig, Eva-Maria; Bakker, Karel; Kiene, Ronald P (2010): Methane production in aerobic oligotrophic surface water in the central Arctic Ocean. Biogeosciences, 7, 1099-1108

Damm, Ellen / Bakker, Karel / Helmke, Elisabeth / Kiene, Ronald P / Nöthig, Eva-Maria / Schauer, Ursula / Thoms, Silke

2010

Abstract: A methane surplus relative to the atmospheric equilibrium is a frequently observed feature of ocean surface water. Despite the common fact that biological processes are responsible for its origin, the formation of methane in aerobic surface water is ... ...

Abstract	A methane surplus relative to the atmospheric equilibrium is a frequently observed feature of ocean surface water. Despite the common fact that biological processes are responsible for its origin, the formation of methane in aerobic surface water is still poorly understood. We report on methane production in the central Arctic Ocean, which was exclusively detected in Pacific derived water but not nearby in Atlantic derived water. The two water masses are distinguished by their different nitrate to phosphate ratios. We show that methane production occurs if nitrate is depleted but phosphate is available as a P source. Apparently the low N:P ratio enhances the ability of bacteria to compete for phosphate while the phytoplankton metabolite dimethylsulfoniopropionate (DMSP) is utilized as a C source. This was verified by experimentally induced methane production in DMSP spiked Arctic sea water. Accordingly we propose that methylated compounds may serve as precursors for methane and thermodynamic calculations show that methylotrophic methanogenesis can provide energy in aerobic environments.
Language	English
Dates of publication	2010-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.5194/bg-7-1099-2010
DOI	10.1594/PANGAEA.787657
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online ; Thesis: Clathrin- and caveolin-1-independent endocytosis of Simian Virus 40

Damm, Eva-Maria

2005

Author's details	by Eva-Maria Damm
Language	English
Size	Online-Ressource (139 S), Ill
Publisher	ETH
Publishing place	Zürich
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Diss., Naturwissenschaften, Eidgenössische Technische Hochschule ETH Zürich, Nr. 16344--Zürich, 1634
Accompanying material	1 CD-ROM
Database	Former special subject collection: coastal and deep sea fishing

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Thesis ; Online: Clathrin- and caveolin-1-independent endocytosis of Simian Virus 40

Damm, Eva-Maria

2005

Keywords	CLATHRIN (COATED PIT PROTEIN) ; ENDOCYTOSE (CYTOLOGIE) ; SV-40-VIRUS (VIROLOGIE) ; ENDOCYTOSIS (CYTOLOGY) ; SV-40-VIRUS (VIROLOGY) ; info:eu-repo/classification/ddc/570 ; Life sciences
Language	English
Publisher	ETH
Publishing country	ch
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arctic warming interrupts the Transpolar Drift and affects long-range transport of sea ice and ice-rafted matter.

Krumpen, Thomas / Belter, H Jakob / Boetius, Antje / Damm, Ellen / Haas, Christian / Hendricks, Stefan / Nicolaus, Marcel / Nöthig, Eva-Maria / Paul, Stephan / Peeken, Ilka / Ricker, Robert / Stein, Rüdiger

Scientific reports

2019 Volume 9, Issue 1, Page(s) 5459

Abstract: Sea ice is an important transport vehicle for gaseous, dissolved and particulate matter in the Arctic Ocean. Due to the recently observed acceleration in sea ice drift, it has been assumed that more matter is advected by the Transpolar Drift from shallow ...

Abstract	Sea ice is an important transport vehicle for gaseous, dissolved and particulate matter in the Arctic Ocean. Due to the recently observed acceleration in sea ice drift, it has been assumed that more matter is advected by the Transpolar Drift from shallow shelf waters to the central Arctic Ocean and beyond. However, this study provides first evidence that intensified melt in the marginal zones of the Arctic Ocean interrupts the transarctic conveyor belt and has led to a reduction of the survival rates of sea ice exported from the shallow Siberian shelves (-15% per decade). As a consequence, less and less ice formed in shallow water areas (<30 m) has reached Fram Strait (-17% per decade), and more ice and ice-rafted material is released in the northern Laptev Sea and central Arctic Ocean. Decreasing survival rates of first-year ice are visible all along the Russian shelves, but significant only in the Kara Sea, East Siberian Sea and western Laptev Sea. Identified changes affect biogeochemical fluxes and ecological processes in the central Arctic: A reduced long-range transport of sea ice alters transport and redistribution of climate relevant gases, and increases accumulation of sediments and contaminates in the central Arctic Ocean, with consequences for primary production, and the biodiversity of the Arctic Ocean.
Language	English
Publishing date	2019-04-02
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-41456-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Systems biology of virus entry in mammalian cells.

Damm, Eva-Maria / Pelkmans, Lucas

Cellular microbiology

2006 Volume 8, Issue 8, Page(s) 1219–1227

Abstract: In this article, we define systems biology of virus entry in mammalian cells as the discipline that combines several approaches to comprehensively understand the collective physical behaviour of virus entry routes, and to understand the coordinated ... ...

Abstract	In this article, we define systems biology of virus entry in mammalian cells as the discipline that combines several approaches to comprehensively understand the collective physical behaviour of virus entry routes, and to understand the coordinated operation of the functional modules and molecular machineries that lead to this physical behaviour. Clearly, these are extremely ambitious aims, but recent developments in different life science disciplines slowly allow us to set them as realistic, although very distant, goals. Besides classical approaches to obtain high-resolution information of the molecules, particles and machines involved, we require approaches that can monitor collective behaviour of many molecules, particles and machines simultaneously, in order to reveal design principles of the systems as a whole. Here we will discuss approaches that fall in the latter category, namely time-lapse imaging and single-particle tracking (SPT) combined with computational analysis and modelling, and genome-wide RNA interference approaches to reveal the host components required for virus entry. These techniques should in the future allow us to assign host genes to the systems' functions and characteristics, and allow emergence-driven, in silico assembly of networks that include interactions with increasing hierarchy (molecules-multiprotein complexes-vesicles and organelles), and kinetics and subcellular spatiality, in order to allow realistic simulations of virus entry in real time.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Cell Membrane/virology ; Gene Expression Profiling ; Humans ; Models, Biological ; RNA Interference ; Simian virus 40/pathogenicity ; Simian virus 40/physiology ; Systems Biology ; Vesicular stomatitis Indiana virus/pathogenicity ; Vesicular stomatitis Indiana virus/physiology ; Virus Diseases/etiology ; Virus Diseases/genetics ; Virus Diseases/physiopathology ; Virus Diseases/virology ; Virus Physiological Phenomena ; Viruses/drug effects ; Viruses/pathogenicity
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2006-06-27
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1468320-9
ISSN	1462-5822 ; 1462-5814
ISSN (online)	1462-5822
ISSN	1462-5814
DOI	10.1111/j.1462-5822.2006.00745.x
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Article ; Online: Arctic warming interrupts the Transpolar Drift and affects long-range transport of sea ice and ice-rafted matter

Thomas Krumpen / H. Jakob Belter / Antje Boetius / Ellen Damm / Christian Haas / Stefan Hendricks / Marcel Nicolaus / Eva-Maria Nöthig / Stephan Paul / Ilka Peeken / Robert Ricker / Rüdiger Stein

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 9

Abstract: Abstract Sea ice is an important transport vehicle for gaseous, dissolved and particulate matter in the Arctic Ocean. Due to the recently observed acceleration in sea ice drift, it has been assumed that more matter is advected by the Transpolar Drift ... ...

Abstract	Abstract Sea ice is an important transport vehicle for gaseous, dissolved and particulate matter in the Arctic Ocean. Due to the recently observed acceleration in sea ice drift, it has been assumed that more matter is advected by the Transpolar Drift from shallow shelf waters to the central Arctic Ocean and beyond. However, this study provides first evidence that intensified melt in the marginal zones of the Arctic Ocean interrupts the transarctic conveyor belt and has led to a reduction of the survival rates of sea ice exported from the shallow Siberian shelves (−15% per decade). As a consequence, less and less ice formed in shallow water areas (<30 m) has reached Fram Strait (−17% per decade), and more ice and ice-rafted material is released in the northern Laptev Sea and central Arctic Ocean. Decreasing survival rates of first-year ice are visible all along the Russian shelves, but significant only in the Kara Sea, East Siberian Sea and western Laptev Sea. Identified changes affect biogeochemical fluxes and ecological processes in the central Arctic: A reduced long-range transport of sea ice alters transport and redistribution of climate relevant gases, and increases accumulation of sediments and contaminates in the central Arctic Ocean, with consequences for primary production, and the biodiversity of the Arctic Ocean.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour.

Frechin, Mathieu / Stoeger, Thomas / Daetwyler, Stephan / Gehin, Charlotte / Battich, Nico / Damm, Eva-Maria / Stergiou, Lilli / Riezman, Howard / Pelkmans, Lucas

Nature

2015 Volume 523, Issue 7558, Page(s) 88–91

Abstract: Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and ... ...

Abstract	Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and substratum, which often correlate with specific features of the population context of single cells, such as local cell crowding. Here we reveal a cell-intrinsic molecular mechanism that allows multicellular patterning without requiring specific communication between cells. It acts by sensing the local crowding of a single cell through its ability to spread and activate focal adhesion kinase (FAK, also known as PTK2), resulting in adaptation of genes controlling membrane homeostasis. In cells experiencing low crowding, FAK suppresses transcription of the ABC transporter A1 (ABCA1) by inhibiting FOXO3 and TAL1. Agent-based computational modelling and experimental confirmation identified membrane-based signalling and feedback control as crucial for the emergence of population patterns of ABCA1 expression, which adapts membrane lipid composition to cell crowding and affects multiple signalling activities, including the suppression of ABCA1 expression itself. The simple design of this cell-intrinsic system and its broad impact on the signalling state of mammalian single cells suggests a fundamental role for a tunable membrane lipid composition in collective cell behaviour.
MeSH term(s)	ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Adaptation, Physiological ; Animals ; Cell Communication/physiology ; Cell Count ; Cell Line, Tumor ; Cell Membrane/chemistry ; Fibroblasts/chemistry ; Fibroblasts/cytology ; Fibroblasts/enzymology ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Homeostasis ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipids/chemistry ; Mice ; Models, Biological ; Signal Transduction ; Transcriptome
Chemical Substances	ATP Binding Cassette Transporter 1 ; Forkhead Transcription Factors ; Intracellular Signaling Peptides and Proteins ; Lipids ; Focal Adhesion Protein-Tyrosine Kinases (EC 2.7.10.2)
Language	English
Publishing date	2015-07-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature14429
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Article: Kinder, die stillen Verlierer? Soziale Benachteiligung und Gesundheitsleistungen bei Kindern und Jugendlichen - biopsychosoziale Aspekte der Kindergesundheit

Damm, Lilly / Miggitsch, Eva-Maria / Trapp, Michael / Egger, Josef W.

Psychologische Medizin

2009 Volume 20, Issue 4, Page(s) 4

Language	German
Document type	Article
ZDB-ID	1479333-7
ISSN	1014-8167
Database	Current Contents Medicine

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Article ; Online: Simple and Reliable Method for Studying the Adsorption Behavior of Aquivion Ionomers on Carbon Black Surfaces.

Thoma, Martin / Lin, Wei / Hoffmann, Eva / Sattes, Maria-Melanie / Segets, Doris / Damm, Cornelia / Peukert, Wolfgang

Langmuir : the ACS journal of surfaces and colloids

2018 Volume 34, Issue 41, Page(s) 12324–12334

Abstract: A better understanding of the interactions of carbon black and perfluorinated sulfonic acid (PFSA) ionomer helps to improve the effectiveness of polymer electrolyte membrane fuel cells. We present a simple and fast method for quantitative PFSA ionomer ... ...

Abstract	A better understanding of the interactions of carbon black and perfluorinated sulfonic acid (PFSA) ionomer helps to improve the effectiveness of polymer electrolyte membrane fuel cells. We present a simple and fast method for quantitative PFSA ionomer analysis based on suspension density measurements. After validation of the reliability of our method by thermogravimetric analysis and isothermal titration calorimetry (ITC), we investigate the adsorption equilibrium of short-side-chain PFSA ionomers of different equivalent weights (EW) and polarities on carbon black. The measured adsorption isotherms exhibit a plateau in the ionomer surface concentration for ionomer equilibrium concentrations ≤2 g/L. In this concentration range, the adsorption isotherms are described by the Langmuir model, whereby the surface concentrations in the plateau region are between 0.041 and 0.070 g/g. The plateau value of the ionomer surface concentration increases with EW and therefore with decreasing number of side chains with terminal sulfonic acid group per ionomer molecule, while the amount of adsorbed sulfonic acid groups remains constant for all investigated ionomers, resulting in similar ζ-potentials and sedimentation stability of the suspensions. The free energies of adsorption Δ G calculated from the association constants of the adsorption isotherms agree well with Δ G values obtained by isothermal titration calorimetry (ITC) and thus validate the adsorption isotherm measurement method. From the values of adsorption enthalpy Δ H ((-7.3 ± 0.8) kJ/mol) and entropy Δ S (ca. 100 J/(mol K)), which were extracted from ITC, we conclude that the ionomer adsorption on carbon black is a spontaneous physisorption process.
Language	English
Publishing date	2018-10-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.8b02726
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Article ; Online: Population context determines cell-to-cell variability in endocytosis and virus infection.

Snijder, Berend / Sacher, Raphael / Rämö, Pauli / Damm, Eva-Maria / Liberali, Prisca / Pelkmans, Lucas

Nature

2009 Volume 461, Issue 7263, Page(s) 520–523

Abstract: Single-cell heterogeneity in cell populations arises from a combination of intrinsic and extrinsic factors. This heterogeneity has been measured for gene transcription, phosphorylation, cell morphology and drug perturbations, and used to explain various ... ...

Abstract	Single-cell heterogeneity in cell populations arises from a combination of intrinsic and extrinsic factors. This heterogeneity has been measured for gene transcription, phosphorylation, cell morphology and drug perturbations, and used to explain various aspects of cellular physiology. In all cases, however, the causes of heterogeneity were not studied. Here we analyse, for the first time, the heterogeneous patterns of related cellular activities, namely virus infection, endocytosis and membrane lipid composition in adherent human cells. We reveal correlations with specific cellular states that are defined by the population context of a cell, and we derive probabilistic models that can explain and predict most cellular heterogeneity of these activities, solely on the basis of each cell's population context. We find that accounting for population-determined heterogeneity is essential for interpreting differences between the activity levels of cell populations. Finally, we reveal that synergy between two molecular components, focal adhesion kinase and the sphingolipid GM1, enhances the population-determined pattern of simian virus 40 (SV40) infection. Our findings provide an explanation for the origin of heterogeneity patterns of cellular activities in adherent cell populations.
MeSH term(s)	Cell Adhesion ; Cell Count ; Cell Line, Tumor ; Cell Size ; Clone Cells/pathology ; Clone Cells/virology ; Dengue Virus/physiology ; Endocytosis ; Focal Adhesion Kinase 1/metabolism ; G(M1) Ganglioside/metabolism ; Humans ; Membrane Lipids/analysis ; Membrane Lipids/metabolism ; Murine hepatitis virus/physiology ; Rotavirus/physiology ; Simian virus 40/physiology ; Virus Diseases/pathology ; Virus Diseases/virology
Chemical Substances	Membrane Lipids ; G(M1) Ganglioside (37758-47-7) ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; PTK2 protein, human (EC 2.7.10.2)
Language	English
Publishing date	2009-08-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature08282
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