LIVIVO - Search results -

Search results

Result 1 - 10 of total 173

Search options

Article ; Online: Method for screening antimicrobial gels against multi-species oral biofilms.

Chathoth, Kanchana / Martin, Bénédicte / Bonnaure-Mallet, Martine / Baysse, Christine

2021 Volume 187, Page(s) 106253

Abstract: We described a microtiter plate-based method that was effectively tailored for testing gel formulations against oral multispecies biofilms established on peg-lids. This method lifts the limitations imposed mainly by the anaerobic nature of the targeted ... ...

Abstract	We described a microtiter plate-based method that was effectively tailored for testing gel formulations against oral multispecies biofilms established on peg-lids. This method lifts the limitations imposed mainly by the anaerobic nature of the targeted bacterial species and the viscous properties of the targeted treatments.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/growth & development ; Biofilms/drug effects ; Biofilms/growth & development ; Gels ; Humans ; Microbial Sensitivity Tests/methods ; Mouth/microbiology ; Porphyromonas gingivalis/drug effects ; Porphyromonas gingivalis/growth & development ; Streptococcus gordonii/drug effects ; Streptococcus gordonii/growth & development ; Treponema denticola/drug effects ; Treponema denticola/growth & development
Chemical Substances	Anti-Bacterial Agents ; Gels
Language	English
Publishing date	2021-06-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2021.106253
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1849: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Compliance with best practice guidelines on publication ethics

Christine Hamel / Julie Méthot / Louise Mallet

European Science Editing, Vol 47, Iss , Pp 1-

Where does Pharmactuel stand? A case study

2021 Volume 6

Abstract: Background: The Committee on Publication Ethics (COPE) and the International Committee of Medical Journal Editors (ICMJE) are two internationally recognised organisations in the field of publication ethics. Guidelines from these two organisations were ... ...

Abstract	Background: The Committee on Publication Ethics (COPE) and the International Committee of Medical Journal Editors (ICMJE) are two internationally recognised organisations in the field of publication ethics. Guidelines from these two organisations were updated in 2018.Objectives: To assess the extent to which the journal Pharmactuel is compliant with the guidelines on publication ethics updated by ICMJE and COPE in 2018 and, where the journal is found wanting, to take the necessary steps to make it compliant.Methods: A list of updated criteria – 56 by ICMJE and 22 by COPE – was compiled. In January 2020, compliance with each of these criteria was evaluated by the editor-in-chief and validated by all six associate editors. The evaluation was followed by an action plan to improve compliance, and the evaluation was repeated in November 2020.Results: Of the 56 ICMJE criteria, Pharmactuel was fully compliant with 31 and partly compliant with 10 criteria (a compliance rate of 73%, taking the two together). The corresponding figures for the 22 COPE criteria were 17, 3, and 91%. By modifying its editorial policies, training its associate editors, and creating appropriate guidelines for its editorial board and editors, Pharmactuel achieved almost 100% compliance by the end of 2020.Conclusions: Pharmactuel has been fully compliant with ICMJE and COPE recommendations since January 2021. Minor modifications to Pharmactuel’s publication process have enabled the editorial team to ensure that the journal continues to be almost totally compliant with COPE and ICMJE guidelines and to uphold its high ethical standards.
Keywords	Compliance ; COPE ; ICMJE ; editorial policies ; instr ; Academies and learned societies ; AS1-945 ; Bibliography. Library science. Information resources ; Z
Subject code	170
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT.

Al Sayed, Zeina R / Pereira, Céline / Le Borgne, Rémi / Viaris de Lesegno, Christine / Jouve, Charlène / Pénard, Esthel / Mallet, Adeline / Masurkar, Nihar / Loussouarn, Gildas / Verbavatz, Jean-Marc / Lamaze, Christophe / Trégouët, David-Alexandre / Hulot, Jean-Sébastien

Circulation

2024

Abstract: Background: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably ... ...

Abstract	Background: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably the hERG (human ether-a-go-go-related gene) channels that generate the delayed-rectifier potassium current (I Methods: We measured electrophysiological activity and cellular distribution of hERG channels after hERG blocker treatment in iPS-CMs derived from patients with highest sensitivity (HS) or lowest sensitivity (LS) to sotalol administration in vivo (ie, on the basis of the measure of the maximal change in QT interval 3 hours after administration). Specific small interfering RNAs and CAVIN1-T2A-GFP adenovirus were used to manipulate Results: Whereas HS and LS iPS-CMs showed similar electrophysiological characteristics at baseline, the late repolarization phase was prolonged and I Conclusions: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.123.063917
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.60: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prenatal exposure to persistent organic pollutants and molar-incisor hypomineralization among 12-year-old children in the French mother-child cohort PELAGIE.

Boyer, Emile / Monfort, Christine / Lainé, Fabrice / Gaudreau, Éric / Tillaut, Hélène / Bonnaure-Mallet, Martine / Cordier, Sylvaine / Meuric, Vincent / Chevrier, Cécile

Environmental research

2023 Volume 231, Issue Pt 3, Page(s) 116230

Abstract: Background: Exceptional episodes of exposure to high levels of persistent organic pollutants have already been associated with developmental defects of enamel among children, but knowledge is still scarce concerning the contribution of background levels ...

Abstract	Background: Exceptional episodes of exposure to high levels of persistent organic pollutants have already been associated with developmental defects of enamel among children, but knowledge is still scarce concerning the contribution of background levels of environmental contamination. Methods: Children of the French PELAGIE mother-child cohort were followed from birth, with collection of medical data and cord blood samples that were used to measure polychlorinated biphenyls (PCBs), organochlorine pesticides (OCs), and perfluorinated alkyl substances (PFASs). At 12 years of age, molar-incisor hypomineralization (MIH) and other enamel defects (EDs) were recorded for 498 children. Associations were studied using logistic regression models adjusted for potential prenatal confounders. Results: An increasing log-concentration of β-HCH was associated with a reduced risk of MIH and EDs (OR = 0.55; 95% CI, 0.32-0.95, and OR = 0.65; 95% CI, 0.43-0.98, respectively). Among girls, intermediate levels of p,p'-DDE were associated with a reduced risk of MIH. Among boys, we observed an increased risk of EDs in association with intermediate levels of PCB 138, PCB 153, PCB 187, and an increased risk of MIH with intermediate levels of PFOA and PFOS. Conclusions: Two OCs were associated with a reduced risk of dental defects, whereas the associations between PCBs and PFASs and EDs or MIH were generally close to null or sex-specific, with an increased risk of dental defects in boys. These results suggest that POPs could impact amelogenesis. Replication of this study is required and the possible underlying mechanisms need to be explored.
MeSH term(s)	Male ; Pregnancy ; Female ; Humans ; Child ; Polychlorinated Biphenyls ; Persistent Organic Pollutants ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/epidemiology ; Molar Hypomineralization ; Dichlorodiphenyl Dichloroethylene ; Fluorocarbons ; Mother-Child Relations ; Prevalence
Chemical Substances	Polychlorinated Biphenyls (DFC2HB4I0K) ; Persistent Organic Pollutants ; Dichlorodiphenyl Dichloroethylene (4M7FS82U08) ; Fluorocarbons
Language	English
Publishing date	2023-05-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116230
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion.

Alsayyah, Cynthia / Singh, Manish K / Morcillo-Parra, Maria Angeles / Cavellini, Laetitia / Shai, Nadav / Schmitt, Christine / Schuldiner, Maya / Zalckvar, Einat / Mallet, Adeline / Belgareh-Touzé, Naïma / Zimmer, Christophe / Cohen, Mickaël M

PLoS biology

2024 Volume 22, Issue 4, Page(s) e3002602

Abstract: Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum (ER), the yeast mitofusin Fzo1 stimulates contacts between Peroxisomes ... ...

Abstract	Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum (ER), the yeast mitofusin Fzo1 stimulates contacts between Peroxisomes and Mitochondria when overexpressed. Yet, the physiological significance and function of these "PerMit" contacts remain unknown. Here, we demonstrate that Fzo1 naturally localizes to peroxisomes and promotes PerMit contacts in physiological conditions. These contacts are regulated through co-modulation of Fzo1 levels by the ubiquitin-proteasome system (UPS) and by the desaturation status of fatty acids (FAs). Contacts decrease under low FA desaturation but reach a maximum during high FA desaturation. High-throughput genetic screening combined with high-resolution cellular imaging reveal that Fzo1-mediated PerMit contacts favor the transit of peroxisomal citrate into mitochondria. In turn, citrate enters the TCA cycle to stimulate the mitochondrial membrane potential and maintain efficient mitochondrial fusion upon high FA desaturation. These findings thus unravel a mechanism by which inter-organelle contacts safeguard mitochondrial fusion.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3002602
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Legalisation of euthanasia and assisted suicide: advanced cancer patient opinions - cross-sectional multicentre study.

Salas, Sebastien / Economos, Guillaume / Hugues, Damien / Gilbert, Elise / Gracia, Dominique / Poulain, Philippe / Mateus, Christine / Collet, Elsa / Planchet-Barraud, Brigitte / Colpaert, Andre / Perceau-Chambard, Élise / Calvel, Laurent Yves / Franck, Cecile / Mallet, Donatien / Baumstarck, Karine / Evin, Adrien

BMJ supportive & palliative care

2024 Volume 13, Issue e3, Page(s) e1335–e1341

Abstract: Objectives: The French government voted a new law in February 2016 called the Claeys-Leonetti Law, which established the right to deep and continuous sedation, confirmed the ban on euthanasia and ruled out physician-assisted suicide. The aim of this ... ...

Abstract	Objectives: The French government voted a new law in February 2016 called the Claeys-Leonetti Law, which established the right to deep and continuous sedation, confirmed the ban on euthanasia and ruled out physician-assisted suicide. The aim of this work was to gather the opinion of patients on continuous sedation and the legalisation of medical assistance in dying and to explore determinants associated with favourable and unfavourable opinions. Methods: This was a French national prospective multicentre study between 2016 and 2020. Results: 331 patients with incurable cancer suffering from locally advanced or metastatic cancer in 14 palliative care units were interviewed. 48.6% of participants expressed a favourable opinion about physician-assisted suicide and 27.2% an unfavourable opinion about its legalisation. Regarding euthanasia, 52% of patients were in favour of its legalisation. In univariate analysis, the only factor determining opinion was belief in God. Conclusions: While most healthy French people are in favour of legalising euthanasia, only half of palliative care patients expressed this opinion. Medical palliative care specialists were largely opposed to euthanasia. The only determining factor identified was a cultural factor that was independent of the other studied variables. This common factor was found in other studies conducted on cohorts from other countries. This study contributes to the knowledge and thinking about the impact of patients' personal beliefs and values regarding their opinions about euthanasia and assisted suicide. Trial registration number: NCT03664856.
MeSH term(s)	Humans ; Suicide, Assisted ; Cross-Sectional Studies ; Prospective Studies ; Attitude of Health Personnel ; Euthanasia ; Palliative Care ; Neoplasms ; European People
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Multicenter Study ; Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2022-004134
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Method for screening antimicrobial gels against multi-species oral biofilms

Chathoth, Kanchana / Martin, Bénédicte / Bonnaure-Mallet, Martine / Baysse, Christine

Journal of microbiological methods. 2021 Aug., v. 187

2021

Abstract	We described a microtiter plate-based method that was effectively tailored for testing gel formulations against oral multispecies biofilms established on peg-lids. This method lifts the limitations imposed mainly by the anaerobic nature of the targeted bacterial species and the viscous properties of the targeted treatments.
Keywords	biofilm ; gels ; journals ; screening
Language	English
Dates of publication	2021-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2021.106253
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1849: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The events that may contribute to subgingival dysbiosis: a focus on the interplay between iron, sulfide and oxygen.

Chathoth, Kanchana / Martin, Bénédicte / Cornelis, Pierre / Yvenou, Stéven / Bonnaure-Mallet, Martine / Baysse, Christine

FEMS microbiology letters

2020 Volume 367, Issue 14

Abstract: This minireview considers the disruption of the host-microbiota harmless symbiosis in the subgingival niche. The establishment of a chronic infection by subversion of a commensal microbiota results from a complex and multiparametric sequence of events. ... ...

Abstract	This minireview considers the disruption of the host-microbiota harmless symbiosis in the subgingival niche. The establishment of a chronic infection by subversion of a commensal microbiota results from a complex and multiparametric sequence of events. This review narrows down to the interplay between oxygen, iron and sulfide that can result in a vicious cycle that would favor peroxygenic and glutathione producing streptococci as well as sulfidogenic anaerobic pathogens in the subgingival niche. We propose hypothesis and discuss strategies for the therapeutic modulation of the microbiota to prevent periodontitis and promote oral health.
MeSH term(s)	Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/metabolism ; Dysbiosis/metabolism ; Dysbiosis/microbiology ; Humans ; Iron/metabolism ; Microbiota ; Oxygen/metabolism ; Periodontitis/metabolism ; Periodontitis/microbiology ; Sulfides/metabolism
Chemical Substances	Sulfides ; Iron (E1UOL152H7) ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-07-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1093/femsle/fnaa100
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1372: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Solid-state NMR molecular snapshots of

Lamon, Gaëlle / Lends, Alons / Valsecchi, Isabel / Wong, Sarah Sze Wah / Duprès, Vincent / Lafont, Frank / Tolchard, James / Schmitt, Christine / Mallet, Adeline / Grélard, Axelle / Morvan, Estelle / Dufourc, Erick J / Habenstein, Birgit / Guijarro, J Iñaki / Aimanianda, Vishukumar / Loquet, Antoine

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 6, Page(s) e2212003120

Abstract: While establishing an invasive infection, the dormant conidia ... ...

Abstract	While establishing an invasive infection, the dormant conidia of
MeSH term(s)	Aspergillus fumigatus/metabolism ; Spores, Fungal/metabolism ; Fungal Proteins/metabolism ; Polysaccharides/metabolism ; Chitin/metabolism ; Glucans/metabolism ; Cell Wall/metabolism
Chemical Substances	Fungal Proteins ; Polysaccharides ; Chitin (1398-61-4) ; Glucans
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2212003120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.

Jean, Philippe / Wong Jun Tai, Fabienne / Singh-Estivalet, Amrit / Lelli, Andrea / Scandola, Cyril / Megharba, Sébastien / Schmutz, Sandrine / Roux, Solène / Mechaussier, Sabrina / Sudres, Muriel / Mouly, Enguerran / Heritier, Anne-Valérie / Bonnet, Crystel / Mallet, Adeline / Novault, Sophie / Libri, Valentina / Petit, Christine / Michalski, Nicolas

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 26, Page(s) e2221744120

Abstract: Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a result, the search for curative treatments, which are sorely lacking in the hearing field, has ... ...

Abstract	Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a result, the search for curative treatments, which are sorely lacking in the hearing field, has become a potentially achievable objective, particularly
MeSH term(s)	Animals ; Mice ; Transcriptome ; Cochlea/physiology ; Basilar Membrane ; Hearing/physiology ; Deafness/metabolism
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2221744120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito