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  1. Article ; Online: Efficacy and Safety of Co-Administered St. John’s Wort and Ginkgo biloba Extracts in Patients with Subjective Tinnitus

    Hantai Kim / Jungho Ha / Hun Yi Park / Yun-Hoon Choung / Jeong Hun Jang

    Journal of Clinical Medicine, Vol 12, Iss 3261, p

    A Preliminary Prospective Randomized Controlled Trial

    2023  Volume 3261

    Abstract: It is widely accepted that extracts of St. John’s wort ( Hypericum perforatum ) improve ... whether co-administration of St. John’s wort and Ginkgo biloba extracts can suppress tinnitus. Participants ... with subjective tinnitus aged 30–70 years were randomly assigned to the experimental (co-administration of St. John’s wort ...

    Abstract It is widely accepted that extracts of St. John’s wort ( Hypericum perforatum ) improve depressive symptoms, and tinnitus patients commonly presented with either mild depression or anxiety. We investigated whether co-administration of St. John’s wort and Ginkgo biloba extracts can suppress tinnitus. Participants with subjective tinnitus aged 30–70 years were randomly assigned to the experimental (co-administration of St. John’s wort and Ginkgo biloba extract; n = 20) or control ( Ginkgo biloba extract only; n = 26) group for 12 weeks. Participants were blinded to the group assignments. After 12 weeks of treatment, no significant change in the minimum masking level on the tinnitogram was observed in either group. In the co-administration group, the Tinnitus Handicap Inventory (THI) score decreased from 34.7 (SD, 15.9) to 29.6 (16.0) ( p = 0.102). However, the control group showed a significant decrease in THI score, from 30.5 (16.7) to 25.6 (17.1) ( p = 0.046). Regarding the Short Form-36 Health Survey (SF-36), only the “Social Functioning” domain score changed significantly after extract co-administration, from 74.5 (21.5) to 83.9 (20.5) ( p = 0.047). Co-administration of St. John’s wort and Ginkgo biloba extracts did not improve the symptoms of subjective tinnitus compared to administration of Ginkgo biloba extract alone.
    Keywords subjective tinnitus ; Hypericum ; Saint John’s wort ; Ginkgo biloba ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Optimization of Light Intensity, Temperature, and Nutrients to Enhance the Bioactive Content of Hyperforin and Rutin in St. John’s Wort

    Chia-Hung Kuo / Yi-Chin Chou / Kuo-Chun Liao / Chwen-Jen Shieh / Tzu-Shing Deng

    Molecules, Vol 25, Iss 4256, p

    2020  Volume 4256

    Abstract: St. John’s wort ( Hypericum perforatum L.) is a medicinal plant that alleviates depression and ... and important, ingredients in St. John’s wort that alleviate depression. In order to investigate ... methodology (RSM) was employed in this study. Two-month-old St John’s wort plants were cultivated ...

    Abstract St. John’s wort ( Hypericum perforatum L.) is a medicinal plant that alleviates depression and other disorders due to its abundance of active ingredients. Hyperforin, rutin, and melatonin are the main active, and important, ingredients in St. John’s wort that alleviate depression. In order to investigate the optimal conditions for accumulating these active ingredients, design of experiments and response surface methodology (RSM) was employed in this study. Two-month-old St John’s wort plants were cultivated in growth chambers at varying temperatures, light intensities, and nutrient solution concentrations before analysis by HPLC, for determining differences in hyperforin, rutin, and melatonin content. The results showed that hyperforin and rutin contents were significantly influenced by temperature (18–23 °C) and light intensity (49–147 μmol m −2 s −1 photosynthetic photon flux density (PPFD)), whereas Hoagland’s nutrient solution concentration (25–75%) had little effect. The accumulation of melatonin might not be influenced by cultivation conditions. Light intensity and temperature are easily controlled environmental factors in artificial cultivation, both of which are related to secondary metabolite production in the plant. Based on RSM, the optimal conditions for the accumulation of hyperforin and rutin were obtained. The maximum content of hyperforin was 5.6 mg/g, obtained at a temperature of 19 °C, a nutrient solution concentration of 45%, and a light intensity of 49 μmol m −2 s −1 PPFD. The maximum content of rutin was 3.8 mg/g obtained at a temperature of 18 °C, a nutrient solution concentration of 50%, and a light intensity of 147 μmol m −2 s −1 PPFD. This evaluation of suitable conditions for the accumulation of bioactive compounds in St. John’s wort can be applied to plant factories on a large scale.
    Keywords St. John’s wort ; leaf extracts ; hyperforin ; rutin ; melatonin ; optimization ; Organic chemistry ; QD241-441
    Subject code 333
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  3. Article: Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum

    Guo, Yi / Zhang Na / Chen Chunmei / Huang Jinfeng / Li Xiao-Nian / Liu Junjun / Zhu Hucheng / Tong Qingyi / Zhang Jinwen / Luo Zengwei / Xue Yongbo / Zhang Yonghui

    Journal of natural products. 2017 May 26, v. 80, no. 5

    2017  

    Abstract: The new polyprenylated acylphloroglucinol derivatives 1–15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute ... ...

    Abstract The new polyprenylated acylphloroglucinol derivatives 1–15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh₂(OCOCF₃)₄-induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicyclo[3.3.1]nonane core. Hyperforatins G (10) and H (11) are similarly the first examples of naturally occurring [3.3.1]-type polycyclic prenylated acylphloroglucinols possessing a carbonyl functionality at C-32. The compounds were tested for their acetylcholinesterase (AChE) inhibitory activities and cytotoxic activities against a panel of human tumor cell lines. Compounds 3, 5, 6, 8, and 9 exerted moderate inhibitory activities (IC₅₀ 3.98–9.13 μM) against AChE.
    Keywords Hypericum perforatum ; X-ray diffraction ; acetylcholinesterase ; anticarcinogenic activity ; circular dichroism spectroscopy ; crystallography ; cytotoxicity ; enzyme inhibition ; humans ; inhibitory concentration 50 ; leaves ; neoplasm cells ; nuclear magnetic resonance spectroscopy ; stems
    Language English
    Dates of publication 2017-0526
    Size p. 1493-1504.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021%2Facs.jnatprod.6b01178
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Real-World Evidence of Multiple Air Pollutants and Mortality: A Prospective Cohort Study in an Oldest-Old Population.

    Liu, Linxin / Zeng, Yi / Ji, John S

    Environment & health (Washington, D.C.)

    2023  Volume 2, Issue 1, Page(s) 23–33

    Abstract: We aimed to report real-world longitudinal ambient air pollutants levels compared to WHO Air Quality Guidelines (AQG) and analyze multiple air pollutants' joint effect on longevity, and the modification and confounding from the climate and urbanization ... ...

    Abstract We aimed to report real-world longitudinal ambient air pollutants levels compared to WHO Air Quality Guidelines (AQG) and analyze multiple air pollutants' joint effect on longevity, and the modification and confounding from the climate and urbanization with a focus on the oldest-old. This study included 13,207 old participants with 73.3% aged 80 and beyond, followed up from 2008 to 2018 in 23 Chinese provinces. We used the Cox-proportional hazards model and quantile-based g-computation model to measure separate and joint effects of the multiple pollutants. We adjusted for climate and area economic factors based on a directed acyclic graph. In 2018, no participants met the WHO AQG for PM
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2833-8278
    ISSN (online) 2833-8278
    DOI 10.1021/envhealth.3c00106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Overview of the Effect of Aging on the Female Urethra.

    Afyouni, Andrew S / Wu, Yi Xi / Balis, Ulysses G J / DeLancey, John / Sadeghi, Zhina

    The Urologic clinics of North America

    2024  Volume 51, Issue 2, Page(s) 239–251

    Abstract: Urethral function declines by roughly 15% per decade and profoundly contributes to the pathogenesis of urinary incontinence. Individuals with poor urethral function are more likely to fail surgical management for stress incontinence that focus on ... ...

    Abstract Urethral function declines by roughly 15% per decade and profoundly contributes to the pathogenesis of urinary incontinence. Individuals with poor urethral function are more likely to fail surgical management for stress incontinence that focus on improving urethral support. The reduced number of intramuscular nerves and the morphologic changes in muscle and connective tissue collectively impact urethral function as women age. Imaging technologies like MRI and ultrasound have advanced our understanding of these changes. However, substantial knowledge gaps remain. Addressing these gaps can be crucial for developing better prevention and treatment strategies, ultimately enhancing the quality of life for aging women.
    MeSH term(s) Humans ; Female ; Urethra/diagnostic imaging ; Quality of Life ; Vulva ; Aging ; Urinary Incontinence
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 192293-2
    ISSN 1558-318X ; 0094-0143
    ISSN (online) 1558-318X
    ISSN 0094-0143
    DOI 10.1016/j.ucl.2024.02.001
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    Se 269: Show issues Location:
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  6. Article ; Online: Correction to "A structural, biochemical, and bioinformatic basis for identifying radical SAM cyclopropyl synthases."

    Lien, Yi / Lachowicz, Jake C / Mendauletova, Aigera / Zizola, Cynthia / Ngendahimana, Thacien / Kostenko, Anastasiia / Eaton, Sandra S / Latham, John A / Grove, Tyler L

    ACS chemical biology

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Published Erratum
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.4c00225
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  7. Article ; Online: Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.

    Desai, Ankit K / Smith, P Brian / Yi, John S / Rosenberg, Amy S / Burt, Trevor D / Kishnani, Priya S

    Frontiers in immunology

    2024  Volume 14, Page(s) 1301912

    Abstract: Introduction: The efficacy of enzyme replacement therapy (ERT) with alglucosidase alfa for infantile-onset Pompe disease (IOPD) is limited in some patients due to the development of high and sustained antibody titers (HSAT; ≥12,800).: Methods: We ... ...

    Abstract Introduction: The efficacy of enzyme replacement therapy (ERT) with alglucosidase alfa for infantile-onset Pompe disease (IOPD) is limited in some patients due to the development of high and sustained antibody titers (HSAT; ≥12,800).
    Methods: We carried out detailed immunophenotyping of IOPD patients (n=40), including analysis of circulating cell populations by flow cytometry and plasma cytokines by multiplex array, to determine whether patients with HSAT have unique immunological characteristics compared to those with low titers (LT; <12,800).
    Results: Compared to patients with LT, patients who develop HSAT were skewed toward a type 2 immune profile, with an increased frequency of Th2 cells that was positively correlated with levels of Th2 (IL-4, IL-5, IL-13) and pro-inflammatory (IL-6, TNF-α, MIP-1α, MIP-1β) cytokines. B cells were increased in HSAT patients with a decreased fraction of unswitched memory B cells. Plasma GM-CSF concentrations were lower on average in HSAT patients, while CXCL11 was elevated. Finally, using principal components analysis, we derived an HSAT Signature Score that successfully stratified patients according to their antibody titers.
    Discussion: The immune profiles revealed in this study not only identify potential biomarkers of patients that developed HSAT but also provide insights into the pathophysiology of HSAT that will ultimately lead to improved immunotherapy strategies.
    MeSH term(s) Humans ; Glycogen Storage Disease Type II/drug therapy ; Immunophenotyping ; Enzyme Replacement Therapy ; Cytokines ; B-Lymphocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1301912
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  8. Article ; Online: Different pedagogical approaches to motor imagery both demonstrate individualized movement patterns to achieve improved performance outcomes when learning a complex motor skill

    Riki S. Lindsay / John Komar / Jia Yi Chow / Paul Larkin / Michael Spittle

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  9. Book ; Online: An Operational Architecture for Improving Air Force Command and Control Through Enhanced Agile Combat Support Planning, Execution, Monitoring, and Control Processes

    Lynch, Kristin F / Drew, John G / Tripp, Robert S / Romano, Daniel M / Yi, Jin Woo

    2014  

    Keywords Defence strategy, planning & research ; Air forces & warfare ; Military engineering ; History ; Technology
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030612988
    ISBN 9780833081407 ; 0833081403
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Book ; Online: Implementation Actions for Improving Air Force Command and Control Through Enhanced Agile Combat Support Planning, Execution, Monitoring, and Control Processes

    Lynch, Kristin F / Drew, John G / Tripp, Robert S / Romano, Daniel M / Yi, Jin Woo

    2014  

    Keywords Defence strategy, planning & research ; Air forces & warfare ; Military engineering ; History ; Technology
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030609743
    ISBN 9780833081414 ; 0833081411
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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