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  1. Article ; Online: Upstream current for a downstream flow.

    Filosa, Jessica A

    Nature neuroscience

    2017  Volume 20, Issue 5, Page(s) 631–633

    MeSH term(s) Cerebrovascular Circulation
    Language English
    Publishing date 2017-04-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/nn.4542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4891: Show issues Location:
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    Zs.MG 67: Show issues

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  2. Article ; Online: Stroke and the neurovascular unit: glial cells, sex differences, and hypertension.

    Morrison, Helena W / Filosa, Jessica A

    American journal of physiology. Cell physiology

    2019  Volume 316, Issue 3, Page(s) C325–C339

    Abstract: A functional neurovascular unit (NVU) is central to meeting the brain's dynamic metabolic needs. Poststroke damage to the NVU within the ipsilateral hemisphere ranges from cell dysfunction to complete cell loss. Thus, understanding poststroke cell-cell ... ...

    Abstract A functional neurovascular unit (NVU) is central to meeting the brain's dynamic metabolic needs. Poststroke damage to the NVU within the ipsilateral hemisphere ranges from cell dysfunction to complete cell loss. Thus, understanding poststroke cell-cell communication within the NVU is of critical importance. Loss of coordinated NVU function exacerbates ischemic injury. However, particular cells of the NVU (e.g., astrocytes) and those with ancillary roles (e.g., microglia) also contribute to repair mechanisms. Epidemiological studies support the notion that infarct size and recovery outcomes are heterogeneous and greatly influenced by modifiable and nonmodifiable factors such as sex and the co-morbid condition common to stroke: hypertension. The mechanisms whereby sex and hypertension modulate NVU function are explored, to some extent, in preclinical laboratory studies. We present a review of the NVU in the context of ischemic stroke with a focus on glial contributions to NVU function and dysfunction. We explore the impact of sex and hypertension as modifiable and nonmodifiable risk factors and the underlying cellular mechanisms that may underlie heterogeneous stroke outcomes. Most of the preclinical investigative studies of poststroke NVU dysfunction are carried out primarily in male stroke models lacking underlying co-morbid conditions, which is very different from the human condition. As such, the evolution of translational medicine to target the NVU for improved stroke outcomes remains elusive; however, it is attainable with further research.
    MeSH term(s) Aged ; Astrocytes/pathology ; Blood-Brain Barrier/pathology ; Brain/pathology ; Female ; Humans ; Hypertension/pathology ; Male ; Middle Aged ; Neuroglia/pathology ; Neurovascular Coupling/physiology ; Sex Characteristics ; Stroke/pathology
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00333.2018
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  3. Article: Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension.

    Presa, Jessica L / Saravia, Flavia / Bagi, Zsolt / Filosa, Jessica A

    Frontiers in physiology

    2020  Volume 11, Page(s) 584135

    Abstract: Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological ... ...

    Abstract Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating evidence for cellular elements of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling. We discuss how alterations in the cellular mechanisms governing NVU homeostasis can lead to pathological changes in which vascular endothelial and smooth muscle cell, pericyte and astrocyte function may play a key role. Because hypertension is a modifiable risk factor for stroke and accelerated cognitive decline in aging, we focus on hypertension-associated changes on cerebral arteriole function and structure, and the molecular mechanisms through which these may contribute to cognitive decline. We gather recent emerging evidence concerning cognitive loss in hypertension and the link with vascular dementia and Alzheimer's disease. Collectively, we summarize how vascular dysfunction, chronic hypoperfusion, oxidative stress, and inflammatory processes can uncouple communication at the NVU impairing cerebral perfusion and contributing to neurodegeneration.
    Language English
    Publishing date 2020-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.584135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction.

    Buncha, Vadym / Fopiano, Katie Anne / Lang, Liwei / Williams, Celestine / Horuzsko, Anatolij / Filosa, Jessica Andrea / Kapuku, Gaston / Bagi, Zsolt

    Physiological reports

    2023  Volume 11, Issue 6, Page(s) e15643

    Abstract: Endothelial cell-selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. Here, we examined the role of ESAM in cardiac vascularization, inflammatory cell infiltration, and left ventricle (LV) ... ...

    Abstract Endothelial cell-selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. Here, we examined the role of ESAM in cardiac vascularization, inflammatory cell infiltration, and left ventricle (LV) diastolic function under basal and hemodynamic stress conditions. We employed mice with homozygous genetic deletion of ESAM (ESAM
    MeSH term(s) Mice ; Animals ; Endothelial Cells/metabolism ; Heart Ventricles ; Microvascular Rarefaction/metabolism ; Ventricular Dysfunction, Left ; Heart ; Ventricular Function, Left ; Diastole
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Exploring the Psychological Nexus of Virtual and Augmented Reality on Physical Activity in Older Adults: A Rapid Review.

    Chirico, Andrea / Avellone, Marco / Palombi, Tommaso / Alivernini, Fabio / Alessandri, Guido / Filosa, Lorenzo / Pistella, Jessica / Baiocco, Roberto / Lucidi, Fabio

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 14, Issue 1

    Abstract: With the global population of older adults projected to double to 2.1 billion by 2050, it becomes crucial to promote healthy aging to alleviate the associated disease burden. In this context, technology, particularly virtual reality (VR) and augmented ... ...

    Abstract With the global population of older adults projected to double to 2.1 billion by 2050, it becomes crucial to promote healthy aging to alleviate the associated disease burden. In this context, technology, particularly virtual reality (VR) and augmented reality (AR), has garnered attention for its potential to augment physical activity in older adults. These immersive technologies offer interactive and enjoyable exercise experiences, making physical activity more appealing. However, the effectiveness of these interventions is not solely attributed to technology itself but is deeply intertwined with psychological processes. This rapid review examines the effectiveness of VR and AR interventions in enhancing physical exercise among healthy older adults while exploring the role of psychological variables, including mood, self-efficacy, and motivation. The results of the study show that technology-enhanced physical activity interventions hold great promise but call attention to the need for a comprehensive understanding of psychological dynamics that will pave the way for more tailored and effective interventions. Future research endeavors should aim to bridge these gaps in knowledge to optimize the impact of technology on healthy aging.
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer's disease.

    Tian, Yanna / Fopiano, Katie Anne / Buncha, Vadym / Lang, Liwei / Suggs, Hayden A / Wang, Rongrong / Rudic, R Daniel / Filosa, Jessica A / Bagi, Zsolt

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1125932

    Abstract: Introduction: The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may ... ...

    Abstract Introduction: The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regulate vascular homeostatic responses, including vasomotor function, vascular wall morphology, and formation of new blood vessels. The role of vascular ADAM17 in neurodegenerative diseases remains poorly understood. Here, we hypothesized that cerebrovascular ADAM17 plays a role in the pathogenesis of Alzheimer's disease (AD).
    Methods and results: We found that 9-10 months old APP/PS1 mice with b-amyloid accumulation and short-term memory and cognitive deficits display a markedly reduced expression of ADAM17 in cerebral microvessels. Systemic delivery and adeno-associated virus (AAV)-mediated re-expression of ADAM17 in APP/PS1 mice improved cognitive functioning, without affecting b-amyloid plaque density. In isolated and pressurized cerebral arteries of APP/PS1 mice the endothelium-dependent dilation to acetylcholine was significantly reduced, whereas the vascular smooth muscle-dependent dilation to the nitric oxide donor, sodium nitroprusside was maintained when compared to WT mice. The impaired endothelium-dependent vasodilation of cerebral arteries in APP/PS1 mice was restored to normal level by ADAM17 re-expression. The cerebral artery biomechanical properties (wall stress and elasticity) and microvascular network density was not affected by ADAM17 re-expression in the APP/PS1 mice. Additionally, proteomic analysis identified several differentially expressed molecules involved in AD neurodegeneration and neuronal repair mechanisms that were reversed by ADAM17 re-expression.
    Discussion: Thus, we propose that a reduced ADAM17 expression in cerebral microvessels impairs vasodilator function, which may contribute to the development of cognitive dysfunction in APP/PS1 mice, and that ADAM17 can potentially be targeted for therapeutic intervention in AD.
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1125932
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  7. Article ; Online: Daily associations between global self-esteem and self-concept clarity and their relationships with subjective well-being in a sample of adult workers.

    Filosa, Lorenzo / Sommovigo, Valentina / Tavolucci, Simone / Rosa, Valentina / Alivernini, Fabio / Baiocco, Roberto / Borghi, Anna / Chirico, Andrea / Fini, Chiara / Palombi, Tommaso / Pistella, Jessica / Lucidi, Fabio / Alessandri, Guido

    Journal of personality

    2024  

    Abstract: Objectives: The present pre-registered study examined the reciprocal day-to-day associations between global self-esteem and self-concept clarity and their incremental validity with respect to daily life satisfaction, positive affect, and negative affect. ...

    Abstract Objectives: The present pre-registered study examined the reciprocal day-to-day associations between global self-esteem and self-concept clarity and their incremental validity with respect to daily life satisfaction, positive affect, and negative affect.
    Methods: We used intensive longitudinal data from 153 adult workers (45.1% women), over a period of 31 days. Data were analyzed using dynamic structural equation modeling.
    Results: Results attested higher global self-esteem and self-concept clarity mean levels for older vs. younger participants, and lower global self-esteem and self-concept clarity variability for older vs. younger participants. Furthermore, global self-esteem and self-concept clarity were correlated at a cross-sectional daily level, yet only self-concept clarity states positively predicted subsequent global self-esteem states, while global self-esteem states did not predict subsequent self-concept clarity states. Daily global self-esteem and daily self-concept clarity further predicted subsequent daily higher life satisfaction and positive affect, respectively.
    Conclusion: Overall, our findings shed light on the short-term relationships linking global self-esteem and self-concept clarity, pointing to their discriminant validity in predicting individuals' subjective well-being.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 420745-2
    ISSN 1467-6494 ; 0022-3506
    ISSN (online) 1467-6494
    ISSN 0022-3506
    DOI 10.1111/jopy.12934
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    Zs.A 1363: Show issues Location:
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  8. Book: The neurovascular unit and the role of astrocytes in the regulation of vascular tone

    Filosa, Jessica A

    (Colloquium digital library of life sciences ; Colloquium series on neuroglia in biology and medicine, ; #6)

    2015  

    Author's details Jessica A. Filosa
    Series title Colloquium digital library of life sciences
    Colloquium series on neuroglia in biology and medicine, ; #6
    MeSH term(s) Astrocytes/physiology ; Cerebrovascular Circulation/physiology ; Vasoconstriction/physiology ; Vasodilation/physiology ; Signal Transduction/physiology
    Language English
    Size vii, 58 pages :, illustrations.
    Document type Book
    ISBN 9781615046782 ; 9781615046799 ; 161504678X ; 1615046798
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice.

    Morrison, Helena W / Filosa, Jessica A

    Neuroscience

    2016  Volume 339, Page(s) 85–99

    Abstract: Epidemiological studies report that infarct size is decreased and stroke outcomes are improved in young females when compared to males. However, mechanistic insight is lacking. We posit that sex-specific differences in glial cell functions occurring ... ...

    Abstract Epidemiological studies report that infarct size is decreased and stroke outcomes are improved in young females when compared to males. However, mechanistic insight is lacking. We posit that sex-specific differences in glial cell functions occurring immediately after ischemic stroke are a source of dichotomous outcomes. In this study we assessed astrocyte Ca
    MeSH term(s) Animals ; Aquaporin 4/metabolism ; Astrocytes/metabolism ; Astrocytes/pathology ; CD11b Antigen/metabolism ; CX3C Chemokine Receptor 1 ; Calcium/metabolism ; Cations, Divalent/metabolism ; Cell Size ; Disease Models, Animal ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/metabolism ; Microglia/pathology ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; S100 Calcium Binding Protein beta Subunit/metabolism ; Sex Characteristics ; Time Factors ; Tissue Culture Techniques
    Chemical Substances Aqp4 protein, mouse ; Aquaporin 4 ; CD11b Antigen ; CX3C Chemokine Receptor 1 ; Cations, Divalent ; Cx3cr1 protein, mouse ; Receptors, Chemokine ; S100 Calcium Binding Protein beta Subunit ; S100b protein, mouse ; Green Fluorescent Proteins (147336-22-9) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2016.09.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vascular tone and neurovascular coupling: considerations toward an improved in vitro model.

    Filosa, Jessica A

    Frontiers in neuroenergetics

    2010  Volume 2

    Abstract: Neurovascular research has made significant strides toward understanding how the brain neurovascular unit accomplishes rapid and spatial increases in blood flow following neuronal activation. Among the experimental models used, the in vitro brain slice ... ...

    Abstract Neurovascular research has made significant strides toward understanding how the brain neurovascular unit accomplishes rapid and spatial increases in blood flow following neuronal activation. Among the experimental models used, the in vitro brain slice preparation provides unique information revealing the potential signals and cellular mechanisms involved in functional hyperemia. The most crucial limitation of this model, however, is the lack of intraluminal pressure and flow in the vessels being studied. Moreover, differences in basal vascular tone have led to varied interpretations regarding the polarity of vascular responses following neuron-to-glial stimulation. Given the complexity of astrocyte-induced neurovascular responses, we propose the use of a modified in vitro brain slice preparation, where intraluminal arteriolar pressure and flow are retained. Throughout this review, we discuss the advantages and disadvantages to be considered when using brain slices for neurovascular studies. Potential ways to overcome the current limitations are proposed.
    Language English
    Publishing date 2010-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2474552-2
    ISSN 1662-6427 ; 1662-6427
    ISSN (online) 1662-6427
    ISSN 1662-6427
    DOI 10.3389/fnene.2010.00016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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