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Article ; Online: Epithelial-mesenchymal transition is the main way in which glioma-associated microglia/macrophages promote glioma progression.

He, Xin / Guo, Yuduo / Yu, Chunjiang / Zhang, Hongwei / Wang, Shengdian

2023 Volume 14, Page(s) 1097880

Abstract: Microglia/macrophages make up the largest population of tumor-infiltrating cells. Numerous studies have demonstrated that glioma-associated microglia/macrophages (GAMs) could promote the malignant progression of gliomas in various pathways. However, the ... ...

Abstract	Microglia/macrophages make up the largest population of tumor-infiltrating cells. Numerous studies have demonstrated that glioma-associated microglia/macrophages (GAMs) could promote the malignant progression of gliomas in various pathways. However, the primary function of GAMs in glioma remains inconclusive. First, by the CIBERSORT algorithm, we evaluated the content of microglia/macrophages in glioma tissues by bioinformatic analysis of omic data from thousands of glioma samples. Subsequently, we analyzed and confirmed the significant relationship between GAMs and the malignant phenotype of glioma, including survival time, IDH mutation status, and time of symptom onset. Afterward, Epithelial-Mesenchymal Transition (EMT) was identified by Gene Set Enrichment Analysis (GSEA) from numerous biological processes as the most relevant mechanism of malignant progression to GAMs. Moreover, a series of clinical samples were detected, including normal brain and various-grade glioma tissues. The results not only showed that GAMs were significantly associated with gliomas and their malignancy but also that GAMs were highly correlated with the degree of EMT in gliomas. In addition, we isolated GAMs from glioma samples and constructed co-culture models (
MeSH term(s)	Humans ; Microglia/metabolism ; Brain Neoplasms/metabolism ; Epithelial-Mesenchymal Transition ; Tumor Microenvironment ; Glioma/metabolism ; Macrophages/metabolism
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1097880
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to: CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion.

Wang, Fei / Yang, Li / Gao, Qun / Huang, Lan / Wang, Liping / Wang, Jing / Wang, Shengdian / Zhang, Bin / Zhang, Yi

Cancer immunology, immunotherapy : CII

2021 Volume 70, Issue 10, Page(s) 3057–3059

Language	English
Publishing date	2021-05-18
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-021-03023-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1237: Show issues

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Article: A novel workflow for cancer blood biomarker identification.

Wang, Xiang / Qiu, Zhiqiang / Ji, Xiangwen / Ning, Weihai / An, Yihua / Wang, Shengdian / Zhang, Hongwei

Annals of translational medicine

2022 Volume 8, Issue 21, Page(s) 1430

Abstract: Background: Over the last few years, great progress has been made in the development of key technologies to detect peripheral blood-based, tumor-specific biomarkers, such as circulating tumor cells (CTCs) and circulating cell free tumor DNA (ctDNA). ... ...

Abstract	Background: Over the last few years, great progress has been made in the development of key technologies to detect peripheral blood-based, tumor-specific biomarkers, such as circulating tumor cells (CTCs) and circulating cell free tumor DNA (ctDNA). Despite the considerable advances and their multiple clinical values, liquid biopsies are challenged by the very low concentrations of CTCs and ctDNA in blood samples. Additionally, blood biomarkers which were found using data-driven methods may only be effective in few datasets. Methods: We firstly collected the genes which have expression correlations between blood and the other tissues/organs using Genotype-Tissue Expression (GTEx). Survival hazard genes and differential expression genes of each cancer type in The Cancer Genome Atlas (TCGA) were then selected by Cox regression model and Wilcoxon rank sum test, respectively. By combining the P values of two steps, several blood biomarkers can be inferred for each cancer type. After applying these potential blood biomarker sets to 13 datasets of blood samples from solid tumor patients using single sample gene set enrichment analyses (ssGSEA), we got an enrichment score (ES) for each sample. Results: The inferred blood biomarker (BB infer) genes showed reliable predictive value in various malignancies. In all the blood samples that were analyzed, the ESs of positive BB Infer genes in cancer patients are higher than healthy people. Conversely, the ESs of negative BB Infer genes in cancer patients are lower than healthy people. Furthermore, lower ES of negative BB infer genes signify the dismal outcome of patients. Conclusions: We developed a novel solid tumor blood biomarker inference workflow for cancer screening and diagnosis. Moreover, we demonstrated the utility of this inference method in a series of blood sample datasets of solid tumor patients. These results suggested the potential value of this method in the screening, diagnosis and prognosis of cancers.
Language	English
Publishing date	2022-06-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-2047
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Article ; Online: A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients

Liu, Lei / Liu, Wanbing / Wang, Shengdian / Zheng, Shangen

medRxiv

Keywords	covid19
Language	English
Publishing date	2020-03-08
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.03.06.20031856
Database	COVID19

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Book ; Online: A Synchronized Layer-by-layer Growing Approach for Plausible Neuronal Morphology Generation

Yang, Nianzu / Zeng, Kaipeng / Lu, Haotian / Wu, Yexin / Yuan, Zexin / Jiang, Shengdian / Wu, Jiaxiang / Wang, Yimin / Yan, Junchi

2024

Abstract: Neuronal morphology is essential for studying brain functioning and understanding neurodegenerative disorders. As the acquiring of real-world morphology data is expensive, computational approaches especially learning-based ones e.g. MorphVAE for ... ...

Abstract	Neuronal morphology is essential for studying brain functioning and understanding neurodegenerative disorders. As the acquiring of real-world morphology data is expensive, computational approaches especially learning-based ones e.g. MorphVAE for morphology generation were recently studied, which are often conducted in a way of randomly augmenting a given authentic morphology to achieve plausibility. Under such a setting, this paper proposes \textbf{MorphGrower} which aims to generate more plausible morphology samples by mimicking the natural growth mechanism instead of a one-shot treatment as done in MorphVAE. Specifically, MorphGrower generates morphologies layer by layer synchronously and chooses a pair of sibling branches as the basic generation block, and the generation of each layer is conditioned on the morphological structure of previous layers and then generate morphologies via a conditional variational autoencoder with spherical latent space. Extensive experimental results on four real-world datasets demonstrate that MorphGrower outperforms MorphVAE by a notable margin. Our code will be publicly available to facilitate future research.
Keywords	Quantitative Biology - Neurons and Cognition
Subject code	004
Publishing date	2024-01-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oncolytic virus Ad-TD-nsIL-12 inhibits glioma growth and reprograms the tumor immune microenvironment.

Li, Shenglun / Guo, Yuduo / Ning, Weihai / Chen, Yujia / Xu, Jiacheng / Zhao, Chao / Wang, Jun / Qu, Yanming / Zhang, Mingshan / Wang, Pengju / Wang, Yaohe / Wang, Shengdian / Zhang, Hongwei

Life sciences

2023 Volume 336, Page(s) 122254

Abstract: Aims: Gliomas are the most common central nervous system malignancies, with limited therapeutic options and poor prognosis, which are primarily attributed to the "immune desert" microenvironment. Previously, we constructed a three-gene-deleted oncolytic ...

Abstract	Aims: Gliomas are the most common central nervous system malignancies, with limited therapeutic options and poor prognosis, which are primarily attributed to the "immune desert" microenvironment. Previously, we constructed a three-gene-deleted oncolytic adenovirus (Ad-TD) loaded with non-secreting interleukin-12 (nsIL-12), which could be amplified in tumor cells and induce immunity to suppress tumors. However, the effects of this oncolytic virus on gliomas and their immune microenvironment remain unclear. There is an urgent need for further research. Materials and methods: We constructed a Syrian hamster brain tumor model and demonstrated the efficacy and mechanism of the novel oncolytic virus in treating brain tumors through a series of in vitro and in vivo experiments. We investigated the efficacy and safety (the number of hamsters in each group is either 5 or 10) of the oncolytic virus treatment in Syrian hamsters using a virus-treated group, a control virus-treated group, and a blank control group. Key findings: In vitro assays showed that Ad-TD-nsIL-12 could specifically proliferate in brain tumor cells which induce tumor cell apoptosis and intracellular expression of interleukin (IL)-12. Moreover, in vivo experiments demonstrated that Ad-TD-nsIL-12 could effectively inhibit the progression of brain tumors and prolong survival. Ad-TD-nsIL-12 significantly enhanced T-cell infiltration in the brain tumor microenvironment. Significance: Ad-TD-nsIL-12 can inhibit glioma progression and increase T-cell infiltration in the tumor tissue, particularly infiltration by cytotoxic T cells (CD8+). Ad-TD-nsIL-12 can amplify and produce IL-12, inducing anti-glioma immune responses to inhibit tumor progression.
MeSH term(s)	Cricetinae ; Animals ; Humans ; Oncolytic Viruses/genetics ; Interleukin-12/genetics ; Oncolytic Virotherapy ; Tumor Microenvironment ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Glioma/therapy ; Brain Neoplasms/therapy ; Mesocricetus
Chemical Substances	Interleukin-12 (187348-17-0)
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.122254
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Uc I Zs.368: Show issues

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Article ; Online: Glucocorticoid-induced expansion of classical monocytes contributes to bone loss.

Liu, Pei / Gao, Youshui / Luo, Pengbo / Yu, Hongping / Guo, Shang / Liu, Fuyun / Gao, Junjie / Xu, Jianzhong / Wang, Shengdian / Zhang, Changqing

Experimental & molecular medicine

2022 Volume 54, Issue 6, Page(s) 765–776

Abstract: Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow. The role of this cell ... ...

Abstract	Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow. The role of this cell population in high-dose exogenous GC-induced osteoporosis (GIOP) remains to be elucidated. In this study, GIOP was established in rats and mice by daily methylprednisolone injection, and monocyte subsets were analyzed by flow cytometry. We demonstrated that classical monocytes accumulate in bone marrow during GIOP. Similarly, the monocyte proportion among bone marrow nucleated cells was also increased in patients with steroid treatment history. We sorted classical monocytes and analyzed their transcriptional profile in response to GCs by RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that classical monocytes isolated from GC-treated rats exhibited osteoclast differentiation potential. Deletion of classical monocytes by clodronate liposome treatment prevented GIOP via inhibition of osteoclastogenesis and restoration of CD31
MeSH term(s)	Animals ; Glucocorticoids/adverse effects ; Mice ; Monocytes/metabolism ; Osteoclasts/metabolism ; Osteogenesis ; Osteoporosis/chemically induced ; Rats
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-022-00764-6
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Zs.A 4775: Show issues

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Article: Antibody Therapies in Cancer.

Wang, Shengdian / Jia, Mingming

Advances in experimental medicine and biology

2016 Volume 909, Page(s) 1–67

Abstract: Antibody-based immunotherapy has become a standard treatment for a variety of cancers. Many well-developed antibodies disrupt signaling of various growth factor receptors for the treatment of a number of cancers by targeting surface antigens expressed on ...

Abstract	Antibody-based immunotherapy has become a standard treatment for a variety of cancers. Many well-developed antibodies disrupt signaling of various growth factor receptors for the treatment of a number of cancers by targeting surface antigens expressed on tumor cells. In recent years, a new family of antibodies is currently emerging in the clinic, which target immune cells rather than cancer cells. These immune-targeted therapies strive to augment antitumor immune responses by antagonizing immunosuppressive pathways or providing exogenous immune-activating stimuli, which have achieved dramatic results in several cancers. The future of cancer therapies is likely to combine these approaches with other treatments, including conventional therapies, to generate more effective treatments.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Antineoplastic Agents/therapeutic use ; Combined Modality Therapy ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Immunotherapy/methods ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/immunology ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/pathology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/pathology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Signal Transduction ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Antigens, Neoplasm ; Antineoplastic Agents ; Intercellular Signaling Peptides and Proteins ; Neoplasm Proteins
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-94-017-7555-7_1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Prognostic Value of EMT in Glioma and its Role in the Glioma Immune Microenvironment.

Ning, Weihai / Qiu, Zhiqiang / Ji, Xiangwen / Wang, Xiang / An, Yihua / Wang, Shengdian / Zhang, Hongwei

Journal of molecular neuroscience : MN

2020 Volume 70, Issue 10, Page(s) 1501–1511

Abstract: Diffuse glioma is the deadliest form of brain cancer, and the median survival of grade IV glioma (glioblastoma, GBM) is no more than 2 years even with maximal surgical resection followed by radiotherapy and chemotherapy, which are now the standard of ... ...

Abstract	Diffuse glioma is the deadliest form of brain cancer, and the median survival of grade IV glioma (glioblastoma, GBM) is no more than 2 years even with maximal surgical resection followed by radiotherapy and chemotherapy, which are now the standard of care for GBM. Glioma shares common characteristics with most malignant tumours, such as invasiveness, rapid progression, resistance to various therapies and inevitable recurrence, while it also has its own unique features, such as high aggressiveness and immunotherapy resistance, which can be, respectively, attributed to epithelial-mesenchymal transition (EMT) and the immunosuppressive microenvironment. Here, we calculated the EMT score of glioma using The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA) and the Gene Expression Omnibus (GEO) datasets and validated its prognostic value. Then, we investigated its role in the glioma immune microenvironment, identified the enriched EMT-related immune genes and determined their specific biological functions in glioma. Furthermore, clinical relevance analysis showed the translational value of these EMT-related immune genes. In short, our findings reveal a critical link between EMT and the glioma immune microenvironment and offer important clues for further investigation of the underlying molecular mechanism.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Glioma/genetics ; Glioma/immunology ; Glioma/pathology ; Humans ; Proteome/genetics ; Proteome/metabolism ; Transcriptome ; Tumor Microenvironment/immunology
Chemical Substances	Biomarkers, Tumor ; Proteome
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-020-01583-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3006: Show issues

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Article ; Online: Olgotrelvir, a dual inhibitor of SARS-CoV-2 M

Mao, Long / Shaabani, Namir / Zhang, Xiaoying / Jin, Can / Xu, Wanhong / Argent, Christopher / Kushnareva, Yulia / Powers, Colin / Stegman, Karen / Liu, Jia / Xie, Hui / Xu, Changxu / Bao, Yimei / Xu, Lijun / Zhang, Yuren / Yang, Haigang / Qian, Shengdian / Hu, Yong / Shao, Jianping /

Zhang, Can / Li, Tingting / Li, Yi / Liu, Na / Lin, Zhenhao / Wang, Shanbo / Wang, Chao / Shen, Wei / Lin, Yuanlong / Shu, Dan / Zhu, Zhenhong / Kotoi, Olivia / Kerwin, Lisa / Han, Qing / Chumakova, Ludmila / Teijaro, John / Royal, Mike / Brunswick, Mark / Allen, Robert / Ji, Henry / Lu, Hongzhou / Xu, Xiao

Med (New York, N.Y.)

2024 Volume 5, Issue 2, Page(s) 169–171

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Published Erratum
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2024.01.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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