LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 212

Search options

  1. Book ; Thesis: Function of circulating T follicular helper cells after exposure to virulent tuberculosis proteins

    Gröger, Susan / Streeck, Hendrik

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Susan Gröger ; 1. Gutachter: Herr Univ.-Prof. Dr. med. H. Streeck, 2. Gutachter: Herr Priv.-Doz. D. med. J. Kehrmann
    Language English
    Size 77 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2022
    HBZ-ID HT021829250
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 776 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation

    Streeck, Hendrik

    Journal of immunological methods, 473:112630

    2019  

    Abstract: The complement system plays a critical role in innate immune defense against pathogens, both via non-specific direct pathogen recognition and killing or via antigen-specific indirect recruitment by complement fixing antibodies. While various assays for ... ...

    Abstract The complement system plays a critical role in innate immune defense against pathogens, both via non-specific direct pathogen recognition and killing or via antigen-specific indirect recruitment by complement fixing antibodies. While various assays for measuring complement activation have been developed, few provide a high-throughput, sample-sparing approach to interrogate the qualitative differences in the ability of antibodies to drive complement activation. Here we present a high-throughput, sample-sparing, bead-based assay to evaluate antigen-specific antibody-dependent complement activation against nearly any antigen. Optimization of buffer composition, kinetics of immune complex formation, as well as complement source all contribute critically to the development of a robust, highly flexible and high-throughput approach to analyze antibody-dependent complement deposition (ADCD). Thus, the optimized bead-based, antigen-specific assay represents a simple, highly adaptable platform to profile antibody-dependent complement activation across pathogens and diseases.
    Keywords Complement ; ADCD ; Antibody-dependent effector function ; Fc receptor ; High-throughput
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Hotspot

    Streeck, Hendrik / Trebbe-Plath, Margret

    Leben mit dem neuen Coronavirus

    2021  

    Abstract: ... Denn was in Heinsberg passierte, würde bald überall passieren. Für Hendrik Streeck stand deshalb fest, dass man nicht ...

    Author's details Hendrik Streeck ; unter Mitarbeit von Margret Trebbe-Plath
    Abstract Der erste große Ausbruch von COVID-19 in Deutschland bot eine unglaubliche Chance. Denn was in Heinsberg passierte, würde bald überall passieren. Für Hendrik Streeck stand deshalb fest, dass man nicht tatenlos zuschauen konnte, wie sich das Infektionsgeschehen entwickelte. Vielmehr stellte er sich die Frage: Was können wir dazu beitragen, das Virus zu bekämpfen, seine Ausbreitung einzudämmen? Antworten darauf fand er bei seiner Studie in Gangelt im Kreis Heinsberg, denn dort gab es zu dieser Zeit eine solche Dichte an Infizierten wie nirgendwo sonst in Deutschland, und da das öffentliche Leben dort weitestgehend zum Erliegen gekommen war, ließ sich das Infektionsgeschehen gut nachvollziehen. Dadurch bot sich die einmalige Gelegenheit, kurz- und langfristig Wissen auf vielen Ebenen zu generieren, um damit das neuartige Virus und das Pandemiegeschehen besser einschätzen zu können: Wie breitete sich das Virus aus, welches Ausmaß hatte das Infektionsgeschehen überhaupt? Wie verhielt es sich mit der Immunität? Und was machte dieses Virus mit dem Menschen, was waren die Symptome, und wie reagierte das Immunsystem? »Hotspot« bietet einen spannenden Einblick in die aktuelle Forschung und liefert zugleich neueste Erkenntnisse zu Sars-CoV-2 und dem Pandemiegeschehen.
    Keywords Covid-19 ; Sars-CoV-2 ; Pandemie ; Heinsberg Studie ; Virologen ; Virus ; Quarantäne ; Hot Spot ; Lockdown ; Shutdown ; Ausgangsbeschränkungen ; Infektionsketten ; Ausbruch ; Gesellschaft ; Ausnahmezustand ; Krise ; Isolation ; Vorsichtsmaßnahme ; Drosten ; Christian Drosten ; Alexander Kekulé ; Corona-Kompass ; COVID-19 ; Coronaviren ; Medizinische Mikrobiologie ; Gesellschaftsleben
    Subject Gesellschaftliches Leben ; Soziales Leben ; Klinische Mikrobiologie ; Molekulare Infektionsbiologie ; Coronavirus ; Coronaviridae ; Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
    Language German
    Size 191 Seiten, 21 cm x 13 cm
    Publisher Piper Verlag
    Publishing place München
    Publishing country Germany
    Document type Book
    Note Hier auch später erschienene, unveränderte als Nachdruck behandelte Auflagen
    HBZ-ID HT020800167
    ISBN 978-3-492-07103-1 ; 3-492-07103-1 ; 9783492975926 ; 3492975925
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Vel 1 available for loan (reading room) Lesesaal EG Gesundheitsliteratur

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Subdominant Gag-specific anti-HIV efficacy in an HLA-B*57-positive elite controller

    Streeck, Hendrik

    AIDS London, 30(6):972-974

    2016  

    Abstract: Despite the discovery of HIV over three decades ago, the 2008 ‘Berlin patient’ is the only case of sustained HIV remission. Other cases of apparent ‘cure’ eventually relapsed [1] and although early antiretroviral therapy (ART) has recently gained ... ...

    Abstract Despite the discovery of HIV over three decades ago, the 2008 ‘Berlin patient’ is the only case of sustained HIV remission. Other cases of apparent ‘cure’ eventually relapsed [1] and although early antiretroviral therapy (ART) has recently gained traction as a factor contributing to remission [2,3], most cases are likely to relapse [4]. In contrast, relapse in ‘elite controllers’ of HIV infection is less common. These are ART-naïve individuals who spontaneously suppress viremia to undetectable levels. Approximately 40% of elite controllers express HLA-B*57 [5], an example being the original 1999 ‘Berlin patient’, in whom virologic control has been maintained for >15 years to date [6].
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book: Coronavirus

    Heepen, Günther H. / Streeck, Hendrik

    Alles, was Sie wissen müssen: großes Interview mit Prof. Dr. Hendrik Streeck

    2020  

    Author's details Günther H. Heepen
    Keywords Virus-Infektionen ; Halsschmerzen ; Schmerzen ; Corona ; Lungenentzündung ; Entzündung ; Coronavirus ; Erkrankungen ; Atemwegserkrankungen ; SARS-CoV-2 ; COVID-19
    Subject Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion ; Schweres akutes Atemwegssyndrom Coronavirus 2 ; Severe acute respiratory syndrome coronavirus 2 ; 2019-nCoV ; 2019-novel Corona virus ; Wuhan-Coronavirus
    Subject code 610
    Language German
    Size 48 Seiten, 21 cm
    Edition 2. Auflage
    Publisher GRÄFE UND UNZER Verlag GmbH
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT020488768
    ISBN 978-3-8338-7714-8 ; 3-8338-7714-6 ; 9783833877117 ; 3833877111
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Vel 1 on loan 0 Vormerkungen

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

    Streeck, Hendrik

    Nature Communications, 6:7562

    2015  

    Abstract: Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether ... ...

    Abstract Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells. IL-21 promotes transcription of all miR-29 species through STAT3, whose binding to putative regulatory regions within the MIR29 gene is enriched by IL-21 signalling. Notably, exogenous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated with higher miR-29 expression. Together, these findings reveal a novel antiviral IL-21-miR-29 axis that promotes CD4 T-cell-intrinsic resistance to HIV-1 infection, and suggest a role for IL-21 in initial HIV-1 control in vivo.
    Keywords CD4-positive T cells ; Antivirals ; HIV infections ; Interleukins
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

    Streeck, Hendrik / Eller, Michael

    Nature Communications, 9:1212

    2018  

    Abstract: Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further ...

    Abstract Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK cells responding to models of direct cell recognition, ADCC, and cytokine activation have unique transcriptional fingerprints. Compared with healthy volunteers, individuals with chronic HIV-1 infection have higher expression of genes commonly associated with activation, and lower expression of genes associated with direct cell recognition and cytokine stimulation in their NK cells. By contrast, NK cell transcriptional profiles of individuals receiving a modified vaccinia Ankara (MVA) vectored HIV-1 vaccine show upregulation of genes associated with direct cell recognition. These findings demonstrate that targeted transcriptional profiling provides a sensitive assessment of NK cell activity, which helps understand how NK cells respond to viral infections and vaccination.
    Keywords Cell death and immune response ; HIV infections ; Innate lymphoid cells ; Microarray analysis ; NK cells
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

    Streeck, Hendrik

    Journal of experimental medicine, 209(1):61-75

    2012  

    Abstract: Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we comprehensively characterized the ... ...

    Institution Heinrich-Pette-Institut
    Abstract Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we comprehensively characterized the breadth, specificity, and quality of the HCV-specific CD4+ T cell response in 31 patients with acute HCV infection and varying clinical outcomes. We analyzed in vitro T cell expansion in the presence of interleukin-2, and ex vivo staining with HCV peptide-loaded MHC class II tetramers. Surprisingly, broadly directed HCV-specific CD4+ T cell responses were universally detectable at early stages of infection, regardless of the clinical outcome. However, persistent viremia was associated with early proliferative defects of the HCV-specific CD4+ T cells, followed by rapid deletion of the HCV-specific response. Only early initiation of antiviral therapy was able to preserve CD4+ T cell responses in acute, chronically evolving infection. Our results challenge the paradigm that HCV persistence is the result of a failure to prime HCV-specific CD4+ T cells. Instead, broadly directed HCV-specific CD4+ T cell responses are usually generated, but rapid exhaustion and deletion of these cells occurs in the majority of patients. The data further suggest a short window of opportunity to prevent the loss of CD4+ T cell responses through antiviral therapy.
    Keywords Host Defense ; Microbial Pathogenesis
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: [No title information]

    Streeck, Hendrik / Streeck, Hendrik

    MMW Fortschritte der Medizin

    2021  Volume 163, Issue 13, Page(s) 29

    Title translation Missverständnis Herdenimmunität.
    Language German
    Publishing date 2021-07-08
    Publishing country Germany
    Document type News
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-021-0165-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 72: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Thesis: Einfluss einer antiretroviralen Frühtherapie während der akuten HIV-1-Infektion auf den klinischen, virologischen und immunologischen Verlauf der HIV-1-Erkrankung

    Streeck, Hendrik

    2007  

    Author's details Hendrik Streeck
    Language German
    Size 154 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2007
    HBZ-ID HT015118901
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 D 915 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top