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  1. Article: Zahnmedizin in der Bundeswehr. Dentale Radiologie damals und heute - Entwicklungen in der Bundeswehr. C. J. Klein et al.

    Klein, C. J.

    Wehrmedizin und Wehrpharmazie

    2020  Volume 44, Issue 4, Page(s) 25

    Language German
    Document type Article
    ZDB-ID 506117-9
    ISSN 0043-2148
    Database Current Contents Medicine

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  2. Article: J/psi and psi(2S) Radiative Transitions to eta_{c}.

    Mitchell, R E / Shepherd, M R / Besson, D / Pedlar, T K / Cronin-Hennessy, D / Gao, K Y / Hietala, J / Kubota, Y / Klein, T / Lang, B W / Poling, R / Scott, A W / Zweber, P / Dobbs, S / Metreveli, Z / Seth, K K / Tomaradze, A / Libby, J / Powell, A /
    Wilkinson, G / Ecklund, K M / Love, W / Savinov, V / Lopez, A / Mendez, H / Ramirez, J / Ge, J Y / Miller, D H / Shipsey, I P J / Xin, B / Adams, G S / Anderson, M / Cummings, J P / Danko, I / Hu, D / Moziak, B / Napolitano, J / He, Q / Insler, J / Muramatsu, H / Park, C S / Thorndike, E H / Yang, F / Artuso, M / Blusk, S / Khalil, S / Li, J / Mountain, R / Nisar, S / Randrianarivony, K / Sultana, N / Skwarnicki, T / Stone, S / Wang, J C / Zhang, L M / Bonvicini, G / Cinabro, D / Dubrovin, M / Lincoln, A / Naik, P / Rademacker, J / Asner, D M / Edwards, K W / Reed, J / Briere, R A / Ferguson, T / Tatishvili, G / Vogel, H / Watkins, M E / Rosner, J L / Alexander, J P / Cassel, D G / Duboscq, J E / Ehrlich, R / Fields, L / Galik, R S / Gibbons, L / Gray, R / Gray, S W / Hartill, D L / Heltsley, B K / Hertz, D / Hunt, J M / Kandaswamy, J / Kreinick, D L / Kuznetsov, V E / Ledoux, J / Mahlke-Krüger, H / Mohapatra, D / Onyisi, P U E / Patterson, J R / Peterson, D / Riley, D / Ryd, A / Sadoff, A J / Shi, X / Stroiney, S / Sun, W M / Wilksen, T / Athar, S B / Patel, R / Yelton, J / Rubin, P / Eisenstein, B I / Karliner, I / Mehrabyan, S / Lowrey, N / Selen, M / White, E J / Wiss, J

    Physical review letters

    2009  Volume 102, Issue 1, Page(s) 11801

    Abstract: ... We measure B(psi(2S)-->gammaeta_{c})=(4.32+/-0.16+/-0.60)x10;{-3}, B(J/psi-->gammaeta_{c})/B(psi(2S ... gammaeta_{c})=4.59+/-0.23+/-0.64, and B(J/psi-->gammaeta_{c})=(1.98+/-0.09+/-0.30)%. We observe ... Using 2.45x10;{7} psi(2S) decays collected with the CLEO-c detector at the Cornell Electron Storage ...

    Abstract Using 2.45x10;{7} psi(2S) decays collected with the CLEO-c detector at the Cornell Electron Storage Ring we present the most precise measurements of magnetic dipole transitions in the charmonium system. We measure B(psi(2S)-->gammaeta_{c})=(4.32+/-0.16+/-0.60)x10;{-3}, B(J/psi-->gammaeta_{c})/B(psi(2S)-->gammaeta_{c})=4.59+/-0.23+/-0.64, and B(J/psi-->gammaeta_{c})=(1.98+/-0.09+/-0.30)%. We observe a distortion in the eta_{c} line shape due to the photon-energy dependence of the magnetic dipole transition rate. We find that measurements of the eta_{c} mass are sensitive to the line shape, suggesting an explanation for the discrepancy between measurements of the eta_{c} mass in radiative transitions and other production mechanisms.
    Language English
    Publishing date 2009-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.102.011801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Observation of a J(PC)=1-+ exotic resonance in diffractive dissociation of 190   GeV/c π- into π- π- π+.

    Alekseev, M G / Alexakhin, V Yu / Alexandrov, Yu / Alexeev, G D / Amoroso, A / Austregesilo, A / Badełek, B / Balestra, F / Ball, J / Barth, J / Baum, G / Bedfer, Y / Bernhard, J / Bertini, R / Bettinelli, M / Birsa, R / Bisplinghoff, J / Bordalo, P / Bradamante, F /
    Bravar, A / Bressan, A / Brona, G / Burtin, E / Bussa, M P / Chapiro, A / Chiosso, M / Chung, S U / Cicuttin, A / Colantoni, M / Crespo, M L / Dalla Torre, S / Dafni, T / Das, S / Dasgupta, S S / Denisov, O Yu / Dhara, L / Diaz, V / Dinkelbach, A M / Donskov, S V / Doshita, N / Duic, V / Dünnweber, W / Efremov, A / El Alaoui, A / Eversheim, P D / Eyrich, W / Faessler, M / Ferrero, A / Finger, M / Fischer, H / Franco, C / Friedrich, J M / Garfagnini, R / Gautheron, F / Gavrichtchouk, O P / Gazda, R / Gerassimov, S / Geyer, R / Giorgi, M / Gobbo, B / Goertz, S / Grabmüller, S / Grajek, O A / Grasso, A / Grube, B / Gushterski, R / Guskov, A / Haas, F / von Harrach, D / Hasegawa, T / Heckmann, J / Heinsius, F H / Hermann, R / Herrmann, F / Hess, C / Hinterberger, F / Horikawa, N / Höppner, Ch / d'Hose, N / Ilgner, C / Ishimoto, S / Ivanov, O / Ivanshin, Yu / Iwata, T / Jahn, R / Jasinski, P / Jegou, G / Joosten, R / Kabuss, E / Kang, D / Ketzer, B / Khaustov, G V / Khokhlov, Yu A / Kisselev, Yu / Klein, F / Klimaszewski, K / Koblitz, S / Koivuniemi, J H / Kolosov, V N / Komissarov, E V / Kondo, K / Königsmann, K / Konopka, R / Konorov, I / Konstantinov, V F / Korzenev, A / Kotzinian, A M / Kouznetsov, O / Kowalik, K / Krämer, M / Kral, A / Kroumchtein, Z V / Kuhn, R / Kunne, F / Kurek, K / Lauser, L / Le Goff, J M / Lednev, A A / Lehmann, A / Levorato, S / Lichtenstadt, J / Liska, T / Maggiora, A / Maggiora, M / Magnon, A / Mallot, G K / Mann, A / Marchand, C / Marroncle, J / Martin, A / Marzec, J / Massmann, F / Matsuda, T / Maximov, A N / Meyer, W / Michigami, T / Mikhailov, Yu V / Moinester, M A / Mutter, A / Nagaytsev, A / Nagel, T / Nassalski, J / Negrini, T / Nerling, F / Neubert, S / Neyret, D / Nikolaenko, V I / Olshevsky, A G / Ostrick, M / Padee, A / Panknin, R / Panzieri, D / Parsamyan, B / Paul, S / Pawlukiewicz-Kaminska, B / Perevalova, E / Pesaro, G / Peshekhonov, D V / Piragino, G / Platchkov, S / Pochodzalla, J / Polak, J / Polyakov, V A / Pontecorvo, G / Pretz, J / Quintans, C / Rajotte, J-F / Ramos, S / Rapatsky, V / Reicherz, G / Reggiani, D / Richter, A / Robinet, F / Rocco, E / Rondio, E / Ryabchikov, D I / Samoylenko, V D / Sandacz, A / Santos, H / Sapozhnikov, M G / Sarkar, S / Savin, I A / Sbrizzai, G / Schiavon, P / Schill, C / Schlüter, T / Schmitt, L / Schopferer, S / Schröder, W / Shevchenko, O Yu / Siebert, H-W / Silva, L / Sinha, L / Sissakian, A N / Slunecka, M / Smirnov, G I / Sosio, S / Sozzi, F / Srnka, A / Stolarski, M / Sulc, M / Sulej, R / Takekawa, S / Tessaro, S / Tessarotto, F / Teufel, A / Tkatchev, L G / Uhl, S / Uman, I / Venugopal, G / Virius, M / Vlassov, N V / Vossen, A / Weitzel, Q / Windmolders, R / Wiślicki, W / Wollny, H / Zaremba, K / Zavertyaev, M / Zemlyanichkina, E / Ziembicki, M / Zhao, J / Zhuravlev, N / Zvyagin, A

    Physical review letters

    2010  Volume 104, Issue 24, Page(s) 241803

    Abstract: ... into the π- π- π+ final state using a 190  GeV/c pion beam hitting a lead target. A partial wave analysis has ... with spin-exotic quantum numbers J(PC)=1-+ at 1.66  GeV/c2 decaying to ρπ. The resonant nature of this wave ... is evident from the mass-dependent phase differences to the J(PC)=2-+ and 1++ waves. From a mass ...

    Abstract The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the π- π- π+ final state using a 190  GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420,000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1  GeV2/c2. The well-known resonances a1(1260), a2(1320), and π2(1670) are clearly observed. In addition, the data show a significant natural-parity exchange production of a resonance with spin-exotic quantum numbers J(PC)=1-+ at 1.66  GeV/c2 decaying to ρπ. The resonant nature of this wave is evident from the mass-dependent phase differences to the J(PC)=2-+ and 1++ waves. From a mass-dependent fit a resonance mass of (1660±10(-64)(+0))  MeV/c2 and a width of (269±21(-64)(+42))  MeV/c2 are deduced, with an intensity of (1.7±0.2)% of the total intensity.
    Language English
    Publishing date 2010-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.104.241803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A dependence of J/ psi and psi ' production at 800 GeV/c.

    Alde / Baer / Carey / Garvey / Klein / Lee / Leitch / Lillberg / McGaughey / Mishra / Moss / Peng / Brown / Cooper / Hsiung / Adams / Guo / Kaplan / McCarthy /
    Danner / Wang / Barlett / Hoffmann

    Physical review letters

    1991  Volume 66, Issue 2, Page(s) 133–136

    Language English
    Publishing date 1991-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.66.133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Differences and similarities in permissive A/J versus non-permissive BALB/c murine macrophages infected with Legionella pneumophila: the role of iron.

    Gebran, S J / Yamamoto, Y / McHugh, S / Newton, C / Klein, T W / Friedman, H

    FEMS immunology and medical microbiology

    1994  Volume 9, Issue 1, Page(s) 7–14

    Abstract: ... thioglycolate-elicited (TG) macrophages from A/J mice, while growth is inhibited in TG macrophages from BALB/c ... mice which show no impaired viability. The role of iron in BALB/c and A/J macrophages regarding ... between A/J TG macrophages and BALB/c TG macrophages was not due to intracellular iron availability. BALB ...

    Abstract Legionella pneumophila, a facultative intracellular pathogen, replicates within and kills thioglycolate-elicited (TG) macrophages from A/J mice, while growth is inhibited in TG macrophages from BALB/c mice which show no impaired viability. The role of iron in BALB/c and A/J macrophages regarding their permissiveness to L. pneumophila intracellular growth was investigated. We previously reported that TG macrophages from the A/J mouse strain readily supported the intracellular growth of L. pneumophila, while resident macrophages from the same strain of mice were not permissive. Recently we also found that such a difference in permissiveness between both A/J macrophage populations may be explained, at least in part, to intracellular availability of iron. In this report, differences in permissiveness to L. pneumophila growth between A/J TG macrophages and BALB/c TG macrophages was not due to intracellular iron availability. BALB/c and A/J TG macrophages exhibited similar expression of transferrin receptor and cellular iron content. The treatment of BALB/c TG macrophages with different iron compounds, namely ferric nitrilotriacetate (12.5-100 microM), ferric citrate (12.5-100 microM) and transferrin (0.5-5 mg ml-1), did not stimulate the intracellular proliferation of L. pneumophila. The reduction of intracellular iron availability by treatment with antibodies against transferrin receptor or with desferrioxamine suppressed the growth of L. pneumophila within BALB/c TG macrophages, suggesting that these cells do not restrict L. pneumophila growth because of iron. The production of nitric oxide was also similar in both macrophage populations, as measured by the Griess reaction. However, the synthesis of oxygen reactive species was three times higher in non-permissive BALB/c macrophages.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Animals ; Cells, Cultured ; Female ; Ferric Compounds/pharmacology ; Iron/metabolism ; Iron Chelating Agents/pharmacology ; Legionella pneumophila/growth & development ; Legionella pneumophila/pathogenicity ; Macrophages/metabolism ; Macrophages/microbiology ; Mice ; Mice, Inbred A ; Mice, Inbred BALB C ; Receptors, Transferrin/metabolism
    Chemical Substances Ferric Compounds ; Iron Chelating Agents ; Receptors, Transferrin ; Iron (E1UOL152H7)
    Language English
    Publishing date 1994-06
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1143208-1
    ISSN 1574-695X ; 0928-8244
    ISSN (online) 1574-695X
    ISSN 0928-8244
    DOI 10.1111/j.1574-695X.1994.tb00467.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Work study in a doll's house: C. W. Post EMS. Interview by Carl J. Post.

    Panarello, J / Minsky, R / Fusco, C / Klein, L / Harris, K / Mohr, D / Jensen, J / Boford, F / Milford, B

    Emergency medical services

    1987  Volume 16, Issue 8, Page(s) 26–27

    MeSH term(s) Emergency Medical Services/organization & administration ; New York
    Language English
    Publishing date 1987-09
    Publishing country United States
    Document type Interview
    ZDB-ID 424455-2
    ISSN 0094-6575
    ISSN 0094-6575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Differential induction of gamma interferon in Legionella pneumophila-infected macrophages from BALB/c and A/J mice.

    Salins, S / Newton, C / Widen, R / Klein, T W / Friedman, H

    Infection and immunity

    2001  Volume 69, Issue 6, Page(s) 3605–3610

    Abstract: ... elicited macrophages (TG-macrophages) from A/J mice, while TG-macrophages from BALB/c mice restrict ... bacterial growth after an initial period of growth. BALB/c TG-macrophages were shown to express IFN-gamma ... growth in the macrophages. In contrast, no IFN-gamma mRNA was expressed in TG-macrophages from A/J mice ...

    Abstract Gamma interferon (IFN-gamma), a pleiotropic cytokine, is now known to be produced by macrophages as well as by NK cells, gammadelta cells, and activated T cells. The autocrine biological functions of IFN-gamma on the macrophage include the upregulation of major histocompatibility complex MHC class II and the activation to an antiviral state. In this study, the production of IFN-gamma by macrophages was demonstrated to correspond to antibacterial activity. Legionella pneumophila replicates intracellularly in thioglycolate (TG)-elicited macrophages (TG-macrophages) from A/J mice, while TG-macrophages from BALB/c mice restrict bacterial growth after an initial period of growth. BALB/c TG-macrophages were shown to express IFN-gamma mRNA at 24 and 28 h, which corresponded to the initiation of anti-L. pneumophila activity. Moreover, IFN-gammaneutralization by antibody treatment of the cultures resulted in increased L. pneumophila growth in the macrophages. In contrast, no IFN-gamma mRNA was expressed in TG-macrophages from A/J mice, where L. pneumophila grew unrestricted. As would be expected, IFN-gamma treatment decreased bacterial growth. An IFN-gamma-mediated antibacterial activity was, however, inducible in A/J macrophages by the addition of interleukin-12 following L. pneumophila infection. Thus, autocrine IFN-gamma is involved in anti-L. pneumophila activity associated with different growth patterns and appears to be important during intracellular infection.
    MeSH term(s) Animals ; Female ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interleukin-12/pharmacology ; Legionella pneumophila/growth & development ; Legionella pneumophila/immunology ; Legionnaires' Disease/immunology ; Legionnaires' Disease/microbiology ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Mice ; Mice, Inbred BALB C ; RNA, Messenger/metabolism ; Thioglycolates/pharmacology
    Chemical Substances RNA, Messenger ; Thioglycolates ; Interleukin-12 (187348-17-0) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2001-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.69.6.3605-3610.2001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice.

    Letscher-Bru, Valerie / Pfaff, Alexander W / Abou-Bacar, Ahmed / Filisetti, Denis / Antoni, Elisabeth / Villard, Odile / Klein, Jean-Paul / Candolfi, Ermanno

    Infection and immunity

    2003  Volume 71, Issue 11, Page(s) 6615–6619

    Abstract: ... congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced ... the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J ...

    Abstract We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2(k)), vaccination increased the number of infected fetuses by 50% and was associated with a predominant type 2 response. Our results indicate that the effect of vaccination with SAG1 is controlled by the genetic background of the mouse.
    MeSH term(s) Animals ; Antibodies, Protozoan/blood ; Antigens, Protozoan/immunology ; Cytokines/biosynthesis ; Female ; Immunization ; Infectious Disease Transmission, Vertical ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; Protozoan Proteins/immunology ; Protozoan Vaccines/immunology ; Species Specificity ; Toxoplasma/immunology ; Toxoplasmosis, Congenital/prevention & control ; Vaccination
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; Cytokines ; Protozoan Proteins ; Protozoan Vaccines ; SAG1 antigen, Toxoplasma
    Language English
    Publishing date 2003-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.71.11.6615-6619.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9.

    Klein, David C / Lardo, Santana M / Hainer, Sarah J

    Cancer research communications

    2024  Volume 4, Issue 1, Page(s) 237–252

    Abstract: The non-canonical BAF complex (ncBAF) subunit BRD9 is essential for acute myeloid leukemia (AML) cell viability but has an unclear role in leukemogenesis. Because BRD9 is required for ncBAF complex assembly through its DUF3512 domain, precise bromodomain ...

    Abstract The non-canonical BAF complex (ncBAF) subunit BRD9 is essential for acute myeloid leukemia (AML) cell viability but has an unclear role in leukemogenesis. Because BRD9 is required for ncBAF complex assembly through its DUF3512 domain, precise bromodomain inhibition is necessary to parse the role of BRD9 as a transcriptional regulator from that of a scaffolding protein. To understand the role of BRD9 bromodomain function in regulating AML, we selected a panel of five AML cell lines with distinct driver mutations, disease classifications, and genomic aberrations and subjected these cells to short-term BRD9 bromodomain inhibition. We examined the bromodomain-dependent growth of these cell lines, identifying a dependency in AML cell lines but not HEK293T cells. To define a mechanism through which BRD9 maintains AML cell survival, we examined nascent transcription, chromatin accessibility, and ncBAF complex binding genome-wide after bromodomain inhibition. We identified extensive regulation of transcription by BRD9 bromodomain activity, including repression of myeloid maturation factors and tumor suppressor genes, while standard AML chemotherapy targets were repressed by inhibition of the BRD9 bromodomain. BRD9 bromodomain activity maintained accessible chromatin at both gene promoters and gene-distal putative enhancer regions, in a manner that qualitatively correlated with enrichment of BRD9 binding. Furthermore, we identified reduced chromatin accessibility at GATA, ETS, and AP-1 motifs and increased chromatin accessibility at SNAIL-, HIC-, and TP53-recognized motifs after BRD9 inhibition. These data suggest a role for BRD9 in regulating AML cell differentiation through modulation of accessibility at hematopoietic transcription factor binding sites.
    Significance: The bromodomain-containing protein BRD9 is essential for AML cell viability, but it is unclear whether this requirement is due to the protein's role as an epigenetic reader. We inhibited this activity and identified altered gene-distal chromatin regulation and transcription consistent with a more mature myeloid cell state.
    MeSH term(s) Humans ; Transcription Factors/genetics ; Nuclear Proteins/genetics ; Gene Expression Regulation ; Chromatin/genetics ; Leukemia, Myeloid, Acute/genetics ; Bromodomain Containing Proteins
    Chemical Substances Transcription Factors ; Nuclear Proteins ; Chromatin ; BRD9 protein, human ; Bromodomain Containing Proteins
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-23-0382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Late Diagnosis of Langerhans Cell Histiocytosis by Skin Biopsy in a Lung Transplant Candidate Patient.

    Klein, Francisco R / Klein, Julia / Otalora Lozano, Diego / Vigliano, Carlos

    Cureus

    2024  Volume 16, Issue 2, Page(s) e55226

    Abstract: We present the case of a lung transplant candidate under veno-venous membrane oxygenation assistance (VV ECMO) whose diagnosis of emphysema of undetermined etiology was redefined as Langerhans cell histiocytosis (LCH) due to a scalp skin biopsy performed ...

    Abstract We present the case of a lung transplant candidate under veno-venous membrane oxygenation assistance (VV ECMO) whose diagnosis of emphysema of undetermined etiology was redefined as Langerhans cell histiocytosis (LCH) due to a scalp skin biopsy performed years after the beginning of his respiratory symptoms. A 20-year-old patient started three years before his admission with progressive dyspnea leading to a diagnosis of bullous emphysema of undetermined cause, which evolved into respiratory failure and evaluation for bilateral lung transplant. Three years later, he developed bilateral pneumonia requiring mechanical ventilation. When refractory hypoxemia ensued, he had to be placed on VV ECMO. Under these conditions, he was transferred to our center and listed for a bilateral pulmonary transplantation. Forty-eight hours after admission, and due to intense polyuria, central diabetes insipidus was diagnosed. In this clinical context, the presence of cutaneous lesions on the scalp was reconsidered and biopsied under the presumption of possible LCH, with pathology analysis confirming the diagnosis. He continued to be assisted with VV ECMO for 66 more days as a bridge to transplantation, developing multi-organ failure and passing away before a donor organ was available. The diagnosis of LCH should be considered in any adult patient with bullous emphysema of undetermined cause. Given the possibility of early therapeutic interventions, the search for its clinical associations (e.g., diabetes insipidus and/or skin lesions) should be a systematic part of the etiologic workup. The availability of skin specimens to reach a diagnosis makes its thorough search an important part of the diagnostic approach.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55226
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