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  1. Article ; Online: Reports from 2023 Great Wall International Congress of Cardiology in China.

    Cao, Feng / Wang, Yabin / Wu, Yongjian / Ma, Changsheng

    European heart journal

    2024  Volume 45, Issue 2, Page(s) 81–83

    MeSH term(s) Humans ; Cardiology ; Cardiovascular System ; China
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad737
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 640: Show issues

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  2. Article: Editorial: Gut-liver-brain axis: a complex network influences human health and diseases.

    Wu, Hongjin / Zhang, Yongjian / Yu, Juehua / Shi, Ming

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1241069

    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1241069
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  3. Article ; Online: Randomised controlled trial of early magnetically controlled capsule endoscopy for the prevention of gastrointestinal bleeding in patients at high bleeding risk scheduled for percutaneous coronary intervention: MACE-GPS study protocol.

    Li, Minghui / Liu, Rong / Wu, Yongjian

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e077852

    Abstract: Introduction: Limited data are available regarding the decision-making process for preventing gastrointestinal bleeding in patients at high risk of bleeding scheduled for percutaneous coronary intervention (HBPCI), especially due to the lack of a simple, ...

    Abstract Introduction: Limited data are available regarding the decision-making process for preventing gastrointestinal bleeding in patients at high risk of bleeding scheduled for percutaneous coronary intervention (HBPCI), especially due to the lack of a simple, accurate and sensitive methods for gastrointestinal injury detection. This randomised trial aims to assess the effects of early magnetically controlled capsule endoscopy (MCE) in patients with HBPCI for the prevention of gastrointestinal bleeding compared with conventional management.
    Methods and analysis: The Magnetic-Assisted Capsule Endoscopy Gastrointestinal bleeding Protection Strategy (MACE-GPS) is a multicentre, open-label, randomised controlled trial. Patients admitted for HBPCI will be randomised and placed into two study groups. In the early MCE group, 1228 patients will undergo MCE following admission to the hospital. If necessary, these patients may further undergo a multidisciplinary approach to determine treatment based on the MCE findings. A total of 1228 patients in the control group will undergo conventional treatment based on the attending cardiologist's interpretation of their clinical presentations. The primary end point is the incidence of gastrointestinal bleeding within 12 months of enrolment.
    Ethics and dissemination: The MACE-GPS trial has been approved by the ethics committees of all participating sites. Participant recruitment began in April 2023 and will be completed in April 2025, and the 1-year follow-up will be completed in April 2026. The study results will be disseminated through conference presentations and peer-reviewed publications.
    Trial registration number: ChiCTR2300070025.
    MeSH term(s) Humans ; Capsule Endoscopy ; Gastrointestinal Hemorrhage ; Control Groups ; Ethics Committees ; Percutaneous Coronary Intervention ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-077852
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  4. Article ; Online: Unveiling therapeutic prospects: targeting MDM-2 in non-muscle invasive bladder cancer.

    Wu, Hongjian / Jin, Hui / Cai, Yongjian

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–10

    Abstract: Non-muscle invasive bladder cancer (NMIBC) is considered one of the most costly malignancies, requiring significant surgical and therapeutic measures. However, progression and non-responsiveness to immunotherapy are common outcomes of treatment. In this ... ...

    Abstract Non-muscle invasive bladder cancer (NMIBC) is considered one of the most costly malignancies, requiring significant surgical and therapeutic measures. However, progression and non-responsiveness to immunotherapy are common outcomes of treatment. In this study, we conducted comparative transcriptomic analysis of non-responders from two distinct populations (Asian and American) and identified six common genes associated with disease prognosis. Among these genes, MDM-2 is a major oncogenic protein linked to seven different types of cancers, as it is involved in the degradation of the tumor suppressor protein p53. To address this, we explored novel therapeutic drugs to block the binding of p53 and MDM-2 using a targeted molecular docking approach. High-throughput screening of 2500 drugs from the FDA-approved drug database led to the identification of three drug compounds: Mol-126, Mol-679, and Mol-768. Subsequently, we evaluated the structural stability and binding of these drugs for the targeted inhibition of the MDM-2 active site (hydrophobic cleft) using molecular dynamics simulations. Analysis of five trajectories, including RMSD, RMSF, hydrogen bond, radius of gyration, coulomb short-range electrostatic spectra, and free binding energy, confirmed that Mol-126 exhibited the highest structural stability compared to the reference drug (Alrizomadlin). Notably, Mol-126 is a derivative of 3-phenoxypropionic acid, which shows promise for the development of alternative therapeutic treatments for non-responsive bladder cancer patients.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2329799
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    Zs.A 2093: Show issues Location:
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  5. Article ; Online: Transcatheter aortic valve implantation with a novel short frame-self expanding valve.

    Chen, Yang / Ferdous, Md Misbahul / Kottu, Lakshme / Wu, Yongjian

    European heart journal. Case reports

    2023  Volume 7, Issue 5, Page(s) ytad216

    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad216
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  6. Article ; Online: The complete chloroplast genome of

    Xu, Tian / Liao, Yongjian / Wu, Tao

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 2, Page(s) 399–400

    Abstract: Chimonobambusa ... ...

    Abstract Chimonobambusa angustifolia
    Language English
    Publishing date 2022-02-20
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2040391
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  7. Article ; Online: The complete chloroplast genome of

    Xiao, Liangjun / Wu, Tao / Liao, Yongjian / Xu, Tian

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 3, Page(s) 492–494

    Abstract: The whole chloroplast (cp) genome sequence ... ...

    Abstract The whole chloroplast (cp) genome sequence of
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2049986
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  8. Article: Plant Essential Oils: Dual Action of Toxicity and Egg-Laying Inhibition on

    Zhu, Yijing / Wu, Taoqi / Hu, Qianyu / He, Wenze / Zheng, Yushi / Xie, Yongjian / Rao, Qiong / Liu, Xunyue

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: Tetranychus ... ...

    Abstract Tetranychus urticae
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13060763
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  9. Article: Mentha

    Wu, Ziwei / Jin, Chunzhe / Chen, Yiyang / Yang, Shimeng / Yang, Xi / Zhang, Dayu / Xie, Yongjian

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 23

    Abstract: In this study, we analyzed the components ... ...

    Abstract In this study, we analyzed the components of
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12234034
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  10. Article ; Online: Effect of chemotherapy in tumor on coronary arteries: Mechanisms and management.

    Jiang, Chengqing / Xu, Haiyan / Wu, Yongjian

    Life sciences

    2023  Volume 338, Page(s) 122377

    Abstract: Coronary artery disease (CAD) is an important contributor to the cardiovascular burden in cancer survivors. The development of coronary ischemia events, myocardial infarction, and heart failure has been associated with many conventional chemotherapeutic ... ...

    Abstract Coronary artery disease (CAD) is an important contributor to the cardiovascular burden in cancer survivors. The development of coronary ischemia events, myocardial infarction, and heart failure has been associated with many conventional chemotherapeutic agents, new targeted therapies, and immunotherapy. The most frequent pathological manifestations of chemotherapy-mediated coronary damage include acute vasospasm, acute thrombosis, accelerated atherosclerosis development, and microvascular dysfunction. Potential screening techniques for CAD patients include baseline risk factor evaluation, polygenic risk factors, and coronary artery calcium scores. Determining the risk requires consideration of both the type of chemotherapy and the type of cancer being treated. Cardiology-oncology guidelines offer some suggestions for the care of coronary artery disease, which might involve medication, lifestyle changes, and coronary revascularization.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnosis ; Myocardial Ischemia ; Myocardial Infarction ; Neoplasms/drug therapy
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122377
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    Uc I Zs.368: Show issues Location:
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