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  1. Article ; Online: Imaging Intratumoral Heterogeneity of Diffuse Pancreatic Neuroendocrine Tumor With Multitracer PET/CT.

    Du, Bulin / Wang, Shu / Ma, Yu / Li, Xuena / Li, Yaming

    Clinical nuclear medicine

    2024  

    Abstract: Abstract: Diffuse involvement of pancreatic neuroendocrine tumor (PNET) is a rare presentation. Here, we report a case of suspected autoimmune pancreatitis with 18F-FDG and 18F-FAPI-42 PET/CT showing increased tracer uptake in the entire pancreas, which ...

    Abstract Abstract: Diffuse involvement of pancreatic neuroendocrine tumor (PNET) is a rare presentation. Here, we report a case of suspected autoimmune pancreatitis with 18F-FDG and 18F-FAPI-42 PET/CT showing increased tracer uptake in the entire pancreas, which was eventually confirmed by biopsy pathologic analysis as diffuse PNET. 18F-AlF-NOTA-octreotide PET/CT imaging showed heterogeneous tracer uptake in the entire pancreas.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [The correlation between preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and postoperative recurrence of chronic rhinosinusitis].

    Zhang, Yaming / Li, Zhiyong / Wang, Shujing / Guo, Dandan / Wang, Guanghui

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2024  Volume 38, Issue 2, Page(s) 133–139

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Neutrophils ; Platelet Count ; Rhinosinusitis ; Blood Platelets ; Lymphocytes ; Prognosis ; Rhinitis, Allergic ; Retrospective Studies
    Language Chinese
    Publishing date 2024-02-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2024.02.010
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  3. Article ; Online: DECTNet: Dual Encoder Network combined convolution and Transformer architecture for medical image segmentation.

    Li, Boliang / Xu, Yaming / Wang, Yan / Zhang, Bo

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301019

    Abstract: Automatic and accurate segmentation of medical images plays an essential role in disease diagnosis and treatment planning. Convolution neural networks have achieved remarkable results in medical image segmentation in the past decade. Meanwhile, deep ... ...

    Abstract Automatic and accurate segmentation of medical images plays an essential role in disease diagnosis and treatment planning. Convolution neural networks have achieved remarkable results in medical image segmentation in the past decade. Meanwhile, deep learning models based on Transformer architecture also succeeded tremendously in this domain. However, due to the ambiguity of the medical image boundary and the high complexity of physical organization structures, implementing effective structure extraction and accurate segmentation remains a problem requiring a solution. In this paper, we propose a novel Dual Encoder Network named DECTNet to alleviate this problem. Specifically, the DECTNet embraces four components, which are a convolution-based encoder, a Transformer-based encoder, a feature fusion decoder, and a deep supervision module. The convolutional structure encoder can extract fine spatial contextual details in images. Meanwhile, the Transformer structure encoder is designed using a hierarchical Swin Transformer architecture to model global contextual information. The novel feature fusion decoder integrates the multi-scale representation from two encoders and selects features that focus on segmentation tasks by channel attention mechanism. Further, a deep supervision module is used to accelerate the convergence of the proposed method. Extensive experiments demonstrate that, compared to the other seven models, the proposed method achieves state-of-the-art results on four segmentation tasks: skin lesion segmentation, polyp segmentation, Covid-19 lesion segmentation, and MRI cardiac segmentation.
    MeSH term(s) Humans ; Physical Examination ; COVID-19 ; Electric Power Supplies ; Heart ; Neural Networks, Computer ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301019
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  4. Article ; Online: 18 F-FAPI-42 PET/CT Findings in a Patient With Left Ventricular Mural Thrombus.

    Wang, Shu / Cheng, Zhiming / Cui, Yan / Li, Xuena / Li, Yaming

    Clinical nuclear medicine

    2024  Volume 49, Issue 3, Page(s) 274–275

    Abstract: Abstract: 18 F-FAPI-42 PET/CT is a novel imaging tool targeting fibroblast activation protein (FAP). We describe the 18 F-FAPI-42 PET/CT findings of a left ventricular mural thrombus in a 50-year-old man who had chest tightness. The 18 F-FAPI-42 PET/CT ... ...

    Abstract Abstract: 18 F-FAPI-42 PET/CT is a novel imaging tool targeting fibroblast activation protein (FAP). We describe the 18 F-FAPI-42 PET/CT findings of a left ventricular mural thrombus in a 50-year-old man who had chest tightness. The 18 F-FAPI-42 PET/CT showed annular uptake at the apex of the left ventricle, but there was no uptake of 18 F-FDG. This case showed that abnormal 18 F-FAPI-42 uptake in the heart may be associated with mural thrombus and should be evaluated clinically.
    MeSH term(s) Male ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Heart Diseases ; Heart ; Biological Transport ; Fluorodeoxyglucose F18 ; Thrombosis/complications ; Thrombosis/diagnostic imaging ; Gallium Radioisotopes
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A visible-light-catalyzed sulfonylation reaction of an aryl selenonium salt

    Wang, Yuqing / Zhao, Liang / Hao, Xinyu / Jin, Kun / Zhang, Rong / Duan, Chunying / Li, Yaming

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 12, Page(s) 2451–2455

    Abstract: An efficient synthesis of sulfone structures through selenonium salts and sodium sulfinates was developed. Under the irradiation of a blue LED lamp, the two substrates generate aryl and sulfonyl radicals through the activation of the intermediate ... ...

    Abstract An efficient synthesis of sulfone structures through selenonium salts and sodium sulfinates was developed. Under the irradiation of a blue LED lamp, the two substrates generate aryl and sulfonyl radicals through the activation of the intermediate electron donor acceptor (EDA) complex, thereby synthesizing aromatic, heteroaromatic and aliphatic sulfones in medium to good yields. The advantages of this strategy are metal-free, mild conditions and the leaving group is recycled to construct new selenonium salts.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00060a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Amino Acid‐Starved Cancer Cells Utilize Macropinocytosis and Ubiquitin‐Proteasome System for Nutrient Acquisition

    Tianyi Wang / Yaming Zhang / Yuwei Liu / Yi Huang / Weiping Wang

    Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)

    2024  

    Abstract: Abstract To grow in nutrient‐deprived tumor microenvironment, cancer cells often internalize and degrade extracellular proteins to refuel intracellular amino acids. However, the nutrient acquisition routes reported by previous studies are mainly ... ...

    Abstract Abstract To grow in nutrient‐deprived tumor microenvironment, cancer cells often internalize and degrade extracellular proteins to refuel intracellular amino acids. However, the nutrient acquisition routes reported by previous studies are mainly restricted in autophagy‐lysosomal pathway. It remains largely unknown if other protein degradation systems also contribute to the utilization of extracellular nutrients. Herein, it is demonstrated that under amino acid starvation, extracellular protein internalization through macropinocytosis and protein degradation through ubiquitin‐proteasome system are activated as a nutrient supply route, sensitizing cancer cells to proteasome inhibition. By inhibiting both macropinocytosis and ubiquitin‐proteasome system, an innovative approach to intensify amino acid starvation for cancer therapy is presented. To maximize therapeutic efficacy and minimize systemic side effects, a pH‐responsive polymersome nanocarrier is developed to deliver therapeutic agents specifically to tumor tissues. This nanoparticle system provides an approach to exacerbate amino acid starvation for cancer therapy, which represents a promising strategy for cancer treatment.
    Keywords amino acid starvation ; cancer starvation therapy ; macropinocytosis ; pH‐responsive polymersomes ; ubiquitin‐proteasome system ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Practice and exploration of planned regionalization in territorial spatial planning under the guidance of strategy

    Wang Yaming / Qin Xiaojuan

    E3S Web of Conferences, Vol 352, p

    2022  Volume 03023

    Abstract: Reasonable planning and zoning plays an important role in effectively implementing the goal of land and space development and transmitting the requirements of land use control. On the basis of relevant research, taking the preparation of land and space ... ...

    Abstract Reasonable planning and zoning plays an important role in effectively implementing the goal of land and space development and transmitting the requirements of land use control. On the basis of relevant research, taking the preparation of land and space planning in Baiyin City, Gansu Province as an example, this paper proposes to construct the planning division of “functional division + specific policy area” under the guidance of the implementation of strategic positioning requirements, and carry out the practical exploration of planning division, in order to provide some reference for the preparation of land and space planning in relevant areas.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Deformation characteristics of overlying strata in room and pillar mined-out areas under coal pillar instability

    Yaming Liu / Tianfeng Gu / Yanchao Wang / Wei Xiong / Xuanyu Yang

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 12

    Abstract: Abstract Under the condition of small roof deformation before the occurrence of fractures and collapse in room and pillar mined-out areas caused by coal pillar instability, the surface deformation may be large, which threatens the safety of ground ... ...

    Abstract Abstract Under the condition of small roof deformation before the occurrence of fractures and collapse in room and pillar mined-out areas caused by coal pillar instability, the surface deformation may be large, which threatens the safety of ground structures. Interferometric synthetic aperture radar, geophysical exploration, geotechnical exploration and physical simulation tests were conducted to analyse the deformation and development mechanism of the overlying strata in the mined-out area in this case. The results show that in terms of surface deformation, the surface deformation caused by coal pillar instability in the room and pillar mined-out area exhibits the slow deformation stage, uniform deformation stage and accelerated deformation stage. In terms of deformation of overlying strata, after the completion of room and pillar mining, a strip-shaped deformation area and trapezoidal deformation area are developed in the overlying rock. With the occurrence of coal pillar instability, a trapezoidal deformation area and inverted funnel-shaped deformation area are developed in the overlying rock. The deformation characteristics of unconsolidated formations transition from trapezoidal deformation after room and pillar mining to funnel-shaped deformation due to coal pillar instability. Moreover, the maximum surface deformation point is located at the centre of the funnel. In terms of spatial morphology of mined-out area deformation, the maximum surface deformation point corresponds to the position of the initial coal pillar instability and the crack in the mined-out area roof along the vertical direction. The mined-out area treatment method can be optimized based on the deformation characteristics of the overlying strata in the room and pillar mined-out area under the condition of coal pillar instability.
    Keywords Medicine ; R ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Molecular Dynamics Study on the Diffusion Mass Transfer Behaviour of CO

    Wang, Shuang / Cheng, Qinglin / Li, Zhidong / Qi, Yaming / Liu, Yue

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 24

    Abstract: Carbon dioxide flooding is one of the main methods used to improve crude oil recovery. It can not only improve oil recovery but also reduce greenhouse gas emissions. However, the addition of carbon dioxide makes crude oil become a more complex multiphase ...

    Abstract Carbon dioxide flooding is one of the main methods used to improve crude oil recovery. It can not only improve oil recovery but also reduce greenhouse gas emissions. However, the addition of carbon dioxide makes crude oil become a more complex multiphase fluid; that is, carbon dioxide flooding-produced fluid, in which CO
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28247948
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    Zs.MO 81: Show issues

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  10. Article ; Online: OPUS-Rota5: A highly accurate protein side-chain modeling method with 3D-Unet and RotaFormer.

    Xu, Gang / Luo, Zhenwei / Yan, Yaming / Wang, Qinghua / Ma, Jianpeng

    Structure (London, England : 1993)

    2024  

    Abstract: Accurate protein side-chain modeling is crucial for protein folding and design. This is particularly true for molecular docking as ligands primarily interact with side chains. In this study, we introduce a two-stage side-chain modeling approach called ... ...

    Abstract Accurate protein side-chain modeling is crucial for protein folding and design. This is particularly true for molecular docking as ligands primarily interact with side chains. In this study, we introduce a two-stage side-chain modeling approach called OPUS-Rota5. It leverages a modified 3D-Unet to capture the local environmental features, including ligand information of each residue, and then employs the RotaFormer module to aggregate various types of features. Evaluation on three test sets, including recently released targets from CAMEO and CASP15, shows that OPUS-Rota5 significantly outperforms some other leading side-chain modeling methods. We also employ OPUS-Rota5 to refine the side chains of 25 G protein-coupled receptor targets predicted by AlphaFold2 and achieve a significantly improved success rate in a subsequent "back" docking of their natural ligands. Therefore, OPUS-Rota5 is a useful and effective tool for molecular docking, particularly for targets with relatively accurate predicted backbones but not side chains such as high-homology targets.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2024.03.015
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