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  1. Article: Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3.

    Lee, Kristi Y / Beatson, Erica L / Knechel, Martina A / Sommer, Elijah R / Napoli, Giulia C / Risdon, Emily N / Leon, Andres F / Depaz, Roger D / Strope, Jonathan D / Price, Douglas K / Chau, Cindy H / Figg, William D

    Journal of Cancer

    2024  Volume 15, Issue 3, Page(s) 615–622

    Abstract: Extracellular vesicles (EVs) provide a minimally invasive liquid biopsy source of tumor-specific markers for patients who have already undergone prostatectomies. Our laboratory has previously demonstrated enrichment of the cancer-type solute carrier ... ...

    Abstract Extracellular vesicles (EVs) provide a minimally invasive liquid biopsy source of tumor-specific markers for patients who have already undergone prostatectomies. Our laboratory has previously demonstrated enrichment of the cancer-type solute carrier organic anion transporter family 1B3 (
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 Clinical Diagnostics and Testing Technology.

    Chau, Cindy H / Strope, Jonathan D / Figg, William D

    Pharmacotherapy

    2020  Volume 40, Issue 8, Page(s) 857–868

    Abstract: Given the global nature of the coronavirus disease 2019 (COVID-19) pandemic, the need for disease detection and expanding testing capacity remains critical priorities. This review discusses the technological advances in testing capability and methodology ...

    Abstract Given the global nature of the coronavirus disease 2019 (COVID-19) pandemic, the need for disease detection and expanding testing capacity remains critical priorities. This review discusses the technological advances in testing capability and methodology that are currently used or in development for detecting the novel coronavirus. We describe the current clinical diagnostics and technology, including molecular and serological testing approaches, for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) testing as well as address their advantages and limitations. Nucleic acid amplification technology for molecular diagnostics remains the gold standard for virus detection. We highlight alternative molecular detection techniques used for developing novel COVID-19 diagnostics on the horizon. Antibody response against SARS-CoV-2 remains poorly understood and proper validation of serology tests is necessary to demonstrate their accuracy and clinical utility. In order to bring the pandemic under control, we must speed up the development of rapid and widespread testing through improvements in clinical diagnostics and testing technology as well as access to these tools.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Clinical Protocols ; Coronavirus Infections/diagnosis ; Diagnostic Errors ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Point-of-Care Systems ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2 ; Sensitivity and Specificity ; Serologic Tests/methods ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.2439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 585: Show issues

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  3. Article ; Online: Are sex discordant outcomes in COVID-19 related to sex hormones?

    Strope, Jonathan D / Chau, Cindy H / Figg, William D

    Seminars in oncology

    2020  Volume 47, Issue 5, Page(s) 335–340

    Abstract: COVID-19 has a clear sex disparity in clinical outcome. Globally, infection rates between men and women are similar; however, men are more likely to have more severe disease and are more likely to die. The causes for this disparity are currently under ... ...

    Abstract COVID-19 has a clear sex disparity in clinical outcome. Globally, infection rates between men and women are similar; however, men are more likely to have more severe disease and are more likely to die. The causes for this disparity are currently under investigation and are most likely multifactorial. Sex hormones play an important role in the immune response with estrogen seen as immune boosting and testosterone as immunosuppressing. Additionally, an important protease involved in viral entry, TMPRSS2, is regulated by androgens. Many observational and prospective studies are ongoing or initiating to further examine the role of sex hormones in SARS-CoV-2 infection and if modulation of them is a realistic treatment option.
    MeSH term(s) Androgen Antagonists/therapeutic use ; COVID-19/epidemiology ; COVID-19/metabolism ; Female ; Gonadal Steroid Hormones/metabolism ; Humans ; Male ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Pandemics ; Protease Inhibitors/therapeutic use ; Serine Endopeptidases/metabolism ; Sex Factors ; COVID-19 Drug Treatment
    Chemical Substances Androgen Antagonists ; Gonadal Steroid Hormones ; Protease Inhibitors ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2020.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1348: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: TMPRSS2: Potential Biomarker for COVID-19 Outcomes.

    Strope, Jonathan D / PharmD, Cindy H Chau / Figg, William D

    Journal of clinical pharmacology

    2020  Volume 60, Issue 7, Page(s) 801–807

    MeSH term(s) Alleles ; Androgen Antagonists/pharmacology ; Angiotensin-Converting Enzyme 2 ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Biomarkers ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Drug Therapy, Combination ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; Polymorphism, Single Nucleotide ; SARS-CoV-2 ; Serine Endopeptidases/drug effects ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Sex Distribution ; Transcriptional Regulator ERG/drug effects ; Transcriptional Regulator ERG/metabolism
    Chemical Substances Androgen Antagonists ; Antiviral Agents ; Biomarkers ; ERG protein, human ; Transcriptional Regulator ERG ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.1641
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    Uf I Zs.176: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: COVID‐19 Clinical Diagnostics and Testing Technology

    Chau, Cindy H. / Strope, Jonathan D. / Figg, William D.

    Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

    2020  Volume 40, Issue 8, Page(s) 857–868

    Keywords Pharmacology (medical) ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.2439
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 585: Show issues

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  6. Article ; Online: Are sex discordant outcomes in COVID-19 related to sex hormones?

    Strope, Jonathan D. / Chau, Cindy H. / Figg, William D.

    Seminars in Oncology

    2020  Volume 47, Issue 5, Page(s) 335–340

    Keywords Oncology ; Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2020.06.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1348: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: How do you take your coffee?

    Sissung, Tristan M / Huang, Phoebe A / Strope, Jonathan D / Figg, William D

    The Lancet. Oncology

    2019  Volume 20, Issue 7, Page(s) 913–914

    MeSH term(s) Coffee/adverse effects ; Enema/adverse effects ; Enema/methods ; Humans ; Neoplasms/therapy ; Quackery
    Chemical Substances Coffee
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30387-0
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    Zs.A 5696: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  8. Article: Are sex discordant outcomes in COVID-19 related to sex hormones?

    Strope, Jonathan D / Chau, Cindy H / Figg, William D

    Semin Oncol

    Abstract: COVID-19 has a clear sex disparity in clinical outcome. Globally, infection rates between men and women are similar; however, men are more likely to have more severe disease and are more likely to die. The causes for this disparity are currently under ... ...

    Abstract COVID-19 has a clear sex disparity in clinical outcome. Globally, infection rates between men and women are similar; however, men are more likely to have more severe disease and are more likely to die. The causes for this disparity are currently under investigation and are most likely multifactorial. Sex hormones play an important role in the immune response with estrogen seen as immune boosting and testosterone as immunosuppressing. Additionally, an important protease involved in viral entry, TMPRSS2, is regulated by androgens. Many observational and prospective studies are ongoing or initiating to further examine the role of sex hormones in SARS-CoV-2 infection and if modulation of them is a realistic treatment option.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610872
    Database COVID19

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  9. Article: COVID-19 Clinical Diagnostics and Testing Technology

    Chau, Cindy H / Strope, Jonathan D / Figg, William D

    Pharmacotherapy

    Abstract: Given the global nature of the coronavirus disease 2019 (COVID-19) pandemic, the need for disease detection and expanding testing capacity remains critical priorities. This review discusses the technological advances in testing capability and methodology ...

    Abstract Given the global nature of the coronavirus disease 2019 (COVID-19) pandemic, the need for disease detection and expanding testing capacity remains critical priorities. This review discusses the technological advances in testing capability and methodology that are currently used or in development for detecting the novel coronavirus. We describe the current clinical diagnostics and technology, including molecular and serological testing approaches, for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) testing as well as address their advantages and limitations. Nucleic acid amplification technology for molecular diagnostics remains the gold standard for virus detection. We highlight alternative molecular detection techniques used for developing novel COVID-19 diagnostics on the horizon. Antibody response against SARS-CoV-2 remains poorly understood and proper validation of serology tests is necessary to demonstrate their accuracy and clinical utility. In order to bring the pandemic under control, we must speed up the development of rapid and widespread testing through improvements in clinical diagnostics and testing technology as well as access to these tools.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #638776
    Database COVID19

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