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  1. Article: Editorial: Editor's Pick 2021: Highlights in Cell Death and Survival.

    He, You-Wen / Walsh, Craig M

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 887688

    Language English
    Publishing date 2022-05-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.887688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparing Pharmacotherapies for ADHD in Adults: Evidence From Outcome-Focused Analysis of Food and Drug Administration Drug Label Registration Trials.

    Surman, Craig B H / Walsh, Daniel M / Bond, Joseph B

    Journal of attention disorders

    2024  Volume 28, Issue 5, Page(s) 800–809

    Abstract: Objective: We appraised whether FDA registration trials for ADHD pharmacotherapy in adults provides comparable information to inform treatment expectations.: Method: Comparison of ADHD outcome measure patterns in ADHD pharmacotherapy FDA drug label ... ...

    Abstract Objective: We appraised whether FDA registration trials for ADHD pharmacotherapy in adults provides comparable information to inform treatment expectations.
    Method: Comparison of ADHD outcome measure patterns in ADHD pharmacotherapy FDA drug label source studies.
    Results: Among stimulants, from fixed-dose titration data, amphetamine agents had numerically higher placebo-corrected symptom improvement and symptom effect sizes than methylphenidate agents. Symptom effect sizes were lower in the flexible dosing registration studies of atomoxetine and viloxazine. Varying responder definitions were analyzable, based on ≥30% symptom improvement and/or CGI-I improvement of "much" or "very much improved." Number of exposures needed to create these responses were lower for stimulants than for viloxazine.
    Conclusion: Heterogeneity in the design and analysis of FDA drug label source trials restricts implications for clinical practice. Research conducted using replicated designs, direct comparison of available treatments, and outcome analyses that generalize to clinical care could better inform clinical decision making.
    MeSH term(s) United States ; Adult ; Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Viloxazine/therapeutic use ; United States Food and Drug Administration ; Central Nervous System Stimulants/therapeutic use ; Methylphenidate/therapeutic use ; Atomoxetine Hydrochloride/therapeutic use ; Treatment Outcome
    Chemical Substances Viloxazine (5I5Y2789ZF) ; Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49) ; Atomoxetine Hydrochloride (57WVB6I2W0)
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231218041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5196: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Do ADHD Treatments Improve Executive Behavior Beyond Core ADHD Symptoms in Adults? Evidence From Systematic Analysis of Clinical Trials.

    Surman, Craig B H / Walsh, Daniel M

    Journal of clinical pharmacology

    2023  Volume 63, Issue 6, Page(s) 640–653

    Abstract: We sought to understand the effect of current treatments for attention deficit hyperactivity disorder (ADHD) on executive functioning deficits, which are often comorbid with ADHD, via a systematic analysis of adult ADHD treatment studies evaluating ... ...

    Abstract We sought to understand the effect of current treatments for attention deficit hyperactivity disorder (ADHD) on executive functioning deficits, which are often comorbid with ADHD, via a systematic analysis of adult ADHD treatment studies evaluating change in behavioral measures beyond the core symptoms of Diagnostic and Statistical Manual of Mental Disorders ADHD. The standardized mean difference for behavioral measures of executive functioning was determined from controlled trials of adults with ADHD and compared with effects on core ADHD symptoms. Several studies of atomoxetine revealed small to large standardized mean differences. Nonreplicated studies revealed small to medium effects for triple-bead mixed amphetamine salts, lisdexamfetamine, and forms of cognitive behavioral therapy. Proportional effect versus core ADHD symptoms ranged from 0.78 to 1.16 for atomoxetine, and from 0.65 to 1.44 across all the studies. ADHD treatments have effects on executive functioning behavior beyond core ADHD symptoms in adults. Clinicians can measure and treat this morbidity using available clinical tools.
    MeSH term(s) Adult ; Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Atomoxetine Hydrochloride/pharmacology ; Atomoxetine Hydrochloride/therapeutic use ; Amphetamine/therapeutic use ; Lisdexamfetamine Dimesylate/therapeutic use ; Executive Function ; Central Nervous System Stimulants/therapeutic use ; Central Nervous System Stimulants/pharmacology
    Chemical Substances Atomoxetine Hydrochloride (57WVB6I2W0) ; Amphetamine (CK833KGX7E) ; Lisdexamfetamine Dimesylate (SJT761GEGS) ; Central Nervous System Stimulants
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.176: Show issues Location:
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  4. Article ; Online: Editorial

    You-Wen He / Craig M. Walsh

    Frontiers in Cell and Developmental Biology, Vol

    Editor’s Pick 2021: Highlights in Cell Death and Survival

    2022  Volume 10

    Keywords cell death ; autophagy ; survival ; T lymphocyte ; antitumor immunity ; immunotherapy ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Understanding the Impact of Stimulants on Sleep in ADHD: Evidence from Systematic Assessment of Sleep in Adults.

    Surman, Craig B H / Walsh, Daniel M

    CNS drugs

    2022  Volume 36, Issue 3, Page(s) 253–260

    Abstract: Stimulants are widely prescribed to manage attention-deficit/hyperactivity disorder (ADHD) in adults. Stimulants promote wakefulness and can produce insomnia side effects. We hypothesized that systematic studies of sleep effects would reveal patterns of ... ...

    Abstract Stimulants are widely prescribed to manage attention-deficit/hyperactivity disorder (ADHD) in adults. Stimulants promote wakefulness and can produce insomnia side effects. We hypothesized that systematic studies of sleep effects would reveal patterns of sleep impairment that may be important for clinicians to monitor and manage. We conducted a review and analysis of studies that measured sleep systematically during stimulant treatment in adults. We identified nine studies that met our search criteria, including four double-blind placebo-controlled studies. All studies recorded self-report subjective sleep quality data, three studies collected actigraphy data, and three studies collected polysomnography data. One study found better subjective sleep quality under open-label treatment conditions. Both polysomnography studies found improvement in aspects of sleep patterns. Two of the actigraphy studies suggested that adults receiving stimulant treatment may have less movement during sleep, and one showed reduction in amount of sleep. Further research could inform best practices for maintaining sleep quality during stimulant treatment.
    MeSH term(s) Adult ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/adverse effects ; Humans ; Methylphenidate/therapeutic use ; Polysomnography ; Randomized Controlled Trials as Topic ; Sleep
    Chemical Substances Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49)
    Language English
    Publishing date 2022-03-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-022-00905-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Do Treatments for Adult ADHD Improve Emotional Behavior? A Systematic Review and Analysis.

    Surman, Craig B H / Walsh, Daniel M

    Journal of attention disorders

    2022  Volume 26, Issue 14, Page(s) 1822–1832

    Abstract: Objective: Dysregulated emotional behavior occurs often in adults with ADHD. Analysis of clinical trials may guide clinical intervention and future research.: Method: Controlled trials of adult ADHD measuring emotional behavior were included if ... ...

    Abstract Objective: Dysregulated emotional behavior occurs often in adults with ADHD. Analysis of clinical trials may guide clinical intervention and future research.
    Method: Controlled trials of adult ADHD measuring emotional behavior were included if another study offered a comparable analysis of the same treatment method. Standardized Mean Difference (SMD) of effects were calculated, and the size of effects for emotional and non-emotional ADHD behavior were compared.
    Results: 13 out of 14 studies of methylphenidate, atomoxetine, and lisdexamfetamine demonstrated significant improvement in emotional behavior measures, with small to high SMDs. The proportional effect on emotional versus non-emotional behavior ranged from 46% to 110% for methylphenidate, 56% to 129% for atomoxetine, and 36% to 96% for lisdexamfetamine.
    Conclusion: Psychopharmacological treatments for ADHD are likely to improve emotional behavior, and available scales are sensitive to these effects. Studies dedicated to treatment of this domain of function can further refine clinical approaches.
    MeSH term(s) Adult ; Humans ; Atomoxetine Hydrochloride/therapeutic use ; Lisdexamfetamine Dimesylate/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Methylphenidate/pharmacology ; Methylphenidate/therapeutic use ; Treatment Outcome
    Chemical Substances Atomoxetine Hydrochloride (57WVB6I2W0) ; Lisdexamfetamine Dimesylate (SJT761GEGS) ; Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49)
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547221110926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Use of the Bath Ankylosing Spondylitis Disease Activity Index in Patients With Psoriatic Arthritis With and Without Axial Disease.

    Reddy, Soumya M / Xue, Katie / Husni, M Elaine / Scher, Jose U / Stephens-Shields, Alisa J / Goel, Niti / Koplin, Joelle / Craig, Ethan T / Walsh, Jessica A / Ogdie, Alexis

    The Journal of rheumatology

    2024  Volume 51, Issue 2, Page(s) 139–143

    Abstract: Objective: To evaluate whether the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a responsive instrument in psoriatic arthritis (PsA) and whether it differentiates between axial and peripheral disease activity in PsA.: Methods: ... ...

    Abstract Objective: To evaluate whether the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a responsive instrument in psoriatic arthritis (PsA) and whether it differentiates between axial and peripheral disease activity in PsA.
    Methods: Individuals with PsA initiating therapy in a longitudinal cohort study based in the United States were included. Axial PsA (axPsA), most often also associated with peripheral disease, was defined as fulfillment of the Assessment of Spondyloarthritis international Society axial spondyloarthritis classification criteria or presence of axial disease imaging features. Baseline BASDAI, individual BASDAI items, patient global assessment, patient pain, and Routine Assessment of Patient Index Data 3, and score changes following therapy initiation were descriptively reported. Standardized response means (SRMs) were calculated as the mean change divided by the SD of the change.
    Results: The mean (SD) baseline BASDAI score at the time of therapy initiation was 5.0 (2.2) among those with axPsA (n = 40) and 4.8 (2.0) among those with peripheral-only disease (n = 79). There was no significant difference in patient-reported outcome scores between the groups. The mean change for BASDAI was similar among axial vs peripheral disease (-0.75 vs -0.83). SRMs were similar across axial vs peripheral disease for BASDAI (-0.37 vs -0.44) and the individual BASDAI items.
    Conclusion: BASDAI has reasonable responsiveness in PsA but does not differentiate between axPsA and peripheral PsA. (ClinicalTrials.gov: NCT03378336).
    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/complications ; Spondylitis, Ankylosing/diagnostic imaging ; Spondylitis, Ankylosing/drug therapy ; Longitudinal Studies ; Severity of Illness Index ; Spondylarthritis/complications
    Language English
    Publishing date 2024-02-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-0504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1168: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 135: Show issues

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  8. Article: Managing Sleep in Adults with ADHD: From Science to Pragmatic Approaches.

    Surman, Craig B H / Walsh, Daniel M

    Brain sciences

    2021  Volume 11, Issue 10

    Abstract: Background: Sleep disorders and sleep problems commonly occur in adults with ADHD and add to functional impairment. Evidence-based treatments for sleep could improve function in the adult ADHD population.: Methods: A literature review was conducted ... ...

    Abstract Background: Sleep disorders and sleep problems commonly occur in adults with ADHD and add to functional impairment. Evidence-based treatments for sleep could improve function in the adult ADHD population.
    Methods: A literature review was conducted to present the clinical science informing treatment of sleep in adults with ADHD.
    Results: Six systematic prospective studies of sleep intervention in adults with ADHD were identified. Three of these, all including well-characterized ADHD patients, offered evidence for a significant effect of morning light therapy. Across the studies, preliminary evidence for melatonin, behavioral therapy, and weighted blankets were also found.
    Implication: Low-risk interventions such as light therapy may improve sleep in adults with ADHD, but many sleep interventions currently in use remain unstudied in the ADHD population. Considerations for evidence-informed practice and future research directions are discussed.
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11101361
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  9. Article ; Online: Editorial: Tweaking T cell receptor signaling thresholds through DAG: the role of diacylglycerol kinase ζ in T cell responses to TGF-β.

    Walsh, Craig M

    Journal of leukocyte biology

    2015  Volume 98, Issue 5, Page(s) 685–687

    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Diacylglycerol Kinase/immunology ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction/immunology ; Transforming Growth Factor beta/immunology
    Chemical Substances Receptors, Antigen, T-Cell ; Transforming Growth Factor beta ; Diacylglycerol Kinase (EC 2.7.1.107)
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.2CE0615-278
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  10. Article: Grand challenges in cell death and survival: apoptosis vs. necroptosis.

    Walsh, Craig M

    Frontiers in cell and developmental biology

    2014  Volume 2, Page(s) 3

    Language English
    Publishing date 2014-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2014.00003
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