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  1. Article ; Online: Cyclophilin E (CypE) Functions as a Positive Regulator in Osteoblast Differentiation by Regulating the Transcriptional Activity of Runx2.

    Piao, Meiyu / Lee, Sung Ho / Li, Yuankuan / Choi, Joong-Kook / Yeo, Chang-Yeol / Lee, Kwang Youl

    Cells

    2023  Volume 12, Issue 21

    Abstract: Cyclophilin E (CypE) belongs to the cyclophilin family and exhibits peptidyl- ... ...

    Abstract Cyclophilin E (CypE) belongs to the cyclophilin family and exhibits peptidyl-prolyl
    MeSH term(s) Cyclophilins/genetics ; Osteoblasts/metabolism
    Chemical Substances Cyclophilins (EC 5.2.1.-)
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12212549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metallothionein 3 Inhibits 3T3-L1 Adipocyte Differentiation via Reduction of Reactive Oxygen Species.

    Li, Yuankuan / Lee, Sung Ho / Piao, Meiyu / Kim, Hyung Sik / Lee, Kwang Youl

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). ... ...

    Abstract Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). However, less is known about the role of MT3 in the differentiation of 3T3-L1 cells into adipocytes. In this study, we observed that MT3 levels were downregulated during 3T3-L1 adipocyte differentiation.
    Language English
    Publishing date 2023-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deubiquitinase USP17 Regulates Osteoblast Differentiation by Increasing Osterix Protein Stability.

    Kim, Myeong Ji / Piao, Meiyu / Li, Yuankuan / Lee, Sung Ho / Lee, Kwang Youl

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Deubiquitinases (DUBs) are essential for bone remodeling by regulating the differentiation of osteoblast and osteoclast. USP17 encodes for a deubiquitinating enzyme, specifically known as ubiquitin-specific protease 17, which plays a critical role in ... ...

    Abstract Deubiquitinases (DUBs) are essential for bone remodeling by regulating the differentiation of osteoblast and osteoclast. USP17 encodes for a deubiquitinating enzyme, specifically known as ubiquitin-specific protease 17, which plays a critical role in regulating protein stability and cellular signaling pathways. However, the role of USP17 during osteoblast differentiation has not been elusive. In this study, we initially investigated whether USP17 could regulate the differentiation of osteoblasts. Moreover,
    MeSH term(s) Sp7 Transcription Factor/genetics ; Sp7 Transcription Factor/metabolism ; Osteogenesis/genetics ; Osteoblasts/metabolism ; Cell Differentiation/genetics ; Protein Stability ; Deubiquitinating Enzymes/genetics ; Deubiquitinating Enzymes/metabolism
    Chemical Substances Sp7 Transcription Factor ; Deubiquitinating Enzymes (EC 3.4.19.12)
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Inhibitory Effects of

    Lim, Jae Sung / Lee, Sung Ho / Yun, Hyosuk / Lee, Da Young / Cho, Namki / Yoo, Guijae / Choi, Jeong Uk / Lee, Kwang Youl / Bach, Tran The / Park, Su-Jin / Cho, Young-Chang

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: ... Ehretia ... ...

    Abstract Ehretia tinifolia
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12101792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metallothionein 3 Inhibits 3T3-L1 Adipocyte Differentiation via Reduction of Reactive Oxygen Species

    Li, Yuankuan / Lee, Sung-Ho / Piao, Meiyu / Kim, Hyung Sik / Lee, Kwang Youl

    Antioxidants. 2023 Mar. 04, v. 12, no. 3

    2023  

    Abstract: Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). ... ...

    Abstract Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). However, less is known about the role of MT3 in the differentiation of 3T3-L1 cells into adipocytes. In this study, we observed that MT3 levels were downregulated during 3T3-L1 adipocyte differentiation. Mt3 overexpression inhibited adipocyte differentiation and reduced the levels of the adipogenic transcription factors C/EBPα and PPARγ. Further analyses showed that MT3 also suppressed the transcriptional activity of PPARγ, and this effect was not mediated by a direct interaction between MT3 with PPARγ. In addition, Mt3 overexpression resulted in a decrease in ROS levels during early adipocyte differentiation, while treatment with antimycin A, which induces ROS generation, restored the ROS levels. Mt3 knockdown, on the other hand, elevated ROS levels, which were suppressed upon treatment with the antioxidant N-acetylcysteine. Our findings indicate a previously unknown role of MT3 in the differentiation of 3T3-L1 cells into adipocytes and provide a potential novel target that might facilitate obesity treatment.
    Keywords acetylcysteine ; adipocytes ; antimycin A ; metallothionein ; neurons ; obesity ; reactive oxygen species ; toxicity ; transcription (genetics)
    Language English
    Dates of publication 2023-0304
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030640
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.

    Kim, Garam / Bhattarai, Poshan Yugal / Lim, Sung-Chul / Lee, Kwang Youl / Choi, Hong Seok

    Cellular oncology (Dordrecht)

    2023  

    Abstract: Purpose: Nuclear accumulation of YAP/TAZ promotes tumorigenesis in several cancers, including melanoma. Although the mechanisms underlying the nuclear retention of YAP are known, those underlying the retention of TAZ remain unclear. Our study ... ...

    Abstract Purpose: Nuclear accumulation of YAP/TAZ promotes tumorigenesis in several cancers, including melanoma. Although the mechanisms underlying the nuclear retention of YAP are known, those underlying the retention of TAZ remain unclear. Our study investigates a novel acetylation/deacetylation switch in TAZ, governing its subcellular localization in melanoma tumorigenesis.
    Methods: Immunoprecipitation/Western blot assessed TAZ protein interactions and acetylation. SIRT5 activity was quantified with enzyme-linked immunosorbent assay. Immunofluorescence indicated TAZ nuclear localization. TEAD transcriptional activity was measured through luciferase reporter assays. ChIP detected TAZ binding to the CTGF promoter. Transwell and wound healing assays quantified melanoma cell invasiveness and migration. Metastasis was evaluated using a mouse model via tail vein injections. Clinical relevance was explored via immunohistochemical staining of patient tumors.
    Results: CBP facilitated TAZ acetylation at K54 in response to epidermal growth factor stimulation, while SIRT5 mediated deacetylation. Acetylation correlated with phosphorylation, regulating TAZ's binding with LATS2 or TEAD. TAZ K54 acetylation enhanced its S89 phosphorylation, promoting cytosolic retention via LATS2 interaction. SIRT5-mediated deacetylation enhanced TAZ-TEAD interaction and nuclear retention. Chromatin IP showed SIRT5-deacetylated TAZ recruited to CTGF promoter, boosting transcriptional activity. In a mouse model, SIRT5 overexpression induced melanoma metastasis to lung tissue following the injection of B16F10 melanocytes via the tail vein, and this effect was prevented by verteporfin treatment.
    Conclusions: Our study revealed a novel mechanism of TAZ nuclear retention regulated by SIRT5-mediated K54 deacetylation and demonstrated the significance of TAZ deacetylation in CTGF expression. This study highlights the potential implications of the SIRT5/TAZ axis for treating metastatic melanoma.
    Language English
    Publishing date 2023-12-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2595109-9
    ISSN 2211-3436 ; 1875-8606 ; 2211-3428
    ISSN (online) 2211-3436
    ISSN 1875-8606 ; 2211-3428
    DOI 10.1007/s13402-023-00910-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6908: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Microbial Transformation of Broussochalcones A and B by

    Xiao, Yina / Han, Fubo / Kim, Myeong Ji / Lee, Kwang Youl / Lee, Ik-Soo

    Journal of natural products

    2021  Volume 84, Issue 3, Page(s) 601–607

    Abstract: Broussochalcones A (BCA, ...

    Abstract Broussochalcones A (BCA,
    MeSH term(s) Aspergillus niger/metabolism ; Biotransformation ; Cell Line, Tumor ; Chalcones/metabolism ; Chalcones/pharmacology ; Humans ; Molecular Structure
    Chemical Substances Chalcones
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c01102
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Response.

    Choi, Joon Young / Kim, Ki Uk / Kim, Deog Kyeom / Kim, Yu-Il / Kim, Tae-Hyung / Lee, Won-Yeon / Park, Seong Ju / Park, Yong Bum / Song, Jin Woo / Shin, Kyeong-Cheol / Um, Soo-Jung / Yoo, Kwang Ha / Yoon, Hyoung Kyu / Lee, Chang Youl / Lee, Ho Sung / Leem, Ah Young / Choi, Won-Il / Lim, Seong Yong / Rhee, Chin Kook

    Chest

    2024  Volume 165, Issue 4, Page(s) e126–e128

    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.11.003
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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  9. Article ; Online: YY2 Promotes Osteoblast Differentiation by Upregulating Osterix Transcriptional Activity.

    Piao, Meiyu / Lee, Sung Ho / Kim, Myeong Ji / Kim, Hyung Sik / Lee, Kwang Youl

    International journal of molecular sciences

    2022  Volume 23, Issue 8

    Abstract: Yin Yang 2 (YY2) is a paralog of YY1, a well-known multifunctional transcription factor containing a C-terminal zinc finger domain. Although the role of YY1 in various biological processes, such as the cell cycle, cell differentiation and tissue ... ...

    Abstract Yin Yang 2 (YY2) is a paralog of YY1, a well-known multifunctional transcription factor containing a C-terminal zinc finger domain. Although the role of YY1 in various biological processes, such as the cell cycle, cell differentiation and tissue development, is well established, the function of YY2 has not been fully determined. In this study, we investigated the functional role of YY2 during osteoblast differentiation.
    MeSH term(s) Cell Differentiation/genetics ; Osteoblasts/metabolism ; Osteogenesis/genetics ; Sp7 Transcription Factor/genetics ; Sp7 Transcription Factor/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Yin-Yang
    Chemical Substances Sp7 Transcription Factor ; Transcription Factors
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23084303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 6-Pentyl-α-Pyrone from

    Lim, Jae Sung / Hong, Joo-Hyun / Lee, Da Young / Li, Xiangying / Lee, Da Eun / Choi, Jeong Uk / Lee, Kwang Youl / Kim, Ki Hyun / Cho, Young-Chang

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Filamentous fungi produce several beneficial secondary metabolites, including bioactive compounds, food additives, and biofuels. ...

    Abstract Filamentous fungi produce several beneficial secondary metabolites, including bioactive compounds, food additives, and biofuels.
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12122028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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