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  1. Article ; Online: Special issue entitled lipid transporters edited by Shamshad Cockcroft and Padinjat Raghu.

    Padinjat, Raghu / Cockcroft, Shamshad

    Biochimica et biophysica acta. Molecular and cell biology of lipids

    2022  Volume 1867, Issue 6, Page(s) 159152

    MeSH term(s) Biological Transport ; Lipids ; Membrane Transport Proteins
    Chemical Substances Lipids ; Membrane Transport Proteins
    Language English
    Publishing date 2022-03-21
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 60-7
    ISSN 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2022.159152
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  2. Article ; Online: Emerging cell biological functions of phosphatidylinositol 5 phosphate 4 kinase.

    Raghu, Padinjat

    Current opinion in cell biology

    2021  Volume 71, Page(s) 15–20

    Abstract: The generation of phosphoinositides (PIs) with spatial and temporal control is a key mechanism in cellular organization and signaling. The synthesis of PIs is mediated by PI kinases, proteins that are able to phosphorylate unique substrates at specific ... ...

    Abstract The generation of phosphoinositides (PIs) with spatial and temporal control is a key mechanism in cellular organization and signaling. The synthesis of PIs is mediated by PI kinases, proteins that are able to phosphorylate unique substrates at specific positions on the inositol headgroup to generate signaling molecules. Phosphatidylinositol 5 phosphate 4 kinase (PIP4K) is one such lipid kinase that is able to specifically phosphorylate phosphatidylinositol 5 phosphate, the most recently discovered PI to generate the well-known and abundant PI, phosphatidylinositol 4,5 bisphosphate [PI(4,5)P
    MeSH term(s) Animals ; Cell Membrane ; Endosomes ; Phosphates ; Phosphatidylinositols ; Signal Transduction
    Chemical Substances Phosphates ; Phosphatidylinositols
    Language English
    Publishing date 2021-03-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2021.01.012
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  3. Article ; Online: Functional diversity in a lipidome.

    Raghu, Padinjat

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 21, Page(s) 11191–11193

    MeSH term(s) Diglycerides ; Lipid Metabolism ; Lipidomics ; Lipids
    Chemical Substances Diglycerides ; Lipids
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2004764117
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  4. Article ; Online: Challenges and opportunities for discovering the biology of rare genetic diseases of the brain.

    Raghu, Padinjat / Sharma, Yojet / Suseela Devi, Aswathy Bhuvanendran Nair / Krishnan, Harini

    Journal of biosciences

    2024  Volume 49

    Abstract: Diseases of the human nervous system are an important cause of morbidity and mortality worldwide. These disorders arise out of multiple aetiologies of which rare genetic mutations in genes vital to nervous system development and function are an important ...

    Abstract Diseases of the human nervous system are an important cause of morbidity and mortality worldwide. These disorders arise out of multiple aetiologies of which rare genetic mutations in genes vital to nervous system development and function are an important cause. The diagnosis of such rare disorders is challenging due to the close overlap of clinical presentations with other diseases that are not of genetic origin. Further, understanding the mechanisms by which mutations lead to altered brain structure and function is also challenging, given that the brain is not readily accessible for tissue biopsy. However, recent developments in modern technologies have opened up new opportunities for the analysis of rare genetic disorders of the brain. In this review, we discuss these developments and strategies by which they can be applied effectively for better understanding of rare diseases of the brain. This will lead to the development of new clinical strategies to manage brain disorders.
    MeSH term(s) Humans ; Rare Diseases/diagnosis ; Rare Diseases/genetics ; Brain ; Mutation ; Biology
    Language English
    Publishing date 2024-02-21
    Publishing country India
    Document type Review ; Journal Article
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
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  5. Article ; Online: IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium.

    Saha, Sankhanil / Krishnan, Harini / Raghu, Padinjat

    Life science alliance

    2023  Volume 7, Issue 2

    Abstract: Lithium (Li) is widely used as a mood stabilizer to treat bipolar affective disorder. However, the molecular targets of Li that underpin its therapeutic effect remain unresolved. Inositol monophosphatase (IMPA1) is an enzyme involved in ... ...

    Abstract Lithium (Li) is widely used as a mood stabilizer to treat bipolar affective disorder. However, the molecular targets of Li that underpin its therapeutic effect remain unresolved. Inositol monophosphatase (IMPA1) is an enzyme involved in phosphatidylinositol 4,5-bisphosphate (PIP
    MeSH term(s) Humans ; Lithium/pharmacology ; Phosphatidylinositols ; Calcium ; Calcium Signaling
    Chemical Substances Lithium (9FN79X2M3F) ; Phosphatidylinositols ; myo-inositol-1 (or 4)-monophosphatase (EC 3.1.3.25) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302425
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  6. Article ; Online: Structural rationale to understand the effect of disease-associated mutations on Myotubularin.

    Bhattacharyya, Teerna / Ghosh, Avishek / Verma, Shailya / Raghu, Padinjat / Sowdhamini, Ramanathan

    Current research in structural biology

    2023  Volume 5, Page(s) 100100

    Abstract: Myotubularin or MTM1 is a lipid phosphatase that regulates vesicular trafficking in the cell. ... ...

    Abstract Myotubularin or MTM1 is a lipid phosphatase that regulates vesicular trafficking in the cell. The
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-928X
    ISSN (online) 2665-928X
    DOI 10.1016/j.crstbi.2023.100100
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  7. Article ; Online: Label-Free Quantification of Phosphoinositides in Drosophila by Mass Spectrometry.

    Ghosh, Avishek / Raghu, Padinjat

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2251, Page(s) 19–37

    Abstract: Phosphoinositides (PIs), the seven phosphorylated derivatives of phosphatidylinositol, are recognized as key molecules in the control of multiple molecular events in eukaryotic cells. Within cells, PIs are low-abundance lipids making their detection and ... ...

    Abstract Phosphoinositides (PIs), the seven phosphorylated derivatives of phosphatidylinositol, are recognized as key molecules in the control of multiple molecular events in eukaryotic cells. Within cells, PIs are low-abundance lipids making their detection and quantification challenging. While many methods that allow radiolabeling and quantification of PIs in the context of cultured cells are available, these are not useful in the context of in vivo animal models where cell and developmental processes are best studied. In this chapter, we describe radionuclide-free, mass spectrometry-based methods for the detection and quantification of PIs from Drosophila tissues in vivo. The use of these methods should facilitate the discovery of novel modes by which PIs regulate cellular and developmental processes in complex metazoans.
    MeSH term(s) Animals ; Biochemical Phenomena ; Cell Line ; Cells, Cultured ; Drosophila/metabolism ; Inositol/chemistry ; Mass Spectrometry/methods ; Phosphatidylinositol 3-Kinases/analysis ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol Phosphates/analysis ; Phosphatidylinositol Phosphates/chemistry ; Phosphatidylinositol Phosphates/metabolism ; Phosphatidylinositols/analysis ; Phosphatidylinositols/chemistry ; Phosphatidylinositols/metabolism ; Signal Transduction/physiology
    Chemical Substances Phosphatidylinositol Phosphates ; Phosphatidylinositols ; Inositol (4L6452S749)
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1142-5_2
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  8. Article ; Online: Septins tune lipid kinase activity and PI(4,5)P

    Kumari, Aastha / Ghosh, Avishek / Kolay, Sourav / Raghu, Padinjat

    Life science alliance

    2022  Volume 5, Issue 6

    Abstract: Phosphatidylinositol 4,5-bisphosphate [PI(4,5) ... ...

    Abstract Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P
    MeSH term(s) Animals ; Drosophila/metabolism ; GTP-Binding Proteins ; Phosphates ; Phosphatidylinositol 4,5-Diphosphate/physiology ; Phosphatidylinositols ; Phosphorylation ; Septins ; Type C Phospholipases/metabolism
    Chemical Substances Phosphates ; Phosphatidylinositol 4,5-Diphosphate ; Phosphatidylinositols ; Type C Phospholipases (EC 3.1.4.-) ; GTP-Binding Proteins (EC 3.6.1.-) ; Septins (EC 3.6.1.-)
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202101293
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  9. Article ; Online: Correction: Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.

    Georgiev, Plamen / Garcia-Murillas, Isaac / Ulahannan, Danny / Hardie, Roger C / Raghu, Padinjat

    Journal of cell science

    2023  Volume 136, Issue 18

    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.261574
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  10. Article ; Online: Analysis of Lipid Signaling in Drosophila Photoreceptors using Mass Spectrometry.

    Panda, Aniruddha / Thakur, Rajan / Kumari, Aastha / Raghu, Padinjat

    Journal of visualized experiments : JoVE

    2022  , Issue 181

    Abstract: The activation of phospholipase Cβ (PLCβ) is an essential step during sensory transduction in Drosophila photoreceptors. PLCβ activity results in the hydrolysis of the membrane lipid phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2] leading ultimately to ...

    Abstract The activation of phospholipase Cβ (PLCβ) is an essential step during sensory transduction in Drosophila photoreceptors. PLCβ activity results in the hydrolysis of the membrane lipid phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2] leading ultimately to the activation of transient receptor potential (TRP) and TRP like (TRPL) channels. The activity of PLCβ also leads subsequently to the generation of many lipid species several of which have been proposed to play a role in TRP and TRPL activation. In addition, several classes of lipids have been proposed to play key roles in organizing the cell biology of photoreceptors to optimize signaling reactions for optimal sensory transduction. Historically, these discoveries have been driven by the ability to isolate Drosophila mutants for enzymes that control the levels of specific lipids and perform analysis of photoreceptor physiology in these mutants. More recently, powerful mass spectrometry methods for isolation and quantitative analysis of lipids with high sensitivity and specificity have been developed. These are particularly suited for use in Drosophila where lipid analysis is now possible from photoreceptors without the need for radionuclide labeling. In this article, the conceptual and practical considerations in the use of lipid mass spectrometry for the robust, sensitive, and accurate quantitative assessment of various signaling lipids in Drosophila photoreceptors are covered. Along with existing methods in molecular genetics and physiological analysis such lipid is likely to enhance the power of photoreceptors as a model system for discoveries in biology.
    MeSH term(s) Animals ; Drosophila/physiology ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Mass Spectrometry ; Phosphatidylinositols ; Photoreceptor Cells, Invertebrate/physiology
    Chemical Substances Drosophila Proteins ; Phosphatidylinositols
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/63516
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