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  1. Article ; Online: Arthritis in the hands of saints.

    Manolios, Nicholas

    Rheumatology international

    2021  Volume 41, Issue 9, Page(s) 1705–1706

    MeSH term(s) Arthritis/diagnosis ; Hand ; Humans ; Saints
    Language English
    Publishing date 2021-01-20
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-021-04786-7
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    Zs.A 1639: Show issues Location:
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  2. Article ; Online: Anti-inflammatory Effects of First-line Anti-arthritic Drugs on T-cell Activation.

    Manolios, Nicholas / Hou, Guojiang

    Anti-inflammatory & anti-allergy agents in medicinal chemistry

    2023  Volume 21, Issue 3, Page(s) 188–193

    Abstract: Aim: The in vitro effects of commonly used first-line anti-arthritic drugs on early stages of T-cell activation were examined.: Methods: The 2B4.11 murine T cell hybridoma cell line recognizing pigeon cytochrome c (PCC) as the antigen was co-cultured ...

    Abstract Aim: The in vitro effects of commonly used first-line anti-arthritic drugs on early stages of T-cell activation were examined.
    Methods: The 2B4.11 murine T cell hybridoma cell line recognizing pigeon cytochrome c (PCC) as the antigen was co-cultured with the histocompatible antigen presenting B cell hybridoma line LK35.2, PCC, and anti-arthritic drugs, including methotrexate, hydroxychloroquine, salazopyrine, cyclosporin, and leflunomide. After 16 hours of incubation, the supernatant was removed, and cytokines were assayed.
    Results: Anti-arthritic drugs inhibited the production of pro-inflammatory cytokines IL-2, IL-6, IFN-γ, GM-CSF, and TNF-α (Th1 cytokines) to a varying extent. Surprisingly, leflunomide, salazopyrine, prednisone and indomethacin as well as blocking Th1 cytokines, stimulated the production of the anti-inflammatory cytokine IL-10, a Th2 cytokine.
    Conclusion: Anti-arthritic medications can inhibit the production of pro-inflammatory cytokines and in some cases, incite a Th2 response that could potentially inhibit the progression of the immune response.
    MeSH term(s) Mice ; Animals ; Th1 Cells/metabolism ; Leflunomide/pharmacology ; Leflunomide/therapeutic use ; Arthritis, Experimental ; Cytokines/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Th2 Cells
    Chemical Substances Leflunomide (G162GK9U4W) ; Cytokines ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-27
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2227189-2
    ISSN 1875-614X ; 1871-5230
    ISSN (online) 1875-614X
    ISSN 1871-5230
    DOI 10.2174/1871523022666230201144553
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    Zs.A 5989: Show issues Location:
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  3. Article ; Online: Coturnism.

    Manolios, Nicholas

    Internal medicine journal

    2018  Volume 48, Issue 8, Page(s) 1009

    Language English
    Publishing date 2018-08-20
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.13989
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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  4. Article ; Online: The role of ion channels in T cell function and disease.

    Manolios, Nicholas / Papaemmanouil, John / Adams, David J

    Frontiers in immunology

    2023  Volume 14, Page(s) 1238171

    Abstract: T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired ...

    Abstract T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion "channelome" and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets.
    MeSH term(s) Humans ; T-Lymphocytes ; Signal Transduction ; Autoimmune Diseases ; Cell Membrane ; Drug Delivery Systems
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1238171
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  5. Article ; Online: Correspondence on 'Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?'

    Angelides, Socrates / Manolios, Nicholas

    Annals of the rheumatic diseases

    2021  Volume 82, Issue 3, Page(s) e57

    MeSH term(s) Humans ; Glucosamine ; Inflammation/drug therapy ; Synovitis ; Synovial Membrane
    Chemical Substances Glucosamine (N08U5BOQ1K)
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-219694
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    Zs.MO 167: Show issues

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  6. Article ; Online: Prevalence, Severity, and Measures of Anxiety in Rheumatoid Arthritis: A Systematic Review.

    Meade, Tanya / Joyce, Caroline / Perich, Tania / Manolios, Nicholas / Conaghan, Phillip G / Katz, Patricia

    Arthritis care & research

    2024  Volume 76, Issue 2, Page(s) 171–180

    Abstract: Objective: Many studies have reported high rates of anxiety in adults with rheumatoid arthritis (RA). The aim of this systematic review was to examine those findings and determine the overall prevalence, severity, and commonly used measures of anxiety ... ...

    Abstract Objective: Many studies have reported high rates of anxiety in adults with rheumatoid arthritis (RA). The aim of this systematic review was to examine those findings and determine the overall prevalence, severity, and commonly used measures of anxiety in individuals with RA.
    Methods: Six databases were searched from January 2000 without restrictions on language/location, study design, or gray literature. All identified studies that examined anxiety prevalence and severity in adults with RA, as assessed with clinical diagnostic interview and/or standardized self-report measures, were considered for inclusion. Quality assessment of included studies was conducted using a modified Newcastle-Ottawa Evaluation Scale, and the findings were synthesized via a narrative approach.
    Results: Across the 47 studies (n = 11,085 participants), the sample size ranged from 60 to 1,321 participants with seven studies including healthy controls or groups with other health conditions. The studies were conducted across 23 countries, and anxiety prevalence ranged from 2.4% to 77%, predominantly determined with standardized self-report measures, of which Hospital Anxiety and Depression scale was used most frequently; only eight studies used a clinical diagnostic interview to confirm a specific anxiety diagnosis. Notable associations with anxiety in RA were physical disability, pain, disease activity, depression, and quality of life.
    Conclusion: The reported prevalence of anxiety in RA varied widely potentially because of use of different self-report measures and cutoff points. Such cutoff points will need to be standardized to clinical thresholds to inform appropriate interventions for anxiety comorbidity in RA.
    MeSH term(s) Adult ; Humans ; Quality of Life ; Prevalence ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Anxiety/diagnosis ; Anxiety/epidemiology ; Comorbidity ; Depression/diagnosis ; Depression/epidemiology
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25245
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    Zs.A 2446: Show issues Location:
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    Zs.A 24: Show issues Location:
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  7. Article: The spectrum of cutaneous polyarteritis nodosa. A case report of two contrasting cases and review of the literature.

    Liang, Ian / Hamid, Mariya / Sebaratnam, Deshan / Manolios, Nicholas

    Clinical case reports

    2022  Volume 10, Issue 11, Page(s) e6659

    Abstract: Cutaneous polyarteritis nodosa is a rare neutrophilic vasculitis. We present two cases that reflect the gamut of this disorder including one case whose delayed diagnosis led to permanent nerve deficit and scarring. ...

    Abstract Cutaneous polyarteritis nodosa is a rare neutrophilic vasculitis. We present two cases that reflect the gamut of this disorder including one case whose delayed diagnosis led to permanent nerve deficit and scarring.
    Language English
    Publishing date 2022-11-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6659
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  8. Article: Leptomeningitis in rheumatoid arthritis.

    Manolios, Emmanuel / Manolios, Nicholas / Spencer, David

    European journal of rheumatology

    2020  Volume 8, Issue 1, Page(s) 48–50

    Abstract: In this case report, we describe the case of a patient given the presumptive diagnosis of rheumatoid leptomeningitis on the basis of clinical findings and clinical response to antirheumatic medications after other causes of meningitis were excluded. ... ...

    Abstract In this case report, we describe the case of a patient given the presumptive diagnosis of rheumatoid leptomeningitis on the basis of clinical findings and clinical response to antirheumatic medications after other causes of meningitis were excluded. Numerous case reports describe rheumatoid meningitis; however, rheumatoid leptomeningitis, in the absence of pachymeningitis, is a rare phenomenon. As such, the literature about it is scant. This unique case provides an opportunity to further characterize the symptoms and radiological findings of leptomeningitis in a patient with rheumatoid arthritis.
    Language English
    Publishing date 2020-10-08
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.20063
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  9. Article ; Online: Non-Antigenic Modulation of Antigen Receptor (TCR) Cβ-FG Loop Modulates Signalling: Implications of External Factors Influencing T-Cell Responses.

    Manolios, Nicholas / Pham, Son / Hou, Guojiang / Du, Jonathan / Quek, Camelia / Hibbs, David

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: T-cell recognition of antigens is complex, leading to biochemical and cellular events that impart both specific and targeted immune responses. The end result is an array of cytokines that facilitate the direction and intensity of the immune reaction-such ...

    Abstract T-cell recognition of antigens is complex, leading to biochemical and cellular events that impart both specific and targeted immune responses. The end result is an array of cytokines that facilitate the direction and intensity of the immune reaction-such as T-cell proliferation, differentiation, macrophage activation, and B-cell isotype switching-all of which may be necessary and appropriate to eliminate the antigen and induce adaptive immunity. Using in silico docking to identify small molecules that putatively bind to the T-cell Cβ-FG loop, we have shown in vitro using an antigen presentation assay that T-cell signalling is altered. The idea of modulating T-cell signalling independently of antigens by directly targeting the FG loop is novel and warrants further study.
    MeSH term(s) T-Lymphocytes ; Signal Transduction ; Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen/metabolism ; Cytokines/metabolism ; Receptors, Antigen, T-Cell/metabolism
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen ; Cytokines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119334
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  10. Article ; Online: Biologics in peripheral ulcerative keratitis.

    Clarke, Daniel / Sartor, Lauren / Do, Vu / Manolios, Nicholas / Swaminathan, Sanjay / Samarawickrama, Chameen

    Seminars in arthritis and rheumatism

    2023  Volume 63, Page(s) 152269

    Abstract: Over the past two decades biologic therapies have seen a rapid uptake in the management of ocular inflammation. Peripheral ulcerative keratitis (PUK), once a harbinger of blindness and mortality in refractory rheumatological disease, is now increasingly ... ...

    Abstract Over the past two decades biologic therapies have seen a rapid uptake in the management of ocular inflammation. Peripheral ulcerative keratitis (PUK), once a harbinger of blindness and mortality in refractory rheumatological disease, is now increasingly being treated with these agents. We conducted a review to evaluate the evidence base for this application and to provide a road map for their clinical usage in PUK, including dosage and adverse effects. A literature search across Medline, Embase and Cochrane Database of Systematic Reviews was undertaken to identify all patients with PUK that were treated with a biologic in a peer viewed article. Overall, whilst the evidence base for biologic use in PUK was poor, reported cases demonstrate an increasingly powerful and effective role for biologics in refractory PUK. This was particularly the case for rituximab in PUK secondary to granulomatous with polyangiitis.
    MeSH term(s) Humans ; Corneal Ulcer/drug therapy ; Systematic Reviews as Topic ; Rituximab/therapeutic use ; Biological Products/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6) ; Biological Products
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152269
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    Zs.A 790: Show issues Location:
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