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  1. Article ; Online: Diagnosis and treatment of tuberculosis infection: can it contribute to achieving tuberculosis elimination?

    Matteelli, Alberto / Alffenaar, Jan-Willem C

    The European respiratory journal

    2022  Volume 60, Issue 1

    MeSH term(s) China ; Clinical Protocols ; Follow-Up Studies ; Humans ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00540-2022
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  2. Article ; Online: Programmatic management of tuberculosis preventive therapy: Past, present, future.

    Matteelli, Alberto / Lovatti, Sofia / Sforza, Anita / Rossi, Luca

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 130 Suppl 1, Page(s) S43–S46

    Abstract: Background: Tuberculosis (TB) infection (TBI) is an emerging public health priority, involving about one-fourth of the world population. Because patients with TBI are the reservoir for TB, stopping the progression to active disease by preventive ... ...

    Abstract Background: Tuberculosis (TB) infection (TBI) is an emerging public health priority, involving about one-fourth of the world population. Because patients with TBI are the reservoir for TB, stopping the progression to active disease by preventive treatment is one of the main interventions needed to achieve TB elimination. As of today, the proportion of people with TBI receiving treatment is minimal at the global level, mostly because current international policies recommend systematic testing and treatment for less than 2% of infected people.
    Present: FACTS AND GAPS: The programmatic management of TB preventive treatment involves a set of cascading interventions, of which the effectiveness is limited by the poor predictivity of diagnostic tests, the length and the potential toxicity of treatment, and the suboptimal prioritization within global policies. Partly because of this, competing priorities and the lack of adequate funding are significant barriers for scale-up, particularly in low- and middle-income countries.
    Monitoring and evaluation: To date, there is no universal system of monitoring and evaluation for the programmatic management of TB preventive treatment elements, and just a few countries use the standard recording and reporting tools, contributing to leaving TBI a neglected condition.
    Conclusion: Better financed research and resources reallocation are essential steps to progress toward TB elimination worldwide.
    MeSH term(s) Humans ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Latent Tuberculosis/diagnosis
    Language English
    Publishing date 2023-03-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.02.016
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  3. Article ; Online: A scoping review on the risk of tuberculosis in specific population groups: can we expand the World Health Organization recommendations?

    Bigio, Jacob / Viscardi, Angelo / Gore, Genevieve / Matteelli, Alberto / Sulis, Giorgia

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 167

    Abstract: Since 2015, the World Health Organization (WHO) has recommended prioritising testing and treatment of tuberculosis (TB) infection (TBI) in 11 high-risk groups. With new options emerging for TB preventive treatment, we conducted a scoping review, in ... ...

    Abstract Since 2015, the World Health Organization (WHO) has recommended prioritising testing and treatment of tuberculosis (TB) infection (TBI) in 11 high-risk groups. With new options emerging for TB preventive treatment, we conducted a scoping review, in consultation with the WHO's Global Tuberculosis Programme, to explore the evidence for other population groups at potentially high risk of progression to active TB. We searched six databases for preprints and articles published between 2000 and August 2022. 18 out of 33 668 screened records were included (six meta-analyses and 12 original research studies). Most were observational studies reporting the incidence of active TB in a risk group
    MeSH term(s) Humans ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Population Groups ; Risk Factors ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; World Health Organization ; Meta-Analysis as Topic ; Observational Studies as Topic
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0127-2022
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  4. Article ; Online: Mycobacterial skin infection.

    Gardini, Giulia / Gregori, Natalia / Matteelli, Alberto / Castelli, Francesco

    Current opinion in infectious diseases

    2022  Volume 35, Issue 2, Page(s) 79–87

    Abstract: Purpose of review: The aim of this article is to review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020--2021.: Recent findings: Mycobacterial skin infections include a ... ...

    Abstract Purpose of review: The aim of this article is to review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020--2021.
    Recent findings: Mycobacterial skin infections include a heterogeneous group of cutaneous diseases.Cutaneous tuberculosis is usually the result of hematogenous dissemination or spread from underlying foci and it must be distinguished from tuberculids, resulting from the immunological reaction to Mycobacterium tuberculosis antigens. Leprosy prevalence was drastically reduced after introduction of multidrug therapy in the 1980 s, but cases are still reported due to underdiagnosis, and animal and environmental reservoirs. Recent advances concentrate in the diagnostic field. Specific guidelines for the treatment of nontuberculous mycobacteria skin infections are missing and surgical procedures may be required. Prognosis is better as compared to nontuberculous mycobacteria lung disease. Rapid laboratory-confirmed diagnosis of Buruli ulcer may be achieved by the IS2404 PCR. Among new drugs, telacebec is promising in terms of potency, shorter duration and tolerability in animal studies. A clinical trial in humans is planned.
    Summary: Mycobacterial cutaneous lesions are nonpathognomonic and clinical suspicion must be confirmed by culture or molecular detection. Long-course multidrug treatment is required based on susceptibility tests. Surgical intervention may also be required. Rehabilitation and psychosocial support reduce long-term physical and mental consequences mostly in Buruli ulcer and leprosy.
    MeSH term(s) Animals ; Buruli Ulcer/drug therapy ; Buruli Ulcer/epidemiology ; Drug Therapy, Combination ; Humans ; Leprostatic Agents/therapeutic use ; Mycobacterium ; Mycobacterium Infections ; Mycobacterium Infections, Nontuberculous/diagnosis
    Chemical Substances Leprostatic Agents
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000820
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  5. Article ; Online: PASS to End TB in Europe: Accelerated efforts on prevention and systematic screening to end tuberculosis in the WHO European Region by 2030.

    Dadu, Andrei / Yedilbayev, Askar / Migliori, Giovanni Battista / Ahmedov, Sevim / Falzon, Dennis / den Boon, Saskia / Kanchar, Avinash / Matteelli, Alberto

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 141S, Page(s) 106980

    Abstract: Objectives: Outline the objectives, methods, and initial stages of the Prevention and Systematic Screening (PASS) initiative, a complimentary element of the innovative new approach of technical assistance mechanisms of WHO and its partners to countries ... ...

    Abstract Objectives: Outline the objectives, methods, and initial stages of the Prevention and Systematic Screening (PASS) initiative, a complimentary element of the innovative new approach of technical assistance mechanisms of WHO and its partners to countries aligned to the Regional TB Action Plan to End TB in the European Region by 2030.
    Design: To provide an objective and critical overview of the existing landscape on TB epidemic in the WHO European Region (the European Region) and ii) identify the strategic significance of proactive measures aimed at approaching TB pre-elimination in the Region.
    Results: Interventions primarily include systematic screening for TB disease and treatment for TB infection (TBI).
    Conclusions: PASS to End TB is an exemplary initiative of how technical and funding partners are joining hands to support national health programmes to work towards global commitments to curb major public health challenges like TB.
    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Europe/epidemiology ; Public Health ; World Health Organization
    Language English
    Publishing date 2024-02-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.02.023
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  6. Article ; Online: Perception and Awareness about Monkeypox and Vaccination Acceptance in an At-Risk Population in Brescia, Italy: An Investigative Survey.

    Crosato, Verena / Formenti, Beatrice / Gulletta, Maurizio / Odolini, Silvia / Compostella, Silvia / Tomasoni, Lina Rachele / Matteelli, Alberto / Castelli, Francesco

    AIDS and behavior

    2024  

    Abstract: Before 2022, monkeypox virus (Mpox) infection in humans was seldom reported outside Africa. During the May 2022 outbreak, most cases were detected among men who have sex with men (MSM). Since Mpox is largely unknown to the general population, through a ... ...

    Abstract Before 2022, monkeypox virus (Mpox) infection in humans was seldom reported outside Africa. During the May 2022 outbreak, most cases were detected among men who have sex with men (MSM). Since Mpox is largely unknown to the general population, through a self-completion questionnaire, we investigated the behaviours and knowledge of our at-risk population belonging to the sexually transmitted infection (STI) outpatient clinic of the Infectious Diseases Unit of the ASST Spedali Civili of Brescia, Italy, between August and October 2022. Most patients that took part in the compilation are HIV positive MSM. The other participants were HIV-seronegative patients with other STIs. Overall, 144 questionnaires were compiled. Most of the participants were Italians (130;90%) and males (139;96.5%) between 30 and 60 years (118;82%). Almost all (136;94%) reported having heard about Mpox and more than half (80;56%) received information about the transmission. Twenty-four respondents (16%) received information from health professionals and 14 (10%) believed that the information received was complete. Although 41% of respondents thought they were at risk of getting the infection and 62% were afraid to get it, the majority (56%) did not increase the precautions taken. When asked if they would accept a vaccine to prevent the disease, more than a third (32%) of respondents expressed hesitation or complete refusal to be vaccinated. Based on our results, what emerges is that there is still a lack of knowledge and awareness about Mpox. To address this issue, targeted health promotion and education strategies that provide the necessary resources to reduce risk behaviours and enhance connections with healthcare professionals are needed.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-024-04271-9
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  7. Article ; Online: The role of IGRA in the diagnosis of tuberculosis infection, differentiating from active tuberculosis, and decision making for initiating treatment or preventive therapy of tuberculosis infection.

    Goletti, Delia / Delogu, Giovanni / Matteelli, Alberto / Migliori, Giovanni Battista

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 124 Suppl 1, Page(s) S12–S19

    Abstract: Objectives: The World Health Organization estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the ... ...

    Abstract Objectives: The World Health Organization estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to register the infections and treatment completion.
    Design: we reviewed the literature regarding the tests available for TB infection diagnosis, the preventive therapies options and the cascade of care for controlling TB at a public health level.
    Results: current tests for TB infection diagnosis as IFN-γ release assays or tuberculin skin tests are based on the detection of an immune response to Mtb in the absence of clinical disease. The main limit is their low accuracy to detect progressors to disease. New preventive treatments are available with short duration that are associated with better adherence. Options to register TB infections are presented.
    Conclusions: Tests to diagnose TB infection are available but they lack accuracy to identify the progressors from infection to TB disease. Shorter preventive TB therapy are available but need to be implemented worldwide. A TB infection registry is crucial for improving the cascade of care leading to a better TB control.
    Language English
    Publishing date 2022-03-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.02.047
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  8. Article: Actinomyces

    Del Fabro, Giovanni / Volpi, Sara / Fumarola, Benedetta / Migliorati, Manuela / Bertelli, Davide / Signorini, Liana / Matteelli, Alberto / Meschiari, Marianna

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Background: Actinomycosis represents a challenging and under-reported complication of vascular surgery. Optimal management of : Methods: We conducted a retrospective case-series of : Results: We report five original cases of : Conclusions: This ...

    Abstract Background: Actinomycosis represents a challenging and under-reported complication of vascular surgery. Optimal management of
    Methods: We conducted a retrospective case-series of
    Results: We report five original cases of
    Conclusions: This case-series aims to raise the diagnostic suspicion and to describe the current management of
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122931
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  9. Article ; Online: Tailoring Treatment of Latent Tuberculosis to the Needs of Patients and Families.

    Getahun, Haileyesus / Matteelli, Alberto

    Annals of internal medicine

    2017  Volume 167, Issue 10, Page(s) 742–743

    MeSH term(s) Antitubercular Agents ; Humans ; Latent Tuberculosis
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M17-2639
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  10. Article ; Online: Global tuberculosis prevention: should we start from the beginning?

    Sotgiu, Giovanni / Goletti, Delia / Matteelli, Alberto

    The European respiratory journal

    2019  Volume 54, Issue 3

    MeSH term(s) Humans ; Latent Tuberculosis ; Prevalence ; Tuberculosis, Miliary ; Tuberculosis, Pulmonary
    Language English
    Publishing date 2019-09-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01394-2019
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