Article: Asociación de células NKT con la expresión del gen CTSL en población pediátrica mexicana con diabetes tipo 1 de reciente diagnóstico.
2016 Volume 152, Issue Suppl 2, Page(s) 14–21
Abstract: ... Percentages and absolute numbers of NKT cells were measured with expression of the CTSL gene.: Results: 124 ... higher in siblings (0.246 ± 0.188; p = 0.002). Lower level of expression of the CTSL gene associated ...
Title translation | Level of expression of gene CTSL and its correlation with natural killer T-Cells in mexican pediatric patients with recent-onset type 1 diabetes. |
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Abstract | Objective: To compare the level of expression of the gene CTSL and its correlation with NKT cells in patients with recent-onset type 1 diabetes (T1D), their siblings, and healthy controls. Methods: Analytical cross-sectional design. Patients with T1D < 3 months evolution, their siblings, and healthy controls were included. Percentages and absolute numbers of NKT cells were measured with expression of the CTSL gene. Results: 124 subjects: with T1D (n = 48), siblings (n = 44) and controls (n = 32) were included. HbA1c was greater and C-peptide lower in T1D than the other groups and sibling age was higher (p < 0.001). There were no differences in NKT cells between T1D (0.176 ± 0.202) and controls (0.118 ± 0.133), but the percentage was higher in siblings (0.246 ± 0.188; p = 0.002). Lower level of expression of the CTSL gene associated with both absolute number (r: 0.4607; 95% CI: -0.08425 to -0.7935; p = 0.043) and percentage of NKT cells (r: 0.4540; 95% CI: -0.0927 to -0.7903; p = 0.045) in the T1D group. Conclusions: Patients with T1D have lower percentage and absolute number of NKT cells compared to their siblings. NKT cells absolute numbers are correlated with the expression of CTSL in T1D patients. |
MeSH term(s) | Adolescent ; Case-Control Studies ; Cathepsin L/genetics ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Lymphocyte Count ; Male ; Natural Killer T-Cells/cytology ; Siblings |
Chemical Substances | Glycated Hemoglobin A ; hemoglobin A1c protein, human ; CTSL protein, human (EC 3.4.22.15) ; Cathepsin L (EC 3.4.22.15) |
Language | Spanish |
Publishing date | 2016-10-27 |
Publishing country | Mexico |
Document type | Journal Article |
ZDB-ID | 425456-9 |
ISSN | 0016-3813 |
ISSN | 0016-3813 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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