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  1. Article ; Online: Gallstone Disease: Cholecystitis, Mirizzi Syndrome, Bouveret Syndrome, Gallstone Ileus.

    Alemi, Farzad / Seiser, Natalie / Ayloo, Subhashini

    The Surgical clinics of North America

    2019  Volume 99, Issue 2, Page(s) 231–244

    Abstract: Gallstone disease is a leading cause of morbidity in the United States and usually requires surgical or endoscopic interventions for diagnosis and/or treatment. Although gallstone disease is classically associated with the inflammatory sequela of ... ...

    Abstract Gallstone disease is a leading cause of morbidity in the United States and usually requires surgical or endoscopic interventions for diagnosis and/or treatment. Although gallstone disease is classically associated with the inflammatory sequela of cholecystitis, gallstones can also contribute to other clinical presentations such as gallstone ileus, Mirizzi syndrome, and Bouveret syndrome. This article explores the common-and uncommon-causes of surgical pathology owing to gallstones with an emphasis on clinical identification, diagnostics, and management options.
    MeSH term(s) Cholecystitis/diagnosis ; Cholecystitis/etiology ; Cholecystitis/therapy ; Gallstones/diagnosis ; Gallstones/etiology ; Gallstones/therapy ; Humans ; Ileus/diagnosis ; Ileus/etiology ; Ileus/therapy ; Mirizzi Syndrome/diagnosis ; Mirizzi Syndrome/etiology ; Mirizzi Syndrome/therapy
    Language English
    Publishing date 2019-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2018.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multidisciplinary management of locally advanced pancreatic ductal adenocarcinoma.

    Alemi, Farzad / Alseidi, Adnan / Scott Helton, W / Rocha, Flavio G

    Current problems in surgery

    2015  Volume 52, Issue 9, Page(s) 362–398

    MeSH term(s) Ablation Techniques/methods ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/therapy ; Combined Modality Therapy ; Humans ; Interdisciplinary Communication ; Neoplasm Staging ; Pancreatectomy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Patient Care Team ; Prognosis ; Survival Rate ; United States
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 753169-2
    ISSN 1535-6337 ; 0011-3840
    ISSN (online) 1535-6337
    ISSN 0011-3840
    DOI 10.1067/j.cpsurg.2015.07.003
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  3. Article ; Online: WITHDRAWN: Classification and techniques of en bloc venous reconstruction for pancreaticoduodenectomy.

    Alemi, Farzad / Rocha, Flavio G / Helton, William S / Biehl, Thomas / Alseidi, Adnan

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2016  

    Abstract: The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.hpb.2016.09.006. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article ... ...

    Abstract The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.hpb.2016.09.006. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
    Language English
    Publishing date 2016-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2016.09.006
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  4. Article ; Online: Preoperative imaging characteristics predict poor survival and inadequate resection for left-sided pancreatic adenocarcinoma: a multi-institutional analysis.

    Alemi, Farzad / Jutric, Zeljka / Marshall, George R / Scott, Elliot J / Grendar, Jan / Roch, Alexandra M / Pereira, Lucio L / Cheng, An-Lin / Hansen, Paul D / Ceppa, Eugene P / Asbun, Horacio J / Warner, Susanne / Alseidi, Adnan A

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2020  Volume 22, Issue 8, Page(s) 1216–1221

    Abstract: Background: Optimal treatment of pancreatic ductal adenocarcinoma of the neck, body and tail (PDAC-NBT) necessitates R0 surgical resection. Preoperative radiographic identification of patients likely to achieve successful oncologic resection remains ... ...

    Abstract Background: Optimal treatment of pancreatic ductal adenocarcinoma of the neck, body and tail (PDAC-NBT) necessitates R0 surgical resection. Preoperative radiographic identification of patients likely to achieve successful oncologic resection remains difficult. This study seeks to identify preoperative imaging characteristics predictive of non-R0 resections or impaired survival for PDAC-NBT.
    Methods: Patients at five high-volume centers who underwent resection for PDAC-NBT were retrospectively analyzed. The most immediate preoperative cross-sectional scan was assessed along with outcome measures of overall survival and margin status.
    Results: 330 patients were treated between 2001 and 2016. Margin status included 247 R0 (78.2%), 67 R1 (21.2%), and 2 R2 (0.6%). A non-R0 resection predicted worse survival (p = 0.0002). On preoperative imaging, patients with tumors greater than 20 mm, tumor attenuation greater than 70 Hounsfield units, or who demonstrated pancreatic atrophy and/or calcifications also had worse survival (p = 0.010, p = 0.036, p = 0.025 respectively). Patients with tumors interfacing with the splenic artery or vein or extending posteriorly achieved fewer R0 resections (p = 0.0006, p = 0.0004, p = 0.001, respectively).
    Conclusion: Preoperative cross-sectional imaging can identify tumor characteristics associated with poor survival and non-R0 resection. Further investigation is needed to identify the appropriate surgical and treatment modifications necessary to clinically benefit this subset of patients.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/surgery ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/surgery ; Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Prognosis ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2020-01-11
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2019.12.012
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  5. Article ; Online: Classification and techniques of en bloc venous reconstruction for pancreaticoduodenectomy.

    Alemi, Farzad / Rocha, Flavio G / Helton, William S / Biehl, Thomas / Alseidi, Adnan

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2016  Volume 18, Issue 10, Page(s) 827–834

    Abstract: Background: Surgical resection is the only cure for hepato-pancreato-biliary (HPB) malignancy. In the era of multidisciplinary approaches and neoadjuvant therapies for locally advanced, borderline resectable tumors, the feasibility and efficacy of en ... ...

    Abstract Background: Surgical resection is the only cure for hepato-pancreato-biliary (HPB) malignancy. In the era of multidisciplinary approaches and neoadjuvant therapies for locally advanced, borderline resectable tumors, the feasibility and efficacy of en bloc vascular resection has been validated across multiple studies. However, the variability of venous anatomy within the perihepatic and peri-portal regions necessitates familiarity with alternative resection and reconstruction techniques appropriate to the specific region of tumor invasion.
    Methods: To organize these paradigms, the venous system has been divided into five zones: 1) hepatic hilum; 2) hepatoduodenal ligament; 3) portal vein/splenic vein confluence, which is further subdivided into right (3a) and left (3b); 4) infra-confluence; and 5) splenic vein.
    Results: This study systematically analyzes the anatomic considerations and clinical scenarios specific to each zone to organize the necessary preparative maneuvers, surgical procedures, and vascular reconstruction techniques to achieve an R0 resection. The anatomic and tumor-specific factors which deem a specimen unresectable are also explored. Surgical videos demonstrating these techniques are presented.
    Discussion: Preparation and familiarity with venous reconstruction maneuvers is essential for an oncologically effective operation, and can be safely achieved by utilizing this logical anatomic and procedural framework.
    MeSH term(s) Computed Tomography Angiography ; Digestive System Neoplasms/diagnostic imaging ; Digestive System Neoplasms/pathology ; Digestive System Neoplasms/surgery ; Hepatic Veins/abnormalities ; Hepatic Veins/diagnostic imaging ; Hepatic Veins/surgery ; Humans ; Ligaments/abnormalities ; Ligaments/diagnostic imaging ; Ligaments/surgery ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/methods ; Phlebography/methods ; Portal Vein/abnormalities ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Predictive Value of Tests ; Risk Factors ; Splenic Vein/abnormalities ; Splenic Vein/diagnostic imaging ; Splenic Vein/surgery ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2016.05.015
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  6. Article ; Online: What is a better predictor of clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD): postoperative day one drain amylase (POD1DA) or the fistula risk score (FRS)?

    Bertens, Kimberly A / Crown, Angelena / Clanton, Jesse / Alemi, Farzad / Alseidi, Adnan A / Biehl, Thomas / Helton, William S / Rocha, Flavio G

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2017  Volume 19, Issue 1, Page(s) 75–81

    Abstract: Background: Both fistula risk score (FRS) and drain amylase in postoperative day 1 (POD1DA) have been promoted as tools to guide placement and removal of surgical drains following pancreaticoduodenectomy (PD). However, their individual utility has not ... ...

    Abstract Background: Both fistula risk score (FRS) and drain amylase in postoperative day 1 (POD1DA) have been promoted as tools to guide placement and removal of surgical drains following pancreaticoduodenectomy (PD). However, their individual utility has not been compared.
    Methods: A consecutive cohort of PD patients from 2013 to 2015 were identified from a prospectively collected institutional database. Pearson correlation coefficients and receiver operating characteristic (ROC) curves were calculated for FRS (negligible/low vs. moderate/high) and POD1DA of 600 U/L and 5000 U/L as predictors of clinically relevant postoperative pancreatic fistula (CR-POPF).
    Results: The incidence of CR-POPF was 27% in 216 patients. Sensitivity and specificity of FRS, POD1DA >600 U/L, and POD1DA >5000 U/L for predicting CR-POPF were 83% and 55%, 94% and 60%, 33% and 90%. The ROC area under the curve (AUC) for POD1DA >600 U/L (0.764) and FRS (0.749) were not significantly different (p = 0.713). However, POD1DA >5000 U/L (0.615) was significantly worse at predicting CR-POPF (p = 0.015). When FRS and POD1DA >600 U/L were combined; there was no improvement (p = 0.624).
    Discussion: FRS and POD1DA are equally accurate in predicting CR-POPF. Patients with negligible/low FRS or POD1DA <600 U/L should be considered for drain removal.
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2016.10.001
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  7. Article ; Online: Acute paraplegia during weightlifting: an unusual vascular catastrophe.

    Parikh, Rushi V / Alemi, Farzad / Kievlan, Daniel R / Vu, Thienkhai H / Barnett, Christopher F

    Texas Heart Institute journal

    2014  Volume 41, Issue 4, Page(s) 451–452

    MeSH term(s) Acute Disease ; Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/physiopathology ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm/diagnosis ; Aortic Aneurysm/etiology ; Aortic Aneurysm/physiopathology ; Aortic Aneurysm/surgery ; Aortography/methods ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/etiology ; Arterial Occlusive Diseases/physiopathology ; Arterial Occlusive Diseases/surgery ; Hemodynamics ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Paraplegia/diagnosis ; Paraplegia/etiology ; Predictive Value of Tests ; Risk Factors ; Thrombosis/diagnosis ; Thrombosis/etiology ; Thrombosis/physiopathology ; Thrombosis/surgery ; Tomography, X-Ray Computed ; Treatment Outcome ; Weight Lifting
    Language English
    Publishing date 2014-08-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-13-3522
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  8. Article ; Online: Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway.

    Ma, Yiming / Yu, Wei / Shrivastava, Anju / Alemi, Farzad / Lankachandra, Kamani / Srivastava, Rakesh K / Shankar, Sharmila

    Carcinogenesis

    2017  Volume 38, Issue 10, Page(s) 1047–1056

    Abstract: Sonic hedgehog pathway is highly activated in pancreatic cancer stem cells (CSC) which play crucial roles in cancer initiation, progression and metastasis. However, the molecular mechanisms by which sanguinarine regulates pancreatic CSC characteristics ... ...

    Abstract Sonic hedgehog pathway is highly activated in pancreatic cancer stem cells (CSC) which play crucial roles in cancer initiation, progression and metastasis. However, the molecular mechanisms by which sanguinarine regulates pancreatic CSC characteristics is not well understood. The objectives of this study were to examine the molecular mechanisms by which sanguinarine regulates pancreatic CSC characteristics. Sanguinarine inhibited cell proliferation and colony formation and induced apoptosis through oxidative damage. Sanguinarine inhibited self-renewal capacity of pancreatic CSCs isolated from human and KrasG12D mice. Furthermore, sanguinarine suppressed epithelial-mesenchymal transition (EMT) by up-regulating E-cadherin and inhibiting N-cadherin. Significant decrease in expression level of Snail, Slug and Zeb1 corroborated the suppression of EMT in sanguinarine treated pancreatic CSCS. The ability of sanguinarine to inhibit pluripotency maintaining factors and CSC markers suggest that sanguinarine can be an effective agent for inhibiting pancreatic cancer growth and development by targeting CSCs. Furthermore, sanguinarine inhibited Shh-Gli pathway leading to modulation of Gli target genes in pancreatic CSCs. Chromatin immunoprecipitation assay demonstrated that Nanog directly binds to promoters of Cdk2, Cdk6, FGF4, c-Myc and Oct4, and sanguinarine inhibits the binding of Nanog with these genes, suggesting the direct involvement of Nanog in cell cycle, pluripotency and self-renewal. To further investigate the role of Shh-Gli-Nanog pathway, we regulated Shh signaling either by Shh protein or Nanog overexpression. Enforced activation of Shh or overexpression of Nanog counteracted the inhibitory effects of sanguinarine on pancreatic CSC proliferation, suggesting the actions of sanguinarine are mediated, at least in part, through Shh-Gli-Nanog pathway. Our studies suggest that sanguinarine can be used for the treatment and/or prevention of pancreatic cancer by targeting CSCs.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Benzophenanthridines/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Hedgehog Proteins/metabolism ; Humans ; Isoquinolines/pharmacology ; Mice ; Nanog Homeobox Protein/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Oxidative Stress/drug effects ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Signal Transduction/drug effects ; Spheroids, Cellular/drug effects ; Zinc Finger Protein GLI1/metabolism
    Chemical Substances Antineoplastic Agents ; Benzophenanthridines ; GLI1 protein, human ; Hedgehog Proteins ; Isoquinolines ; NANOG protein, human ; Nanog Homeobox Protein ; SHH protein, human ; Zinc Finger Protein GLI1 ; sanguinarine (AV9VK043SS)
    Language English
    Publishing date 2017-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgx070
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    Zs.A 1558: Show issues Location:
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  9. Article ; Online: Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.

    Cottrell, Graeme S / Alemi, Farzad / Kirkland, Jacob G / Grady, Eileen F / Corvera, Carlos U / Bhargava, Aditi

    Peptides

    2012  Volume 35, Issue 2, Page(s) 202–211

    Abstract: Calcitonin gene-related peptide (CGRP) exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 ...

    Abstract Calcitonin gene-related peptide (CGRP) exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). Despite the importance of CLR·RAMP1 in human disease, little is known about its distribution in the human gastrointestinal (GI) tract, where it participates in inflammation and pain. In this study, we determined that CLR and RAMP1 mRNAs are expressed in normal human stomach, ileum and colon by RT-PCR. We next characterized antibodies that we generated to rat CLR and RAMP1 in transfected HEK cells. Having characterized these antibodies in vitro, we then localized CLR-, RAMP1-, CGRP- and intermedin-immunoreactivity (IMD-IR) in various human GI segments. In the stomach, nerve bundles in the myenteric plexus and nerve fibers throughout the circular and longitudinal muscle had prominent CLR-IR. In the proximal colon and ileum, CLR was found in nerve varicosities of the myenteric plexus and surrounding submucosal neurons. Interestingly, CGRP expressing fibers did not co-localize, but were in close proximity to CLR. However, CLR and RAMP1, the two subunits of a functional CGRP receptor were clearly localized in myenteric plexus, where they may form functional cell-surface receptors. IMD, another member of calcitonin peptide family was also found in close proximity to CLR, and like CGRP, did not co-localize with either CLR or RAMP1 receptors. Thus, CGRP and IMD appear to be released locally, where they can mediate their effect on their receptors regulating diverse functions such as inflammation, pain and motility.
    MeSH term(s) Animals ; Calcitonin Gene-Related Peptide/immunology ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Receptor-Like Protein/genetics ; Calcitonin Receptor-Like Protein/immunology ; Calcitonin Receptor-Like Protein/metabolism ; Cell Line ; Colon/innervation ; Colon/metabolism ; Fluorescent Antibody Technique ; Gastric Mucosa/metabolism ; HEK293 Cells ; Humans ; Ileum/innervation ; Ileum/metabolism ; Inflammation/metabolism ; Myenteric Plexus/metabolism ; Neurons/metabolism ; Peptide Hormones/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Receptor Activity-Modifying Protein 1/genetics ; Receptor Activity-Modifying Protein 1/immunology ; Receptor Activity-Modifying Protein 1/metabolism ; Stomach/innervation ; Transfection
    Chemical Substances ADM2 protein, human ; CALCRL protein, human ; Calcitonin Receptor-Like Protein ; Peptide Hormones ; RAMP1 protein, human ; RNA, Messenger ; Receptor Activity-Modifying Protein 1 ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2012-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2012.03.020
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  10. Article ; Online: Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.

    Alemi, Farzad / Kwon, Edwin / Chiu, Jonathan / Aoki, Hisae / Stewart, Lygia / Corvera, Carlos U

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2011  Volume 13, Issue 9, Page(s) 656–664

    Abstract: Background: Many hepatobiliary centres are increasingly utilizing thermocoagulative devices such as bipolar-radiofrequency ablation (B-RFA). Compared with monopolar-radiofrequency ablation (M-RFA), B-RFA does not require grounding pads, thereby avoiding ...

    Abstract Background: Many hepatobiliary centres are increasingly utilizing thermocoagulative devices such as bipolar-radiofrequency ablation (B-RFA). Compared with monopolar-radiofrequency ablation (M-RFA), B-RFA does not require grounding pads, thereby avoiding dermal burn injuries, and does not position probes directly into the tumour but rather on the perimeter. Additionally, B-RFA can precoagulate parenchyma to assist in hepatic resection. Herein, we report our early experience using B-RFA.
    Methods: A retrospective review identified 68 patients who underwent M-RFA or B-RFA between June 2004 and September 2010 in an academic centre. Peri-operative metrics were analysed.
    Results: M-RFA was used to treat 30 patients, whereas B-RFA was used for 17 patients. There were no differences in peri-operative metrics, survival or disease recurrence between M-RFA and B-RFA. Seventeen additional patients underwent B-RFA precoagulation during laparoscopic resection (segmentectomy in eleven patients and multi-segmental resection in six patients). Four patients with multifocal disease underwent procedures that combined B-RFA with resection.
    Conclusions: The early experience utilizing B-RFA demonstrates equivalency to M-RFA with respect to peri-operative metrics and survival. Moreover, B-RFA can be utilized to precoagulate tissue during a planned resection, making it not only a useful tool for tumour therapy but also a useful adjunct during surgical resections.
    MeSH term(s) Academic Medical Centers ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/instrumentation ; Catheter Ablation/mortality ; Equipment Design ; Female ; Humans ; Kaplan-Meier Estimate ; Laparoscopy/adverse effects ; Laparoscopy/instrumentation ; Laparoscopy/mortality ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Retrospective Studies ; San Francisco ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2011-07-13
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1111/j.1477-2574.2011.00347.x
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