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  1. Article ; Online: Serogroup C

    Findlow, Helen / Campbell, Helen / Lucidarme, Jay / Andrews, Nick / Linley, Ezra / Ladhani, Shamez / Borrow, Ray

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2019  Volume 24, Issue 1

    Abstract: BackgroundIn 1999, the United Kingdom (UK) was the first country to introduce meningococcal group C ...

    Abstract BackgroundIn 1999, the United Kingdom (UK) was the first country to introduce meningococcal group C (MenC) conjugate vaccination. This vaccination programme has evolved with further understanding, new vaccines and changing disease epidemiology.AimTo characterise MenC disease and population protection against MenC disease in England.MethodsBetween 1998/99-2015/16, surveillance data from England for laboratory-confirmed MenC cases were collated; using the screening method, we updated vaccine effectiveness (VE) estimates. Typing data and genomes were obtained from the Meningitis Research Foundation Meningococcus Genome Library and PubMLST
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; England/epidemiology ; Female ; Humans ; Immunization Programs ; Incidence ; Infant ; Male ; Meningitis, Meningococcal/epidemiology ; Meningitis, Meningococcal/prevention & control ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines/administration & dosage ; Meningococcal Vaccines/immunology ; Neisseria meningitidis, Serogroup C/immunology ; Neisseria meningitidis, Serogroup C/isolation & purification ; Seroepidemiologic Studies ; Vaccination ; Young Adult
    Chemical Substances Meningococcal Vaccines ; serogroup C meningococcal conjugate vaccine
    Language English
    Publishing date 2019-01-08
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2019.24.1.1700818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.

    DeGiosio, R A / Needham, P G / Andrews, O A / Tristan, H / Grubisha, M J / Brodsky, J L / Camacho, C / Sweet, R A

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 10, Page(s) e23194

    Abstract: ... proline-rich and C-terminal domains of MAP2. We sought to understand the contribution of MAP2-P ... actin-binding affinity but did not affect MT-binding, while C-terminal domain mutants S426E and S439D ... in the proline-rich and C-terminal domains and point to distinct, domain-dependent regulations of MAP2 function ...

    Abstract MAP2 is a critical cytoskeletal regulator in neurons. The phosphorylation of MAP2 (MAP2-P) is well known to regulate core functions of MAP2, including microtubule (MT)/actin binding and facilitation of tubulin polymerization. However, site-specific studies of MAP2-P function in regions outside of the MT-binding domain (MTBD) are lacking. We previously identified a set of MAP2 phosphopeptides which are differentially expressed and predominantly increased in the cortex of individuals with schizophrenia relative to nonpsychiatric comparison subjects. The phosphopeptides originated not from the MTBD, but from the flanking proline-rich and C-terminal domains of MAP2. We sought to understand the contribution of MAP2-P at these sites on MAP2 function. To this end, we isolated a series of phosphomimetic MAP2C constructs and subjected them to cell-free tubulin polymerization, MT-binding, actin-binding, and actin polymerization assays. A subset of MAP2-P events significantly impaired these functions, with the two domains displaying different patterns of MAP2 regulation: proline-rich domain mutants T293E and T300E impaired MT assembly and actin-binding affinity but did not affect MT-binding, while C-terminal domain mutants S426E and S439D impaired all three functions. S443D also impaired MT assembly with minimal effects on MT- or actin-binding. Using heterologous cells, we also found that S426E but not T293E had a lower capability for process formation than the wild-type protein. These findings demonstrate the functional utility of MAP2-P in the proline-rich and C-terminal domains and point to distinct, domain-dependent regulations of MAP2 function, which can go on to affect cellular morphology.
    MeSH term(s) Humans ; Phosphorylation ; Actins ; Phosphopeptides ; Tubulin ; Proline ; Microtubule-Associated Proteins
    Chemical Substances Actins ; Phosphopeptides ; Tubulin ; Proline (9DLQ4CIU6V) ; MAP2 protein, human ; Microtubule-Associated Proteins
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202300486R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Observation of an Excited B_{c}^{+} State.

    Aaij, R / Abellán Beteta, C / Adeva, B / Adinolfi, M / Aidala, C A / Ajaltouni, Z / Akar, S / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Alkhazov, G / Alvarez Cartelle, P / Alves, A A / Amato, S / Amhis, Y / An, L / Anderlini, L /
    Andreassi, G / Andreotti, M / Andrews, J E / Archilli, F / d'Argent, P / Arnau Romeu, J / Artamonov, A / Artuso, M / Arzymatov, K / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Back, J J / Baker, S / Balagura, V / Baldini, W / Baranov, A / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Batozskaya, V / Batsukh, B / Battig, A / Battista, V / Bay, A / Bedeschi, F / Bediaga, I / Beiter, A / Bel, L J / Belin, S / Beliy, N / Bellee, V / Belloli, N / Belous, K / Ben-Haim, E / Bencivenni, G / Benson, S / Beranek, S / Berezhnoy, A / Bernet, R / Berninghoff, D / Bertholet, E / Bertolin, A / Betancourt, C / Betti, F / Bettler, M O / van Beuzekom, M / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bieker, M S / Bifani, S / Billoir, P / Birnkraut, A / Bizzeti, A / Bjørn, M / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Bocci, V / Boente Garcia, O / Boettcher, T / Bondar, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Boubdir, M / Bowcock, T J V / Bozzi, C / Braun, S / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buchanan, E / Buonaura, A / Burr, C / Bursche, A / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camboni, A / Campana, P / Campora Perez, D H / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carniti, P / Carvalho Akiba, K / Casse, G / Cattaneo, M / Cavallero, G / Cenci, R / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chekalina, V / Chen, C / Chen, S / Chitic, S-G / Chobanova, V / Chrzaszcz, M / Chubykin, A / Ciambrone, P / Cid Vidal, X / Ciezarek, G / Cindolo, F / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Comerma-Montells, A / Contu, A / Coombs, G / Coquereau, S / Corti, G / Costa Sobral, C M / Couturier, B / Cowan, G A / Craik, D C / Crocombe, A / Cruz Torres, M / Currie, R / D'Ambrosio, C / Da Silva, C L / Dall'Occo, E / Dalseno, J / Danilina, A / Davis, A / De Aguiar Francisco, O / De Bruyn, K / De Capua, S / De Cian, M / De Miranda, J M / De Paula, L / De Serio, M / De Simone, P / Dean, C T / Dean, W / Decamp, D / Del Buono, L / Delaney, B / Dembinski, H-P / Demmer, M / Dendek, A / Derkach, D / Deschamps, O / Desse, F / Dettori, F / Dey, B / Di Canto, A / Di Nezza, P / Didenko, S / Dijkstra, H / Dordei, F / Dorigo, M / Dosil Suárez, A / Douglas, L / Dovbnya, A / Dreimanis, K / Dufour, L / Dujany, G / Durante, P / Durham, J M / Dutta, D / Dzhelyadin, R / Dziewiecki, M / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Eitschberger, U / Ekelhof, R / Eklund, L / Ely, S / Ene, A / Escher, S / Esen, S / Evans, T / Falabella, A / Farley, N / Farry, S / Fazzini, D / Fernandez Declara, P / Fernandez Prieto, A / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Franco Lima, V / Frank, M / Frei, C / Fu, J / Funk, W / Färber, C / Féo, M / Gabriel, E / Gallas Torreira, A / Galli, D / Gallorini, S / Gambetta, S / Gan, Y / Gandelman, M / Gandini, P / Gao, Y / Garcia Martin, L M / Garcia Plana, B / García Pardiñas, J / Garra Tico, J / Garrido, L / Gascon, D / Gaspar, C / Gazzoni, G / Gerick, D / Gersabeck, E / Gersabeck, M / Gershon, T / Gerstel, D / Ghez, Ph / Gibson, V / Girard, O G / Gironella Gironell, P / Giubega, L / Gizdov, K / Gligorov, V V / Golubkov, D / Golutvin, A / Gomes, A / Gorelov, I V / Gotti, C / Govorkova, E / Grabowski, J P / Graciani Diaz, R / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A / Greim, R / Griffith, P / Grillo, L / Gruber, L / Gruberg Cazon, B R / Gu, C / Guo, X / Gushchin, E / Guth, A / Guz, Yu / Gys, T / Göbel, C / Hadavizadeh, T / Hadjivasiliou, C / Haefeli, G / Haen, C / Haines, S C / Hamilton, B / Han, Q / Han, X / Hancock, T H / Hansmann-Menzemer, S / Harnew, N / Harrison, T / Hasse, C / Hatch, M / He, J / Hecker, M / Heinicke, K / Heister, A / Hennessy, K / Henry, L / van Herwijnen, E / Heuel, J / Heß, M / Hicheur, A / Hidalgo Charman, R / Hill, D / Hilton, M / Hopchev, P H / Hu, J / Hu, W / Huang, W / Huard, Z C / Hulsbergen, W / Humair, T / Hushchyn, M / Hutchcroft, D / Hynds, D / Ibis, P / Idzik, M / Ilten, P / Inglessi, A / Inyakin, A / Ivshin, K / Jacobsson, R / Jakobsen, S / Jalocha, J / Jans, E / Jashal, B K / Jawahery, A / Jiang, F / John, M / Johnson, D / Jones, C R / Joram, C / Jost, B / Jurik, N / Kandybei, S / Karacson, M / Kariuki, J M / Karodia, S / Kazeev, N / Kecke, M / Keizer, F / Kelsey, M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Khurewathanakul, C / Kim, K E / Kirn, T / Kirsebom, V S / Klaver, S / Klimaszewski, K / Koliiev, S / Kolpin, M / Kopecna, R / Koppenburg, P / Kostiuk, I / Kotriakhova, S / Kozeiha, M / Kravchuk, L / Kreps, M / Kress, F / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kunde, G J / Kuonen, A K / Kvaratskheliya, T / Lacarrere, D / Lafferty, G / Lai, A / Lancierini, D / Lanfranchi, G / Langenbruch, C / Latham, T / Lazzeroni, C / Le Gac, R / Leflat, A / Lefèvre, R / Lemaitre, F / Leroy, O / Lesiak, T / Leverington, B / Li, H / Li, P-R / Li, X / Li, Y / Li, Z / Liang, X / Likhomanenko, T / Lindner, R / Ling, P / Lionetto, F / Lisovskyi, V / Liu, G / Liu, X / Loh, D / Loi, A / Longstaff, I / Lopes, J H / Loustau, G / Lovell, G H / Lucchesi, D / Lucio Martinez, M / Luo, Y / Lupato, A / Luppi, E / Lupton, O / Lusiani, A / Lyu, X / Ma, R / Machefert, F / Maciuc, F / Macko, V / Mackowiak, P / Maddrell-Mander, S / Maev, O / Maguire, K / Maisuzenko, D / Majewski, M W / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Malygina, H / Manca, G / Mancinelli, G / Marangotto, D / Maratas, J / Marchand, J F / Marconi, U / Marin Benito, C / Marinangeli, M / Marino, P / Marks, J / Marshall, P J / Martellotti, G / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Mathe, Z / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Maurin, B / McCann, M / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meaux, C / Meinert, N / Melnychuk, D / Merk, M / Merli, A / Michielin, E / Milanes, D A / Millard, E / Minard, M-N / Minzoni, L / Mitzel, D S / Mogini, A / Moise, R D / Mombächer, T / Monroy, I A / Monteil, S / Morandin, M / Morello, G / Morello, M J / Moron, J / Morris, A B / Mountain, R / Muheim, F / Mukherjee, M / Mulder, M / Murphy, C H / Murray, D / Mödden, A / Müller, D / Müller, J / Müller, K / Müller, V / Naik, P / Nakada, T / Nandakumar, R / Nandi, A / Nanut, T / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Newcombe, R / Nguyen, T D / Nguyen-Mau, C / Nieswand, S / Niet, R / Nikitin, N / Nolte, N S / O'Hanlon, D P / Oblakowska-Mucha, A / Obraztsov, V / Ogilvy, S / Oldeman, R / Onderwater, C J G / Osborn, J D / Ossowska, A / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Pais, P R / Pajero, T / Palano, A / Palutan, M / Panshin, G / Papanestis, A / Pappagallo, M / Pappalardo, L L / Parker, W / Parkes, C / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pearce, A / Pellegrino, A / Penso, G / Pepe Altarelli, M / Perazzini, S / Pereima, D / Perret, P / Pescatore, L / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pietrzyk, B / Pietrzyk, G / Pikies, M / Pili, M / Pinci, D / Pinzino, J / Pisani, F / Piucci, A / Placinta, V / Playfer, S / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Pomery, G J / Ponce, S / Popov, A / Popov, D / Poslavskii, S / Price, E / Prouve, C / Pugatch, V / Puig Navarro, A / Pullen, H / Punzi, G / Qian, W / Qin, J / Quagliani, R / Quintana, B / Raab, N V / Rachwal, B / Rademacker, J H / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Ravonel Salzgeber, M / Reboud, M / Redi, F / Reichert, S / Dos Reis, A C / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Ricciardi, S / Richards, S / Rinnert, K / Robbe, P / Robert, A / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Roehrken, M / Roiser, S / Rollings, A / Romanovskiy, V / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Vidal, J / Saborido Silva, J J / Sagidova, N / Saitta, B / Salustino Guimaraes, V / Sanchez Gras, C / Sanchez Mayordomo, C / Sanmartin Sedes, B / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Sarpis, G / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Schael, S / Schellenberg, M / Schiller, M / Schindler, H / Schmelling, M / Schmelzer, T / Schmidt, B / Schneider, O / Schopper, A / Schreiner, H F / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciubba, A / Semennikov, A / Sepulveda, E S / Sergi, A / Serra, N / Serrano, J / Sestini, L / Seuthe, A / Seyfert, P / Shapkin, M / Shears, T / Shekhtman, L / Shevchenko, V / Shmanin, E / Siddi, B G / Silva Coutinho, R / Silva de Oliveira, L / Simi, G / Simone, S / Skiba, I / Skidmore, N / Skwarnicki, T / Slater, M W / Smeaton, J G / Smith, E / Smith, I T / Smith, M / Soares, M / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spradlin, P / Stagni, F / Stahl, M / Stahl, S / Stefko, P / Stefkova, S / Steinkamp, O / Stemmle, S / Stenyakin, O / Stepanova, M / Stevens, H / Stocchi, A / Stone, S / Stracka, S / Stramaglia, M E / Straticiuc, M / Straumann, U / Strokov, S / Sun, J / Sun, L / Sun, Y / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / T'Jampens, S / Tang, Z / Tekampe, T / Tellarini, G / Teubert, F / Thomas, E / van Tilburg, J / Tilley, M J / Tisserand, V / Tobin, M / Tolk, S / Tomassetti, L / Tonelli, D / Tou, D Y / Tourinho Jadallah Aoude, R / Tournefier, E / Traill, M / Tran, M T / Trisovic, A / Tsaregorodtsev, A / Tuci, G / Tully, A / Tuning, N / Ukleja, A / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valat, S / Valenti, G / Van Hecke, H / Van Hulse, C B / Vasiliev, A / Vazquez Gomez, R / Vazquez Regueiro, P / Vecchi, S / van Veghel, M / Velthuis, J J / Veltri, M / Venkateswaran, A / Vernet, M / Veronesi, M / Vesterinen, M / Viana Barbosa, J V / Vieira, D / Vieites Diaz, M / Viemann, H / Vilasis-Cardona, X / Vitkovskiy, A / Vitti, M / Volkov, V / Vollhardt, A / Vom Bruch, D / Voneki, B / Vorobyev, A / Vorobyev, V / Voropaev, N / de Vries, J A / Vázquez Sierra, C / Waldi, R / Walsh, J / Wang, J / Wang, M / Wang, Y / Wang, Z / Ward, D R / Wark, H M / Watson, N K / Websdale, D / Weiden, A / Weisser, C / Whitehead, M / Wilkinson, G / Wilkinson, M / Williams, I / Williams, M R J / Williams, M / Williams, T / Wilson, F F / Winn, M / Wislicki, W / Witek, M / Wormser, G / Wotton, S A / Wyllie, K / Xiao, D / Xie, Y / Xing, H / Xu, A / Xu, M / Xu, Q / Xu, Z / Yang, Z / Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zarebski, K A / Zavertyaev, M / Zeng, M / Zhang, D / Zhang, L / Zhang, W C / Zhang, Y / Zhelezov, A / Zheng, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S

    Physical review letters

    2019  Volume 122, Issue 23, Page(s) 232001

    Abstract: ... _{c}^{+} state in the B_{c}^{+}π^{+}π^{-} invariant-mass spectrum is reported. The observed peak has ... a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(B_{c}^{+})  MeV/c^{2}, where the last uncertainty is due ... to the limited knowledge of the B_{c}^{+} mass. It is consistent with expectations of the B_{c}^{*}(2^{3}S_{1 ...

    Abstract Using pp collision data corresponding to an integrated luminosity of 8.5  fb^{-1} recorded by the LHCb experiment at center-of-mass energies of sqrt[s]=7, 8, and 13 TeV, the observation of an excited B_{c}^{+} state in the B_{c}^{+}π^{+}π^{-} invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(B_{c}^{+})  MeV/c^{2}, where the last uncertainty is due to the limited knowledge of the B_{c}^{+} mass. It is consistent with expectations of the B_{c}^{*}(2^{3}S_{1})^{+} state reconstructed without the low-energy photon from the B_{c}^{*}(1^{3}S_{1})^{+}→B_{c}^{+}γ decay following B_{c}^{*}(2^{3}S_{1})^{+}→B_{c}^{*}(1^{3}S_{1})^{+}π^{+}π^{-}. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(B_{c}^{+})  MeV/c^{2}, and is consistent with the B_{c}(2^{1}S_{0})^{+} state. These mass measurements are the most precise to date.
    Language English
    Publishing date 2019-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.232001
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  4. Article ; Online: Observation of a Narrow Pentaquark State, P_{c}(4312)^{+}, and of the Two-Peak Structure of the P_{c}(4450)^{+}.

    Aaij, R / Abellán Beteta, C / Adeva, B / Adinolfi, M / Aidala, C A / Ajaltouni, Z / Akar, S / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Alkhazov, G / Alvarez Cartelle, P / Alves, A A / Amato, S / Amhis, Y / An, L / Anderlini, L /
    Andreassi, G / Andreotti, M / Andrews, J E / Archilli, F / d'Argent, P / Arnau Romeu, J / Artamonov, A / Artuso, M / Arzymatov, K / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Back, J J / Baker, S / Balagura, V / Baldini, W / Baranov, A / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Batozskaya, V / Batsukh, B / Battig, A / Battista, V / Bay, A / Bedeschi, F / Bediaga, I / Beiter, A / Bel, L J / Belavin, V / Belin, S / Beliy, N / Bellee, V / Belloli, N / Belous, K / Belyaev, I / Ben-Haim, E / Bencivenni, G / Benson, S / Beranek, S / Berezhnoy, A / Bernet, R / Berninghoff, D / Bertholet, E / Bertolin, A / Betancourt, C / Betti, F / Bettler, M O / van Beuzekom, M / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bieker, M S / Bifani, S / Billoir, P / Birnkraut, A / Bizzeti, A / Bjørn, M / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Bocci, V / Boente Garcia, O / Boettcher, T / Bondar, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Boubdir, M / Bowcock, T J V / Bozzi, C / Braun, S / Brea Rodriguez, A / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buchanan, E / Buonaura, A / Burr, C / Bursche, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camboni, A / Campana, P / Campora Perez, D H / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carniti, P / Carvalho Akiba, K / Casais Vidal, A / Casse, G / Cattaneo, M / Cavallero, G / Cenci, R / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chekalina, V / Chen, C / Chen, S / Chitic, S-G / Chobanova, V / Chrzaszcz, M / Chubykin, A / Ciambrone, P / Cid Vidal, X / Ciezarek, G / Cindolo, F / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Comerma-Montells, A / Contu, A / Coombs, G / Coquereau, S / Corti, G / Costa 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    Physical review letters

    2019  Volume 122, Issue 22, Page(s) 222001

    Abstract: A narrow pentaquark state, P_{c}(4312)^{+}, decaying to J/ψp, is discovered with a statistical ... than that previously analyzed by the LHCb Collaboration. The P_{c}(4450)^{+} pentaquark structure formerly reported ... by LHCb is confirmed and observed to consist of two narrow overlapping peaks, P_{c}(4440)^{+} and P_{c ...

    Abstract A narrow pentaquark state, P_{c}(4312)^{+}, decaying to J/ψp, is discovered with a statistical significance of 7.3σ in a data sample of Λ_{b}^{0}→J/ψpK^{-} decays, which is an order of magnitude larger than that previously analyzed by the LHCb Collaboration. The P_{c}(4450)^{+} pentaquark structure formerly reported by LHCb is confirmed and observed to consist of two narrow overlapping peaks, P_{c}(4440)^{+} and P_{c}(4457)^{+}, where the statistical significance of this two-peak interpretation is 5.4σ. The proximity of the Σ_{c}^{+}D[over ¯]^{0} and Σ_{c}^{+}D[over ¯]^{*0} thresholds to the observed narrow peaks suggests that they play an important role in the dynamics of these states.
    Language English
    Publishing date 2019-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.222001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Measurement of Peak C-Peptide at Diagnosis Informs Glycemic Control but not Hypoglycemia in Adults With Type 1 Diabetes.

    Carr, Alice L J / Oram, Richard A / Marren, Shannon M / McDonald, Timothy J / Narendran, Parth / Andrews, Robert C

    Journal of the Endocrine Society

    2021  Volume 5, Issue 10, Page(s) bvab127

    Abstract: Context: High-residual C-peptide in longer-duration type 1 diabetes (T1D) is associated with fewer ... hypoglycemic events and reduced glycemic variability. Little is known about the impact of C-peptide close ... adults with T1D, we aimed to explore if variation in C-peptide close to diagnosis influenced glycemic ...

    Abstract Context: High-residual C-peptide in longer-duration type 1 diabetes (T1D) is associated with fewer hypoglycemic events and reduced glycemic variability. Little is known about the impact of C-peptide close to diagnosis.
    Objective: Using continuous glucose monitoring (CGM) data from a study of newly diagnosed adults with T1D, we aimed to explore if variation in C-peptide close to diagnosis influenced glycemic variability and risk of hypoglycemia.
    Methods: We studied newly diagnosed adults with T1D who wore a Dexcom G4 CGM for 7 days as part of the Exercise in Type 1 Diabetes (EXTOD) study. We examined the relationship between peak stimulated C-peptide and glycemic metrics of variability and hypoglycemia for 36 CGM traces from 23 participants.
    Results: For every 100 pmol/L-increase in peak C-peptide, the percentage of time spent in the range 3.9 to 10 mmol/L increased by 2.4% (95% CI, 0.5-4.3),
    Conclusion: C-peptide is associated with time spent in the normal glucose range and with less hyperglycemia, but not risk of hypoglycemia in newly diagnosed people with T1D.
    Language English
    Publishing date 2021-07-17
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvab127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Measurement of the Ω_{c}^{0} Baryon Lifetime.

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Boubdir, M / Bowcock, T J V / Bozzi, C / Braun, S / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buchanan, E / Buonaura, A / Burr, C / Bursche, A / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calladine, R / Calvi, M / Calvo Gomez, M / Camboni, A / Campana, P / Campora Perez, D H / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carniti, P / Carson, L / Carvalho Akiba, K / Casse, G / Cassina, L / Cattaneo, M / Cavallero, G / Cenci, R / Chamont, D / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chekalina, V / Chen, C / Chen, S / Chitic, S-G / Chobanova, V / Chrzaszcz, M / Chubykin, A / Ciambrone, P / Cid Vidal, X / Ciezarek, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Comerma-Montells, A / Contu, A / Coombs, G / Coquereau, S / Corti, G / Corvo, M / Costa Sobral, C M / Couturier, B 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Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zarebski, K A / Zavertyaev, M / Zhang, D / Zhang, L / Zhang, W C / Zhang, Y / Zhelezov, A / Zheng, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S

    Physical review letters

    2018  Volume 121, Issue 9, Page(s) 92003

    Abstract: We report a measurement of the lifetime of the Ω_{c}^{0} baryon using proton-proton collision data ... collected by the LHCb experiment. The sample consists of about 1000  Ω_{b}^{-}→Ω_{c}^{0}μ^{-}ν[over ¯]_{μ}X ... signal decays, where the Ω_{c}^{0} baryon is detected in the pK^{-}K^{-}π^{+} final state and X ...

    Abstract We report a measurement of the lifetime of the Ω_{c}^{0} baryon using proton-proton collision data at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3.0  fb^{-1} collected by the LHCb experiment. The sample consists of about 1000  Ω_{b}^{-}→Ω_{c}^{0}μ^{-}ν[over ¯]_{μ}X signal decays, where the Ω_{c}^{0} baryon is detected in the pK^{-}K^{-}π^{+} final state and X represents possible additional undetected particles in the decay. The Ω_{c}^{0} lifetime is measured to be τ_{Ω_{c}^{0}}=268±24±10±2  fs, where the uncertainties are statistical, systematic, and from the uncertainty in the D^{+} lifetime, respectively. This value is nearly four times larger than, and inconsistent with, the current world-average value.
    Language English
    Publishing date 2018-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.121.092003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; E-Book: Navigating voice disorders

    Andrews, Carolyn

    around the larynx in 50 tips

    (Navigating speech and language therapy ; Volume 4)

    2023  

    Abstract: This book comprises fifty tips for speech and language therapy practitioners who are new to, or less experienced in, working with adult voice disorders. It considers the full clinical pathway from assessment to management and on through to discharge. ... ...

    Author's details Carolyn Andrews
    Series title Navigating speech and language therapy ; Volume 4
    Abstract "This book comprises fifty tips for speech and language therapy practitioners who are new to, or less experienced in, working with adult voice disorders. It considers the full clinical pathway from assessment to management and on through to discharge. Packed with easily accessible, practical hints about therapy and useful self-development activities for the reader, sections cover: assessment, management, specific diagnoses, professional voice user groups, onward referral and beyond diagnosis. The resource concludes with a handy appendix providing further reading and useful resources. Presenting diagnosis-specific and client group-specific tips alongside widely applicable guidance, this is a go-to book for accessible and practical support for voice newbies"--
    Keywords Voice disorders ; Speech disorders
    Subject code 616.8556
    Language English
    Size 1 online resource (247 pages)
    Publisher Routledge, Taylor & Francis Group
    Publishing place London ; New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-324545-5 ; 1-003-24545-5 ; 1-000-78805-9 ; 1-000-78810-5 ; 9781032157276 ; 978-1-00-324545-2 ; 978-1-003-24545-2 ; 978-1-000-78805-1 ; 978-1-000-78810-5 ; 1032157275
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

    Thompson, Aiysha / Davies, Luke C / Liao, Chia-Te / da Fonseca, Diogo M / Griffiths, James S / Andrews, Robert / Jones, Adam V / Clement, Mathew / Brown, Gordon D / Humphreys, Ian R / Taylor, Philip R / Orr, Selinda J

    PLoS pathogens

    2019  Volume 15, Issue 6, Page(s) e1007850

    Abstract: ... recognition receptors (PRRs) including C-type lectin-like receptors (CLRs) that bind C. albicans to initiate ... to contribute to the immune response to C. albicans. However how these receptors collaborate to clear ... collaborative and collective roles of Dectin-1, Dectin-2 and Mincle during systemic C. albicans infection ...

    Abstract Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-like receptors (CLRs) that bind C. albicans to initiate an immune response. Multiple CLRs including Dectin-1, Dectin-2 and Mincle have been proposed individually to contribute to the immune response to C. albicans. However how these receptors collaborate to clear a fungal infection is unknown. Herein, we used novel multi-CLR knockout (KO) mice to decipher the individual, collaborative and collective roles of Dectin-1, Dectin-2 and Mincle during systemic C. albicans infection. These studies revealed an unappreciated and profound role for CLR co-operation in anti-fungal immunity. The protective effect of multiple CLRs was markedly greater than any single receptor, and was mediated through inflammatory monocytes via recognition and phagocytosis of C. albicans, and production of C. albicans-induced cytokines and chemokines. These CLRs were dispensable for mediating similar responses from neutrophils, likely due to lower expression of these CLRs on neutrophils compared to inflammatory monocytes. Concurrent deletion of Dectin-1 and Dectin-2, or all three CLRs, resulted in dramatically increased susceptibility to systemic C. albicans infection compared to mice lacking a single CLR. Multi-CLR KO mice were unable to control fungal growth due to an inadequate early inflammatory monocyte-mediated response. In response to excessive fungal growth, the multi-CLR KO mice mounted a hyper-inflammatory response, likely leading to multiple organ failure. Thus, these data reveal a critical role for CLR co-operation in the effective control of C. albicans and maintenance of organ function during infection.
    MeSH term(s) Animals ; Candida albicans/immunology ; Candidiasis/genetics ; Candidiasis/immunology ; Chemokines/genetics ; Chemokines/immunology ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Lectins, C-Type/genetics ; Lectins, C-Type/immunology ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Mice ; Mice, Knockout ; Monocytes/immunology ; Monocytes/pathology ; Neutrophils/pathology
    Chemical Substances Chemokines ; Clecsf8 protein, mouse ; Lectins, C-Type ; Membrane Proteins ; dectin 1 ; dectin-2, mouse
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1007850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Observation of the B_{c}^{+} Meson in Pb-Pb and pp Collisions at sqrt[s_{NN}]=5.02  TeV and Measurement of its Nuclear Modification Factor.

    Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Dragicevic, M / Del Valle, A Escalante / Frühwirth, R / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Pitters, F M / Schieck, J / Schöfbeck, R / Schwarz, D / Templ, S /
    Waltenberger, W / Wulz, C-E / Chekhovsky, V / Litomin, A / Makarenko, V / Darwish, M R / De Wolf, E A / Janssen, T / Kello, T / Lelek, A / Sfar, H Rejeb / Van Mechelen, P / Van Putte, S / Van Remortel, N / Blekman, F / Bols, E S / D'Hondt, J / Delcourt, M / Faham, H El / Lowette, S / Moortgat, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Van Doninck, W / Van Mulders, P / Beghin, D / Bilin, B / Clerbaux, B / De Lentdecker, G / Favart, L / Grebenyuk, A / Kalsi, A K / Lee, K / Mahdavikhorrami, M / Makarenko, I / Moureaux, L / Pétré, L / Popov, A / Postiau, N / Starling, E / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / Wezenbeek, L / Cornelis, T / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Niedziela, M / Roskas, C / Samalan, A / Skovpen, K / Tytgat, M / Vermassen, B / Vit, M / Benecke, A / Bethani, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Prisciandaro, J / Taliercio, A / Teklishyn, M / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Hensel, C / Moraes, A / Júnior, W L Aldá / Pereira, M Alves Gallo / Filho, M Barroso Ferreira / Malbouisson, H Brandao / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / Damiao, D De Jesus / De Souza, S Fonseca / Figueiredo, D Matos / Herrera, C Mora / Amarilo, K Mota / Mundim, L / Nogima, H / Teles, P Rebello / Santoro, A / Amaral, S M Silva Do / Sznajder, A / Thiel, M / De Araujo, F Torres Da Silva / Pereira, A Vilela / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Lemos, D S / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Cheng, T / Javaid, T / Mittal, M / Yuan, L / Ahmad, M / Bauer, G / Dozen, C / Hu, Z / Martins, J / Wang, Y / Yi, K / Chapon, E / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Kapoor, A / Leggat, D / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhao, J / Agapitos, A / An, Y / Ban, Y / Chen, C / Levin, A / Li, Q / Lyu, X / Mao, Y / Qian, S J / Wang, D / Wang, Q / Xiao, J / Lu, M / You, Z / Gao, X / Okawa, H / Lin, Z / Xiao, M / Avila, C / Cabrera, A / Florez, C / Fraga, J / Guisao, J Mejia / Ramirez, F / Alvarez, J D Ruiz / González, C A Salazar / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Ferencek, D / Majumder, D / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Erodotou, E / Ioannou, A / Kole, G / Kolosova, M / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Finger, M / Kveton, A / Ayala, E / Jarrin, E Carrera / Elgammal, S / Kamel, A Ellithi / Mahmoud, M A / Mohammed, Y / Bhowmik, S / Dewanjee, R K / Ehataht, K / 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    Physical review letters

    2022  Volume 128, Issue 25, Page(s) 252301

    Abstract: The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS ... detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp ... collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^ ...

    Abstract The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^{+}μ^{-})μ^{+}ν_{μ} decay. The B_{c}^{+} nuclear modification factor, derived from the Pb-Pb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the Pb-Pb collision centrality. The B_{c}^{+} meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.252301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Observation of B_{c}^{+}→D^{0}K^{+} Decays.

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    Physical review letters

    2017  Volume 118, Issue 11, Page(s) 111803

    Abstract: ... recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}→D^{0}K^{+} decay is ... π^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c ... relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})×B(B_{c}^{+}→D^{0}K^ ...

    Abstract Using proton-proton collision data corresponding to an integrated luminosity of 3.0  fb^{-1}, recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}→D^{0}K^{+} decay is observed with a statistical significance of 5.1 standard deviations. By normalizing to B^{+}→D[over ¯]^{0}π^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c}^{+} relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})×B(B_{c}^{+}→D^{0}K^{+})=(9.3_{-2.5}^{+2.8}±0.6)×10^{-7}, where the first uncertainty is statistical and the second is systematic. This decay is expected to proceed predominantly through weak annihilation and penguin amplitudes, and is the first B_{c}^{+} decay of this nature to be observed.
    Language English
    Publishing date 2017-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.118.111803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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