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Article: Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4/NF-

Xu, Lie-Qiang / Yu, Xiu-Ting / Gui, Shu-Hua / Xie, Jian-Hui / Wang, Xiu-Fen / Su, Zu-Qing / Li, Yu-Cui / Lai, Xiao-Ping / Zhan, Janis Ya-Xian / Xie, You-Liang

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 1791789

Abstract: Li-Fei-Xiao-Yan prescription (LFXY) has been clinically used in China to treat inflammatory and ...

Abstract	Li-Fei-Xiao-Yan prescription (LFXY) has been clinically used in China to treat inflammatory and infectious diseases including inflammatory lung diseases. The present study was aimed at evaluating the potential therapeutic effects and potential mechanisms of LFXY in a murine model of lipopolysaccharide- (LPS-) induced acute lung injury (ALI). In this study, the mice were orally pretreated with LFXY or dexamethasone (positive drug) before the intratracheal instillation of LPS. Our data indicated that pretreatment with LFXY enhanced the survival rate of ALI mice, reversed pulmonary edema and permeability, improved LPS-induced lung histopathology impairment, suppressed the excessive inflammatory responses
Language	English
Publishing date	2017-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/1791789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4/NF-κB Pathway

Lie-Qiang Xu / Xiu-Ting Yu / Shu-Hua Gui / Jian-hui Xie / Xiu-Fen Wang / Zu-Qing Su / Yu-Cui Li / Xiao-Ping Lai / Janis Ya-Xian Zhan / You-Liang Xie

Evidence-Based Complementary and Alternative Medicine, Vol

2017 Volume 2017

Abstract: Li-Fei-Xiao-Yan prescription (LFXY) has been clinically used in China to treat inflammatory and ...

Abstract	Li-Fei-Xiao-Yan prescription (LFXY) has been clinically used in China to treat inflammatory and infectious diseases including inflammatory lung diseases. The present study was aimed at evaluating the potential therapeutic effects and potential mechanisms of LFXY in a murine model of lipopolysaccharide- (LPS-) induced acute lung injury (ALI). In this study, the mice were orally pretreated with LFXY or dexamethasone (positive drug) before the intratracheal instillation of LPS. Our data indicated that pretreatment with LFXY enhanced the survival rate of ALI mice, reversed pulmonary edema and permeability, improved LPS-induced lung histopathology impairment, suppressed the excessive inflammatory responses via decreasing the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokine (MIP-2) and inhibiting inflammatory cells migration, and repressed oxidative stress through the inhibition of MPO and MDA contents and the upregulation of antioxidants (SOD and GSH) activities. Mechanistically, treatment with LFXY significantly prevented LPS-induced TLR4 expression and NF-κB (p65) phosphorylation. Overall, the present study suggests that LFXY protected mice from acute lung injury induced by LPS via inhibition of TLR4/NF-κB p65 activation and upregulation of antioxidative enzymes and it may be a potential preventive and therapeutic agent for ALI in the clinical setting.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway.

Zhang, Zhihui / Zheng, Yihan / Chen, Nan / Xu, Chenqin / Deng, Jie / Feng, Xia / Liu, Wei / Ma, Chao / Chen, Jian / Cai, Tongkai / Xu, Yicheng / Wang, Song / Cao, Yemin / Ge, Guangbo / Jia, Chenglin / Cao, Yongbing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154931

Abstract: ... pathogenesis of DF. The traditional prescription San Huang Xiao Yan Recipe (SHXY) has been used in the clinical ...

Abstract	Background: Diabetic foot (DF) is one of the serious complications of diabetes and lacks of therapeutic drugs. Abnormal and chronic inflammation promoting foot infection and wound healing delay are the main pathogenesis of DF. The traditional prescription San Huang Xiao Yan Recipe (SHXY) has been used in the clinical treatment of DF for several decades as approved hospital experience prescription and showed remarkable therapeutic effect, but the mechanisms by which SHXY treats DF are still unclear. Purpose: Objectives of this study were to investigate SHXY anti-inflammatory effect on DF and explore the molecular mechanism for SHXY. Methods: We detected the effects of SHXY on DF in C57 mouse and SD rat DF models. Animal blood glucose, weight and wound area were detected every week. Serum inflammatory factors were detected by ELISA. H&E and Masson's trichrome were used to observe tissue pathology. Single-cell sequencing data reanalysis revealed the role of M1 macrophages in DF. Venn analysis showed the co-target genes between DF M1 macrophages and compound-disease network pharmacology. Western blotting was used to explored target protein expression. Meanwhile, RAW264.7 cells were treated with drug-containing serum of SHXY to further unravel the roles of target proteins during high glucose-induced inflammation in vitro. The Nrf2 inhibitor ML385 was used on RAW 264.7 cells to further explore the relationship between Nrf2, AMPK and HMGB1. The main components of SHXY were analysed by HPLC. Finally, the treatment effect of SHXY on DF were detected on rat DF model. Results: In vivo, SHXY can ameliorate inflammatory, accelerate wound healing and upregulate expression of Nrf2, AMPK and downregulate of HMGB1. Bioinformatic analysis showed that M1 macrophages were the main inflammatory cell population in DF. Moreover, the Nrf2 downstream proteins HO-1 and HMGB1 were potential DF therapeutic targets for SHXY. In vitro, we also found that SHXY increased AMPK and Nrf2 protein levels and downregulated HMGB1 expression in RAW264.7 cells. Inhibiting the expression of Nrf2 impaired the inhibition effect of SHXY on HMGB1. SHXY promoted Nrf2 translocation into the nucleus and increased the phosphorylation of Nrf2. SHXY also inhibited HMGB1 extracelluar release under high glucose. In rat DF models, SHXY also exhibited significant anti-inflammatory effect. Conclusion: The SHXY activated AMPK/Nrf2 pathway to suppress abnormal inflammation on DF via inhibiting HMGB1 expression. These findings provide novel insight into the mechanisms by which SHXY treats DF.
MeSH term(s)	Rats ; Mice ; Animals ; AMP-Activated Protein Kinases/metabolism ; NF-E2-Related Factor 2/metabolism ; Diabetic Foot ; HMGB1 Protein/metabolism ; Rats, Sprague-Dawley ; Inflammation/drug therapy ; Anti-Inflammatory Agents/therapeutic use ; Glucose/metabolism ; Lipopolysaccharides/pharmacology ; Diabetes Mellitus/drug therapy
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; NF-E2-Related Factor 2 ; HMGB1 Protein ; Anti-Inflammatory Agents ; Glucose (IY9XDZ35W2) ; Lipopolysaccharides
Language	English
Publishing date	2023-06-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154931
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4115: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Use of tumor suppressor genes of naked mole rats for human cancer treatment.

Xia, Pu / Xu, Xiao-Yan

American journal of translational research

2023 Volume 15, Issue 8, Page(s) 5356–5363

Abstract: Cancer not only has a significant prevalence in the human population, but is also leading cause of death in animals. Despite a long history, our battle against cancer continues. Cross-species comparative genomics offers insight into shared genes and ... ...

Abstract	Cancer not only has a significant prevalence in the human population, but is also leading cause of death in animals. Despite a long history, our battle against cancer continues. Cross-species comparative genomics offers insight into shared genes and pathways by analyzing genomic data across species, enhancing our understanding of cancer mechanisms, evolutionary processes, and possible therapeutic targets. However, no previous study has demonstrated the inhibitory effects of tumor suppressor genes from one species on tumor cells from another. The naked mole rat is the only mammal yet to be found with cancer that is attributed to its tumor suppressor genes. In this study, we constructed phylogenetic trees and assessed the anti-tumor activity of two suppressor genes, programmed cell death molecule 5 (PDCD5) and dickkopf 3 (DKK3), from rats, mice, and humans. DKK3 robustly inhibited the proliferation of breast cancer cells within and across species due to its highly conserved protein sequence. However, the cross-species inhibitory effect of PDCD5 on breast cancer cells was inconsistent due to significant sequence variations. Intriguingly, PDCD5 from the naked mole rat demonstrated potent anti-tumor activity against breast cancer cells from mice, rats, and humans, surpassing that of PDCD5 from parental species. Our results demonstrate that the suppressor genes from the naked mole rat have a strong inhibitory effect on cancer cells, indicating that the powerful anti-cancer functions of the naked mole rat may be useful for human tumor treatment.
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: [Xiao er er bi yan hou bing]

Mao, Chengyue / Xu, Yuan

[Otorhinolaryngology in children,

1958

Author's details	by Mao Chengyue and Xu Yuan
MeSH term(s)	Otolaryngology
Language	Chinese
Size	2, 2, 254 p., ill.
Publisher	Shanghai wei sheng chu ban she
Publishing place	Shanghai
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity.

Gao, Xiao-Yan / Li, Xu-Yang / Zhang, Cong-Ying / Bai, Chun-Ying

Frontiers in pharmacology

2024 Volume 15, Page(s) 1268464

Abstract: Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, ...

Abstract	Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, and toxicity of scopoletin is provided. In addition, the prospects and outlook for future studies are appraised. Scopoletin is indicated to have antimicrobial, anticancer, anti-inflammation, anti-angiogenesis, anti-oxidation, antidiabetic, antihypertensive, hepatoprotective, and neuroprotective properties and immunomodulatory effects in both
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1268464
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Machine learning applied to epilepsy: bibliometric and visual analysis from 2004 to 2023.

Huo, Qing / Luo, Xu / Xu, Zu-Cai / Yang, Xiao-Yan

Frontiers in neurology

2024 Volume 15, Page(s) 1374443

Abstract: Background: Epilepsy is one of the most common serious chronic neurological disorders, which can have a serious negative impact on individuals, families and society, and even death. With the increasing application of machine learning techniques in ... ...

Abstract	Background: Epilepsy is one of the most common serious chronic neurological disorders, which can have a serious negative impact on individuals, families and society, and even death. With the increasing application of machine learning techniques in medicine in recent years, the integration of machine learning with epilepsy has received close attention, and machine learning has the potential to provide reliable and optimal performance for clinical diagnosis, prediction, and precision medicine in epilepsy through the use of various types of mathematical algorithms, and promises to make better parallel advances. However, no bibliometric assessment has been conducted to evaluate the scientific progress in this area. Therefore, this study aims to visually analyze the trend of the current state of research related to the application of machine learning in epilepsy through bibliometrics and visualization. Methods: Relevant articles and reviews were searched for 2004-2023 using Web of Science Core Collection database, and bibliometric analyses and visualizations were performed in VOSviewer, CiteSpace, and Bibliometrix (R-Tool of R-Studio). Results: A total of 1,284 papers related to machine learning in epilepsy were retrieved from the Wo SCC database. The number of papers shows an increasing trend year by year. These papers were mainly from 1,957 organizations in 87 countries/regions, with the majority from the United States and China. The journal with the highest number of published papers is EPILEPSIA. Acharya, U. Rajendra (Ngee Ann Polytechnic, Singapore) is the authoritative author in the field and his paper "Deep Convolutional Neural Networks for Automated Detection and Diagnosis of Epileptic Seizures Using EEG Signals" was the most cited. Literature and keyword analysis shows that seizure prediction, epilepsy management and epilepsy neuroimaging are current research hotspots and developments. Conclusions: This study is the first to use bibliometric methods to visualize and analyze research in areas related to the application of machine learning in epilepsy, revealing research trends and frontiers in the field. This information will provide a useful reference for epilepsy researchers focusing on machine learning.
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1374443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effective capping of dissolved sulfide generated in Ulva prolifera-rich marine sediments by iron-rich red soil.

Guo, Yang-Yang / Li, Tie / Cao, Xiao-Yan / Zhu, Mao-Xu

Marine pollution bulletin

2024 Volume 203, Page(s) 116424

Abstract: Bloom-induced macroalgal enrichment on the seafloor can substantially facilitate dissolved sulfide (DS) production through sulfate reduction. The reaction of DS with sedimentary reactive iron (Fe) is the main mechanism of DS consumption, which however ... ...

Abstract	Bloom-induced macroalgal enrichment on the seafloor can substantially facilitate dissolved sulfide (DS) production through sulfate reduction. The reaction of DS with sedimentary reactive iron (Fe) is the main mechanism of DS consumption, which however usually could not effectively prevent DS accumulation caused by pulsed macroalgal enrichment. Here we used incubations to investigate the performance of Fe-rich red soil for buffering of DS produced from macroalgae (Ulva prolifera)-enriched sediment. Based on our results, a combination of red soil additions (6.8 kg/m
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2024.116424
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PET/CT Examination of Teratomas after Stem Cell Transplantation for a Spinal Cord Injury: A Case Report.

Chi, Xiao-Tong / Tian, Jun / Zhao, Xiu-Yi / Zhang, Xiao-Yan / Xu, Chen / Deng, Kai

Current medical imaging

2024 Volume 20, Page(s) 1–7

Abstract: Background: In clinical practice, stem cell transplantation has become an effective method for treating spinal cord nerve injury. Up to now, there has been no report on teratoma caused by transplanted stem cell's abnormal differentiation in the clinic, ... ...

Abstract	Background: In clinical practice, stem cell transplantation has become an effective method for treating spinal cord nerve injury. Up to now, there has been no report on teratoma caused by transplanted stem cell's abnormal differentiation in the clinic, especially in the analysis of imaging manifestations. Therefore, this article aims to analyze the PET/CT imaging manifestations of teratoma caused by stem cell transplantation to improve the imaging diagnosing capability. Case presentation: A patient with a spinal cord injury who had received a stem cell transplant was examined by PET/CT on September 10th, 2020. The PET/CT images of the lesion showed irregular mixed low density on the right side of the erector spinae muscle area at the level of the cervical 3-5 vertebral body, with a maximum cross-section of 9.1×3.9 cm. The 18F-FDG metabolism of the lesion was increased, and the maximum standard uptake value (SUVmax) was 10.7. The boundary was unclear with the third cervical vertebra and cervical 3 and 4-level vertebral plates. Based on the patient's medical history, the lesion was diagnosed as an abnormal proliferative tumor, which was consistent with the pathological examination results. Conclusion: To date, there have been no clinical reports on teratomas caused by stem cell transplantation for spinal cord injury at home or abroad. This case report enhances the knowledge of the diagnosis and treatment methods of this type of disease and confirms the diagnostic value of PET/CT examination.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed/methods ; Teratoma/diagnostic imaging ; Teratoma/surgery ; Spinal Cord Injuries/diagnostic imaging ; Spinal Cord Injuries/surgery ; Stem Cell Transplantation ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2024-02-22
Publishing country	United Arab Emirates
Document type	Case Reports
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/0115734056264182231115104635
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Expression of Cancer-derived Immunoglobulin G is Associated with Poor Survival in Metastatic Clear Cell Renal Cell Carcinoma.

Cui, Hong-Lei / Wu, Jie / Xie, Rui-Yang / Xu, Wei-Yan / Shi, Hong-Zhe / Zhou, Ai-Ping / Qiu, Xiao-Yan / Shou, Jian-Zhong

European urology open science

2024 Volume 61, Page(s) 56–58

Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2024.01.001
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