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  1. Book ; Online: On Computing the Kronecker Structure of Polynomial and Rational Matrices using Julia

    Varga, Andreas

    2020  

    Abstract: ... the implementation of a collection of Julia functions in the MatrixPencils package for the determination ...

    Abstract In this paper we discuss the mathematical background and the computational aspects which underly the implementation of a collection of Julia functions in the MatrixPencils package for the determination of structural properties of polynomial and rational matrices. We primarily focus on the computation of the finite and infinite spectral structures (e.g., eigenvalues, zeros, poles) as well as the left and right singular structures (e.g., Kronecker indices), which play a fundamental role in the structure of the solution of many problems involving polynomial and rational matrices. The basic analysis tool is the determination of the Kronecker structure of linear matrix pencils using numerically reliable algorithms, which is used in conjunction with several linearization techniques of polynomial and rational matrices. Examples of polynomial and rational matrices, which exhibit all relevant structural features, are considered to illustrate the main mathematical concepts and the capabilities of implemented tools.

    Comment: 28 pages
    Keywords Mathematics - Numerical Analysis ; Computer Science - Mathematical Software ; 26C10 ; 30C10 ; 93B10 ; 93B60 ; 93C05
    Subject code 512
    Publishing date 2020-06-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Who Binds Better? Let Alphafold2 Decide!

    Varga, Julia K / Schueler-Furman, Ora

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 28, Page(s) e202303526

    Abstract: Deep learning is revolutionizing structural biology to an unprecedented extent. Spearheaded by DeepMind's Alphafold2, structural models of high quality can be generated, and are now available for most known proteins and many protein interactions. The ... ...

    Abstract Deep learning is revolutionizing structural biology to an unprecedented extent. Spearheaded by DeepMind's Alphafold2, structural models of high quality can be generated, and are now available for most known proteins and many protein interactions. The next challenge will be to leverage this rich structural corpus to learn about binding: which protein can contact which partner(s), and at what affinity? In a recent study, Chang and Perez have presented an elegant approach towards this challenging goal for interactions that involve a short peptide binding to its receptor. The basic idea is straightforward: given a receptor that binds to two peptides, if the receptor sequence is presented with both peptides together at the same time, AlphaFold2 should model the tighter binding peptide into the binding site, while excluding the second. A simple idea that works!
    MeSH term(s) Protein Binding ; Proteins/chemistry ; Peptides/chemistry ; Binding Sites ; Protein Domains
    Chemical Substances Proteins ; Peptides
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202303526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Out-migration and attrition of physicians and dentists before and after EU accession (2003 and 2011): the case of Hungary.

    Varga, Júlia

    The European journal of health economics : HEPAC : health economics in prevention and care

    2016  Volume 18, Issue 9, Page(s) 1079–1093

    Abstract: This paper employs a large-scale, individual-level, panel dataset to analyse the effect of EU accession on the probability of out-migration on the part of Hungarian physicians and dentists between 2003 and 2011. The study uses event history modelling and ...

    Abstract This paper employs a large-scale, individual-level, panel dataset to analyse the effect of EU accession on the probability of out-migration on the part of Hungarian physicians and dentists between 2003 and 2011. The study uses event history modelling and competing risk models. The results show that EU accession did not at the time affect the probability of out-migration while after the end of the transitional period of restrictions on the free movement of labour from the new EU member states to Austria and Germany, the probability of doctors' migration increased considerably. Relative wages and peer pressure also exercise a significant role in the out-migration decisions of young medical doctors. We also find that more than half of those medical doctors who left the country during the observation period returned some time later. The data furthermore suggest a massive flow of doctors to domestic jobs outside the health care system.
    MeSH term(s) Austria ; Dentists/supply & distribution ; Emigration and Immigration ; European Union ; Germany ; Hungary ; Physicians/supply & distribution
    Language English
    Publishing date 2016-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2045253-6
    ISSN 1618-7601 ; 1618-7598
    ISSN (online) 1618-7601
    ISSN 1618-7598
    DOI 10.1007/s10198-016-0854-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5475: Show issues Location:
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  4. Book ; Online: The effects of policies concerning teachers' wages on students' performance

    Varga, Júlia

    A @tanári bérek alakulásának hatása a tanulói teljesítményekre

    (Budapest working papers on the labour market ; BWP 2017, 1)

    2017  

    Abstract: Using country panel data of student achievement from PISA, 2003-2012 combined with national-level teacher salary data from the OECD; this study investigates if relatively short term -5-years - changes in the level and structure of statutory teacher ... ...

    Author's details author: Júlia Varga (senior research fellow, Institute of Economics, Centre for Economic and Regional Studies, Hungarian Academy of Sciences)
    Series title Budapest working papers on the labour market ; BWP 2017, 1
    Abstract Using country panel data of student achievement from PISA, 2003-2012 combined with national-level teacher salary data from the OECD; this study investigates if relatively short term -5-years - changes in the level and structure of statutory teacher salaries affect student performance in the European countries. Our results show that there are marked differences between subjects and by the experience of teachers. Higher statutory teacher salaries and larger growth of teacher salaries at the first part of teachers' career increase students' maths and science performance, while the effect was less pronounced on reading performance and at the second part of teacher career. Nevertheless, the reason for the lack of the effect of teacher salaries at the second part of teachers' career may be the result of the lack of data on teachers' actual salaries.
    Keywords teacher salaries ; student performance ; international ; PISA ; random effect ; two-step method
    Language English
    Size 1 Online-Ressource (circa 32 Seiten), Illustrationen
    Publisher Institute of Economics, Centre for Economic and Regional Studies, Hungarian Academy of Sciences, Department of Human Resources
    Publishing place Budapest
    Document type Book ; Online
    Note Zusammenfassung in ungarischer Sprache
    ISBN 9786155594854 ; 6155594856
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  5. Book ; Online: Out-migration and attrition of physicians and dentists before and after EU accession (2003 and 2011)

    Varga, Júlia

    the case of Hungary = Hova lettek az orvosok?

    (Budapest munkagazdaságtani füzetek ; BWP 2016, 4)

    2016  

    Abstract: This paper employs a large-scale, individual-level, panel dataset to analyse the effect of EU accession on the probability of out-migration on the part of Hungarian physicians and dentists between 2003 and 2011. The study uses event history modelling and ...

    Author's details author: Júlia Varga (senior research fellow, Institute of Economics, Centre for Economic and Regional Studies, Hungarian Academy of Sciences)
    Series title Budapest munkagazdaságtani füzetek ; BWP 2016, 4
    Abstract This paper employs a large-scale, individual-level, panel dataset to analyse the effect of EU accession on the probability of out-migration on the part of Hungarian physicians and dentists between 2003 and 2011. The study uses event history modelling and competing risk models. The results show that EU accession did not at the time affect the probability of the out-migration on the part of Hungarian medical doctors, while after the end of the transitional period of restrictions on the free movement of labour from the new EU member states to Austria and Germany (May 2011), the probability of doctors' migration increased considerably, as it did (for other reasons) starting in the spring of 2010. We also found that more than half of those medical doctors who left the country during the observation period returned sometime later. Results also show that in Hungary, in addition to migration, the attrition of doctors' numbers is also a severe problem. It seems that shortages of healthcare professionals are not only due to high outward migration but may also be attributed to other problems in the Hungarian health system. Nevertheless, outward migration plays an important and growing role in the phenomenon.
    Keywords medical doctors' migration ; competing risk model
    Language English
    Size 1 Online-Ressource (circa 29 Seiten), Illustrationen
    Publisher Magyar Tudományos Akadémia Közgazdaság- és Regionális Tudományi Kutatóközpont Közgazdaság-tudományi Intézet
    Publishing place Budapest
    Document type Book ; Online
    Note Zusammenfassung in ungarischer Sprache
    ISBN 9786155594410 ; 6155594414
    Database ECONomics Information System

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  6. Article ; Online: The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities.

    Varga, Julia / Kube, Marie / Luck, Katja / Schick, Sandra

    Biochemical Society transactions

    2021  Volume 49, Issue 4, Page(s) 1489–1503

    Abstract: BAF complexes are multi-subunit chromatin remodelers, which have a fundamental role in genomic regulation. Large-scale sequencing efforts have revealed frequent BAF complex mutations in many human diseases, particularly in cancer and neurological ... ...

    Abstract BAF complexes are multi-subunit chromatin remodelers, which have a fundamental role in genomic regulation. Large-scale sequencing efforts have revealed frequent BAF complex mutations in many human diseases, particularly in cancer and neurological disorders. These findings not only underscore the importance of the BAF chromatin remodelers in cellular physiological processes, but urge a more detailed understanding of their structure and molecular action to enable the development of targeted therapeutic approaches for diseases with BAF complex alterations. Here, we review recent progress in understanding the composition, assembly, structure, and function of BAF complexes, and the consequences of their disease-associated mutations. Furthermore, we highlight intra-complex subunit dependencies and synthetic lethal interactions, which have emerged as promising treatment modalities for BAF-related diseases.
    Language English
    Publishing date 2021-08-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20190960
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
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  7. Article ; Online: The TMCrys server for supporting crystallization of transmembrane proteins.

    Varga, Julia K / Tusnády, Gábor E

    Bioinformatics (Oxford, England)

    2019  Volume 35, Issue 20, Page(s) 4203–4204

    Abstract: Motivation: Due to their special properties, the structures of transmembrane proteins are extremely hard to determine. Several methods exist to predict the propensity of successful completion of the structure determination process. However, available ... ...

    Abstract Motivation: Due to their special properties, the structures of transmembrane proteins are extremely hard to determine. Several methods exist to predict the propensity of successful completion of the structure determination process. However, available predictors incorporate data of any kind of proteins, hence they can hardly differentiate between crystallizable and non-crystallizable membrane proteins.
    Results: We implemented a web server to simplify running TMCrys prediction method that was developed specifically to separate crystallizable and non-crystallizable membrane proteins.
    Availability and implementation: http://tmcrys.enzim.ttk.mta.hu.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Computers ; Crystallization ; Membrane Proteins ; Software
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2019-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btz108
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: [A short overview on the changes of the content of delusions - the impact of technological innovations, historical events and culture].

    Varga, Éva Júlia / Tényi, Tamás

    Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata

    2018  Volume 33, Issue 2, Page(s) 138–144

    Abstract: The content aspect of delusions has been going through fast and great changes over the past hundred years. In this paper we would like to lead the reader through these changes with the brief overview of the related literature, thus giving a better ... ...

    Abstract The content aspect of delusions has been going through fast and great changes over the past hundred years. In this paper we would like to lead the reader through these changes with the brief overview of the related literature, thus giving a better understanding of the underlying causes. In recent years several studies have been published on the impact of technological and cultural changes in delusions, as opposed to the stability of delusional themes over longer periods of time, proved by long-term comparisons and comparative transcultural studies on delusions, allowing for only a certain degree of variability.
    Language Hungarian
    Publishing date 2018-08-17
    Publishing country Hungary
    Document type English Abstract ; Journal Article
    ISSN 0237-7896
    ISSN 0237-7896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Hova lettek az orvosok?

    Varga, Júlia

    az orvosok külföldre vándorlása és pályaelhagyása Magyarországon 2003 - 2011

    (Budapesti munkagazdaságtani füzetek ; 2015/6)

    2015  

    Abstract: This paper employs large-scale individual-level panel data-set to determine the changes in the probability of migration and attrition of Hungarian doctors between 2003 and 2011. The study uses event history modelling, competing risk models. The results ... ...

    Title variant Where have all the doctors gone? : migration and attrition of physicians and dentists in Hungary between 2003 and 2011
    Author's details Varga Júlia
    Series title Budapesti munkagazdaságtani füzetek ; 2015/6
    Abstract This paper employs large-scale individual-level panel data-set to determine the changes in the probability of migration and attrition of Hungarian doctors between 2003 and 2011. The study uses event history modelling, competing risk models. The results show that first after the EU accession, then after the spring of 2010, and finally after the relaxation of the Austrian and German temporary employment limits, the hazard of doctors' migration increased. Results also show that in Hungary, in addition to migration, doctors' attrition is also a severe problem. Exits from physicians' and dentists' pool by migration, going to another job in Hungary and by going to inactivity are about equally likely.
    Keywords Doctors' migration ; doctors' attrition ; competing risk modell
    Language Undetermined
    Size Online-Ressource (31 S.), graph. Darst.
    Publisher Labour Research Department, Institute of Economics, Hungarian Academy of Sciences
    Publishing place Budapest
    Document type Book ; Online
    Note Zsfassung in engl. Sprache
    ISBN 9786155594076 ; 6155594074
    Database ECONomics Information System

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  10. Article: A Chemical Lure for Trapping Both Sexes of

    Szanyi, Szabolcs / Nagy, Antal / Szarukán, István / Varga, Zoltán / Jósvai, Júlia Katalin / Tóth, Miklós

    Insects

    2022  Volume 13, Issue 11

    Abstract: The addition of synthetic eugenol and benzyl acetate to the known floral chemical and moth attractant phenylacetaldehyde synergized the attraction ... ...

    Abstract The addition of synthetic eugenol and benzyl acetate to the known floral chemical and moth attractant phenylacetaldehyde synergized the attraction of
    Language English
    Publishing date 2022-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13111051
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