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Article: Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene

Cameron, Darren / Blake, Derek J / Bray, Nicholas J / Hill, Matthew J

2019 Volume 5, Issue 2, Page(s) 109–114

Abstract: Loss of function mutations ... ...

Abstract	Loss of function mutations in
Language	English
Publishing date	2019-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806946-8
ISSN	2296-9179 ; 2296-9209
ISSN (online)	2296-9179
ISSN	2296-9209
DOI	10.1159/000497181
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection.

Crawford, Liam A / Cuzzucoli Crucitti, Valentina / Stimpson, Amy / Morgan, Chloe / Blake, Jonathan / Wildman, Ricky D / Hook, Andrew L / Alexander, Morgan R / Irvine, Derek J / Avery, Simon V

Green chemistry : an international journal and green chemistry resource : GC

2023 Volume 25, Issue 21, Page(s) 8558–8569

Abstract: Fungicidal compounds are actives widely used for crop protection from fungal infection, but they can also kill beneficial organisms, enter the food chain and promote resistant pathogen strains from overuse. Here we report the first field crop trial of ... ...

Abstract	Fungicidal compounds are actives widely used for crop protection from fungal infection, but they can also kill beneficial organisms, enter the food chain and promote resistant pathogen strains from overuse. Here we report the first field crop trial of homopolymer materials that prevent fungal attachment, showing successful crop protection
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d3gc01911j
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Article: Misfolding of fukutin-related protein (FKRP) variants in congenital and limb girdle muscular dystrophies.

Esapa, Christopher T / McIlhinney, R A Jeffrey / Waite, Adrian J / Benson, Matthew A / Mirzayan, Jasmin / Piko, Henriett / Herczegfalvi, Ágnes / Horvath, Rita / Karcagi, Veronika / Walter, Maggie C / Lochmüller, Hanns / Rizkallah, Pierre J / Lu, Qi L / Blake, Derek J

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1279700

Abstract: Fukutin-related protein (FKRP, MIM ID 606596) variants cause a range of muscular dystrophies associated with hypo-glycosylation of the matrix receptor, α-dystroglycan. These disorders are almost exclusively caused by homozygous or compound heterozygous ... ...

Abstract	Fukutin-related protein (FKRP, MIM ID 606596) variants cause a range of muscular dystrophies associated with hypo-glycosylation of the matrix receptor, α-dystroglycan. These disorders are almost exclusively caused by homozygous or compound heterozygous missense variants in the
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1279700
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Article ; Online: Unprecedented early-summer heat stress and forecast of coral bleaching on the Great Barrier Reef, 2021-2022 [version 4; peer review

Cathy J. McDonald / Jacqueline L. De La Cour / Derek P. Manzello / Blake L. Spady / Gang Liu / William J. Skirving

F1000Research, Vol

2 approved, 1 approved with reservations]

2022 Volume 11

Abstract: The Great Barrier Reef (GBR) is predicted to undergo its sixth mass coral bleaching event during the Southern Hemisphere summer of 2021-2022. Coral bleaching-level heat stress over the GBR is forecast to start earlier than any previous year in the ... ...

Abstract	The Great Barrier Reef (GBR) is predicted to undergo its sixth mass coral bleaching event during the Southern Hemisphere summer of 2021-2022. Coral bleaching-level heat stress over the GBR is forecast to start earlier than any previous year in the satellite record (1985-present). The National Oceanic and Atmospheric Administration (NOAA) Coral Reef Watch (CRW) near real-time satellite-based heat stress products were used to investigate early-summer sea surface temperature (SST) and heat stress conditions on the GBR during late 2021. As of 14 December 2021, values of instantaneous heat stress (Coral Bleaching HotSpots) and accumulated heat stress over a 12-week running window (Degree Heating Weeks) on the GBR were unprecedented in the satellite record. Further, 89% of GBR satellite reef pixels for this date in 2021 had a positive seven-day SST trend of greater than 0.2 degrees Celsius/week. Background temperatures (the minimum temperature over the previous 29 days) were alarmingly high, with 87% of GBR reef pixels on 14 December 2021 being greater than the maximum SST over that same 29-day period for any year from 1985-2020. The GBR is starting the 2021-2022 summer season with more accumulated heat than ever before, which could have disastrous consequences for the health, recovery, and future of this critical reef system.
Keywords	Background temperature ; Bleaching ; Coral ; Degree Heating Week ; Great Barrier Reef ; heat stress ; eng ; Medicine ; R ; Science ; Q
Subject code	551
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unprecedented early-summer heat stress and forecast of coral bleaching on the Great Barrier Reef, 2021-2022 [version 3; peer review

Cathy J. McDonald / Jacqueline L. De La Cour / Derek P. Manzello / Blake L. Spady / Gang Liu / William J. Skirving

F1000Research, Vol

2 approved, 1 approved with reservations]

2022 Volume 11

Abstract	The Great Barrier Reef (GBR) is predicted to undergo its sixth mass coral bleaching event during the Southern Hemisphere summer of 2021-2022. Coral bleaching-level heat stress over the GBR is forecast to start earlier than any previous year in the satellite record (1985-present). The National Oceanic and Atmospheric Administration (NOAA) Coral Reef Watch (CRW) near real-time satellite-based heat stress products were used to investigate early-summer sea surface temperature (SST) and heat stress conditions on the GBR during late 2021. As of 14 December 2021, values of instantaneous heat stress (Coral Bleaching HotSpots) and accumulated heat stress over a 12-week running window (Degree Heating Weeks) on the GBR were unprecedented in the satellite record. Further, 89% of GBR satellite reef pixels for this date in 2021 had a positive seven-day SST trend of greater than 0.2 degrees Celsius/week. Background temperatures (the minimum temperature over the previous 29 days) were alarmingly high, with 87% of GBR reef pixels on 14 December 2021 being greater than the maximum SST over that same 29-day period for any year from 1985-2020. The GBR is starting the 2021-2022 summer season with more accumulated heat than ever before, which could have disastrous consequences for the health, recovery, and future of this critical reef system.
Keywords	Background temperature ; Bleaching ; Coral ; Degree Heating Week ; Great Barrier Reef ; heat stress ; eng ; Medicine ; R ; Science ; Q
Subject code	551
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unprecedented early-summer heat stress and forecast of coral bleaching on the Great Barrier Reef, 2021-2022.

Spady, Blake L / Skirving, William J / Liu, Gang / De La Cour, Jacqueline L / McDonald, Cathy J / Manzello, Derek P

F1000Research

2022 Volume 11, Page(s) 127

Abstract	The Great Barrier Reef (GBR) is predicted to undergo its sixth mass coral bleaching event during the Southern Hemisphere summer of 2021-2022. Coral bleaching-level heat stress over the GBR is forecast to start earlier than any previous year in the satellite record (1985-present). The National Oceanic and Atmospheric Administration (NOAA) Coral Reef Watch (CRW) near real-time satellite-based heat stress products were used to investigate early-summer sea surface temperature (SST) and heat stress conditions on the GBR during late 2021. As of 14 December 2021, values of instantaneous heat stress (Coral Bleaching HotSpots) and accumulated heat stress over a 12-week running window (Degree Heating Weeks) on the GBR were unprecedented in the satellite record. Further, 89% of GBR satellite reef pixels for this date in 2021 had a positive seven-day SST trend of greater than 0.2 degrees Celsius/week. Background temperatures (the minimum temperature over the previous 29 days) were alarmingly high, with 87% of GBR reef pixels on 14 December 2021 being greater than the maximum SST over that same 29-day period for any year from 1985-2020. The GBR is starting the 2021-2022 summer season with more accumulated heat than ever before, which could have disastrous consequences for the health, recovery, and future of this critical reef system.
MeSH term(s)	Heat-Shock Response
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.108724.4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Single, Multimodal Exercise Tolerance Test Can Assess Combat Readiness in Army-ROTC Cadets: A Brief Report.

Crawford, Derek A / Heinrich, Katie M / Haddock, Christopher K / Poston, W S Carlos / Day, R Sue / Kaipust, Christopher / Skola, Blake / Wakeman, Amanda J / Kunkel, Eric / Bell, Addison / Wilhite, Emily / Young, Nathanial / Whitley, Allison / Fritts, Madelyn

Journal of functional morphology and kinesiology

2023 Volume 8, Issue 4

Abstract: The Army Combat Fitness Test (ACFT) is a multi-event assessment battery designed to determine the combat readiness of U.S. Army personnel. However, for Reserve Officers' Training Corps (ROTC) programs the logistical demands of collegiate life make ... ...

Abstract	The Army Combat Fitness Test (ACFT) is a multi-event assessment battery designed to determine the combat readiness of U.S. Army personnel. However, for Reserve Officers' Training Corps (ROTC) programs the logistical demands of collegiate life make repeated administration of the ACFT challenging. The present study sought to design and evaluate a single, multimodal exercise tolerance test (METT) capable of serving as a time-efficient proxy measure of combat readiness. Methods: Using a formal instrument design process, we constructed the METT to mimic the demands of the ACFT and assessed its reliability, validity, and responsiveness. Results: The METT demonstrates minimal measurement error (i.e., a 2% coefficient of variation), concurrent validity with the ACFT (R Conclusions: The METT has the potential to provide a means to monitor progress, identify areas for improvement, and guide informed decision-making regarding individualization of cadet combat training plans.
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Journal Article
ISSN	2411-5142
ISSN (online)	2411-5142
DOI	10.3390/jfmk8040152
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Substitutions near the HA receptor binding site explain the origin and major antigenic change of the B/Victoria and B/Yamagata lineages.

Rosu, Miruna E / Lexmond, Pascal / Bestebroer, Theo M / Hauser, Blake M / Smith, Derek J / Herfst, Sander / Fouchier, Ron A M

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 42, Page(s) e2211616119

Abstract: Influenza B virus primarily infects humans, causing seasonal epidemics globally. Two antigenic variants-Victoria-like and Yamagata-like-were detected in the 1980s, of which the molecular basis of emergence is still incompletely understood. Here, the ... ...

Abstract	Influenza B virus primarily infects humans, causing seasonal epidemics globally. Two antigenic variants-Victoria-like and Yamagata-like-were detected in the 1980s, of which the molecular basis of emergence is still incompletely understood. Here, the antigenic properties of a unique collection of historical virus isolates, sampled from 1962 to 2000 and passaged exclusively in mammalian cells to preserve antigenic properties, were determined with the hemagglutination inhibition assay and an antigenic map was built to quantify and visualize the divergence of the lineages. The antigenic map revealed only three distinct antigenic clusters-Early, Victoria, and Yamagata-with relatively little antigenic diversity in each cluster until 2000. Viruses with Victoria-like antigenic properties emerged around 1972 and diversified subsequently into two genetic lineages. Viruses with Yamagata-like antigenic properties evolved from one lineage and became clearly antigenically distinct from the Victoria-like viruses around 1988. Recombinant mutant viruses were tested to show that insertions and deletions (indels), as observed frequently in influenza B virus hemagglutinin, had little effect on antigenic properties. In contrast, amino-acid substitutions at positions 148, 149, 150, and 203, adjacent to the hemagglutinin receptor binding site, determined the main antigenic differences between the Early, Victoria-like, and Yamagata-like viruses. Surprisingly, substitutions at two of the four positions reverted in recent viruses of the Victoria lineage, resulting in antigenic properties similar to viruses circulating ∼50 y earlier. These data shed light on the antigenic diversification of influenza viruses and suggest there may be limits to the antigenic evolution of influenza B virus.
MeSH term(s)	Animals ; Antigenic Variation/genetics ; Binding Sites ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinins ; Humans ; Influenza B virus/genetics ; Influenza, Human ; Mammals ; Phylogeny
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus ; Hemagglutinins
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2211616119
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Article ; Online: Meta-Analysis of Cell Therapy Studies in Heart Failure and Acute Myocardial Infarction.

Gyöngyösi, Mariann / Haller, Paul M / Blake, Derek J / Martin Rendon, Enca

Circulation research

2018 Volume 123, Issue 2, Page(s) 301–308

Abstract: Heart failure (HF) is one of the leading causes of death worldwide and has reached epidemic proportions in most industrialized nations. Despite major improvements in the treatment and management of the disease, the prognosis for patients with HF remains ... ...

Abstract	Heart failure (HF) is one of the leading causes of death worldwide and has reached epidemic proportions in most industrialized nations. Despite major improvements in the treatment and management of the disease, the prognosis for patients with HF remains poor with approximately only half of patients surviving for 5 years or longer after diagnosis. The poor prognosis of HF patients is in part because of irreparable damage to cardiac tissue and concomitant maladaptive changes associated with the disease. Cell-based therapies may have the potential to transform the treatment and prognosis of HF through regeneration or repair of damaged cardiac tissue. Accordingly, numerous phase I and II randomized clinical trials have tested the clinical benefits of cell transplant, mostly autologous bone marrow-derived mononuclear cells, in patients with HF, ischemic heart disease, and acute myocardial infarction. Although many of these trials were relatively small, meta-analyses of cell-based therapies have attempted to apply rigorous statistical methodology to assess the potential clinical benefits of the intervention. As a prelude to larger phase III trials, meta-analyses, therefore, remain the obvious means of evaluating the available clinical evidence. Here, we review the different meta-analyses of randomized clinical trials that evaluate the safety and potential beneficial effect of cell therapies in HF and acute myocardial infarction spanning nearly 2 decades since the first pioneering trials were conducted.
MeSH term(s)	Animals ; Clinical Studies as Topic ; Heart Failure/therapy ; Humans ; Myocardial Infarction/therapy ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/methods ; Translational Research, Biomedical/methods
Language	English
Publishing date	2018-07-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.117.311302
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Article ; Online: Misfolding of fukutin-related protein (FKRP) variants in congenital and limb girdle muscular dystrophies

Christopher T. Esapa / R. A. Jeffrey McIlhinney / Adrian J. Waite / Matthew A. Benson / Jasmin Mirzayan / Henriett Piko / Ágnes Herczegfalvi / Rita Horvath / Veronika Karcagi / Maggie C. Walter / Hanns Lochmüller / Pierre J. Rizkallah / Qi L. Lu / Derek J. Blake

Frontiers in Molecular Biosciences, Vol

2023 Volume 10

Abstract	Fukutin-related protein (FKRP, MIM ID 606596) variants cause a range of muscular dystrophies associated with hypo-glycosylation of the matrix receptor, α-dystroglycan. These disorders are almost exclusively caused by homozygous or compound heterozygous missense variants in the FKRP gene that encodes a ribitol phosphotransferase. To understand how seemingly diverse FKRP missense mutations may contribute to disease, we examined the synthesis, intracellular dynamics, and structural consequences of a panel of missense mutations that encompass the disease spectrum. Under non-reducing electrophoresis conditions, wild type FKRP appears to be monomeric whereas disease-causing FKRP mutants migrate as high molecular weight, disulfide-bonded aggregates. These results were recapitulated using cysteine-scanning mutagenesis suggesting that abnormal disulfide bonding may perturb FKRP folding. Using fluorescence recovery after photobleaching, we found that the intracellular mobility of most FKRP mutants in ATP-depleted cells is dramatically reduced but can, in most cases, be rescued with reducing agents. Mass spectrometry showed that wild type and mutant FKRP differentially associate with several endoplasmic reticulum (ER)-resident chaperones. Finally, structural modelling revealed that disease-associated FKRP missense variants affected the local environment of the protein in small but significant ways. These data demonstrate that protein misfolding contributes to the molecular pathophysiology of FKRP-deficient muscular dystrophies and suggest that molecules that rescue this folding defect could be used to treat these disorders.
Keywords	fukutin-related protein ; muscular dystrophy ; protein misfolding ; missense mutation ; chaperone ; structural modelling ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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