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Article ; Online: Imaging bruxism.

Bonte, Frederick J / Harris, Thomas S

2013 Volume 38, Issue 6, Page(s) e252–4

Abstract: A 62-year-old woman was referred for SPECT brain blood flow study with a diagnosis of possible dementia or depression. Findings within the brain were noncontributory, but extraneous structures with high blood flow were detected within the soft tissues of ...

Abstract	A 62-year-old woman was referred for SPECT brain blood flow study with a diagnosis of possible dementia or depression. Findings within the brain were noncontributory, but extraneous structures with high blood flow were detected within the soft tissues of temporal regions and face. On questioning, the patient stated that she had sleep bruxism, with gnashing and grinding of her teeth. This did not occur during waking. Bruxisms and its consequences, with effects on the teeth and jaws, are a problem of importance to oral surgeons and dentists. There is considerable active research into methods of treatment of sleep bruxism.
MeSH term(s)	Bruxism/diagnosis ; Bruxism/diagnostic imaging ; Cerebrovascular Circulation ; Diagnostic Imaging/methods ; Female ; Humans ; Middle Aged ; Regional Blood Flow ; Tomography, Emission-Computed, Single-Photon
Language	English
Publishing date	2013-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0b013e318251e18d
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Article ; Online: TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients.

Bonte, Frederick J / Hynan, Linda / Harris, Thomas S / White, Charles L

International journal of molecular imaging

2010 Volume 2011, Page(s) 409101

Abstract: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical ...

Abstract	The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical Parametric Mapping. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 73 subjects were compared with a neuropathologic study of the brain at autopsy. Data were analyzed for sensitivity, specificity, positive and negative predictive values and accuracy. These results are compared with several other studies performed with Tc-99m HMPAO SPECT with histopathologic correlation. This procedure is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses. Further, a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected. The study was approved by our Institutional Review Board.
Language	English
Publishing date	2010-12-01
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2595407-6
ISSN	2090-1720 ; 2090-1712
ISSN (online)	2090-1720
ISSN	2090-1712
DOI	10.1155/2011/409101
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Article ; Online: TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients

Charles L. White / Thomas S. Harris / Linda Hynan / Frederick J. Bonte

International Journal of Molecular Imaging, Vol

2011 Volume 2011

Keywords	Medical technology ; R855-855.5 ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease.

Roney, Celeste A / Arora, Veera / Kulkarni, Padmakar V / Antich, Peter P / Bonte, Frederick J

International journal of Alzheimer's disease

2010 Volume 2009

Abstract: Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I- ... ...

Abstract	Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. (125)I-CQ-PBCA NPs crossed the BBB (2.3 +/- 0.9 ID/g) (P < .05) in the WT mouse (N = 210), compared to (125)I-CQ (1.0 +/- 0.4 ID/g). (125)I-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N = 38; 2.54 x 10(5) +/- 5.31 x 10(4) DLU/mm(2); versus 1.98 x 10(5) +/- 2.22 x 10(4) DLU/mm(2)) and in APP/PS1/Tau. Brain increases were in mice intracranially injected with aggregated Abeta(42) peptide (N = 17; 7.19 x 10(5) +/- 1.25 x 10(5) DLU/mm(2)), versus WT (6.07 x 10(5) +/- 7.47 x 10(4) DLU/mm(2)). Storage phosphor imaging and histopathological staining of the plaques, Fe(2+) and Cu(2+), validated results. (125)I-CQ-PBCA NPs have specificity for Abeta in vitro and in vivo and are promising as in vivo SPECT ((123)I), or PET ((124)I) amyloid imaging agents.
Language	English
Publishing date	2010-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573333-3
ISSN	2090-0252 ; 2090-8024
ISSN (online)	2090-0252
ISSN	2090-8024
DOI	10.4061/2009/481031
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Article: Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign.

Bonte, Frederick J / Harris, Thomas S / Roney, Celeste A / Hynan, Linda S

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2004 Volume 45, Issue 5, Page(s) 771–774

Abstract: Unlabelled: This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis ... ...

Abstract	Unlabelled: This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis important. Methods: Images of 20 patients with clinically confirmed or autopsy-proven (10 patients) Alzheimer's disease and 20 patients with clinically confirmed or autopsy-proven (7 patients) frontotemporal disease were compared with the consolidated images of 20 elderly healthy control subjects. The (99m)Tc-hexamethylpropyleneamine oxime SPECT data on brain blood flow from each patient were compared with the consolidated control image using statistical parametric mapping. Results: Sixteen of 20 patients with Alzheimer's disease showed the posterior cingulate sign in the form of significant blood flow reductions; 1 of 20 patients with frontotemporal disease showed the posterior cingulate sign. That patient's illness has evolved into Alzheimer's disease. The remaining 19 patients were negative for the posterior cingulate sign. Conclusion: When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign. It was absent in 3 patients with proven tangle-predominant Alzheimer's disease.
MeSH term(s)	Aged ; Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Case-Control Studies ; Cerebrovascular Circulation/physiology ; Dementia/diagnostic imaging ; Diagnosis, Differential ; Frontal Lobe/diagnostic imaging ; Gyrus Cinguli/diagnostic imaging ; Humans ; Predictive Value of Tests ; Radiopharmaceuticals ; Sensitivity and Specificity ; Technetium Tc 99m Exametazime ; Temporal Lobe/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Exametazime (3B744AG22N)
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80272-4
ISSN	1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0161-5505 ; 0097-9058 ; 0022-3123
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

Frederick J. Bonte / Peter P. Antich / Padmakar V. Kulkarni / Celeste A. Roney / Veera Arora

International Journal of Alzheimer's Disease, Vol

2009 Volume 2009

Abstract: Detecting aggregated amyloid peptides (Aβ plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity I125-clioquinol ( ...

Abstract	Detecting aggregated amyloid peptides (Aβ plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity I125-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. I125-CQ-PBCA NPs crossed the BBB (2.3±0.9 ID/g) (P<.05) in the WT mouse (N = 210), compared to I125-CQ (1.0±0.4 ID/g). I125-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N = 38; 2.54×105±5.31×104 DLU/mm2; versus 1.98×105±2.22×104 DLU/mm2) and in APP/PS1/Tau. Brain increases were in mice intracranially injected with aggregated Aβ42 peptide (N = 17; 7.19×105±1.25×105 DLU/mm2), versus WT (6.07×105±7.47×104 DLU/mm2). Storage phosphor imaging and histopathological staining of the plaques, Fe2+ and Cu2+, validated results. I125-CQ-PBCA NPs have specificity for Aβ in vitro and in vivo and are promising as in vivo SPECT (I123), or PET (I124) amyloid imaging agents.
Keywords	Geriatrics ; RC952-954.6 ; Special situations and conditions ; RC952-1245 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; DOAJ:Neurology
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.

Bonte, Frederick J / Harris, Thomas S / Hynan, Linda S / Bigio, Eileen H / White, Charles L

Clinical nuclear medicine

2006 Volume 31, Issue 7, Page(s) 376–378

Abstract: Purpose: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease.: Materials and methods: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 ... ...

Abstract	Purpose: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. Materials and methods: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. Results: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI). Conclusions: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Cerebrovascular Circulation ; Dementia/diagnostic imaging ; Dementia/pathology ; Diagnosis, Differential ; False Negative Reactions ; False Positive Reactions ; Female ; Humans ; Male ; Predictive Value of Tests ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Technetium Tc 99m Exametazime ; Tomography, Emission-Computed, Single-Photon/instrumentation ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Exametazime (3B744AG22N)
Language	English
Publishing date	2006-07
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/01.rlu.0000222736.81365.63
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Article ; Online: Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease.

Kulkarni, Padmakar V / Roney, Celeste A / Antich, Peter P / Bonte, Frederick J / Raghu, Anjanapura V / Aminabhavi, Tejraj M

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2010 Volume 2, Issue 1, Page(s) 35–47

Abstract: A survey of research activity on nanoparticles (NPs) based on polymeric devices that could cross the blood-brain barrier (BBB) is given along with the presentation of our own data on the development of NPs of n-butyl-2-cyanoacrylate (BCA) for brain ... ...

Abstract	A survey of research activity on nanoparticles (NPs) based on polymeric devices that could cross the blood-brain barrier (BBB) is given along with the presentation of our own data on the development of NPs of n-butyl-2-cyanoacrylate (BCA) for brain delivery to aid the early diagnosis of Alzheimer's disease (AD), a neurodegenerative disorder of the elderly people, the most prevalent form of dementia. Typical data are presented on in vivo detection of amyloid peptides (A beta) (amyloid plaques) that are used as targets for developing the biological markers for the diagnosis of AD. In order to develop efficient in vivo probes, polymeric n-butyl-2-cyanoacrylate (PBCA) NPs have been prepared and encapsulated with the radio-labeled amyloid affinity drug (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) to improve the transport to brain and amyloid plaque retention of (125)I-CQ using the NPs of PBCA. The (125)I-CQ discriminately binds to the AD post-mortem brain tissue homogenates versus control. (125)I-CQ-PBCA NPs labeled the A beta plaques from the AD human post-mortem frontal cortical sections on paraffin-fixed slides. Storage phosphor imaging verified preferential uptake by AD brain sections compared to cortical control sections. The (125)I-CQ-PBCA NPs crossed the BBB in wild type mouse, giving an increased brain uptake measured in terms of % ID/g i.e., injected dose compared to (125)I-CQ. Brain retention of (125)I-CQ-PBCA NPs was significantly increased in the AD transgenic mice (APP/PS1) and in mice injected with aggregated A beta 42 peptide versus age-matched wild type controls. The results of this study are verified by in vivo storage phosphor imaging and validated by histopathological staining of plaques and select metal ions, viz. Fe(2+) and Cu(2+). The (125)I-CQ-PBCA NPs had more efficient brain entry and rapid clearance in normal mice and enhanced the retention in AD mouse brain demonstrating the ideal in vivo imaging characteristics. The (125)I-CQ-PBCA NPs exhibited specificity for A beta plaques both in vitro and in vivo. This combination offered radio-iodinated CQ-PBCA NPs as the promising delivery vehicle for in vivo single photon emission tomography (SPECT) ((123)I) or PET ((124)I) amyloid imaging agent. The importance of the topic in relation to brain delivery and other similar type of work published in this area are covered to highlight the importance of this research to medical disciplines.
MeSH term(s)	Alzheimer Disease/diagnosis ; Alzheimer Disease/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain/pathology ; Drug Delivery Systems/methods ; Enbucrilate/pharmacokinetics ; Humans ; Mice ; Mice, Transgenic ; Nanoparticles ; Quinolines/pharmacokinetics
Chemical Substances	Quinolines ; Enbucrilate (F8CEP82QNP)
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.59
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Zs.A 6781: Show issues

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Article: Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War.

Haley, Robert W / Spence, Jeffrey S / Carmack, Patrick S / Gunst, Richard F / Schucany, William R / Petty, Frederick / Devous, Michael D / Bonte, Frederick J / Trivedi, Madhukar H

Psychiatry research

2009 Volume 171, Issue 3, Page(s) 207–220

Abstract: Several case definitions of chronic illness in veterans of the 1991 Persian Gulf War have been linked epidemiologically with environmental exposure to cholinesterase-inhibiting chemicals, which cause chronic changes in cholinergic receptors in animal ... ...

Abstract	Several case definitions of chronic illness in veterans of the 1991 Persian Gulf War have been linked epidemiologically with environmental exposure to cholinesterase-inhibiting chemicals, which cause chronic changes in cholinergic receptors in animal models. Twenty-one chronically ill Gulf War veterans (5 with symptom complex 1, 11 with complex 2, and 5 with complex 3) and 17 age-, sex- and education-matched controls, underwent an 99mTc-HMPAO-SPECT brain scan following infusion of saline and >48 h later a second scan following infusion of physostigmine in saline. From each SPECT image mean normalized regional cerebral blood flow (nrCBF) from 39 small blocks of correlated voxels were extracted with geostatistical spatial modeling from eight deep gray matter structures in each hemisphere. Baseline nrCBF in symptom complex 2 was lower than controls throughout deep structures. The change in nrCBF after physostigmine (challenge minus baseline) was negative in complexes 1 and 3 and controls but positive in complex 2 in some structures. Since effects were opposite in different groups, no finding typified the entire patient sample. A hold-out discriminant model of nrCBF from 17 deep brain blocks predicted membership in the clinical groups with sensitivity of 0.95 and specificity of 0.82. Gulf War-associated chronic encephalopathy in a subset of veterans may be due to neuronal dysfunction, including abnormal cholinergic response, in deep brain structures.
MeSH term(s)	Adult ; Brain/blood supply ; Brain/diagnostic imaging ; Cholinesterase Inhibitors/toxicity ; Dominance, Cerebral/physiology ; Environmental Exposure ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Neurons/drug effects ; Neurons/physiology ; Neuropsychological Tests ; Neurotoxicity Syndromes/diagnostic imaging ; Neurotoxicity Syndromes/physiopathology ; Persian Gulf Syndrome/chemically induced ; Persian Gulf Syndrome/diagnostic imaging ; Persian Gulf Syndrome/physiopathology ; Physostigmine ; Receptors, Cholinergic/drug effects ; Regional Blood Flow/drug effects ; Technetium Tc 99m Exametazime ; Tomography, Emission-Computed, Single-Photon ; Veterans
Chemical Substances	Cholinesterase Inhibitors ; Receptors, Cholinergic ; Technetium Tc 99m Exametazime (3B744AG22N) ; Physostigmine (9U1VM840SP)
Language	English
Publishing date	2009-03-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.pscychresns.2008.05.004
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Zs.A 1541: Show issues

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Article: Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.

Bigio, Eileen H / Reisch, Joan S / White, Charles L / Satumtira, Sivapong / Sontag, Estelle / Bonte, Frederick J

Dementia and geriatric cognitive disorders

2003 Volume 15, Issue 2, Page(s) 72–78

Abstract: In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 ... ...

Abstract	In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD.
MeSH term(s)	Aged ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Brain/blood supply ; Brain/pathology ; Brain/ultrastructure ; Case-Control Studies ; Cerebrovascular Circulation ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Synapses/pathology ; Synaptophysin/analysis ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Synaptophysin
Language	English
Publishing date	2003
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1026007-9
ISSN	1420-8008 ; 1013-7424
ISSN	1420-8008 ; 1013-7424
DOI	10.1159/000067970
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