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  1. Article ; Online: Relevance of acquired T cell molecular defects in the immunopathogenesis of SLE.

    Rosetti, Florencia / Madera-Salcedo, Iris K / Crispín, José C

    Clinical immunology (Orlando, Fla.)

    2024  Volume 263, Page(s) 110225

    Abstract: Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the ... ...

    Abstract Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of those observations and argue that they may represent a pathogenic layer between genetic factors and disease development. Acquired changes in T cell phenotype and function in the setting of SLE may affect the immune system, creating a predisposition towards a more inflammatory and pathogenic system that amplifies autoimmunity and facilitates disease development.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2024.110225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article: UNWINDING THE LONG ROAD THAT LEADS TO UNDERSTANDING AUTOIMMUNITY.

    Rosetti, Florencia / Crispín, José C

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2021  Volume 73, Issue 5, Page(s) 297–301

    Abstract: Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current ... ...

    Abstract Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current understanding of the pathogenesis of autoimmunity and indicate four research avenues whose exploration will bring us closer to resolving fundamental questions that remain unanswered in this enigmatic field.
    MeSH term(s) Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity/genetics ; Genetic Predisposition to Disease ; Humans
    Language English
    Publishing date 2021-10-05
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.21000294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 288: Show issues Location:
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  3. Article ; Online: Editorial: Global excellence in inflammatory diseases: Latin America 2021.

    Lima-Júnior, Roberto César Pereira / Crispín, José C / Brito, Gerly Anne Castro

    Frontiers in immunology

    2023  Volume 14, Page(s) 1278212

    MeSH term(s) Latin America/epidemiology ; Inflammation/epidemiology
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1278212
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  4. Article ; Online: Editorial: Innate lymphoid cell development, migration, and function.

    Henao-Mejía, Jorge / Crispín, José C / Licona-Limón, Paula

    Frontiers in immunology

    2023  Volume 14, Page(s) 1242754

    MeSH term(s) Immunity, Innate ; Killer Cells, Natural/physiology ; Cell Differentiation
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1242754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dysregulated protein kinase/phosphatase networks in SLE T cells.

    Suárez-Rojas, Gerardo / Crispín, José C

    Clinical immunology (Orlando, Fla.)

    2022  Volume 236, Page(s) 108952

    Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with multiple phenotypic and functional aberrations in T lymphocytes. Among these, altered expression and/or activity of several protein kinases and phosphatases has been ... ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with multiple phenotypic and functional aberrations in T lymphocytes. Among these, altered expression and/or activity of several protein kinases and phosphatases has been consistently documented in T cells obtained from patients with SLE. In this review, we describe and contextualize some of the kinase and phosphatase defects reported in T cells from patients with SLE, highlighting their relevance and possible consequences. Additionally, we discuss the origin of the defects and its significance for disease development and expression.
    MeSH term(s) Autoimmune Diseases/metabolism ; Humans ; Lupus Erythematosus, Systemic ; Phosphoric Monoester Hydrolases/metabolism ; Protein Kinases/metabolism ; T-Lymphocytes
    Chemical Substances Protein Kinases (EC 2.7.-) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.108952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Unwinding the Long Road that leads to Understanding Autoimmunity

    Florencia Rosetti / José C. Crispín

    Revista de Investigación Clínica, Vol 73, Iss

    2021  Volume 5

    Abstract: Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current ... ...

    Abstract Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current understanding of the pathogenesis of autoimmunity and indicate four research avenues whose exploration will bring us closer to resolving fundamental questions that remain unanswered in this enigmatic field.
    Keywords Autoimmunity. Autoimmune diseases. Immune system ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Editorial: New biomarkers for the diagnosis and treatment of systemic lupus erythematosus.

    Perl, Andras / Agmon-Levin, Nancy / Crispín, José C / Jorgensen, Trine N

    Frontiers in immunology

    2022  Volume 13, Page(s) 1009038

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Lupus Nephritis ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1009038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial: Mechanisms by Which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis.

    Crispín, José C / Morel, Laurence

    Frontiers in immunology

    2019  Volume 10, Page(s) 2808

    MeSH term(s) Animals ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Lupus Erythematosus, Systemic/genetics
    Language English
    Publishing date 2019-12-03
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cancer immunosurveillance by CD8 T cells.

    Crispin, José C / Tsokos, George C

    F1000Research

    2020  Volume 9

    Abstract: Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the ... ...

    Abstract Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function. In particular, we review recent literature that has reported on the phenotype and transcriptome of tumor-infiltrating CD8 T cells and deciphered the mechanisms associated with failed tumor rejection.
    MeSH term(s) CD8-Positive T-Lymphocytes/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Monitoring, Immunologic ; Neoplasms ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.21150.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Regulation of activated T cell survival in rheumatic autoimmune diseases.

    Rosetti, Florencia / Madera-Salcedo, Iris K / Rodríguez-Rodríguez, Noé / Crispín, José C

    Nature reviews. Rheumatology

    2022  Volume 18, Issue 4, Page(s) 232–244

    Abstract: Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones are finely regulated to minimize immunopathology and avoid autoimmunity. ...

    Abstract Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones are finely regulated to minimize immunopathology and avoid autoimmunity. In patients with rheumatic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, activated lymphocytes survive and exert effector functions for prolonged periods, defying the mechanisms that normally curb their capacities during acute and chronic infections. Here, we review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis. We highlight defects that could contribute to the development and progression of autoimmune disease and describe how chronic inflammation can alter the regulation of activated lymphocyte survival, promoting its perpetuation. These concepts might contribute to the understanding of the mechanisms that underlie the chronicity of inflammation in the context of autoimmunity.
    MeSH term(s) Arthritis, Rheumatoid ; Autoimmune Diseases ; Autoimmunity ; Cell Survival ; Humans ; Inflammation ; Lupus Erythematosus, Systemic ; Rheumatic Diseases ; T-Lymphocytes
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-021-00741-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6338: Show issues Location:
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