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  1. Article ; Online: Surgeons' mental distress and risks after severe complications following radical gastrectomy in China: a nationwide cross-sectional questionnaire.

    He, Hongyong / Lin, Chao / Li, Ruochen / Zang, Lu / Huang, Xiao / Liu, Fenglin

    International journal of surgery (London, England)

    2023  Volume 109, Issue 8, Page(s) 2179–2184

    Abstract: Background: This study was designed to investigate incidences of surgeons' mental distress following severe complications after radical gastrectomy.: Methods: A cross-sectional survey was conducted between 1 June 2021 and 30 September 2021 among ... ...

    Abstract Background: This study was designed to investigate incidences of surgeons' mental distress following severe complications after radical gastrectomy.
    Methods: A cross-sectional survey was conducted between 1 June 2021 and 30 September 2021 among Chinese general and/or gastrointestinal surgeons who experienced severe complications after radical gastrectomy. The clinical features collected in the questionnaire included: (i) feeling burnout, anxiety, or depression; (ii) avoiding radical gastrectomy or feeling stress, slowing down the process during radical gastrectomy operations; (iii) having physical reactions, including heart pounding, trouble breathing, or sweating while recalling; (iv) having urges to quit being a surgeon; (v) taking psychiatric medications; and (vi) seeking psychological counselling. Analyses were performed to identify risk factors of severe mental distress, which was defined as meeting three or more of the above-mentioned clinical features.
    Results: A total of 1062 valid questionnaires were received. The survey showed that most of the participating surgeons (69.02%) had at least one clinical feature of mental distress following severe complications after radical gastrectomy, and more than 25% of the surgeons suffered from severe mental distress. Surgeons from non-university affiliated hospitals, the junior surgeons, and existing violent doctor-patient conflicts were recognized as independent risk factors for surgeons' severe mental distress related to the severe complications after radical gastrectomy.
    Conclusions: About 70% of surgeons had mental health problems following severe complications after radical gastrectomy, and more than 25% of the surgeons suffered from severe mental distress. More strategies and policies are needed to improve the mental well-being of these surgeons after such incidences.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Surveys and Questionnaires ; Surgeons ; Mental Disorders ; Gastrectomy/adverse effects
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual PI3K/mTOR inhibitor PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastric cancer cells to 5-FU.

    Zhong, Ziyuan / Wang, Tengkai / Zang, Ruochen / Zang, Yufei / Feng, Yaoyao / Yan, Shujun / Geng, Congcong / Zhu, Na / Wang, Qian

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 170, Page(s) 116086

    Abstract: Gastric cancer (GC) is characterized by high tumor heterogeneity, increased surgical difficulty, and limited chemotherapy efficacy, and it is associated with a poor prognosis. The abnormal proliferation of cells involves abnormal activation of the PI3K/ ... ...

    Abstract Gastric cancer (GC) is characterized by high tumor heterogeneity, increased surgical difficulty, and limited chemotherapy efficacy, and it is associated with a poor prognosis. The abnormal proliferation of cells involves abnormal activation of the PI3K/AKT/mTOR signaling pathway. Inhibition of this signaling pathway can inhibit tumor cell proliferation and induce cell apoptosis. This study evaluated the effect of PF-04979064, a dual inhibitor of PI3K and mTOR, on human GC cells. PF-04979064 significantly inhibited the proliferation of human gastric adenocarcinoma AGS cells and the undifferentiated GC cell line HGC-27, promoting cell apoptosis. Combination treatment with PF-04979064 and the GC first-line clinical drug 5-FU showed synergistic effects, and PF-04979064 markedly increased the sensitivity of GC cells to chemotherapy drugs. Western blot results showed that PF-04979064 significantly inhibited the PI3K/AKT/mTOR signaling pathway in GC cells, whereas RNA seq results demonstrated substantial alterations in gene expression profiles upon treatment with PF-04979064. This study provides insight into the effects of PF-04979064, thereby establishing a solid foundation for its potential clinical application in the treatment of GC.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Cell Proliferation ; Apoptosis ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Cell Line, Tumor
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphoinositide-3 Kinase Inhibitors ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2023-12-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.116086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Octyl substituted butenolides from marine-derived

    Huang, Hongbo / Song, Yongxiang / Zang, Ruochen / Wang, Xin / Ju, Jianhua

    Natural product research

    2019  Volume 35, Issue 15, Page(s) 2602–2607

    Abstract: A new butenolide derivative ( ...

    Abstract A new butenolide derivative (
    MeSH term(s) 4-Butyrolactone/analogs & derivatives ; 4-Butyrolactone/chemistry ; 4-Butyrolactone/isolation & purification ; 4-Butyrolactone/pharmacology ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Herpes Simplex/drug therapy ; Herpes Simplex/physiopathology ; Magnetic Resonance Spectroscopy ; Streptomyces/chemistry
    Chemical Substances Antiviral Agents ; butenolide (8KXK25H388) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1686368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections.

    Wang, Zhenhao / Zang, Ruochen / Niu, Zhao / Wang, Wei / Wang, Xin / Tang, Yu

    Bioorganic & medicinal chemistry letters

    2021  Volume 52, Page(s) 128405

    Abstract: Vidarabine (ARA) was one of the earliest marine-related compounds to be used clinically for antiviral therapy, however, its fast metabolism is the main defect of this drug. To overcome this, we designed and synthesized a group of phosphamide-modified ARA ...

    Abstract Vidarabine (ARA) was one of the earliest marine-related compounds to be used clinically for antiviral therapy, however, its fast metabolism is the main defect of this drug. To overcome this, we designed and synthesized a group of phosphamide-modified ARA compounds using ProTide technology. With a phosphamide modification, these compounds could become the substrate of specific phospholipase enzymes expressed in the liver. Among all 16 synthesized compounds, most showed stronger activity against herpes simplex virus type 1 (HSV-1) than ARA (EC
    MeSH term(s) Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Dimethoate/chemistry ; Dimethoate/pharmacology ; Dose-Response Relationship, Drug ; Herpes Simplex/drug therapy ; Herpesvirus 1, Human/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Vidarabine/chemical synthesis ; Vidarabine/chemistry ; Vidarabine/pharmacology
    Chemical Substances Antiviral Agents ; Vidarabine (FA2DM6879K) ; Dimethoate (W6U08B045O)
    Language English
    Publishing date 2021-10-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2021.128405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Paclitaxel-induced stress granules increase

    Shi, Xiao / Si, Xinxin / Zhang, Ershao / Zang, Ruochen / Yang, Nan / Cheng, He / Zhang, Zhihong / Pan, Beijing / Sun, Yujie

    Journal of biomedical research

    2021  Volume 35, Issue 6, Page(s) 411–424

    Abstract: Abnormal expression of long interspersed element-1 (LINE-1) has been implicated in drug resistance, while our previous study showed that chemotherapy drug paclitaxel (PTX) increased LINE-1 level with unknown mechanism. Bioinformatics analysis suggested ... ...

    Abstract Abnormal expression of long interspersed element-1 (LINE-1) has been implicated in drug resistance, while our previous study showed that chemotherapy drug paclitaxel (PTX) increased LINE-1 level with unknown mechanism. Bioinformatics analysis suggested the regulation of
    Language English
    Publishing date 2021-12-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 2555537-6
    ISSN 1876-4819 ; 1674-8301
    ISSN (online) 1876-4819
    ISSN 1674-8301
    DOI 10.7555/JBR.35.20210105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Octyl substituted butenolides from marine-derived Streptomyces koyangensis

    Huang, Hongbo / Song, Yongxiang / Zang, Ruochen / Wang, Xin / Ju, Jianhua

    Natural product research. 2021 Aug. 3, v. 35, no. 15

    2021  

    Abstract: A new butenolide derivative (1) featuring octyl substitution at γ-position, together with four known analogues (2–5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic ... ...

    Abstract A new butenolide derivative (1) featuring octyl substitution at γ-position, together with four known analogues (2–5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configuration of the stereo centre in lactone ring of 1 was determined by comparison of CD spectrum with those of known compounds. Compound 1 exhibited mild antiviral activity against herpes simplex virus with EC₅₀ value of 25.4 µM.
    Keywords Streptomyces ; antiviral properties ; herpes simplex ; research ; spectral analysis ; viruses
    Language English
    Dates of publication 2021-0803
    Size p. 2602-2607.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1686368
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist.

    Zang, Ruochen / Xue, Liang / Zhang, Meifang / Peng, Xiaoyue / Li, Xionghao / Du, Kaixin / Shi, Chuanqin / Liu, Yuqian / Lin, Yuxi / Han, Wenwei / Yu, Rilei / Wang, Qian / Yang, Jinbo / Wang, Xin / Jiang, Tao

    European journal of medicinal chemistry

    2023  Volume 250, Page(s) 115184

    Abstract: Cyclic GMP-AMP synthase and stimulator of interferon genes (cGAS-STING) signaling stimulators, an essential innate immunity component, monitor invading pathogen DNA and damaged self-DNA, making them an appealing target for drug development. The natural ... ...

    Abstract Cyclic GMP-AMP synthase and stimulator of interferon genes (cGAS-STING) signaling stimulators, an essential innate immunity component, monitor invading pathogen DNA and damaged self-DNA, making them an appealing target for drug development. The natural STING agonist, 2'3'-cGAMP, mounts and stabilizes the STING homodimer to trigger an antiviral or antitumor immune responses. However, cyclic-dinucleotide-based STING agonists show limited clinical effects owing to their short half-lives. To explore whether STING-dimer stabilizers could trigger STING signaling instead of cyclic dinucleotide-based molecules, we analyzed the structural characteristics of STING to design and synthesize a series of compounds based on the covalent STING inhibitor C-170, three of which were 23, 26, and 27, exhibited STING-dependent immune activation, both in vitro and in vivo. Compound 23 could act synergistically with cGAMP and other STING agonists as a promising moderate STING agonist. This indicates that promoting STING dimerization is a promising strategy for designing next-generation STING agonists.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; DNA/pharmacology ; Immunity, Innate ; Nucleotidyltransferases/genetics ; Signal Transduction
    Chemical Substances Antiviral Agents ; DNA (9007-49-2) ; Nucleotidyltransferases (EC 2.7.7.-) ; C-170
    Language English
    Publishing date 2023-02-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived

    Luo, Minghe / Zang, Ruochen / Wang, Xin / Chen, Ziming / Song, Xiaoxian / Ju, Jianhua / Huang, Hongbo

    Journal of natural products

    2019  Volume 82, Issue 9, Page(s) 2594–2600

    Abstract: Four new hydroxamate-containing natural product cyclopeptides designated acremonpeptides A-D ( ...

    Abstract Four new hydroxamate-containing natural product cyclopeptides designated acremonpeptides A-D (
    MeSH term(s) Acremonium/chemistry ; Aluminum/chemistry ; Marine Biology ; Siderophores/chemistry
    Chemical Substances Siderophores ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease.

    Lin, Yuxi / Zang, Ruochen / Ma, Yanlong / Wang, Zhuoya / Li, Li / Ding, Siyuan / Zhang, Rong / Wei, Zhiqiang / Yang, Jinbo / Wang, Xin

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease ( ... ...

    Abstract Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M
    MeSH term(s) 3C Viral Proteases/antagonists & inhibitors ; 3C Viral Proteases/chemistry ; 3C Viral Proteases/metabolism ; Alphacoronavirus/enzymology ; Alphacoronavirus/physiology ; Amino Acid Sequence ; Animals ; Binding Sites ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacology ; Biological Products/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Catalytic Domain ; Chlorocebus aethiops ; Coronavirus/enzymology ; Coronavirus/physiology ; Flavonoids/chemistry ; Flavonoids/metabolism ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Humans ; Molecular Docking Simulation ; Propiophenones/chemistry ; Propiophenones/metabolism ; Propiophenones/pharmacology ; Propiophenones/therapeutic use ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2/enzymology ; SARS-CoV-2/isolation & purification ; Sequence Alignment ; Vero Cells ; Virus Replication/drug effects
    Chemical Substances Biological Products ; Flavonoids ; Propiophenones ; Protease Inhibitors ; 3C Viral Proteases (EC 3.4.22.28) ; xanthohumol (T4467YT1NT)
    Language English
    Publishing date 2021-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease

    Yuxi Lin / Ruochen Zang / Yanlong Ma / Zhuoya Wang / Li Li / Siyuan Ding / Rong Zhang / Zhiqiang Wei / Jinbo Yang / Xin Wang

    International Journal of Molecular Sciences, Vol 22, Iss 12134, p

    2021  Volume 12134

    Abstract: Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M pro ) of coronavirus plays a pivotal role in viral replication and transcription, ...

    Abstract Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M pro ) of coronavirus plays a pivotal role in viral replication and transcription, which, in theory, is an attractive drug target for antiviral drug development. It has been extensively discussed whether Xanthohumol is able to help COVID-19 patients. Here, we report that Xanthohumol, a small molecule in clinical trials from hops ( Humulus lupulus ), was a potent pan-inhibitor for various coronaviruses by targeting M pro , for example, betacoronavirus SARS-CoV-2 (IC 50 value of 1.53 μM), and alphacoronavirus PEDV (IC 50 value of 7.51 μM). Xanthohumol inhibited M pro activities in the enzymatical assays, while pretreatment with Xanthohumol restricted the SARS-CoV-2 and PEDV replication in Vero-E6 cells. Therefore, Xanthohumol is a potent pan-inhibitor of coronaviruses and an excellent lead compound for further drug development.
    Keywords Xanthohumol ; natural product ; SARS-CoV-2 ; PEDV ; coronavirus ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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