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  1. Article ; Online: When the "Piston" Is Nonfunctioning: A 62-Year-Old Woman With Extubation Failure.

    Moore, Jonathan / Kattih, Zein / Meredith, Simon / Oks, Margarita / Singh, Anup

    Chest

    2024  Volume 163, Issue 6, Page(s) e281–e284

    MeSH term(s) Female ; Humans ; Middle Aged ; Airway Extubation ; Prostheses and Implants ; Treatment Failure
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.09.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  2. Article ; Online: The Saga of Testosterone for Menopausal Women at the Food and Drug Administration (FDA).

    Simon, James A / Kapner, Meredith D

    The journal of sexual medicine

    2020  Volume 17, Issue 4, Page(s) 826–829

    Language English
    Publishing date 2020-04-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2020.01.009
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    Zs.A 6417: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 505: Show issues

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  3. Article ; Online: Use of invitations and reminders are associated with higher levels of Herpes zoster (shingles) vaccination uptake. A cross-sectional survey of general practices in Wales, and ecological analysis of uptake data, 2022.

    Rowley, Frances / Cottrell, Simon / Howard, Ceriann / Meredith, Nicola / Song, Jiao / Barrasa, Alicia / Johnson, Christopher

    Vaccine

    2024  Volume 42, Issue 7, Page(s) 1682–1689

    Abstract: In 2013, shingles vaccination was introduced in Wales as a routine immunisation programme for older adults. Invitation for this vaccination has historically been recommended but not mandated by vaccination policy. We surveyed general practices to ... ...

    Abstract In 2013, shingles vaccination was introduced in Wales as a routine immunisation programme for older adults. Invitation for this vaccination has historically been recommended but not mandated by vaccination policy. We surveyed general practices to investigate if invitations and reminders are associated with higher uptake of shingles vaccine. Using data from general practices, we calculated practice-level shingles vaccine uptake between 01/07/2021 and 31/06/2022 for registered patients aged 70-84 years. We distributed an online survey via email to all general practices in Wales on their use of vaccination invitations and reminders, method of invitations, and characteristics of their vaccination delivery. We used linear regression to calculate coefficients and 95 %CI to measure associations between invitations and vaccine uptake, adjusting for key demographics, with a multi-level component to account for similarities between general practices within the same health board. Survey response rate was 37 % (143/384). Median vaccine uptake for responding general practices was 57 % (IQR 50-68 %) compared to 58 % (IQR 48-68 %) nationally. General practices inviting all eligible patients (n = 95) had a 9 % (95 %CI 6-13 %) higher vaccination uptake compared to those inviting none or some (n = 48, p < 0.001). Of practices sending invitations, those who reminded all patients (n = 42) had a 6 % (95 %CI 1-11 %, p = 0.02) higher uptake compared to those that reminded none (n = 30). Practice size was associated with higher uptake, with small practices (n = 11, p = 0.02) having coverage 9 % (95 %CI 2-16 %) higher compared to the reference population (medium-sized practices, n = 78). General practices inviting and reminding all eligible patients for shingles vaccination have a higher uptake compared to those inviting and reminding only some or none. From September 2023, shingles vaccination policy in Wales has been updated to explicitly mandate effective universal call and recall mechanisms in general practices.
    MeSH term(s) Humans ; Aged ; Herpes Zoster Vaccine ; Cross-Sectional Studies ; Wales ; Herpes Zoster/prevention & control ; Herpes Zoster/epidemiology ; Herpesvirus 3, Human ; Vaccination ; Vaccines
    Chemical Substances Herpes Zoster Vaccine ; Vaccines
    Language English
    Publishing date 2024-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.02.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1930: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

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  4. Article ; Online: The Association of Speech/Language Risk With Phonological Awareness, Rapid Naming, and Reading Ability in Children With Cleft Lip and/or Palate.

    Kapp-Simon, Kathleen A / Crilly Bellucci, Claudia / Albert, Meredith / O'Gara, Mary / Richards, Sarah / Morgan, Amy

    Developmental neuropsychology

    2024  Volume 49, Issue 2, Page(s) 61–85

    Abstract: Children with cleft lip and/or palate were assessed for speech, language, phonological awareness (PA), rapid naming (RN) and reading ability using standardized instruments at baseline (T1; ...

    Abstract Children with cleft lip and/or palate were assessed for speech, language, phonological awareness (PA), rapid naming (RN) and reading ability using standardized instruments at baseline (T1;
    MeSH term(s) Male ; Child ; Humans ; Female ; Cleft Lip/complications ; Speech ; Cleft Palate/complications ; Reading
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 632665-1
    ISSN 1532-6942 ; 8756-5641
    ISSN (online) 1532-6942
    ISSN 8756-5641
    DOI 10.1080/87565641.2023.2293715
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    Zs.B 2838: Show issues Location:
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  5. Article: High-flow nasal cannula and noninvasive ventilation: effects on alveolar recruitment and overdistension.

    Saini, Amandeep S / Meredith, Simon / Esquinas, Antonio M / Mina, Bushra A

    ERJ open research

    2022  Volume 8, Issue 2

    Abstract: Both high-flow nasal cannula and noninvasive ventilation are subject to pulmonary ... ...

    Abstract Both high-flow nasal cannula and noninvasive ventilation are subject to pulmonary complications
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00127-2022
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  6. Article: Insights About the Human-Centered Design Analysis as a Tool to Improving Patients' Tolerance with Non-Invasive Ventilation.

    Di Costanzo, Domenica / Meredith, Simon / Mina, Bushra / Esquinas, Antonio M

    Chronic obstructive pulmonary diseases (Miami, Fla.)

    2022  Volume 9, Issue 2, Page(s) 274–276

    Language English
    Publishing date 2022-04-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2771715-X
    ISSN 2372-952X
    ISSN 2372-952X
    DOI 10.15326/jcopdf.2022.0295
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  7. Article ; Online: A targeted approach to vaccine hesitancy.

    Leston, Meredith / de Lusignan, Simon / Hobbs, F D Richard

    Oxford open immunology

    2023  Volume 4, Issue 1, Page(s) iqad007

    Abstract: This short communication makes the case for targeted vaccine research when attempting to counter hesitancy, especially amongst vulnerable or rarefied patient groups. Far from disincentivizing vaccination, the freedom to research and publicize the ... ...

    Abstract This short communication makes the case for targeted vaccine research when attempting to counter hesitancy, especially amongst vulnerable or rarefied patient groups. Far from disincentivizing vaccination, the freedom to research and publicize the limitations of these technologies for certain groups and personalizing dosing, pacing, adjuvants, and time-sensitive alternatives in response is essential for optimizing health outcomes while neutralizing the vaccine research landscape itself. Vaccine evangelism only arouses suspicion when it is not tempered by rigorous research into differential vaccine benefit-risk in this way. That said, the long-standing politicization of vaccination-a topic vulnerable to misinterpretation and media sensationalism-along with the commercial incentives associated with universal adoption makes more comparative and critical research difficult to fund and promote in practice. Likewise, a prescriptive approach to vaccination does little to address the issues of vaccine inequality that contribute to both hesitancy and conspiracy globally and will likely prove financially prohibitive in certain markets. These obstacles are not insurmountable, however, provided that comparative research is centrally subsidized, regulations ensure that vaccine development trials explore differentiated outcomes, especially amongst high-risk or rare groups, and findings are used to prioritize global vaccine allocation to those that stand to benefit most from them.
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article
    ISSN 2633-6960
    ISSN (online) 2633-6960
    DOI 10.1093/oxfimm/iqad007
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  8. Article ; Online: Utility of Bedside Ultrasound in Percutaneous Tracheostomy.

    Meredith, Simon / Kattih, Zein / Garcia, Brenda / Lakticova, Viera / Mina, Bushra / Oks, Margarita / Singh, Anup

    Journal of intensive care medicine

    2023  Volume 39, Issue 5, Page(s) 447–454

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Tracheostomy/adverse effects ; Tracheostomy/methods ; Prospective Studies ; Ultrasonography ; Intensive Care Units ; Vascular Surgical Procedures
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666231212858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2158: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Developing a Faculty Awards Strategy in an Academic Department: Recognizing Faculty and Promoting the Department.

    Mahant, Sanjay / Ling, Simon C / Williams, Suzan / Shah, Prakesh / Fayyaz, Jabeen / Lim-Shue, Catherine / Irwin, Meredith S / Huang, Annie

    The Journal of pediatrics

    2024  , Page(s) 113899

    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2024.113899
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    Um IV Zs.116: Show issues Location:
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  10. Article ; Online: Self-Quenching Behavior of a Fluorescent Probe Incorporated within Lipid Membranes Explored Using Electrophoresis and Fluorescence Lifetime Imaging Microscopy.

    Meredith, Sophie A / Kusunoki, Yuka / Connell, Simon D / Morigaki, Kenichi / Evans, Stephen D / Adams, Peter G

    The journal of physical chemistry. B

    2023  Volume 127, Issue 8, Page(s) 1715–1727

    Abstract: Fluorescent probes are useful in biophysics research to assess the spatial distribution, mobility, and interactions of biomolecules. However, fluorophores can undergo "self-quenching" of their fluorescence intensity at high concentrations. A greater ... ...

    Abstract Fluorescent probes are useful in biophysics research to assess the spatial distribution, mobility, and interactions of biomolecules. However, fluorophores can undergo "self-quenching" of their fluorescence intensity at high concentrations. A greater understanding of concentration-quenching effects is important for avoiding artifacts in fluorescence images and relevant to energy transfer processes in photosynthesis. Here, we show that an electrophoresis technique can be used to control the migration of charged fluorophores associated with supported lipid bilayers (SLBs) and that quenching effects can be quantified with fluorescence lifetime imaging microscopy (FLIM). Confined SLBs containing controlled quantities of lipid-linked Texas Red (TR) fluorophores were generated within 100 × 100 μm corral regions on glass substrates. Application of an electric field in-plane with the lipid bilayer induced the migration of negatively charged TR-lipid molecules toward the positive electrode and created a lateral concentration gradient across each corral. The self-quenching of TR was directly observed in FLIM images as a correlation of high concentrations of fluorophores to reductions in their fluorescence lifetime. By varying the initial concentration of TR fluorophores incorporated into the SLBs from 0.3% to 0.8% (mol/mol), the maximum concentration of fluorophores reached during electrophoresis could be modulated from 2% up to 7% (mol/mol), leading to the reduction of fluorescence lifetime down to 30% and quenching of the fluorescence intensity down to 10% of their original levels. As part of this work, we demonstrated a method for converting fluorescence intensity profiles into molecular concentration profiles by correcting for quenching effects. The calculated concentration profiles have a good fit to an exponential growth function, suggesting that TR-lipids can diffuse freely even at high concentrations. Overall, these findings prove that electrophoresis is effective at producing microscale concentration gradients of a molecule-of-interest and that FLIM is an excellent approach to interrogate dynamic changes to molecular interactions via their photophysical state.
    MeSH term(s) Fluorescent Dyes ; Microscopy, Fluorescence/methods ; Lipid Bilayers/chemistry ; Membranes ; Electrophoresis
    Chemical Substances Fluorescent Dyes ; Lipid Bilayers
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c07652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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