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  1. Article ; Online: THE MULBSTA SCORE

    Tusha, Jurgena / Khanam, Verisha / Tegeltija, Vesna / Kumar, Sarwan

    Chest

    PREDICTING RISK OF MORTALITY AND DISEASE SEVERITY IN PATIENTS WITH COVID-19 PNEUMONIA

    2020  Volume 158, Issue 4, Page(s) A300

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.08.299
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: CLINICAL CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 IN A COMMUNITY HOSPITAL IN MICHIGAN

    Tusha, Jurgena / Khanam, Verisha / Tegeltija, Vesna / Kumar, Sarwan

    Chest

    2020  Volume 158, Issue 4, Page(s) A1175

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.08.1069
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE IN PATIENTS INFECTED WITH SARS COV-2

    Khanam, Verisha / Tusha, Jurgena / Abkouh, Danyal Taheri / Al-janabi, Laith / Tegeltija, Vesna / Kumar, Sarwan

    Chest

    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.chest.2020.08.567
    Database COVID19

    Kategorien

  4. Article ; Online: SUDDEN CARDIAC DEATH AND THE PECULIAR COVID-19 CASE

    Abkouh, Danyal Taheri / Tusha, Jurgena / Khanam, Verisha / Giri, Padmini / Kumar, Sarwan

    Chest

    2020  Volume 158, Issue 4, Page(s) A271

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.08.272
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: BIOMARKER OF COVID PNEUMONIA VS CONGESTIVE HEART FAILURE: A KEY TO DISEASE DIAGNOSIS

    Al-janabi, Laith / Giri, Padmini / Patel, Manishkumar / Khanam, Verisha / Tusha, Jurgena / Zaki, Ahmed / Kumar, Sarwan

    Chest

    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.chest.2020.09.234
    Database COVID19

    Kategorien

  6. Article ; Online: THE SIGNIFICANCE OF ORAL ASCORBIC ACID IN PATIENTS WITH COVID-19

    Patel, Manishkumar / Hong, Gloria / Schmidt, Bernadette / Al-janabi, Laith / Adusumilli, Radha Kishan / Tusha, Jurgena / Giri, Padmini / Kumar, Sarwan

    Chest

    2020  Volume 158, Issue 4, Page(s) A325

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.08.322
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: CORTICOSTEROID TREATMENT IN PATIENTS WITH SEVERE COVID-19 PNEUMONIA

    Hong, Gloria / Patel, Manishkumar / Tusha, Jurgena / Giri, Padmini / Al-janabi, Laith / Adusumilli, Radha Kishan / Schmidt, Bernadette / Kumar, Sarwan

    Chest

    2020  Volume 158, Issue 4, Page(s) A599

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.08.564
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The Mulbsta Score: Predicting Risk of Mortality and Disease Severity in Patients with Covid-19 Pneumonia

    Tusha, J. / Khanam, V. / Tegeltija, V. / Kumar, S.

    Chest

    Abstract: ... relationships by Jurgena Tusha, source=Web Response ...

    Abstract SESSION TITLE: Respiratory Infections: What have We Learned About COVID-19 and New Trial Data for Management of Aspergilloma SESSION TYPE: Original Investigations PRESENTED ON: October 18-21, 2020 PURPOSE: An influx of SARS-COV2 infection has led to several unanswered questions, one such question raised was how to risk stratify these patients in order to better direct further management The MuLBSTA score recently developed by Guo L et al in Shanghai, China is designed to predict 90-day mortality in patients with viral pneumonia Since very little is known regarding patients with SARS COV-2 infection and COVID-19 disease, we aim to explore the applicability of MuLBSTA score in predicting disease severity and risk of mortality in these patients METHODS: A single centre, retrospective chart review of one-hundred and sixty-three hospitalized patients with COVID-19 pneumonia at a community hospital in Michigan from March 15 to April 10, 2020 Several clinical characteristics were reviewed, six risk factors were incorporated into the MulBSTA score which included: multilobe infiltrate, absolute lymphocyte count ≤0 8 x 109/L, bacterial coinfection, smoking history, history of hypertension and age ≥ 60 years The calculated score was then compared to the primary outcome of mortality and secondary outcomes which included length of stay and ventilator support Data collected was then analysed using SPSS, validity of the data was analyzed using regression analysis and receiver operating characteristic curve RESULTS: A total of 163 patients were manually reviewed, of which there was an overall mortality rate of 29 4%, an ICU mortality rate of 50 9% and ventilator associated mortality of 62 8% The MuLBSTA score was applied to each patient manually at time of hospitalization There was a mean MuLBSTA score of 8 67 (4 066) for patients who survived and a mean MuLBSTA score of 13 6 (1 87) for patients who died There was a significant positive correlation of the MuLBSTA score with mortality (OR = 1 37, 95% CI 1 23-1 53, p = 0001) The area under the receiver operating characteristic (ROC) curve of MuLBSTA for predicting in-hospital mortality at time of admission was 0 813(SE 0 037) A positive correlation was also found with ventilator support (OR= 1 30, 95% CI 1 17-1 44, p= 0001) and length of stay (r (161) = 35, p= 0001) CONCLUSIONS: Analysis of data indicated that in patients with COVID-19 pneumonia, the MuLBSTA score successfully stratified hospitalized patients based on severity and accurately predicted overall outcome CLINICAL IMPLICATIONS: This score correlated significantly with mortality, ventilator support and length of stay, which may be used to provide guidance to screen patients and make further clinical decisions Further studies are required to validate this study in larger patient cohorts DISCLOSURES: No relevant relationships by Verisha Khanam, source=Web Response No relevant relationships by Sarwan Kumar, source=Web Response No relevant relationships by vesna tegeltija, source=Web Response No relevant relationships by Jurgena Tusha, source=Web Response
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #871830
    Database COVID19

    Kategorien

  9. Article: Clinical Characteristics and Outcomes of Patients with Covid-19 in a Community Hospital in Michigan

    Tusha, J. / Khanam, V. / Tegeltija, V. / Kumar, S.

    Chest

    Abstract: ... relevant relationships by vesna tegeltija, source=Web Response No relevant relationships by Jurgena Tusha ...

    Abstract SESSION TITLE: Disaster Medicine Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: In December 2019, a viral pneumonia associated with a new coronavirus SARS COV-2 emerged in Wuhan, China and quickly spread throughout the world causing high mortality rates As of May 30th,2020, coronavirus disease 2019 (COVID-19) has been confirmed in 56,884 people in Michigan, with case fatality rate of 10% Since very little is known regarding patients with COVID-19 disease, we aim to describe the clinical characteristics and outcomes of patients hospitalized in a Michigan community hospital METHODS: A single centre, retrospective chart review of 163 hospitalized patients with confirmed cases of COVID-19 at a community hospital from March 15 to April 10, 2020 Cases were confirmed by real-time polymerase chain reaction testing of nasopharyngeal samples Epidemiological, demographic, laboratory and overall outcomes were obtained from electronic medical record Data collected was then analysed using SPSS software RESULTS: A total of 163 patients were reviewed and included in the study Median age of patient with confirmed SARS-COV2 infection was 70 years (mean 68, range, 30-101), of which 52 8% were female, 60 7% white and 33 7% African American The most common comorbidities were hypertension (112, 68 7%), obesity (79, 48 6%), and hyperlipidemia (54, 33 1%) Patients presented with shortness of breath (109, 66 9%), cough (107, 65 6%) and fever (99, 60 7%) Gastrointestinal symptoms were found in 81 (49 6%) of patients with the most common symptom being diarrhea in 44 (27%) patients There were 66 (40 5%) patients with fever >100 4F on admission Multilobe infiltrates were found in chest x-ray of 115 (70 6%) patients Within one-month, overall mortality was noted to be 29 5% Mean length of stay of non-intensive care unit (ICU) patients was 6 46 days (range 1-19) when compared 15 5 days (range 3-46) for ICU patients During hospitalization, 55 patients (33 7%) (median age 68 years, 54 5% female, 60 1% white) were treated in the ICU of which 43(78 2%) required mechanical ventilation and 28 (50 9%) died For patients requiring mechanical ventilation, 27 (62 8%) died and 16 (37 2%) were discharged alive CONCLUSIONS: This study provides insight into presenting characteristics, demographics and overall outcome of patients hospitalized with COVID-19 in a Michigan community hospital CLINICAL IMPLICATIONS: In medical emergencies like the COVID pandemic, it is important to analyze patient demographics in order to help identify the population most at risk Knowledge of the most vulnerable population not only allows us to come up with strategies to help control the spread of disease but also helps us risk stratify the patients for better resource allocation It is crucial to learn from an outbreak like this so we can be better prepared for the future DISCLOSURES: No relevant relationships by Verisha Khanam, source=Web Response No relevant relationships by Sarwan Kumar, source=Web Response No relevant relationships by vesna tegeltija, source=Web Response No relevant relationships by Jurgena Tusha, source=Web Response
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #871857
    Database COVID19

    Kategorien

  10. Article: Sudden Cardiac Death and the Peculiar Covid-19 Case

    Abkouh, D. T. / Tusha, J. / Khanam, V. / Giri, P. / Kumar, S.

    Chest

    Abstract: ... by Jurgena Tusha, source=Web Response ...

    Abstract SESSION TITLE: Medical Student/Resident Cardiovascular Disease Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: The COVID-19 pandemic has left the medical community floundering for answers as patients present with a variety of symptoms, at different stages of the infection As the outbreak spread, the public was made aware of the range of symptoms associated with SARS-COV-2 Respiratory symptoms of dry cough and shortness of breath, Gastrointestinal symptoms such as nausea, vomiting, and even more vague signs such as Anosmia have been observed Our case further highlights the devastating outcomes and the multi systemic involvement, the difficulty of false-negative testing on these patients, the associated hyper-coagulability causing multi-organ dysfunction CASE PRESENTATION: Healthy 32-year-old gentleman presented with nausea, non-bloody emesis, epigastric pain, and poor oral intake of 6 days duration Patient also reported shortness of breath and cough productive of yellow sputum for the past 2 day He denied any sick contacts and initial real-time PCR COVID testing in ED was negative On admission, patient was comfortable on room air, with tachycardia lab findings significant for elevated lactate, Procalcitonin, and LFTs CT abdomen w/o contrast revealed bilateral pleural effusions and ground glass opacities Upon transfer to medical floors, rapid response was called for hypotension Initially, patient was alert, oriented, and in no acute distress Shortly thereafter, he began to gasp for air and complain of chest pain pulse-oximetry decreased to 75% and patient became unresponsive, without a pulse Cardiopulmonary resuscitation was initiated promptly per ACLS protocol reversible causes including tension pneumothorax, cardiac tamponade, and electrolyte/metabolic disturbances were ruled out The course of illness and clinical features were highly suggestive of acute massive pulmonary embolism, and intravenous TPA was administered Thrombectomy was considered, however it was determined that it would not change the outcome After 64 minutes of resuscitation and 21 doses of epinephrine, the efforts came to a halt and patient was pronounced dead A repeat swab for COVID-19 was taken and later reported as positive DISCUSSION: This puzzling case displays a rapid deterioration of a COVID-19 related complication The infection creates a diagnostic dilemma due to the myriad of associated symptoms and multi-system involvement as well as the False-negative testing which may alter the course of management and admission criteria Hypercoagulability triad is seen with lack of mobility, systemic inflammatory response, and endothelial invasion by SARS-CoV-2 causing endothelial damage This phenomena may be the underlying cause of the systemic involvement CONCLUSIONS: Although COVID-19 infection is widely viewed as a respiratory infection, it's crucial to recognize the multi-systemic involvement and array of symptoms Reliable testing may possibly alter medical management, improve outcome, and reduce exposure Reference #1: Magro C Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Translational research : the journal of laboratory and clinical medicine 04/2020 Doi 10 1016/j trsl 2020 04 007 Reference #2: Panigada M Hypercoagulability of COVID-19 patients in intensive care unit A report of thromboelastography findings and other parameters of hemostasis Journal of thrombosis and haemostasis 04/2020 doi: 10 1111/jth 14850 DISCLOSURES: No relevant relationships by Padmini Giri, source=Web Response No relevant relationships by Verisha Khanam, source=Web Response No relevant relationships by Sarwan Kumar, source=Web Response No relevant relationships by DANYAL TAHERI ABKOUH, source=Web Response No relevant relationships by Jurgena Tusha, source=Web Response
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #866517
    Database COVID19

    Kategorien

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