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Article ; Online: Sulfone-Mediated S

Patel, Nitinchandra D / Wei, Xudong / Byrne, Denis / Narayanan, Bikshandarkoil A / Pennino, Scott / Sarvestani, Max / Saha, Anjan / Haddad, Nizar / Kapadia, Suresh / Lorenz, Jon C / DeCroos, Philomen / Ye, Andrew / Lee, Heewon / Grinberg, Nelu / Hossain, Azad / Busacca, Carl A / Yee, Nathan K / Senanayake, Chris H

The Journal of organic chemistry

2020 Volume 85, Issue 13, Page(s) 8339–8351

Abstract: ... a highly reactive S ...

Abstract	An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive S
MeSH term(s)	Antiviral Agents ; Ethers ; Hepacivirus ; Hepatitis C ; Humans ; Protease Inhibitors/pharmacology ; Sulfones ; Viral Nonstructural Proteins
Chemical Substances	Antiviral Agents ; Ethers ; Protease Inhibitors ; Sulfones ; Viral Nonstructural Proteins
Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.0c00554
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Article ; Online: It’s long-term, well it’s for life basically

Georgina Jones / Eva Brown Hajdukova / Esmee Hanna / Rosie Duncan / Brendan Gough / Jane Hughes / Debbie Hughes / Fran Ashworth / Johan Prevot / Jose Drabwell / Leire Solis / Nizar Mahlaoui / Anna Shrimpton

Qualitative Research in Medicine & Healthcare, Vol 4, Iss

Understanding and exploring the burden of immunoglobulin treatment in patients with primary immunodeficiency disorders

2021 Volume 3

Abstract: This paper describes the burden of receiving immunoglobulin (Ig) treatment from the perspective of patients diagnosed with a Primary Immunodeficiency (PID). Thirty semi-structured interviews with patients receiving intravenous (n=21) and subcutaneous ... ...

Abstract	This paper describes the burden of receiving immunoglobulin (Ig) treatment from the perspective of patients diagnosed with a Primary Immunodeficiency (PID). Thirty semi-structured interviews with patients receiving intravenous (n=21) and subcutaneous immunoglobulin (n=9) therapy, either at home or in hospital were undertaken. Underpinned by a phenomenological theoretical framework, and using a qualitative, inductive thematic approach to prioritise patients’ concerns, we identified that Ig treatment requires considerable effort by the patient, particularly in relation to the amount of time, organization and planning that is needed. They also face numerous physical, social, relationship, emotional, role functioning, travelling, and financial challenges in their effort to undergo and maintain their infusions and care for their health. Some qualitative differences in treatment burden were noted between home and hospital settings which contributed to non-adherence to those regimes. Immunoglobulin treatment burden is complex and influenced by therapeutic mode and setting and the personal circumstances of the patient. As choice over treatment method appears to be mainly informed by lifestyle needs, PID patients may benefit from more information about these potential Ig lifestyle influences when selecting which form of treatment to take together with their health professional.
Keywords	Primary immunodeficiency ; immunoglobulin treatment ; qualitative research ; thematic analysis ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
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Article ; Online: Citizens’ or Government’s Will? Exploration of Why Indonesia’s Local Governments Adopt Technologies for Open Government

Hafizh Rafizal Adnan / Achmad Nizar Hidayanto / Sherah Kurnia

Sustainability, Vol 13, Iss 11197, p

2021 Volume 11197

Abstract: Web 2.0 is a technology that enables collaboration between citizens and the government to actualise the concept of open government. The adoption of technology in the public sector is known to have positive impacts in fostering public sector innovation, ... ...

Abstract	Web 2.0 is a technology that enables collaboration between citizens and the government to actualise the concept of open government. The adoption of technology in the public sector is known to have positive impacts in fostering public sector innovation, including in developing countries with various problems that require collaboration between citizens and the government. However, currently studies concerning open government technology adoption in developing countries are limited. Indonesia as an example of a developing and democratic country provides a suitable context to explore this phenomenon. Moreover, there are many local government institutions in Indonesia, especially on Java Island, that have implemented Web 2.0 to support open government initiatives. Therefore, this research aims to explore key factors influencing the adoption of the Web 2.0 platform by local government institutions in Indonesia. Multiple theories are combined to guide the exploration of the influencing factors related to technology, organisations, management, and the environment. Based on a multiple case study involving five local government institutions in Indonesia, we identified fifteen factors affecting the adoption of Web 2.0 technology. This study offers both research and practical implications that can be considered by government and other key stakeholders to optimise public participation and information access through the adoption of open government initiatives.
Keywords	Web 2.0 ; open government ; local government ; adoption ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	306
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Lutembacher’s syndrome accompanied by partial anomalies of pulmonary veins in a 70-year-old male

Mohammad Nasser Khattab / Mohammad Alhalabi / Karam Alkounsol / Majed Othman / Nizar Hujair

European Journal of Case Reports in Internal Medicine (2023)

a case of congenital heart disease in the elderly

2023

Abstract: Lutembacher’s syndrome is a rare disease defined as the combination of atrial septal defect and ... of a previously asymptomatic 70-year-old man having Lutembacher’s syndrome with sinus venosus type of interatrial ... defect associated with partial anomalous pulmonary venous drainage. Our patient’s only complaint was ...

Abstract	Lutembacher’s syndrome is a rare disease defined as the combination of atrial septal defect and mitral stenosis, which relieves the progression of symptoms resulting from mitral stenosis. We present a case of a previously asymptomatic 70-year-old man having Lutembacher’s syndrome with sinus venosus type of interatrial defect associated with partial anomalous pulmonary venous drainage. Our patient’s only complaint was of mild exertional dyspnea, which started six months prior to referral. Clinical suspicion of the combination of defects arose during transthoracic echocardiography. The patient underwent transesophageal echocardiography and multi-slice computed tomography for defect confirmation. The combination of Lutembacher’s syndrome with this complex deformity of pulmonary venous drainage has rarely been described. Such complex congenital defects with multifaceted physiological repercussions can go largely undiagnosed for the patients affected for most of their lifetimes.
Keywords	congenital heart defect ; elderly congenital heart disease ; adult congenital defect ; atrial septal defect ; mitral stenosis ; anomalous pulmonary venous return ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
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Article ; Online: The impact of Turkey’s water resources development on the flow regime of the Tigris River in Iraq

Torabi Haghighi, Ali / Akbari, Mahdi / Noori, Roohollah / Danandeh Mehr, Ali / Gohari, Alireza / Sönmez, Mehmet Emin / Abou Zaki, Nizar / Yilmaz, Nese / Kløve, B.

Journal of Hydrology: Regional Studies. 2023 Aug., v. 48 p.101454-

2023

Abstract: ... before and after the planned water resources development in Turkey. Turkey’s Tigris River regulation goal is ... reservoire’s inflow (135–326 m³/sec). Consequently, some parts of Mosul's hydropower and reservoir capacity ...

Abstract	Once, the Tigris River (with its twin, the Euphrates) was the remarkable river in the west of Asia, making Mesopotamia a cradle of civilization thousands of years ago. Upstream anthropogenic activity has choked the Tigris River, the connecting lifeline across Iraq, and, due to droughts and desertification, caused the country to be plagued by poverty. Here, we give a perspective on flow regime alteration in the main corridor of the Tigris River at five crucial points (Cizre, Mosul, Baiji, Baghdad, and Kut) before and after the planned water resources development in Turkey. Turkey’s Tigris River regulation goal is to generate about 7247 GWh of energy and irrigate over 640,000 ha of farmlands. We reconstructed the natural flow along the Tigris River. In addition, to evaluate hydrological droughts, we proposed a modified streamflow drought index (MSDI) and compared it with the original streamflow drought index (SDI). The results show that the worst hydrological conditions could be found below the Samarra barrage in Iraq before the Tigris River regulation in Turkey. This negative hydrological condition will be extended to the whole corridor of the Tigris River in Iraq after the implementation of Turkey's goal. As a result, for example, Cizre and Mosul will experience extreme conditions in 37.5–87.5% of the years; this means a considerable reduction in the Mosul reservoire’s inflow (135–326 m³/sec). Consequently, some parts of Mosul's hydropower and reservoir capacity will be useless, and hydrological drought upstream of the Samarra barrage will be dominated.
Keywords	Lipotes vexillifer ; anthropogenic activities ; desertification ; drought ; energy ; poverty ; river regulation ; rivers ; stream flow ; water power ; Iraq ; Ilisu dam ; Modified streamflow index ; Impoundment ; River impact
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2814784-4
ISSN	2214-5818
ISSN	2214-5818
DOI	10.1016/j.ejrh.2023.101454
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Predictors and Costs of 30-Day Readmissions After Index Hospitalizations for Alcohol-Related Disorders in U.S. Adults.

Wani, Rajvi J / Tak, Hyo Jung / Watanabe-Galloway, Shinobu / Klepser, Donald G / Wehbi, Nizar K / Chen, Li-Wu / Wilson, Fernando A

Alcoholism, clinical and experimental research

2019 Volume 43, Issue 5, Page(s) 857–868

Abstract: Background: In 2015, the Hospital Readmissions Reduction Program mandated financial penalties to hospitals with greater rates of readmissions for certain conditions. Alcohol-related disorders (ARD) are the fourth leading cause of 30-day readmissions. ... ...

Abstract	Background: In 2015, the Hospital Readmissions Reduction Program mandated financial penalties to hospitals with greater rates of readmissions for certain conditions. Alcohol-related disorders (ARD) are the fourth leading cause of 30-day readmissions. Yet, there is a dearth of national-level research to identify high-risk patient populations and predictors of 30-day readmission. This study examined patient- and hospital-level predictors for index hospitalizations with principal diagnosis of ARD and predicted the cost of 30-day readmissions. Methods: The 2014 Nationwide Readmissions Database was used to identify ARD-related index hospitalizations. Multivariable logistic regression was used to estimate patient- and hospital-level predictors for readmissions, and a 2-part model was used to predict the incremental cost conditional upon readmission. Results: In 2014, 285,767 index hospitalizations for ARD were recorded, and 18.9% of ARD-associated hospitalizations resulted in at least one 30-day readmission. Patients who were males, aged 45 to 64 years, Medicaid enrollees, living in urban and low-income areas, or with 1 to 2 comorbidities had high risk of readmission. Index hospitalization costs were higher among readmitted patients ($8,840 vs. $8,036, p < 0.01). Predicted mean costs for readmissions on index stay with ARD were greater among those aged 45 to 64 years ($1,908, p < 0.001), Medicare enrollees ($2,133, p < 0.001), rural residents ($1,841, p < 0.01), living in high-income areas ($1,876, p < 0.001), with 4 or more comorbidities ($2,415, p < 0.001), or admitted in large metropolitan hospitals ($2,032, p < 0.001), with large number of beds ($1,964, p < 0.001), with government ownership ($2,109, p < 0.001), or with low volume of ARD cases ($2,155, p < 0.001). Conclusions: One in 5 ARD-related index hospitalizations resulted in a 30-day readmission. Overall, costs of index hospitalizations for ARD were $2.3 billion, of which $512 million were spent on hospitalizations that resulted in at least 1 readmission. There is a need to develop patient-centric health programs to reduce readmission rates and costs among ARD patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alcohol-Related Disorders/diagnosis ; Alcohol-Related Disorders/economics ; Alcohol-Related Disorders/epidemiology ; Female ; Forecasting ; Health Care Costs/trends ; Hospital Costs/trends ; Hospitalization/economics ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Patient Readmission/economics ; Patient Readmission/trends ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2019-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	428999-7
ISSN	1530-0277 ; 0145-6008
ISSN (online)	1530-0277
ISSN	0145-6008
DOI	10.1111/acer.14021
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Zs.A 1375: Show issues

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Article ; Online: An extended differential form of Hilbert’s inequality

Nizar Kh. Al-Oushoush

Journal of King Saud University: Science, Vol 31, Iss 1, Pp 21-

2019 Volume 23

Abstract: In this paper we introduce the extention of the differential form of Helbert’s integral inequality ... Hilbert’s integral inequality, Hölder inequality, Hardy inequality ...

Abstract	In this paper we introduce the extention of the differential form of Helbert’s integral inequality, and the reverse form of it. 2000 Mathematics Subject Classification: 26D15, Keywords and phrases: Hilbert’s integral inequality, Hölder inequality, Hardy inequality
Keywords	Science (General) ; Q1-390
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: The Other’s Image in Arabic Feminist Narrative

Nizar Qbilat / Awni El-Faouri

Journal of Arts and Social Sciences, Vol 7, Iss 2, Pp 337-

2016 Volume 345

Abstract: This study aims at shedding some light on the images of women in some feminist novels known as Feminist Literature. The research depicts a number of Arabic feminist writers concentrating on the structure of Feminist Literature generally, and Arabic women ...

Abstract	This study aims at shedding some light on the images of women in some feminist novels known as Feminist Literature. The research depicts a number of Arabic feminist writers concentrating on the structure of Feminist Literature generally, and Arabic women writers specifically. The study examines the characters, the narrative angle and the narrative sequence and its objective sensitivity at three levels: the woman as an author, a narrator, and the artistic character dealing with issues of justice, liberty and equality with man, considering the various humanitarian models: the striver, the lover and the educated within the borders of the forbidden, the fear, and the limitations. The popularity of Feminist Literature is one of the issues of modernity in the Arab world. The role of Jordanian women writers is apparent in literature. Their creative works compete with those of dominant men in terms of imagery and artistic presence. The inner persona of the woman writer is dominant even though her work represents a realistic view. The problematic issue of writing for women writers seems to be plunged in paradox and sharp in its novelistic representation. The novelistic modules studied indicate the success the Arab woman writer achieved in terms of the use of artistic tools, and the ability to confront and reveal the untold. Although the feminists’ novels seem to dwell in an anxious environment, they represent an arena of conflict representing the artistic and living realities.
Keywords	Novel ; Feminist Writing ; Women ; The Other’s Image ; Fine Arts ; N ; Social Sciences ; H
Subject code	820
Language	Arabic
Publishing date	2016-06-01T00:00:00Z
Publisher	Sultan Qaboos University
Document type	Article ; Online
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Article ; Online: Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.

The European respiratory journal

2015 Volume 45, Issue 1, Page(s) 87–97

Abstract: S-Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S ... We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 ... from the program as a whole. Airway S-nitrosoglutathione reductase activity was increased in asthma patients (p=0 ...

Abstract	S-Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S-nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients. We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in the Severe Asthma Research Program. We also analysed phenotype and genotype data taken from the program as a whole. Airway S-nitrosoglutathione reductase activity was increased in asthma patients (p=0.032). However, only a subpopulation was affected and this subpopulation was not defined by a "severe asthma" diagnosis. Subjects with increased activity were younger, had higher IgE and an earlier onset of symptoms. Consistent with a link between S-nitrosoglutathione biochemistry and atopy: 1) interleukin 13 increased S-nitrosoglutathione reductase expression and 2) subjects with an S-nitrosoglutathione reductase single nucleotide polymorphism previously associated with asthma had higher IgE than those without this single nucleotide polymorphism. Expression was higher in airway epithelium than in smooth muscle and was increased in regions of the asthmatic lung with decreased airflow. An early-onset, allergic phenotype characterises the asthma population with increased S-nitrosoglutathione reductase activity.
MeSH term(s)	Adolescent ; Adult ; Aldehyde Oxidoreductases/metabolism ; Asthma/enzymology ; Biopsy ; Bronchi/enzymology ; Bronchoalveolar Lavage ; Bronchoscopy ; Case-Control Studies ; Cells, Cultured ; Child ; Female ; Gene Expression Regulation, Enzymologic ; Genotype ; Humans ; Immunoglobulin E/blood ; Immunohistochemistry ; Interleukin-13/metabolism ; Lung/enzymology ; Magnetic Resonance Imaging ; Male ; Metabolism ; Middle Aged ; Muscle, Smooth/enzymology ; Phenotype ; Polymorphism, Single Nucleotide ; Young Adult
Chemical Substances	Interleukin-13 ; Immunoglobulin E (37341-29-0) ; Aldehyde Oxidoreductases (EC 1.2.-) ; formaldehyde dehydrogenase, glutathione-independent (EC 1.2.1.46)
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.00042414
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Mitochondrial DNA and Alzheimer’s disease: a first case–control study of the Tunisian population

Ben Salem, Nesrine / Boussetta, Sami / de Rojas, Itziar / Moreno-Grau, Sonia / Montrreal, Laura / Mokni, Narjes / Mahmoud, Imene / Younes, Samia / Daouassi, Nizar / Frih-Ayed, Mahbouba / Hammami, Afef / Ben Ammar Elgaaied, Amel / Ruiz, Agustín / Cherni, Lotfi

Molecular biology reports. 2022 Mar., v. 49, no. 3

2022

Abstract: BACKGROUND: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in humans and ...

Abstract	BACKGROUND: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial alteration has been proposed as a possible cause of AD. Therefore, several studies have focused on finding an association between inherited mitochondrial DNA variants and AD onset. METHODS: In this study, we looked, for the first time, for a potential association between mitochondrial haplogroups or polymorphisms and AD in the Tunisian population. We also evaluated the distribution of the major genetic risk factor for AD, the apolipoprotein E epsilon 4 (APOE ε4), in this population. In total, 159 single-nucleotide polymorphisms (SNPs) of mitochondrial DNA haplogroups were genotyped in 254 individuals (58 patients and 196 controls). An additional genotyping of APOE ε4 was performed. RESULTS: No significant association between mitochondrial haplogroups and AD was found. However, two individual SNPs, A5656G (p = 0.03821, OR = 10.46) and A13759G (p = 0.03719, OR = 10.78), showed a significant association with AD. APOE 4 was confirmed as a risk factor for AD (p = 0.000014). CONCLUSION: Our findings may confirm the absence of a relation between mitochondrial haplogroups and AD and support the possible involvement of some inherited variants in the pathogenicity of AD.
Keywords	apolipoprotein E ; case-control studies ; etiology ; genotyping ; mitochondria ; mitochondrial DNA ; molecular biology ; neurodegenerative diseases ; pathogenicity ; risk factors
Language	English
Dates of publication	2022-03
Size	p. 1687-1700.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06978-7
Database	NAL-Catalogue (AGRICOLA)

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