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Article: Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer.

Lorenzin, Francesca / Demichelis, Francesca

2022 Volume 14, Issue 5

Abstract: The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate ... ...

Abstract	The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa,
Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14051118
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Article ; Online: Study on the effects of carbon dioxide atmosphere on the production of biochar derived from slow pyrolysis of organic agro-urban waste.

Premchand, Premchand / Demichelis, Francesca / Chiaramonti, David / Bensaid, Samir / Fino, Debora

Waste management (New York, N.Y.)

2023 Volume 172, Page(s) 308–319

Abstract: Slow pyrolysis, a widely recognized thermochemical technique, is employed to produce biochar usually under inert atmospheres. Recently, there is a growing interest in utilizing ... ...

Abstract	Slow pyrolysis, a widely recognized thermochemical technique, is employed to produce biochar usually under inert atmospheres. Recently, there is a growing interest in utilizing CO
MeSH term(s)	Carbon Dioxide ; Pyrolysis ; Food ; Refuse Disposal ; Charcoal
Chemical Substances	Carbon Dioxide (142M471B3J) ; biochar ; Charcoal (16291-96-6)
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2023.10.035
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Article ; Online: Therapy considerations in neuroendocrine prostate cancer: what next?

Beltran, Himisha / Demichelis, Francesca

Endocrine-related cancer

2021 Volume 28, Issue 8, Page(s) T67–T78

Abstract: Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer (NEPC) is an increasingly recognized mechanism of treatment resistance in advanced prostate cancer. This is associated with aggressive clinical features and ... ...

Abstract	Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer (NEPC) is an increasingly recognized mechanism of treatment resistance in advanced prostate cancer. This is associated with aggressive clinical features and poor prognosis. Recent work has identified genomic, epigenomic, and transcriptome changes that distinguish NEPC from prostate adenocarcinoma, pointing to new mechanisms and therapeutic targets. Treatment-related NEPC arises clonally from prostate adenocarcinoma during the course of disease progression, retaining early genomic events and acquiring new molecular features that lead to tumor proliferation independent of androgen receptor activity, and ultimately demonstrating a lineage switch from a luminal prostate cancer phenotype to a small cell neuroendocrine carcinoma. Identifying the subset of prostate tumors most vulnerable to lineage plasticity and developing strategies for earlier detection and intervention for patients with NEPC may ultimately improve prognosis. Clinical trials focused on drug targeting of the lineage plasticity process and/or NEPC will require careful patient selection. Here, we review emerging targets and discuss biomarker considerations that may be informative for the design of future clinical studies.
MeSH term(s)	Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/genetics ; Carcinoma, Neuroendocrine/therapy ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prognosis ; Prostate/pathology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/therapy
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1218450-0
ISSN	1479-6821 ; 1351-0088
ISSN (online)	1479-6821
ISSN	1351-0088
DOI	10.1530/ERC-21-0140
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Article ; Online: Modelling of technical, environmental, and economic evaluations of the effect of the organic loading rate in semi-continuous anaerobic digestion of pre-treated organic fraction municipal solid waste.

Francesca, Demichelis / Elisa, Robotti / Alessandro, Deorsola Fabio / Emilio, Marengo / Tonia, Tommasi / Debora, Fino

Environmental pollution (Barking, Essex : 1987)

2024 Volume 344, Page(s) 123417

Abstract: The study concerned technical feasibility, economic profitability, and carbon footprint (CF) analysis of semi-continuous anaerobic digestion (sAD) of organic fraction of municipal solid waste (OFMSW). The research assessed the pre-treatment effect on sAD ...

Abstract	The study concerned technical feasibility, economic profitability, and carbon footprint (CF) analysis of semi-continuous anaerobic digestion (sAD) of organic fraction of municipal solid waste (OFMSW). The research assessed the pre-treatment effect on sAD by varying organic loading rates (OLR) from 3.38 to 6.75 kgvs/m
MeSH term(s)	Cost-Benefit Analysis ; Solid Waste ; Anaerobiosis ; Algorithms ; Hydrodynamics ; Bioreactors ; Refuse Disposal ; Methane
Chemical Substances	Solid Waste ; Methane (OP0UW79H66)
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123417
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Zs.A 2599: Show issues

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Article ; Online: Life cycle assessment of absorbent hygiene product waste: Evaluation and comparison of different end-of-life scenarios

Demichelis, Francesca / Martina, Carola / Fino, Debora / Tommasi, Tonia / Deorsola, Fabio A.

Institution of Chemical Engineers Sustainable Production and Consumption. 2023 June, v. 38, p. 356-371

2023 , Page(s) 356–371

Abstract: In 2019 in the world, 45·10³ Mt. of Absorbent Hygiene Product (AHP) wastes were produced, and their current disposal through landfills and incineration is causing greenhouse gas emissions and economic issues. This study compared the environmental impacts ...

Abstract	In 2019 in the world, 45·10³ Mt. of Absorbent Hygiene Product (AHP) wastes were produced, and their current disposal through landfills and incineration is causing greenhouse gas emissions and economic issues. This study compared the environmental impacts of four AHP-waste treatments calculated through Life Cycle Assessment. The four AHP-waste treatments included three innovative treatments: the biological process, the mechanical-thermal conversion of AHP-waste into fluff, the recycling process to recover valuable materials, and the baseline scenario including landfill and incineration with energy recovery. The functional unit was 1 t of AHP-waste, and the approach was from bin to grave. The evaluation concerned climate change and human toxicity with ReCiPe 2016 Midpoint (H) and non-renewable energy with cumulative energy demand. Among the four treatments, only the recycling of AHP-waste achieved avoided environmental impacts; −2.68 kg CO₂ eq./t AHP-waste, −0.07 kg1,4 DB eq./t AHP-waste, and −26.36 MJ/t AHP-waste, because the rate of recovered material offset the efforts required to treat AHP-waste. The biological and mechanical-thermal treatment of AHP-waste reached the same rank position, but the latter could be further improved through an energy valorisation of fluff. The sensitivity analyses confirmed the trends of the four treatments and underlined the importance of the proper product recovery rate to counterbalance the effort required by the treatment.
Keywords	absorbents ; climate change ; energy ; energy recovery ; greenhouse gases ; humans ; hygiene ; landfills ; life cycle assessment ; nonrenewable resources ; toxicity ; wastes ; Absorbent hygiene product waste ; Environmental impact ; Recycling ; Waste management improvement ; Sustainability
Language	English
Dates of publication	2023-06
Size	p. 356-371
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2352-5509
DOI	10.1016/j.spc.2023.04.012
Database	NAL-Catalogue (AGRICOLA)

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Article: Better screened than sorry!-an informed panel of inherited DNA repair gene variants for prostate cancer screening and prognostication.

Fracassi, Giulia / Lorenzin, Francesca / Demichelis, Francesca

Annals of translational medicine

2019 Volume 7, Issue Suppl 3, Page(s) S158

Language	English
Publishing date	2019-09-25
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2019.06.59
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Article ; Online: Investigation of the anaerobic digestion of cosmetic industrial wastes: Feasibility and perspectives.

Fiore, Silvia / Demichelis, Francesca / Chiappero, Marco / Onofrio, Maurizio

Journal of environmental management

2021 Volume 299, Page(s) 113678

Abstract: This study assessed the anaerobic digestion (AD) of wastes deriving from cosmetics production: sludge from onsite wastewater treatment plant (sWWTP), residues of shampoo/conditioner (RSC) and sludge from mascara production (MS), considered as single ... ...

Abstract	This study assessed the anaerobic digestion (AD) of wastes deriving from cosmetics production: sludge from onsite wastewater treatment plant (sWWTP), residues of shampoo/conditioner (RSC) and sludge from mascara production (MS), considered as single substrates and as mixture according to the produced amounts (54 %-wt sWWTP, 31 %-wt RSC, 13 %-wt MS, plus 2 %-wt food waste from the canteen, FW). Total COD (COD
MeSH term(s)	Anaerobiosis ; Biofuels ; Bioreactors ; Cosmetics ; Feasibility Studies ; Food ; Industrial Waste/analysis ; Methane ; Refuse Disposal ; Sewage
Chemical Substances	Biofuels ; Cosmetics ; Industrial Waste ; Sewage ; Methane (OP0UW79H66)
Language	English
Publishing date	2021-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.113678
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Article ; Online: Circulating RNAs in prostate cancer patients.

Mugoni, Vera / Ciani, Yari / Nardella, Caterina / Demichelis, Francesca

Cancer letters

2021 Volume 524, Page(s) 57–69

Abstract: Growing bodies of evidence have demonstrated that the identification of prostate cancer (PCa) biomarkers in the patients' blood and urine may remarkably improve PCa diagnosis and progression monitoring. Among diverse cancer-derived circulating materials, ...

Abstract	Growing bodies of evidence have demonstrated that the identification of prostate cancer (PCa) biomarkers in the patients' blood and urine may remarkably improve PCa diagnosis and progression monitoring. Among diverse cancer-derived circulating materials, extracellular RNA molecules (exRNAs) represent a compelling component to investigate cancer-related alterations. Once outside the intracellular environment, exRNAs circulate in biofluids either in association with protein complexes or encapsulated inside extracellular vesicles (EVs). Notably, EV-associated RNAs (EV-RNAs) were used for the development of several assays (such as the FDA-approved Progensa Prostate Cancer Antigen 3 (PCA3 test) aiming at improving early PCa detection. EV-RNAs encompass a mixture of species, including small non-coding RNAs (e.g. miRNA and circRNA), lncRNAs and mRNAs. Several methods have been proposed to isolate EVs and relevant RNAs, and to perform RNA-Seq studies to identify potential cancer biomarkers. However, EVs in the circulation of a cancer patient include a multitude of diverse populations that are released by both cancer and normal cells from different tissues, thereby leading to a heterogeneous EV-RNA-associated transcriptional signal. Decrypting the complexity of such a composite signal is nowadays the major challenge faced in the identification of specific tumor-associated RNAs. Multiple deconvolution algorithms have been proposed so far to infer the enrichment of cancer-specific signals from gene expression data. However, novel strategies for EVs sorting and sequencing of RNA associated to single EVs populations will remarkably facilitate the identification of cancer-related molecules. Altogether, the studies summarized here demonstrate the high potential of using EV-RNA biomarkers in PCa and highlight the urgent need of improving technologies and computational approaches to characterize specific EVs populations and their relevant RNA cargo.
MeSH term(s)	Antigens, Neoplasm/genetics ; Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/genetics ; Extracellular Vesicles/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; MicroRNAs/genetics ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; RNA-Seq
Chemical Substances	Antigens, Neoplasm ; Biomarkers, Tumor ; Cell-Free Nucleic Acids ; MicroRNAs ; prostate cancer antigen 3, human
Language	English
Publishing date	2021-10-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2021.10.011
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Zs.A 1177: Show issues

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Article ; Online: The Genomics of Prostate Cancer: A Historic Perspective.

Rubin, Mark A / Demichelis, Francesca

Cold Spring Harbor perspectives in medicine

2019 Volume 9, Issue 3

Abstract: The genomics of prostate cancer (PCA) has been difficult to study compared with some other cancer types for a multitude of reasons, despite significant efforts since the early 1980s. Overcoming some of these obstacles has paved the way for greater ... ...

Abstract	The genomics of prostate cancer (PCA) has been difficult to study compared with some other cancer types for a multitude of reasons, despite significant efforts since the early 1980s. Overcoming some of these obstacles has paved the way for greater insight into the genomics of PCA. The advent of high-throughput technologies coming from the initial use of microsatellite and oligonucleotide probes gave rise to techniques like comparative genomic hybridization (CGH). With the introduction of massively parallel genomic sequencing, referred to as next-generation sequencing (NGS), a deeper understanding of cancer genomics in general has occurred. Along with these technologic advances, there has been the development of computational biology and statistical approaches to address novel large data sets characterized by single base resolution. This review will provide a historic perspective of PCA genomics with an emphasis on the cardinal mutations and alterations observed to be consistently seen in PCA for both hormone-naïve localized PCA and castration-resistant prostate cancer (CRPC). There will be a focus on alterations that have the greatest potential to play a role in disease progression and therapy management.
MeSH term(s)	Computational Biology ; DNA Copy Number Variations/genetics ; Drug Resistance, Neoplasm/genetics ; Gene Fusion/genetics ; Gene Rearrangement/genetics ; Genomics/history ; High-Throughput Nucleotide Sequencing ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Microsatellite Repeats/genetics ; Neoplasm Proteins/genetics ; Polymorphism, Restriction Fragment Length/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/history
Chemical Substances	Neoplasm Proteins
Language	English
Publishing date	2019-03-01
Publishing country	United States
Document type	Historical Article ; Journal Article ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a034942
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Article ; Online: Ploidy- and Purity-Adjusted Allele-Specific DNA Analysis Using CLONETv2.

Prandi, Davide / Demichelis, Francesca

Current protocols in bioinformatics

2019 Volume 67, Issue 1, Page(s) e81

Abstract: High-throughput DNA sequencing technology provides base-level and statistically rich information about the genomic content of a sample. In the contexts of cancer research and precision oncology, thousands of genomes from paired tumor and matched normal ... ...

Abstract	High-throughput DNA sequencing technology provides base-level and statistically rich information about the genomic content of a sample. In the contexts of cancer research and precision oncology, thousands of genomes from paired tumor and matched normal samples are profiled and processed to determine somatic copy-number changes and single-nucleotide variations. Higher-order informative analyses, in the form of allele-specific copy-number assessments or subclonality quantification, require reliable estimates of tumor DNA ploidy and tumor cellularity. CLONETv2 provides a complete set of functions to process matched normal and tumor pairs using patient-specific genotype data, is independent of low-level tools (e.g., aligner, segmentation algorithm, mutation caller) and offers high-level functions to compute allele-specific copy number from segmented data and to identify subclonal population in the input sample. CLONETv2 is applicable to whole-genome, whole-exome and targeted sequencing data generated either from tissue or from liquid biopsy samples. © 2019 The Authors.
MeSH term(s)	Algorithms ; Alleles ; Computational Biology/methods ; DNA Copy Number Variations ; Exome/genetics ; Gene Dosage/genetics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Neoplasms/genetics ; Ploidies ; Precision Medicine
Language	English
Publishing date	2019-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2179022-X
ISSN	1934-340X ; 1934-3396
ISSN (online)	1934-340X
ISSN	1934-3396
DOI	10.1002/cpbi.81
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