LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1341

Search options

  1. Book ; Online: (Table S1) Chronostratigraphic constrains for sediment core AND1-1B, supplementary data to: Naish, Tim R; Powell, Ross; Levy, R; Wilson, Gary S; Scherer, Reed P; Talarico, Franco; Krissek, Lawrence A; Niessen, Frank; Pompilio, Massimo; Wilson, Terry; Carter, Lionel; DeConto, Robert M; Huybers, P; McKay, R; Pollard, David; Ross, J; Winter, Diane M; Barrett, Peter J; Browne, G; Cody, R; Cowan, Ellen A; Crampton, J; Dunbar, Gavin B; Dunbar, N; Florindo, Fabio; Gebhardt, Andrea Catalina; Graham, IJ; Hannah, Mike J; Hansaraj, D; Harwood, David M; Helling, D; Henrys, Stuart; Hinnov, L; Kuhn, Gerhard; Kyle, Philip R; Läufer, Andreas L; Maffioli, P; Magens, Diana; Mandernack, Kevin W; McIntosh, WC; Millan, C; Morin, Roger H; Ohneiser, Christian; Paulsen, Timothy S; Persico, Davide; Raine, J Ian; Reed, J; Riesselman, C; Sagnotti, Leo; Schmitt, D R; Sjunneskog, C; Strong, P; Taviani, Marco; Vogel, Stefan; Wilch, T; Williams, Trevor (2009): Obliquity-paced Pliocene West Antarctic ice sheet oscillations. Nature, 458(7236), 322-329

    Naish, Tim R / Krissek, Lawrence A / Levy, R / Niessen, Frank / Pompilio, Massimo / Powell, Ross / Scherer, Reed P / Talarico, Franco / Wilson, Gary S / al., et

    2009  

    Abstract: ... when planetary temperatures were up to ~3° C warmer than today ( Kim and Crowley, 2000, doi:10.1029/1999PA000459 ...

    Abstract Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages (Hays et al., 1976, doi:10.1126/science.194.4270.1121), fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles (Raymo and Huybers, 2008, doi:10.1038/nature06589). Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch (~5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming (Solomon et al., 2007). Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, ~40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to ~3° C warmer than today ( Kim and Crowley, 2000, doi:10.1029/1999PA000459) and atmospheric CO2 concentration was as high as ~400 p.p.m.v. (van der Burgh et al., 1993, doi:10.1126/science.260.5115.1788, Raymo et al., 1996, doi:10.1016/0377-8398(95)00048-8). The evidence is consistent with a new ice-sheet/ice-shelf model (Pollard and DeConto, 2009, doi:10.1038/nature07809) that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt (Huybers, 2006, doi:10.1126/science.1125249) under conditions of elevated CO2.
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1038/nature07867
    DOI 10.1594/PANGAEA.769658
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

  2. Article ; Online: Learning from our differences.

    Sant, Andrea J / Wilson, Patrick C

    Nature immunology

    2022  Volume 23, Issue 10, Page(s) 1403–1404

    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01320-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: A Pilot Study Exploring the Impact of a Primary Medication Non-Adherence Intervention among Four Chronic Disease States in One Regional Division of a Large Community Pharmacy Chain.

    Wilson, Danya H / Rein, Leanne J / Fountain, Michele / Brookhart, Andrea / Atchley, Daniel / Hohmeier, Kenneth C

    Pharmacy (Basel, Switzerland)

    2023  Volume 11, Issue 1

    Abstract: There is a 12.2% rate of primary medication non-adherence (PMN) among community pharmacy patients. The Pharmacy Quality Alliance (PQA) has developed a standardized definition of PMN to aid stakeholders in addressing PMN. However, little research had been ...

    Abstract There is a 12.2% rate of primary medication non-adherence (PMN) among community pharmacy patients. The Pharmacy Quality Alliance (PQA) has developed a standardized definition of PMN to aid stakeholders in addressing PMN. However, little research had been conducted to date on how to address PMN. The objective of the study was to determine the impact of an evidence-based adherence intervention program on PMN rates among four chronic disease states and to identify and characterize factors associated with PMN. Patients at risk of PMN were randomized into a control or intervention group. Those in the intervention group received a live call from a pharmacist to determine reason for and to discuss solutions to overcome PMN. Subjects included adult patients with newly prescribed medications used to treat diabetes, hypertension, hyperlipidemia, and/or chronic obstructive pulmonary disease (COPD). This study occurred in six pharmacies across one regional division of a national supermarket, community pharmacy chain. Prescriptions were considered newly initiated when the same drug, or its generic equivalent, had not been filled during the preceding 180 days. Prescriptions were considered at risk if they had not been obtained by day 7 of it being filled. Prescriptions were considered PMN if the patient had not obtained it, or an appropriate alternative, within 30 days after it was prescribed. During the 4-month intervention period, 203 prescriptions were included in the study with 94 in the intervention group and 109 in the control group. There was a 9% difference (
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy11010011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Generating signals at converging liquid fronts to create line-format readouts of soluble assay products in three-dimensional paper-based devices.

    Abdullah, Ibrahim H / Wilson, Daniel J / Mora, Andrea C / Parker, Rayleigh W / Mace, Charles R

    Lab on a chip

    2023  Volume 23, Issue 18, Page(s) 4010–4018

    Abstract: The correct interpretation of the result from a point-of-care device is crucial for an accurate and rapid diagnosis to guide subsequent treatment. Lateral flow tests (LFTs) use a well-established format that was designed to simplify the user experience. ... ...

    Abstract The correct interpretation of the result from a point-of-care device is crucial for an accurate and rapid diagnosis to guide subsequent treatment. Lateral flow tests (LFTs) use a well-established format that was designed to simplify the user experience. However, the LFT device architecture is inherently limited to detecting analytes that can be captured by molecular recognition. Microfluidic paper-based analytical devices (μPADs), like LFTs, have the potential to be used in diagnostic applications at the point of care. However, μPADs have not gained significant traction outside of academic laboratories, in part, because they have often demonstrated a lack of homogeneous shape or color in signal outputs, which consequently can lead to inaccurate interpretation of results by users. Here, we demonstrate a new class of μPADs that form colorimetric signals at the interfaces of converging liquid fronts (
    MeSH term(s) Microfluidic Analytical Techniques ; Acetylcholinesterase ; Ferric Compounds ; Paper ; Biological Assay ; Lab-On-A-Chip Devices
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Ferric Compounds
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00511a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Estropause, Sex Hormones and Metal Homeostasis in the Mouse Brain.

    Liu, Tianbing / Bowen, Richard L / Wilson, Andrea C / Atwood, Craig S

    Frontiers in neurology

    2022  Volume 13, Page(s) 841822

    Abstract: Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess whether age-related changes in hypothalamic-pituitary-gonadal (HPG) hormones might be involved in ... ...

    Abstract Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess whether age-related changes in hypothalamic-pituitary-gonadal (HPG) hormones might be involved in modulating brain metal ion homeostasis, we treated 7.5-month intact, sham-ovariecomized and ovariectomized C57B6SJL mice with vehicle or leuprolide acetate (for 9-months) to differentiate between whether sex steroids or gonadotropins might modulate brain metal ion concentrations. Unlike other aging mammals, there was no increase in plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations following estropause in mice, suggesting there was sufficient residual production by the follicle depleted ovary, of sex steroids like estrogens and protein hormones like the inhibins, in order to suppress pituitary LH/FSH production. Castration on the other hand induced significant increases in circulating LH and FSH. Modulation of plasma sex steroid and gonadotropin levels did not significantly alter the concentrations of brain metals tested (Fe, Zn, Cu, Mn, Co, Ni, Al, Li), although there was a tendency for a decrease in all brain metals following ovariectomy (low estrogens and progesterone, high gonadotropins), a response that was reversed with leuprolide acetate treatment (low sex steroids, low gonadotropins). Brain Cu concentration was the only metal correlated with plasma LH (-0.37,
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.841822
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.

    Pooley, Christopher / Marion, Glenn / Bishop, Stephen / Doeschl-Wilson, Andrea

    Genetics, selection, evolution : GSE

    2022  Volume 54, Issue 1, Page(s) 59

    Abstract: ... contact-group, (b) a multi-group design termed "pure", and (c) a multi-group design termed "mixed ...

    Abstract Background: The spread of infectious diseases in populations is controlled by the susceptibility (propensity to acquire infection), infectivity (propensity to transmit infection), and recoverability (propensity to recover/die) of individuals. Estimating genetic risk factors for these three underlying host epidemiological traits can help reduce disease spread through genetic control strategies. Previous studies have identified important 'disease resistance single nucleotide polymorphisms (SNPs)', but how these affect the underlying traits is an unresolved question. Recent advances in computational statistics make it now possible to estimate the effects of SNPs on host traits from epidemic data (e.g. infection and/or recovery times of individuals or diagnostic test results). However, little is known about how to effectively design disease transmission experiments or field studies to maximise the precision with which these effects can be estimated.
    Results: In this paper, we develop and validate analytical expressions for the precision of the estimates of SNP effects on the three above host traits for a disease transmission experiment with one or more non-interacting contact groups. Maximising these expressions leads to three distinct 'experimental' designs, each specifying a different set of ideal SNP genotype compositions across groups: (a) appropriate for a single contact-group, (b) a multi-group design termed "pure", and (c) a multi-group design termed "mixed", where 'pure' and 'mixed' refer to groupings that consist of individuals with uniformly the same or different SNP genotypes, respectively. Precision estimates for susceptibility and recoverability were found to be less sensitive to the experimental design than estimates for infectivity. Whereas the analytical expressions suggest that the multi-group pure and mixed designs estimate SNP effects with similar precision, the mixed design is preferred because it uses information from naturally-occurring rather than artificial infections. The same design principles apply to estimates of the epidemiological impact of other categorical fixed effects, such as breed, line, family, sex, or vaccination status. Estimation of SNP effect precisions from a given experimental setup is implemented in an online software tool SIRE-PC.
    Conclusions: Methodology was developed to aid the design of disease transmission experiments for estimating the effect of individual SNPs and other categorical variables that underlie host susceptibility, infectivity and recoverability. Designs that maximize the precision of estimates were derived.
    MeSH term(s) Breeding ; Genotype ; Humans ; Models, Genetic ; Polymorphism, Single Nucleotide ; Research Design
    Language English
    Publishing date 2022-09-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 1005838-2
    ISSN 1297-9686 ; 0754-0264 ; 0999-193X
    ISSN (online) 1297-9686
    ISSN 0754-0264 ; 0999-193X
    DOI 10.1186/s12711-022-00747-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Validating the occurrence of the giant mottled eel (Anguilla marmorata) in the Galápagos Islands

    Escobar‐Camacho, Daniel / Andrade, Wilson / Valencia, Nathalia / Encalada, Andrea C. / Pazmiño, Diana A.

    Journal of Fish Biology. 2023 July, v. 103, no. 1 p.183-188

    2023  

    Abstract: The giant mottled eel (Anguilla marmorata) is distributed mostly in the Indo‐West Pacific. However, a few records indicate the presence of this eel in the Tropical Central and East Pacific. In April 2019, an eel specimen was caught in a small stream in ... ...

    Abstract The giant mottled eel (Anguilla marmorata) is distributed mostly in the Indo‐West Pacific. However, a few records indicate the presence of this eel in the Tropical Central and East Pacific. In April 2019, an eel specimen was caught in a small stream in San Cristobal Island, Galápagos. Morphological and molecular characters (16S and Cytb mtDNA sequences) confirmed the species as A. marmorata Quoy & Gaimard, 1824. The re‐discovery of A. marmorata in Galápagos supports the hypothesis of an eastward range expansion from the west, probably through the North Equatorial Counter‐Current.
    Keywords Anguilla marmorata ; eel ; streams
    Language English
    Dates of publication 2023-07
    Size p. 183-188.
    Publishing place Blackwell Publishing Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15409
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article ; Online: Validating the occurrence of the giant mottled eel (Anguilla marmorata) in the Galápagos Islands.

    Escobar-Camacho, Daniel / Andrade, Wilson / Valencia, Nathalia / Encalada, Andrea C / Pazmiño, Diana A

    Journal of fish biology

    2023  Volume 103, Issue 1, Page(s) 183–188

    Abstract: The giant mottled eel (Anguilla marmorata) is distributed mostly in the Indo-West Pacific. However, a few records indicate the presence of this eel in the Tropical Central and East Pacific. In April 2019, an eel specimen was caught in a small stream in ... ...

    Abstract The giant mottled eel (Anguilla marmorata) is distributed mostly in the Indo-West Pacific. However, a few records indicate the presence of this eel in the Tropical Central and East Pacific. In April 2019, an eel specimen was caught in a small stream in San Cristobal Island, Galápagos. Morphological and molecular characters (16S and Cytb mtDNA sequences) confirmed the species as A. marmorata Quoy & Gaimard, 1824. The re-discovery of A. marmorata in Galápagos supports the hypothesis of an eastward range expansion from the west, probably through the North Equatorial Counter-Current.
    MeSH term(s) Animals ; Anguilla/genetics ; Ecuador ; Rivers ; DNA, Mitochondrial/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15409
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Addiction potential of combustible menthol cigarette alternatives: a randomised cross-over trial.

    Wagener, Theodore L / Mehta, Toral / Hinton, Alice / Schulz, Jonathan A / Erath, Tyler G / Tidey, Jennifer / Brinkman, Marielle C / Wilson, Clark / Villanti, Andrea C

    Tobacco control

    2024  Volume 33, Issue e1, Page(s) e97–e105

    Abstract: Introduction: The Food and Drug Administration (FDA) has issued proposed product standards banning menthol as a characterising flavour in cigarettes and cigars. The public health benefits of these product standards may be attenuated by the role of ... ...

    Abstract Introduction: The Food and Drug Administration (FDA) has issued proposed product standards banning menthol as a characterising flavour in cigarettes and cigars. The public health benefits of these product standards may be attenuated by the role of plausible substitutes in the marketplace. Therefore, the present study examined the addiction potential of plausible combustible menthol alternatives compared with usual brand menthol cigarettes (UBMC).
    Methods: Ninety-eight adult menthol cigarette smokers completed four visits, smoking their UBMC at the first session and three menthol cigarette alternatives in random order at the subsequent visits: (1) a preassembled menthol roll-your-own (mRYO) cigarette using menthol pipe tobacco and mentholated cigarette tube, (2) a menthol filtered little cigar (mFLC) and (3) a non-menthol cigarette (NMC). Measures of smoking topography, exhaled carbon monoxide (CO), craving and withdrawal, subjective effects and behavioural economic demand indices were assessed.
    Results: Compared with UBMC, menthol cigarette alternatives resulted in different puffing topography and CO exposure (except mRYO), and lower levels of positive subjective experience and behavioural economic demand indices. Among the alternative products, participants reported the highest level of positive subjective experience and higher demand for mRYO, compared with mFLC and NMC. Similarly, participants were significantly more likely to want to try again, purchase and use the mRYO product regularly compared with mFLC and NMC.
    Conclusions and relevance: mRYO cigarettes were the most highly rated cigarette alternative among study products, suggesting their potential appeal as a menthol cigarette substitute and needed inclusion of menthol pipe tobacco and cigarette tubes in FDA's proposed ban.
    MeSH term(s) Adult ; Humans ; Menthol ; Cross-Over Studies ; Tobacco Products ; Smoking/adverse effects ; Tobacco Smoking
    Chemical Substances Menthol (1490-04-6)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tc-2022-057421
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice.

    Trotter, Timothy N / Wilson, Andrea / McBane, Jason / Dagotto, Carina E / Yang, Xiao-Yi / Wei, Jun-Ping / Lei, Gangjun / Thrash, Hannah / Snyder, Joshua C / Lyerly, Herbert Kim / Hartman, Zachary C

    Cancer research communications

    2024  Volume 4, Issue 4, Page(s) 1050–1062

    Abstract: The ability to temporally regulate gene expression and track labeled cells makes animal models powerful biomedical tools. However, sudden expression of xenobiotic genes [e.g., GFP, luciferase (Luc), or rtTA3] can trigger inadvertent immunity that ... ...

    Abstract The ability to temporally regulate gene expression and track labeled cells makes animal models powerful biomedical tools. However, sudden expression of xenobiotic genes [e.g., GFP, luciferase (Luc), or rtTA3] can trigger inadvertent immunity that suppresses foreign protein expression or results in complete rejection of transplanted cells. Germline exposure to foreign antigens somewhat addresses these challenges; however, native fluorescence and bioluminescence abrogates the utility of reporter proteins and highly spatiotemporally restricted expression can lead to suboptimal xenoantigen tolerance. To overcome these unwanted immune responses and enable reliable cell tracking/gene regulation, we developed a novel mouse model that selectively expresses antigen-intact but nonfunctional forms of GFP and Luc, as well as rtTA3, after CRE-mediated recombination. Using tissue-specific CREs, we observed model and sex-based differences in immune tolerance to the encoded xenoantigens, illustrating the obstacles of tolerizing animals to foreign genes and validating the utility of these "NoGlow" mice to dissect mechanisms of central and peripheral tolerance. Critically, tissue unrestricted NoGlow mice possess no detectable background fluorescence or luminescence and exhibit limited adaptive immunity against encoded transgenic xenoantigens after vaccination. Moreover, we demonstrate that NoGlow mice allow tracking and tetracycline-inducible gene regulation of triple-transgenic cells expressing GFP/Luc/rtTA3, in contrast to transgene-negative immune-competent mice that eliminate these cells or prohibit metastatic seeding. Notably, this model enables de novo metastasis from orthotopically implanted, triple-transgenic tumor cells, despite high xenoantigen expression. Altogether, the NoGlow model provides a critical resource for in vivo studies across disciplines, including oncology, developmental biology, infectious disease, autoimmunity, and transplantation.
    Significance: Multitolerant NoGlow mice enable tracking and gene manipulation of transplanted tumor cells without immune-mediated rejection, thus providing a platform to investigate novel mechanisms of adaptive immunity related to metastasis, immunotherapy, and tolerance.
    MeSH term(s) Animals ; Mice ; Antigens, Heterophile ; Cell Tracking ; Gene Expression Regulation ; Mice, Transgenic ; Disease Models, Animal
    Chemical Substances Antigens, Heterophile
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-24-0062
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top