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  1. Article: Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.

    Primak, Alexandra / Bozov, Kirill / Rubina, Kseniya / Dzhauari, Stalik / Neyfeld, Elena / Illarionova, Maria / Semina, Ekaterina / Sheleg, Dmitriy / Tkachuk, Vsevolod / Karagyaur, Maxim

    Frontiers in molecular neuroscience

    2024  Volume 17, Page(s) 1361764

    Abstract: Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that mental disorders are polygenic and that impaired brain development may lay the ground for their manifestation. Neural tissue development ...

    Abstract Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that mental disorders are polygenic and that impaired brain development may lay the ground for their manifestation. Neural tissue development is a complex and multistage process that involves a large number of distant and contact molecules. In this review, we have considered the key steps of brain morphogenesis, and the major molecule families involved in these process. The review provides many indications of the important contribution of the brain development process and correct functioning of certain genes to human mental health. To our knowledge, this comprehensive review is one of the first in this field. We suppose that this review may be useful to novice researchers and clinicians wishing to navigate the field.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1361764
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  2. Article ; Online: New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies.

    Klimovich, Polina / Rubina, Kseniya / Sysoeva, Veronika / Semina, Ekaterina

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the ... ...

    Abstract Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system.
    MeSH term(s) Animals ; Axons/physiology ; Exosomes ; Humans ; MicroRNAs ; Nerve Regeneration/physiology ; Neurogenesis ; Peripheral Nerve Injuries/therapy ; Peripheral Nerves/metabolism ; Peripheral Nerves/physiology ; Peripheral Nervous System ; Schwann Cells/physiology ; Stromal Cells
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413380
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  3. Article ; Online: New Frontiers in Peripheral Nerve Regeneration

    Polina Klimovich / Kseniya Rubina / Veronika Sysoeva / Ekaterina Semina

    International Journal of Molecular Sciences, Vol 22, Iss 13380, p

    Concerns and Remedies

    2021  Volume 13380

    Abstract: Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the ... ...

    Abstract Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system.
    Keywords peripheral nerve regeneration ; axon growth ; Schwann cells ; exosomes ; microRNA ; multipotent stromal cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article: Three-Dimensional Model of Dorsal Root Ganglion Explant as a Method of Studying Neurotrophic Factors in Regenerative Medicine.

    Klimovich, Polina / Rubina, Kseniya / Sysoeva, Veronika / Semina, Ekaterina

    Biomedicines

    2020  Volume 8, Issue 3

    Abstract: Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of ... ...

    Abstract Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of Nestin-green fluorescent protein (GFP)-positive cells using a 3D model of dorsal root ganglion (DRG) explant culture in Matrigel. Our method generally represents a convenient model for assessing the effects of soluble factors and therapeutic agents on axon growth and nerve regeneration in R&D studies. By analyzing the DRG explants in ex vivo culture for 21 days, one can evaluate the parameters of neurite outgrowth and the rate of cell migration from the DRG explants into the Matrigel. For the current study, we used Nestin-GFP-expressing mice in which neural precursors express Nestin and the green fluorescent protein (GFP) under the same promoter. We revealed that GDNF significantly (two fold) stimulated axon outgrowth (
    Language English
    Publishing date 2020-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines8030049
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  5. Article ; Online: Three-Dimensional Model of Dorsal Root Ganglion Explant as a Method of Studying Neurotrophic Factors in Regenerative Medicine

    Polina Klimovich / Kseniya Rubina / Veronika Sysoeva / Ekaterina Semina

    Biomedicines, Vol 8, Iss 3, p

    2020  Volume 49

    Abstract: Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of ... ...

    Abstract Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of Nestin-green fluorescent protein (GFP)-positive cells using a 3D model of dorsal root ganglion (DRG) explant culture in Matrigel. Our method generally represents a convenient model for assessing the effects of soluble factors and therapeutic agents on axon growth and nerve regeneration in R&D studies. By analyzing the DRG explants in ex vivo culture for 21 days, one can evaluate the parameters of neurite outgrowth and the rate of cell migration from the DRG explants into the Matrigel. For the current study, we used Nestin-GFP-expressing mice in which neural precursors express Nestin and the green fluorescent protein (GFP) under the same promoter. We revealed that GDNF significantly (two fold) stimulated axon outgrowth ( p < 0.05), but not BDNF or NGF. It is well-known that axon growth can be stimulated by activated glial cells that fulfill a trophic function for regenerating nerves. For this reason, we evaluated the number of Nestin-GFP-positive cells that migrated from the DRG into the Matrigel in our 3D ex vivo explant model. We found that NGF and GDNF, but not BDNF, stimulated the migration of Nestin-GFP cells compared to the control ( p < 0.05). On the basis of the aforementioned finding, we concluded that GDNF had the greatest stimulating potential for axon regeneration, as it stimulated not only the axon outgrowth, but also glial cell migration. Although NGF significantly stimulated glial cell migration, its effect on axon growth was insufficient for axon regeneration.
    Keywords axon regeneration ; neurotrophic factors ; nestin-gfp mice ; neurite outgrowth ; 3d dorsal root ganglia explants ; ngf ; bdnf ; gdnf ; matrigel ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Novel missense variants in brain morphogenic genes associated with depression and schizophrenia.

    Karagyaur, Maxim / Primak, Alexandra / Bozov, Kirill / Sheleg, Dmitriy / Arbatsky, Mikhail / Dzhauari, Stalik / Illarionova, Maria / Semina, Ekaterina / Samokhodskaya, Larisa / Klimovich, Polina / Velichko, Arkadiy / Drach, Mikhail / Sotskaya, Ekaterina / Popov, Vladimir / Rubina, Kseniya / Parfenenko, Mariia / Makus, Julia / Tsygankov, Boris / Tkachuk, Vsevolod /
    Neyfeld, Elena

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1338168

    Abstract: Introduction: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). ... ...

    Abstract Introduction: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). Identification of such genes (genes of neurotrophic factors and guidance molecules among them) and their deleterious genetic variants serves as a key to diagnosis, prevention, and possibly treatment of such disorders. In this study, we have examined the prevalence of genomic variants in brain morphogenic genes in individuals with SCZ and MDD within a Russian population.
    Methods: We have performed whole-exome sequencing of 21 DNA samples: 11 from individuals with SCZ and 10 with MDD, followed by ARMS (Amplification-Refractory Mutation System) based screening of detected single nucleotide variants (SNVs) in larger groups: 102 for individuals with SCZ, 79 for those with MDD and 103 for healthy donors.
    Results: Whole-exome sequencing has revealed 226 missense mutations in 79 genes (out of 140 studied), some of which occur in patients with psychiatric disorders significantly more frequently than in healthy donors. We have identified previously undescribed genomic variants in brain morphogenic genes:
    Discussion: However, the functional significance of the SNVs identified has still to be confirmed in cellular and animal models. Once it is fulfilled, these SNVs have the potential to complement the diagnostic toolbox for assessing susceptibility to mental disorders. The data obtained indirectly confirm the importance of adequate brain structure formation for its correct functioning and preservation of mental health.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1338168
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  7. Article ; Online: MicroRNAs in Cancer: From Gene Expression Regulation to the Metastatic Niche Reprogramming.

    Semina, Ekaterina V / Rysenkova, Karina D / Troyanovskiy, Konstantin E / Shmakova, Anna A / Rubina, Kseniya A

    Biochemistry. Biokhimiia

    2021  Volume 86, Issue 7, Page(s) 785–799

    Abstract: By 2003, the Human Genome project had been completed; however, it turned out that 97% of genome sequences did not encode proteins. The explanation came later when it was found the untranslated DNA contain sequences for short microRNAs (miRNAs) and long ... ...

    Abstract By 2003, the Human Genome project had been completed; however, it turned out that 97% of genome sequences did not encode proteins. The explanation came later when it was found the untranslated DNA contain sequences for short microRNAs (miRNAs) and long noncoding RNAs that did not produce any mRNAs or tRNAs, but instead were involved in the regulation of gene expression. Initially identified in the cytoplasm, miRNAs have been found in all cell compartments, where their functions are not limited to the degradation of target mRNAs. miRNAs that are secreted into the extracellular space as components of exosomes or as complexes with proteins, participate in morphogenesis, regeneration, oncogenesis, metastasis, and chemoresistance of tumor cells. miRNAs play a dual role in oncogenesis: on one hand, they act as oncogene suppressors; on the other hand, they function as oncogenes themselves and inactivate oncosuppressors, stimulate tumor neoangiogenesis, and mediate immunosuppressive processes in the tumors, The review presents current concepts of the miRNA biogenesis and their functions in the cytoplasm and nucleus with special focus on the noncanonical mechanisms of gene regulation by miRNAs and involvement of miRNAs in oncogenesis, as well as the authors' opinion on the role of miRNAs in metastasis and formation of the premetastatic niche.
    MeSH term(s) Exosomes/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297921070014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.

    Rubina, Kseniya / Shmakova, Anna / Shabanov, Aslan / Andreev, Yulii / Borovkova, Natalia / Kulabukhov, Vladimir / Evseev, Anatoliy / Popugaev, Konstantin / Petrikov, Sergey / Semina, Ekaterina

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0264072

    Abstract: COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, ... ...

    Abstract COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/mortality ; Female ; Humans ; Interleukin-17/blood ; Lymphocyte Count ; Male ; Middle Aged ; Pandemics ; Pilot Projects ; Plasminogen Activator Inhibitor 1/blood ; Prognosis ; Russia/epidemiology ; Young Adult
    Chemical Substances Interleukin-17 ; Plasminogen Activator Inhibitor 1
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264072
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  9. Article ; Online: Novel prognostic determinants of COVID-19-related mortality

    Kseniya Rubina / Anna Shmakova / Aslan Shabanov / Yulii Andreev / Natalia Borovkova / Vladimir Kulabukhov / Anatoliy Evseev / Konstantin Popugaev / Sergey Petrikov / Ekaterina Semina

    PLoS ONE, Vol 17, Iss 2, p e

    A pilot study on severely-ill patients in Russia.

    2022  Volume 0264072

    Abstract: COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, ... ...

    Abstract COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  10. Article ; Online: T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity.

    Popov, Vladimir S / Brodsky, Ilya B / Balatskaya, Maria N / Balatskiy, Alexander V / Ozhimalov, Ilia D / Kulebyakina, Maria A / Semina, Ekaterina V / Arbatskiy, Mikhail S / Isakova, Viktoria S / Klimovich, Polina S / Sysoeva, Veronika Y / Kalinina, Natalia I / Tkachuk, Vsevolod A / Rubina, Kseniya A

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in ... ...

    Abstract T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in the
    MeSH term(s) Animals ; Mice ; Blood Pressure ; Adiponectin/genetics ; Cadherins/genetics ; Hypertension/genetics
    Chemical Substances H-cadherin ; Adiponectin ; Cadherins
    Language English
    Publishing date 2023-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814204
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