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Article ; Online: Emergence of probable PTSD among U.S. veterans over the military-to-civilian transition.

Copeland, Laurel A / Finley, Erin P / Rubin, Miriam L / Perkins, Daniel F / Vogt, Dawne S

Psychological trauma : theory, research, practice and policy

2022 Volume 15, Issue 4, Page(s) 697–704

Abstract: Objective: Despite theorizing that posttraumatic stress disorder (PTSD) symptomatology may be exacerbated during the military-to-civilian transition, little research has delved into the trajectory of trauma-related symptomatology or the impact of ... ...

Abstract	Objective: Despite theorizing that posttraumatic stress disorder (PTSD) symptomatology may be exacerbated during the military-to-civilian transition, little research has delved into the trajectory of trauma-related symptomatology or the impact of diverse factors on timing of PTSD onset. To understand risk and protective factors for PTSD during the transition into civilian life, this study examined demographic, experiential, and psychosocial characteristics that may explain variation in PTSD symptoms and timing of onset. Method: A nationwide sample representing 48,965 U.S. veterans separating from military service in fall 2016 responded to six Web-based surveys over 3 years. Assessments included PTSD symptoms, stress, warfare exposures, military sexual trauma, moral injury events, resilience, and social support. Multivariable models estimated covariates of positive PTSD screen or symptoms. Results: Trauma exposure during military service was high at 59%. Probable PTSD was detected in 26% of the sample at baseline, with additional cases in each survey wave for an overall rate of 30%. Meeting criteria for probable PTSD covaried with current stress, female gender, and minority race/ethnicity; baseline psychological resilience and concurrent social support mitigated the risk. PTSD symptoms correlated positively with stress levels at current and previous time points. Social support was protective but only when contemporaneous with the PTSD symptoms. Conclusions: This study illustrates the need for ongoing social support for veterans coping with symptoms of PTSD, life stressors, and postmilitary trauma, suggesting a countervailing influence of psychological resilience and contemporaneous (but not historical) social support on symptom exacerbation. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Female ; Veterans/psychology ; Stress Disorders, Post-Traumatic/psychology ; Military Personnel/psychology ; Adaptation, Psychological ; Resilience, Psychological
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001329
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks.

Bassi, Gabriele / Favalli, Nicholas / Vuk, Miriam / Catalano, Marco / Martinelli, Adriano / Trenner, Anika / Porro, Antonio / Yang, Su / Tham, Chuin Lean / Moroglu, Mustafa / Yue, Wyatt W / Conway, Stuart J / Vogt, Peter K / Sartori, Alessandro A / Scheuermann, Jörg / Neri, Dario

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2020 Volume 7, Issue 22, Page(s) 2001970

Abstract: A versatile and Lipinski-compliant DNA-encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB-DEL library, ... ...

Abstract	A versatile and Lipinski-compliant DNA-encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB-DEL library, constructed in single-stranded DNA format, allows de novo identification of specific binders against several pharmaceutically relevant proteins. Moreover, hybridization of the single-stranded DEL with a set of known protein ligands of low to medium affinity coupled to a complementary DNA strand results in self-assembled selectable chemical structures, leading to the identification of affinity-matured compounds.
Language	English
Publishing date	2020-10-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202001970
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Article ; Online: Konzeptualisierung und Messung der Qualität der adaptiven Lernunterstützung in Lernsituationen mit mathematischen Regelspielen im Kindergarten. Eine Studie in Deutschland und der Schweiz.

Meier-Wyder, Anuschka / Wullschleger, Andrea / Lindmeier, Anke / Heinze, Aiso / Leuchter, Miriam / Vogt, Franziska / Moser Opitz, Elisabeth

Journal fur Mathematik-Didaktik

2022 Volume 43, Issue 2, Page(s) 405–434

Abstract: Good adaptive support by educational professionals is crucial for pre-school children's mathematical learning. Thus there is a need for appropriate instruments to evaluate the quality of the planning, implementation, and reflection process for ... ...

Title translation	Conceptualizing and Measuring the Quality of Adaptive Learning Support in Kindergarten Using Mathematical Board Games. A Study in Germany and Switzerland.
Abstract	Good adaptive support by educational professionals is crucial for pre-school children's mathematical learning. Thus there is a need for appropriate instruments to evaluate the quality of the planning, implementation, and reflection process for mathematical learning opportunities in kindergarten. Existing instruments tend to focus on micro-adaptive learning support (MI-ALS), which considers the interaction between the professionals and the children. The quality of macro-adaptive learning support (MA-ALS), the teachers' planning of and reflection on learning opportunities, has yet to be comprehensively investigated. MA-ALS is important for the acquisition of subject-related (mathematical) competence, an aspect of kindergarten education that is gaining in importance in the pre-school curricula of many countries.The quality of mathematical learning support in kindergarten is conceptualized by differentiating between the quality of MA-ALS and MI-ALS. MI-ALS is also divided into general support (group management, emotional warmth) and subject-related support (learning stimulation, subject-specific language). A rating tool for analyzing the quality of mathematical learning support is presented and its psychometric quality is assessed. The tool is then used to analyze the teaching quality in two guided play situations (recorded) and two interviews each with 145 education professionals in Germany and Switzerland. A confirmatory factor analysis (CFA) confirms the validity of the distinction between group management, emotional warmth and subject-related support. The relationship between the level of MI-ALS and MA-ALS, the training of the teachers (academic vs non-academic), and the educational context (Germany vs Switzerland) is examined. The results corroborate the importance of including planning and reflection as a dimension of learning support quality.
Language	German
Publishing date	2022-01-01
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	2537911-2
ISSN	1869-2699 ; 0173-5322
ISSN (online)	1869-2699
ISSN	0173-5322
DOI	10.1007/s13138-021-00195-2
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Article ; Online: The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt

Köhler, Amelie / Geiselhöringer, Anna-Lena / Kolland, Daphne / Kreft, Luisa / Wichmann, Nina / Hils, Miriam / Pasztoi, Maria / Zurkowski, Elena / Vogt, Johannes / Kübelbeck, Tanja / Biedermann, Tilo / Schmitz, Ingo / Hansen, Wiebke / Kramer, Daniela / Gaida, Matthias M / Schmidt-Weber, Carsten B / Hoevelmeyer, Nadine / Ohnmacht, Caspar

Mucosal immunology

2024

Abstract: Peripherally induced regulatory T cells (pTregs) expressing the retinoic acid receptor-related orphan-receptor gamma t (RORγt) are indispensable for intestinal immune homeostasis. NF-κB family members regulate the differentiation of thymic Tregs and ... ...

Abstract	Peripherally induced regulatory T cells (pTregs) expressing the retinoic acid receptor-related orphan-receptor gamma t (RORγt) are indispensable for intestinal immune homeostasis. NF-κB family members regulate the differentiation of thymic Tregs and promote their survival in the periphery. However, the Treg-intrinsic molecular mechanisms controling the size of the pTregs in the intestine and associated lymphoid organs remain unclear. Here, we provide direct evidence that Bcl3 limits the development of pTregs in a T cell-intrinsic manner. Moreover, the absence of Bcl3 allowed for the formation of an unusual intestinal Treg population co-expressing the transcription factors Helios and RORγt. The expanded RORγt
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1016/j.mucimm.2024.04.002
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Article ; Online: Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome.

Feger, Martina / Meier, Leonie / Strotmann, Jörg / Hoene, Miriam / Vogt, Julia / Wisser, Alexandra / Hirschle, Susanna / Kheim, Marie-Jo / Hocher, Berthold / Weigert, Cora / Föller, Michael

Molecular metabolism

2023 Volume 80, Page(s) 101868

Abstract: Objective: Endothelin receptor B (ETB) together with ETA mediates cellular effects of endothelin 1 (ET-1), an autocrine and endocrine peptide produced by the endothelium and other cells. It regulates vascular tone and controls kidney function. Metabolic ...

Abstract	Objective: Endothelin receptor B (ETB) together with ETA mediates cellular effects of endothelin 1 (ET-1), an autocrine and endocrine peptide produced by the endothelium and other cells. It regulates vascular tone and controls kidney function. Metabolic syndrome is due to high caloric intake and is characterized by insulin resistance, dyslipidemia, and white adipose tissue (WAT) accumulation. ETA/ETB antagonism has been demonstrated to favorably influence insulin resistance. Our study explored the role of ETB in metabolic syndrome. Methods: Wild type (etb Results: Compared to etb Conclusions: ETB deficiency confers protection from metabolic syndrome by counteracting glucose intolerance, dyslipidemia, and WAT accumulation due to enhanced energy expenditure, effects at least in part dependent on enhanced production of thyroid hormone/FGF21. ETB antagonism may therefore be a novel therapeutic approach in metabolic syndrome.
MeSH term(s)	Animals ; Mice ; Diet, High-Fat/adverse effects ; Dyslipidemias ; Glucose/metabolism ; Insulin Resistance ; Metabolic Syndrome ; Receptors, Endothelin
Chemical Substances	Glucose (IY9XDZ35W2) ; Receptors, Endothelin ; EDNRB protein, mouse
Language	English
Publishing date	2023-12-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2023.101868
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Article ; Online: A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

Gabriele Bassi / Nicholas Favalli / Miriam Vuk / Marco Catalano / Adriano Martinelli / Anika Trenner / Antonio Porro / Su Yang / Chuin Lean Tham / Mustafa Moroglu / Wyatt W. Yue / Stuart J. Conway / Peter K. Vogt / Alessandro A. Sartori / Jörg Scheuermann / Dario Neri

Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)

2020

Abstract: Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, ...

Abstract	Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, constructed in single‐stranded DNA format, allows de novo identification of specific binders against several pharmaceutically relevant proteins. Moreover, hybridization of the single‐stranded DEL with a set of known protein ligands of low to medium affinity coupled to a complementary DNA strand results in self‐assembled selectable chemical structures, leading to the identification of affinity‐matured compounds.
Keywords	Human alpha‐aminoadipic semialdehyde synthase (AASS) ; affinity maturation ; cyclic‐AMP response element binding protein (CREBBP) ; DNA‐encoded chemical libraries (DEL) ; drug discovery ; encoded self‐assembling chemical libraries (ESAC) ; Science ; Q
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article: Cre-Activation in ErbB4-Positive Neurons of Floxed

Mallien, Anne S / Pfeiffer, Natascha / Vogt, Miriam A / Chourbaji, Sabine / Sprengel, Rolf / Gass, Peter / Inta, Dragos

Frontiers in psychiatry

2021 Volume 12, Page(s) 750106

Abstract: Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence. On the other hand, ... ...

Abstract	Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence. On the other hand, pharmacological models using NMDAR antagonists and the clinical manifestation of anti-NMDAR encephalitis indicate that NMDAR blockade/hypofunction can trigger psychosis also at adult stages, without any early developmental dysfunction. Previous genetic models of NMDAR hypofunction restricted to parvalbumin-positive interneurons indicate the necessity of an early postnatal impairment to trigger schizophrenia-like abnormalities, whereas the cellular substrates of NMDAR-mediated psychosis at adolescent/adult stages are unknown. Neuregulin 1 (NRG1) and its receptor ErbB4 represent schizophrenia-associated susceptibility factors that closely interact with NMDAR. To determine the neuronal populations implicated in "late" NMDAR-driven psychosis, we analyzed the effect of the inducible ablation of NMDARs in
Language	English
Publishing date	2021-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.750106
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Article ; Online: Calibration Method for Particulate Matter Low-Cost Sensors Used in Ambient Air Quality Monitoring and Research.

Venkatraman Jagatha, Janani / Klausnitzer, André / Chacón-Mateos, Miriam / Laquai, Bernd / Nieuwkoop, Evert / van der Mark, Peter / Vogt, Ulrich / Schneider, Christoph

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 12

Abstract: Over the last decade, manufacturers have come forth with cost-effective sensors for measuring ambient and indoor particulate matter concentration. What these sensors make up for in cost efficiency, they lack in reliability of the measured data due to ... ...

Abstract	Over the last decade, manufacturers have come forth with cost-effective sensors for measuring ambient and indoor particulate matter concentration. What these sensors make up for in cost efficiency, they lack in reliability of the measured data due to their sensitivities to temperature and relative humidity. These weaknesses are especially evident when it comes to portable or mobile measurement setups. In recent years many studies have been conducted to assess the possibilities and limitations of these sensors, however mostly restricted to stationary measurements. This study reviews the published literature until 2020 on cost-effective sensors, summarizes the recommendations of experts in the field based on their experiences, and outlines the quantile-mapping methodology to calibrate low-cost sensors in mobile applications. Compared to the commonly used linear regression method, quantile mapping retains the spatial characteristics of the measurements, although a common correction factor cannot be determined. We conclude that quantile mapping can be a useful calibration methodology for mobile measurements given a well-elaborated measurement plan assures providing the necessary data.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Calibration ; Environmental Monitoring ; Particulate Matter/analysis ; Reproducibility of Results
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21123960
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Article ; Online: Effect of three different forms of handling on the variation of aggression-associated parameters in individually and group-housed male C57BL/6NCrl mice.

Mertens, Sinja / Vogt, Miriam A / Gass, Peter / Palme, Rupert / Hiebl, Bernhard / Chourbaji, Sabine

PloS one

2019 Volume 14, Issue 4, Page(s) e0215367

Abstract: Mice are social animals hence group-housing of mice is preferred over individual housing. However, aggression in group-housed male mice under laboratory housing conditions is a well-known problem leading to serious health issues, including injury or ... ...

Abstract	Mice are social animals hence group-housing of mice is preferred over individual housing. However, aggression in group-housed male mice under laboratory housing conditions is a well-known problem leading to serious health issues, including injury or death. Therefore, group-housed mice are frequently separated for welfare reasons. In this study, we investigated the effect of 3 different handling methods (tail, forceps, tube) in 2 different housing conditions (single vs. group) on the variance of aggression-associated parameters in male C57BL/6NCrl mice over 8 weeks. Blood glucose concentration, body weight, body temperature, plus number and severity of bite wounds and barbering intensity in group-housed mice were recorded. An assessment of nest complexity was also performed weekly. Feces were collected in week 3 and 7 for analysis of corticosterone metabolites. We also monitored the level of aggression by recording the behavior of group-housed animals after weekly cage cleaning. An open field test followed by a social novel object test, a light/dark box test, a hotplate and a resident-intruder test were performed at the end of the 8-week handling period. Post-mortem, we assessed organ weights. We found that forceps-handled mice, independent of the housing condition, had significantly higher levels of stress-induced-hyperthermia and enhanced aggression after cage cleaning, and they performed worse in the nest complexity test. In addition, handling male mice by the tail seems to be most effective to reduce aggressiveness after transferring animals into new cages, thereby representing an appropriate refinement.
MeSH term(s)	Aggression/physiology ; Aggression/psychology ; Animal Husbandry/methods ; Animals ; Behavior, Animal/physiology ; Corticosterone/metabolism ; Housing, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Social Behavior ; Stress, Physiological
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2019-04-12
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0215367
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Article ; Online: Granulomatöse Reaktion nach Mikroneedling bei Striae distensae.

Eisert, Lisa / Zidane, Miriam / Waigandt, Irina / Vogt, Peter M / Nast, Alexander

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

2019 Volume 17, Issue 4, Page(s) 443–445

Language	German
Publishing date	2019-07-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2093479-8
ISSN	1610-0387 ; 1610-0379
ISSN (online)	1610-0387
ISSN	1610-0379
DOI	10.1111/ddg.13798_g
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