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  1. Article ; Online: The super-cooling compound icilin stimulates c-Fos and Egr-1 expression and activity involving TRPM8 channel activation, Ca

    Ulrich, Myriam / Wissenbach, Ulrich / Thiel, Gerald

    Biochemical pharmacology

    2020  Volume 177, Page(s) 113936

    Abstract: The TRPM8 cation channel can be activated by the cooling compound icilin. Recently, we showed that stimulation of TRPM8 channels induces a signaling cascade leading to the activation of the transcription factor AP-1. Additionally, expression of the AP-1 ... ...

    Abstract The TRPM8 cation channel can be activated by the cooling compound icilin. Recently, we showed that stimulation of TRPM8 channels induces a signaling cascade leading to the activation of the transcription factor AP-1. Additionally, expression of the AP-1 constituent c-Fos has been shown to be induced following TRPM8 stimulation. c-Fos is frequently used as a marker for neuronal activity. Here, we have analyzed the mechanism connecting TRPM8 stimulation and c-Fos expression. Furthermore, we analyzed the expression of the neuronal activity-responsive transcription factor Egr-1 following TRPM8 activation. The results show that icilin-induced stimulation of TRPM8 channels increased c-Fos promoter activity and induced c-Fos expression. Moreover, icilin stimulation increased Egr-1 promoter activity and induced the expression of Egr-1. Pharmacological inhibition of TRPM8 blocked the icilin-induced expression of Egr-1 and c-Fos. An influx of Ca
    MeSH term(s) Calcium/metabolism ; Calcium Channels/metabolism ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/metabolism ; Gene Expression Regulation/drug effects ; Gene Transfer Techniques ; Genes, fos ; HEK293 Cells ; Humans ; Ions/metabolism ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-fos/metabolism ; Pyrimidinones/pharmacology ; Signal Transduction/drug effects ; TRPM Cation Channels/metabolism ; Transcription, Genetic/drug effects ; Transcriptional Activation/drug effects ; ets-Domain Protein Elk-1/genetics ; ets-Domain Protein Elk-1/metabolism
    Chemical Substances Calcium Channels ; EGR1 protein, human ; ELK1 protein, human ; Early Growth Response Protein 1 ; Ions ; Proto-Oncogene Proteins c-fos ; Pyrimidinones ; TRPM Cation Channels ; TRPM8 protein, human ; ets-Domain Protein Elk-1 ; icilin (CS70PZQ4QJ) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2020.113936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Human TRPV6-pathies caused by gene mutations.

    Nett, Verena / Erhardt, Nicole / Wyatt, Amanda / Wissenbach, Ulrich

    Biochimica et biophysica acta. General subjects

    2021  Volume 1865, Issue 6, Page(s) 129873

    Abstract: The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for ... ...

    Abstract The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for Ca
    MeSH term(s) Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Channelopathies/etiology ; Channelopathies/pathology ; Humans ; Mutation ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemical Substances Calcium Channels ; TRPV Cation Channels ; TRPV6 protein, human ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-02-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2021.129873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comments on the evolution of TRPV6.

    Wolske, Karin / Wyatt, Amanda / Wissenbach, Ulrich

    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

    2021  Volume 238, Page(s) 151753

    Abstract: It is well known that not all biological findings derived from animals can be directly applied to humans. The TRPV6 protein may serve as an example which highlights these inter-species differences as an example of parallel evolutionary pathways. TRPV6 ( ... ...

    Abstract It is well known that not all biological findings derived from animals can be directly applied to humans. The TRPV6 protein may serve as an example which highlights these inter-species differences as an example of parallel evolutionary pathways. TRPV6 (and TRPV5) belong to a family of ion channels from the transient receptor potential group but are selectively permeable for Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels ; Female ; Mice ; Placenta ; Pregnancy ; TRPV Cation Channels/genetics
    Chemical Substances Calcium Channels ; TRPV Cation Channels ; Trpv6 protein, mouse ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-05-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1106738-x
    ISSN 1618-0402 ; 0940-9602
    ISSN (online) 1618-0402
    ISSN 0940-9602
    DOI 10.1016/j.aanat.2021.151753
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  4. Book ; Online ; Thesis: Klonierung und funktionelle Charakterisierung von TRPC1, 4 und 5 Proteinen mit einer Punktmutation eines hochkonservierten Glyzinrestes im S4-S5 Linker

    Speicher, Tilman [Verfasser] / Wissenbach, Ulrich [Akademischer Betreuer]

    2022  

    Author's details Tilman Daniel Speicher ; Betreuer: Ulrich Wissenbach
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Saarländische Universitäts- und Landesbibliothek
    Publishing place Saarbrücken
    Document type Book ; Online ; Thesis
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  5. Article ; Online: Ca

    Kogel, Alexander / Fecher-Trost, Claudia / Wissenbach, Ulrich / Flockerzi, Veit / Schaefer, Michael

    Cell calcium

    2022  Volume 106, Page(s) 102634

    Abstract: Amongst the superfamily of transient receptor potential (TRP) channels, TRPV5 and TRPV6 are specialized members that mediate ... ...

    Abstract Amongst the superfamily of transient receptor potential (TRP) channels, TRPV5 and TRPV6 are specialized members that mediate Ca
    MeSH term(s) Brefeldin A/metabolism ; Brefeldin A/pharmacology ; Calcium/metabolism ; Cell Membrane/metabolism ; Golgi Apparatus/metabolism ; TRPV Cation Channels/metabolism
    Chemical Substances TRPV Cation Channels ; Brefeldin A (20350-15-6) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2022.102634
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  6. Book ; Online ; Thesis: Charakterisierung und Funktion von TRPV2 Ionenkanälen in kortikalen Mikrogliazellen der Maus

    Malihpour, Mahsa [Verfasser] / Wissenbach, Ulrich [Akademischer Betreuer]

    2021  

    Author's details Mahsa Malihpour ; Betreuer: Ulrich Wissenbach
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Saarländische Universitäts- und Landesbibliothek
    Publishing place Saarbrücken
    Document type Book ; Online ; Thesis
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  7. Article: Human TRPV6-pathies caused by gene mutations

    Nett, Verena / Erhardt, Nicole / Wyatt, Amanda / Wissenbach, Ulrich

    Biochimica et biophysica acta. 2021 June, v. 1865, no. 6

    2021  

    Abstract: The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for Ca²⁺ ions. A functional channel is formed by 4 identical ... ...

    Abstract The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for Ca²⁺ ions. A functional channel is formed by 4 identical subunits [1]. A growing number of mutations are present in human TRPV6 genes which alter channel function and can lead to elevated blood levels of the parathyroid hormone accompanied by transient hyperparathyroidism. Recent publications suggest that TRPV6 mutations could also trigger non-alcoholic chronic pancreatitis. This review summarises the consequences of these mutations within the TRPV6 gene.
    Keywords blood ; calcium ; cations ; genes ; humans ; hyperparathyroidism ; pancreatitis ; parathyroid hormone ; permeability ; transient receptor potential vanilloid channels
    Language English
    Dates of publication 2021-06
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 840755-1
    ISSN 0304-4165
    ISSN 0304-4165
    DOI 10.1016/j.bbagen.2021.129873
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca

    Amini, Mahnaz / Chang, Yiming / Wissenbach, Ulrich / Flockerzi, Veit / Schlenstedt, Gabriel / Beck, Andreas

    The Journal of biological chemistry

    2021  Volume 297, Issue 4, Page(s) 101126

    Abstract: Transient receptor potential (TRP) cation channels, which are conserved across mammals, flies, fish, sea squirts, worms, and fungi, essentially contribute to cellular ... ...

    Abstract Transient receptor potential (TRP) cation channels, which are conserved across mammals, flies, fish, sea squirts, worms, and fungi, essentially contribute to cellular Ca
    MeSH term(s) Calcium/chemistry ; Calcium/metabolism ; Calcium Signaling ; Calmodulin/antagonists & inhibitors ; Calmodulin/chemistry ; Calmodulin/genetics ; Calmodulin/metabolism ; HEK293 Cells ; Humans ; Protein Domains ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sesterterpenes/pharmacology ; TRPC Cation Channels/chemistry ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; Vacuoles/chemistry ; Vacuoles/genetics ; Vacuoles/metabolism
    Chemical Substances Calmodulin ; Saccharomyces cerevisiae Proteins ; Sesterterpenes ; TRPC Cation Channels ; Yvc1 protein, S cerevisiae ; ophiobolin A (4611-05-6) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.101126
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  9. Article ; Online: TRPV6: From identification to function.

    Fecher-Trost, Claudia / Wissenbach, Ulrich / Weissgerber, Petra

    Cell calcium

    2017  Volume 67, Page(s) 116–122

    MeSH term(s) Animals ; Breast Neoplasms/metabolism ; Calcium/metabolism ; Epididymis/physiology ; Female ; Humans ; Infertility, Male/metabolism ; Intestines/physiology ; Male ; Mice ; Prostatic Neoplasms/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemical Substances TRPV Cation Channels ; TRPV6 channel ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-04-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2017.04.006
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  10. Article ; Online: Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells.

    Thiel, Gerald / Welck, Jennifer / Wissenbach, Ulrich / Rössler, Oliver G

    The international journal of biochemistry & cell biology

    2019  Volume 110, Page(s) 9–20

    Abstract: A cross-talk between androgen/androgen receptor signaling and the AP-1 transcription factor has been proposed. In this study, we asked whether activation of AP-1 modifies androgen-responsive gene transcription, and whether androgens effect AP-1-regulated ...

    Abstract A cross-talk between androgen/androgen receptor signaling and the AP-1 transcription factor has been proposed. In this study, we asked whether activation of AP-1 modifies androgen-responsive gene transcription, and whether androgens effect AP-1-regulated gene transcription. We show that activation of AP-1 via expression of a constitutively active mutant of mitogen-activated/extracellular signal responsive kinase kinase (MEK) kinase-1 did not increase the activity of the androgen-responsive probasin promoter. Likewise, expression of a constitutively active mutant of the transcription factor c-Jun, which is a major constitutent of AP-1, did not increase the activity of the probasin promoter. In contrast, 5α-dihydrotestosterone (DHT) activated both the probasin promoter and the AP-1-regulated collagenase promoter in LNCaP prostate cancer cells. The AP-1 binding site within the collagenase promoter was identified as DHT-responsive element. In line with this, DHT increased the activities of the c-Jun promoter and the tumor necrosis factor alpha promoter, which both contain AP-1 binding sites. The signal transduction pathway coupling DHT stimulation with AP-1 activation required c-Jun, MAP kinases and androgen receptors, but was independent of transient receptor potential melastatin-8 (TRPM8) channels, proposed to function as ionotropic testosterone receptors. Expression of the GTPase activating protein RGS2 attenuated DHT-induced activation of AP-1, indicating that the DHT-induced signaling cascade involves G proteins.
    MeSH term(s) Androgen-Binding Protein/genetics ; Cell Line, Tumor ; Dihydrotestosterone/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/genetics ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Mutation ; Promoter Regions, Genetic/genetics ; Prostatic Neoplasms/pathology ; Receptors, Androgen/metabolism ; Signal Transduction/drug effects ; TRPM Cation Channels/metabolism ; Transcription Factor AP-1/metabolism ; Transcription, Genetic/drug effects ; Tumor Necrosis Factor-alpha/genetics
    Chemical Substances Androgen-Binding Protein ; Receptors, Androgen ; TRPM Cation Channels ; TRPM8 protein, human ; Transcription Factor AP-1 ; Tumor Necrosis Factor-alpha ; probasin ; Dihydrotestosterone (08J2K08A3Y) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2019-02-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2019.02.005
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