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  1. Article ; Online: Using Patient Perspectives to Inform Better Clinical Trial Design and Conduct: Current Trends and Future Directions.

    Faulkner, Stuart D / Somers, Fabian / Boudes, Mathieu / Nafria, Begõna / Robinson, Paul

    Pharmaceutical medicine

    2023  Volume 37, Issue 2, Page(s) 129–138

    Abstract: The approach to patient engagement (PE) in drug development has changed rapidly due to many factors, including the complexity of innovative drugs and the need to demonstrate outcomes of relevance to patients, the desire to show 'value add' of PE, and the ...

    Abstract The approach to patient engagement (PE) in drug development has changed rapidly due to many factors, including the complexity of innovative drugs and the need to demonstrate outcomes of relevance to patients, the desire to show 'value add' of PE, and the pandemic-related changes to how clinical trials are run, e.g., decentralised studies. In parallel, there have been changes in technology-assisted ways of running clinical trials, capturing patient health outcomes and preferences, an increasing societal demand for diversity and inclusion, and efforts to improve clinical trial efficiency, transparency, and accountability. Organisations are beginning to monitor PE activities and outcomes more effectively to learn and inform future PE strategies. As a result, these factors are facilitating the incorporation of patients' lived experience, preferences and needs into the design and running of clinical trials more than ever before. In this paper, the authors reflect upon these last few years, the emerging trends and their drivers, and where we may expect PE in clinical research to progress in the near future.
    MeSH term(s) Humans ; Clinical Trials as Topic ; Patients ; Patient Participation
    Language English
    Publishing date 2023-01-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2415165-8
    ISSN 1179-1993 ; 1178-2595
    ISSN (online) 1179-1993
    ISSN 1178-2595
    DOI 10.1007/s40290-022-00458-4
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  2. Article ; Online: Cannabinoid receptor 1 also plays a role in healthy bladder.

    Boudes, Mathieu / De Ridder, Dirk

    BJU international

    2014  Volume 113, Issue 1, Page(s) 142–143

    MeSH term(s) Female ; Humans ; Male ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Urinary Bladder/drug effects ; Urinary Bladder/metabolism ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/metabolism
    Chemical Substances Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.12412
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  3. Article ; Online: Urothelial TRPV1: TRPV1-Reporter Mice, a Way to Clarify the Debate?

    Boudes, Mathieu / De Ridder, Dirk

    Frontiers in physiology

    2012  Volume 3, Page(s) 130

    Language English
    Publishing date 2012-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X ; 1664-042X
    ISSN (online) 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2012.00130
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  4. Article ; Online: The expression pattern of TRPV1 in brain.

    Menigoz, Aurélie / Boudes, Mathieu

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2011  Volume 31, Issue 37, Page(s) 13025–13027

    Language English
    Publishing date 2011-09-14
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2589-11.2011
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  5. Article ; Online: Urothelial TRPV1

    MathieuBoudes

    Frontiers in Physiology, Vol

    TRPV1-reporter mice, a way to clarify the debate?

    2012  Volume 3

    Keywords Urothelium ; TRPV1 ; Bladder ; Physiology ; QP1-981 ; Science ; Q
    Language English
    Publishing date 2012-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Calcium-activated chloride current expression in axotomized sensory neurons: what for?

    Boudes, Mathieu / Scamps, Frédérique

    Frontiers in molecular neuroscience

    2012  Volume 5, Page(s) 35

    Abstract: Calcium-activated chloride currents (CaCCs) are activated by an increase in intracellular calcium concentration. Peripheral nerve injury induces the expression of CaCCs in a subset of adult sensory neurons in primary culture including mechano- and ... ...

    Abstract Calcium-activated chloride currents (CaCCs) are activated by an increase in intracellular calcium concentration. Peripheral nerve injury induces the expression of CaCCs in a subset of adult sensory neurons in primary culture including mechano- and proprioceptors, though not nociceptors. Functional screenings of potential candidate genes established that Best1 is a molecular determinant for CaCC expression among axotomized sensory neurons, while Tmem16a is acutely activated by inflammatory mediators in nociceptors. In nociceptors, such CaCCs are preferentially activated under receptor-induced calcium mobilization contributing to cell excitability and pain. In axotomized mechano- and proprioceptors, CaCC activation does not promote electrical activity and prevents firing, a finding consistent with electrical silencing for growth competence of adult sensory neurons. In favor of a role in the process of neurite growth, CaCC expression is temporally correlated to neurons displaying a regenerative mode of growth. This perspective focuses on the molecular identity and role of CaCC in axotomized sensory neurons and the future directions to decipher the cellular mechanisms regulating CaCC during neurite (re)growth.
    Language English
    Publishing date 2012-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099 ; 1662-5099
    ISSN (online) 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2012.00035
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  7. Article ; Online: Sustaining Meaningful Patient Engagement Across the Lifecycle of Medicines: A Roadmap for Action.

    Cavaller-Bellaubi, Maria / Faulkner, Stuart D / Teixeira, Bryan / Boudes, Mathieu / Molero, Eva / Brooke, Nicholas / McKeaveney, Laura / Southerton, Jeffrey / Vicente, Maria José / Bertelsen, Neil / García-Burgos, Juan / Pirard, Vinciane / Reid, Kirsty / Ferrer, Elisa

    Therapeutic innovation & regulatory science

    2021  Volume 55, Issue 5, Page(s) 936–953

    Abstract: Background: There is increased recognition that incorporating patients' perspectives and insights into the medicines development process results in better health outcomes and benefits for all involved stakeholders. Despite the increased interest and the ...

    Abstract Background: There is increased recognition that incorporating patients' perspectives and insights into the medicines development process results in better health outcomes and benefits for all involved stakeholders. Despite the increased interest and the existence of frameworks and practical recommendations, patient engagement (PE) is not yet considered standard practice. The objective of this work was to provide a roadmap to support systematic change in all stakeholder organisations involved in medicines development across Europe, patients and patient organisations, medicines developers, academia, regulatory authorities, Health Technology Assessment bodies, payers, policy-makers and public research funders, to sustain PE practices.
    Methods: A mixed-methods approach was used by the EU-funded Innovative Medicines Initiative PARADIGM Consortium to co-develop the sustainability roadmap including background work to identify success factors and scenarios for sustainable PE. The roadmap development was based on the Theory of Change concept and populated with findings from (1) interviews with national/ and international institutions with the potential to increase PE uptake by other stakeholders; (2) multi-stakeholder workshops and webinars; and (3) consultations with specific stakeholder groups, Consortium members and a consultative body formed by international PE initiatives.
    Results: This roadmap sets strategic goals for the PE community to achieve meaningful and systematic PE through changes in the culture, processes and resources of stakeholder organisations. It brings in key PARADIGM outputs to work in a coordinated fashion with existing frameworks and mechanisms to achieve system-wide sustained PE.
    Conclusions: The roadmap provides a framework for all stakeholders to take collective action within their organisations and across Europe to implement PE in a sustainable manner.
    MeSH term(s) Europe ; Humans ; Patient Participation ; Technology Assessment, Biomedical
    Language English
    Publishing date 2021-05-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-021-00282-z
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  8. Article ; Online: Evaluation of patient engagement in medicine development: A multi-stakeholder framework with metrics.

    Vat, Lidewij Eva / Finlay, Teresa / Robinson, Paul / Barbareschi, Giorgio / Boudes, Mathieu / Diaz Ponce, Ana Maria / Dinboeck, Michaela / Eichmann, Lukas / Ferrer, Elisa / Fruytier, Sevgi E / Hey, Claudia / Broerse, Jacqueline E W / Schuitmaker-Warnaar, Tjerk Jan

    Health expectations : an international journal of public participation in health care and health policy

    2021  Volume 24, Issue 2, Page(s) 491–506

    Abstract: Background: Patient engagement is becoming more customary in medicine development. However, embedding it in organizational decision-making remains challenging, partly due to lack of agreement on its value and the means to evaluate it. The objective of ... ...

    Abstract Background: Patient engagement is becoming more customary in medicine development. However, embedding it in organizational decision-making remains challenging, partly due to lack of agreement on its value and the means to evaluate it. The objective of this project was to develop a monitoring and evaluation framework, with metrics, to demonstrate impact and enhance learning.
    Methods: A consortium of five patient groups, 15 biopharmaceutical companies and two academic groups iteratively created a framework in a multi-phase participatory process, including analysis of its application in 24 cases.
    Results: The framework includes six components, with 87 metrics and 15 context factors distributed among (sub)components: (a) Input: expectations, preparations, resources, representativeness of stakeholders; (b) Activities/process: structure, management, interactions, satisfaction; (c) Learnings and changes; (d) Impacts: research relevance, study ethics and inclusiveness, study quality and efficiency, quality of evidence and uptake of products, empowerment, reputation and trust, embedding of patient engagement; (e) Context: policy, institutional, community, decision-making contextual factors. Case study findings show a wide variation in use of metrics. There is no 'one size fits all' set of metrics appropriate for every initiative or organization. Presented sample sets of metrics can be tailored to individual situations.
    Conclusion: Introducing change into any process is best done when the value of that change is clear. This framework allows participants to select what metrics they value and assess to what extent patient engagement has contributed.
    Patient contribution: Five patient groups were involved in all phases of the study (design, conduct, interpretation of data) and in writing the manuscript.
    MeSH term(s) Benchmarking ; Humans ; Medicine ; Patient Participation ; Research Design
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2119434-8
    ISSN 1369-7625 ; 1369-6513
    ISSN (online) 1369-7625
    ISSN 1369-6513
    DOI 10.1111/hex.13191
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  9. Article ; Online: Non-neuronal BDNF, a key player in development of central sensitization and neuropathic pain.

    Boudes, Mathieu / Menigoz, Aurélie

    The Journal of physiology

    2009  Volume 587, Issue Pt 10, Page(s) 2111–2112

    MeSH term(s) Animals ; Brain-Derived Neurotrophic Factor/pharmacology ; Brain-Derived Neurotrophic Factor/physiology ; Constriction, Pathologic/physiopathology ; Microglia/physiology ; Pain/metabolism ; Pain/physiopathology ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/physiopathology ; Posterior Horn Cells/drug effects ; Posterior Horn Cells/physiopathology ; Rats ; Rats, Inbred Strains ; Sciatic Nerve/pathology ; Sciatic Nerve/physiopathology ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Spinal Cord/physiopathology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
    Chemical Substances Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2009-03-30
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2009.172130
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  10. Article: TRPV4, nouvelle cible thérapeutique des problèmes urinaires.

    Boudes, Mathieu / Uvin, Pieter / De Ridder, Dirk

    Medecine sciences : M/S

    2011  Volume 27, Issue 3, Page(s) 232–234

    Title translation TRPV4, new therapeutic target for urinary problems.
    MeSH term(s) Humans ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/physiology ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/etiology ; Urination Disorders/drug therapy ; Urination Disorders/etiology
    Chemical Substances TRPV Cation Channels ; TRPV4 protein, human
    Language French
    Publishing date 2011-03
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2011273232
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