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Artikel ; Online: Pandemic preparedness strategies must go beyond vaccines.

Gupta, Rajesh / Purcell, Lisa A / Corti, Davide / Virgin, Herbert W

2023 Band 15, Heft 690, Seite(n) eadd3055

Abstract: Monoclonal antibodies can fill a critical gap to help stop the next infectious disease outbreak from becoming the next pandemic. ...

Abstract	Monoclonal antibodies can fill a critical gap to help stop the next infectious disease outbreak from becoming the next pandemic.
Mesh-Begriff(e)	Humans ; Influenza, Human/epidemiology ; Pandemics/prevention & control ; Disease Outbreaks/prevention & control ; Vaccines
Chemische Substanzen	Vaccines
Sprache	Englisch
Erscheinungsdatum	2023-04-05
Erscheinungsland	United States
Dokumenttyp	Editorial
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.add3055
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Tackling COVID-19 with neutralizing monoclonal antibodies.

Corti, Davide / Purcell, Lisa A / Snell, Gyorgy / Veesler, David

Cell

2021 Band 184, Heft 17, Seite(n) 4593–4595

Sprache	Englisch
Erscheinungsdatum	2021-08-20
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.07.027
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MRI radiomics in head and neck cancer from reproducibility to combined approaches.

Corti, Anna / Cavalieri, Stefano / Calareso, Giuseppina / Mattavelli, Davide / Ravanelli, Marco / Poli, Tito / Licitra, Lisa / Corino, Valentina D A / Mainardi, Luca

Scientific reports

2024 Band 14, Heft 1, Seite(n) 9451

Abstract: The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the ... ...

Abstract	The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the reproducibility of radiomic analyses, impeding its translation to clinics. This study aimed to identify and replicate published, reproducible radiomic signatures based on magnetic resonance imaging (MRI), for prognosis of overall survival in head and neck squamous cell carcinoma (HNSCC) patients. Seven signatures were identified and reproduced on 58 HNSCC patients from the DB2Decide Project. The analysis focused on: assessing the signatures' reproducibility and replicating them by addressing the insufficient reporting; evaluating their relationship and performances; and proposing a cluster-based approach to combine radiomic signatures, enhancing the prognostic performance. The analysis revealed key insights: (1) despite the signatures were based on different features, high correlations among signatures and features suggested consistency in the description of lesion properties; (2) although the uncertainties in reproducing the signatures, they exhibited a moderate prognostic capability on an external dataset; (3) clustering approaches improved prognostic performance compared to individual signatures. Thus, transparent methodology not only facilitates replication on external datasets but also advances the field, refining prognostic models for potential personalized medicine applications.
Mesh-Begriff(e)	Humans ; Magnetic Resonance Imaging/methods ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/pathology ; Female ; Male ; Reproducibility of Results ; Middle Aged ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Squamous Cell Carcinoma of Head and Neck/pathology ; Aged ; Adult ; Radiomics
Sprache	Englisch
Erscheinungsdatum	2024-04-24
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60009-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Monoclonal antibodies against rabies: current uses in prophylaxis and in therapy.

de Melo, Guilherme Dias / Hellert, Jan / Gupta, Rajesh / Corti, Davide / Bourhy, Hervé

Current opinion in virology

2022 Band 53, Seite(n) 101204

Abstract: Rabies is a severe viral infection that causes an acute encephalomyelitis, which presents a case fatality of nearly 100% after the manifestation of neurological clinical signs. Rabies can be efficiently prevented with post-exposure prophylaxis (PEP), ... ...

Abstract	Rabies is a severe viral infection that causes an acute encephalomyelitis, which presents a case fatality of nearly 100% after the manifestation of neurological clinical signs. Rabies can be efficiently prevented with post-exposure prophylaxis (PEP), composed of vaccines and anti-rabies immunoglobulins (RIGs); however, no treatment exists for symptomatic rabies. The PEP protocol faces access and implementation obstacles in resource-limited settings, which could be partially overcome by substituting RIGs for monoclonal antibodies (mAbs). mAbs offer lower production costs, consistent supply availability, long-term storage/stability, and an improved safety profile. Here we summarize the key features of the different available mAbs against rabies, focusing on their application in PEP and highlighting their potential in a novel therapeutic approach.
Mesh-Begriff(e)	Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/therapeutic use ; Humans ; Immunologic Factors ; Post-Exposure Prophylaxis/methods ; Rabies/prevention & control ; Rabies Vaccines ; Rabies virus
Chemische Substanzen	Antibodies, Monoclonal ; Antibodies, Viral ; Immunologic Factors ; Rabies Vaccines
Sprache	Englisch
Erscheinungsdatum	2022-02-10
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2611378-8
ISSN	1879-6265 ; 1879-6257
ISSN (online)	1879-6265
ISSN	1879-6257
DOI	10.1016/j.coviro.2022.101204
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Tackling COVID-19 with neutralizing monoclonal antibodies.

Corti, Davide / Purcell, Lisa A / Snell, Gyorgy / Veesler, David

Cell

2021 Band 184, Heft 12, Seite(n) 3086–3108

Abstract: Monoclonal antibodies (mAbs) have revolutionized the treatment of several human diseases, including cancer and autoimmunity and inflammatory conditions, and represent a new frontier for the treatment of infectious diseases. In the last 20 years, ... ...

Abstract	Monoclonal antibodies (mAbs) have revolutionized the treatment of several human diseases, including cancer and autoimmunity and inflammatory conditions, and represent a new frontier for the treatment of infectious diseases. In the last 20 years, innovative methods have allowed the rapid isolation of mAbs from convalescent subjects, humanized mice, or libraries assembled in vitro and have proven that mAbs can be effective countermeasures against emerging pathogens. During the past year, an unprecedentedly large number of mAbs have been developed to fight coronavirus disease 2019 (COVID-19). Lessons learned from this pandemic will pave the way for the development of more mAb-based therapeutics for other infectious diseases. Here, we provide an overview of SARS-CoV-2-neutralizing mAbs, including their origin, specificity, structure, antiviral and immunological mechanisms of action, and resistance to circulating variants, as well as a snapshot of the clinical trials of approved or late-stage mAb therapeutics.
Mesh-Begriff(e)	Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/immunology ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; COVID-19/pathology ; COVID-19/virology ; Humans ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/immunology ; COVID-19 Drug Treatment
Chemische Substanzen	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Sprache	Englisch
Erscheinungsdatum	2021-05-26
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.05.005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Life Project of People with Autism and Intellectual Disability: Investigating Personal Preferences and Values to Enhance Self-Determination.

Corti, Serafino / Cavagnola, Roberto / Carnevali, Davide / Leoni, Mauro / Francesco, Fioriti / Galli, Laura / Alzani, Laura / Michelini, Giovanni / Miselli, Giovanni / Chiodelli, Giuseppe

Psychiatria Danubina

2023 Band 35, Heft Suppl 3, Seite(n) 17–23

Abstract: People with autism and intellectual disabilities, much like individuals with typical development, share a fundamental right and aspiration to realise their own life projects. However, this natural pursuit is uniquely challenging for individuals with ... ...

Abstract	People with autism and intellectual disabilities, much like individuals with typical development, share a fundamental right and aspiration to realise their own life projects. However, this natural pursuit is uniquely challenging for individuals with autism and intellectual disabilities due to their communication and adaptive hurdles. This growing need has prompted the development of a specific procedure for crafting life projects geared toward enhancing their quality of life. In the present work, we will describe the six key steps and the corresponding assessment, support, and verification tools essential for establishing and actualising the life project for individuals with disabilities, as conceptualised by the Italian Society of Neurodevelopmental Disorders (SIDIN). We will start by delineating diverse preference and value assessment procedures, showcasing an array of tools tailored to accommodate the distinct characteristics of adaptive and communicative functioning in individuals with disabilities. Following this, we will provide a succinct overview of support needs assessment tools. Subsequently, we will introduce the Ecological Life Balance, which serves as an integrative tool for harmonising various assessment systems. We will propose methods for defining existential goals that prioritise quality of life and suggest strategies for implementing support plans. Lastly, we will delve into the methodologies for monitoring and verifying outcomes in the final section.
Mesh-Begriff(e)	Humans ; Autistic Disorder ; Intellectual Disability ; Quality of Life ; Disabled Persons ; Communication
Sprache	Englisch
Erscheinungsdatum	2023-11-23
Erscheinungsland	Croatia
Dokumenttyp	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Studying the impact of magnitude pruning on contrastive learning methods

Corti, Francesco / Entezari, Rahim / Hooker, Sara / Bacciu, Davide / Saukh, Olga

2022

Abstract: We study the impact of different pruning techniques on the representation learned by deep neural networks trained with contrastive loss functions. Our work finds that at high sparsity levels, contrastive learning results in a higher number of ... ...

Abstract	We study the impact of different pruning techniques on the representation learned by deep neural networks trained with contrastive loss functions. Our work finds that at high sparsity levels, contrastive learning results in a higher number of misclassified examples relative to models trained with traditional cross-entropy loss. To understand this pronounced difference, we use metrics such as the number of PIEs (Hooker et al., 2019), Q-Score (Kalibhat et al., 2022), and PD-Score (Baldock et al., 2021) to measure the impact of pruning on the learned representation quality. Our analysis suggests the schedule of the pruning method implementation matters. We find that the negative impact of sparsity on the quality of the learned representation is the highest when pruning is introduced early on in the training phase.
Schlagwörter	Computer Science - Machine Learning ; Computer Science - Computer Vision and Pattern Recognition
Erscheinungsdatum	2022-07-01
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Tackling COVID-19 with neutralizing monoclonal antibodies

Corti, Davide / Purcell, Lisa A / Snell, Gyorgy / Veesler, David

Cell. 2021 June 10, v. 184, no. 12

2021

Abstract	Monoclonal antibodies (mAbs) have revolutionized the treatment of several human diseases, including cancer and autoimmunity and inflammatory conditions, and represent a new frontier for the treatment of infectious diseases. In the last 20 years, innovative methods have allowed the rapid isolation of mAbs from convalescent subjects, humanized mice, or libraries assembled in vitro and have proven that mAbs can be effective countermeasures against emerging pathogens. During the past year, an unprecedentedly large number of mAbs have been developed to fight coronavirus disease 2019 (COVID-19). Lessons learned from this pandemic will pave the way for the development of more mAb-based therapeutics for other infectious diseases. Here, we provide an overview of SARS-CoV-2-neutralizing mAbs, including their origin, specificity, structure, antiviral and immunological mechanisms of action, and resistance to circulating variants, as well as a snapshot of the clinical trials of approved or late-stage mAb therapeutics.
Schlagwörter	COVID-19 infection ; autoimmunity ; humans ; pandemic ; therapeutics
Sprache	Englisch
Erscheinungsverlauf	2021-0610
Umfang	p. 3086-3108.
Erscheinungsort	Elsevier Inc.
Dokumenttyp	Artikel
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.05.005
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Increased breadth and neutralization of antibodies against SARS-CoV-2 variants after infection and vaccination: A serosurveillance study in pediatric patients of Southern Switzerland.

Mazzara, Calogero / Bassi, Jessica / Silacci-Fregni, Chiara / Muoio, Francesco / Passini, Nadia / Corti, Davide / Simonetti, Giacomo D / Vanoni, Federica / Kottanattu, Lisa / Piccoli, Luca

European journal of pediatrics

2024 Band 183, Heft 3, Seite(n) 1425–1434

Abstract: Little information is available about the nature of the immune response in children after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination. The aim of this study is to define the seroprevalence and the features of the ...

Abstract	Little information is available about the nature of the immune response in children after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination. The aim of this study is to define the seroprevalence and the features of the antibody response in children of Southern Switzerland during the different waves of Coronavirus Disease 2019 (COVID-19) pandemic. By analyzing 756 sera collected from children aged 0 to 16 years admitted to the Institute of Pediatrics of Southern Switzerland during the prepandemic period (before March 2020) and the first four pandemic waves (between March 2020 and June 2022), we investigated binding titers, cross-reactivity, and neutralizing properties of the serum antibodies against SARS-CoV-2 variants. Seroprevalence varied from 6% during the first wave to 14% and 17% during the second and third waves, respectively, peaking at 39% during the fourth wave. The 96 seropositive cases were mostly asymptomatic (42.7%) or showed mild (20.8%) to moderate (32.3%) symptoms. Moderate symptoms and close contact with COVID-19-positive individuals were associated with a higher infection risk (P < 0.001). The antibody response was mainly driven by IgG directed to the receptor-binding domain (RBD) of Wuhan-1 SARS-CoV-2 Spike (S). Children infected in the first three waves produced antibodies with up to 11-fold and 5.5-fold reduction in binding and neutralizing titers, respectively, against different SARS-CoV-2 variants, including Beta, Delta, and Omicron BA.1, BA.2, and BA.5. Such reductions were less pronounced in children infected during the fourth wave, who showed the highest frequency and titers of neutralizing antibodies against the same variants. Compared to infection, vaccination with a Wuhan-1-based messenger RNA (mRNA) vaccine induced higher and heterogenous levels of antibodies cross-reacting to the different SARS-CoV-2 variants analyzed. Conclusions: Despite the high burden of COVID-19 in Southern Switzerland, we observed an initial low seroprevalence of SARS-CoV-2 in children, which increased in the later waves. The antibody response was poor in the first three waves and improved in the fourth wave, when children produced higher levels of neutralizing antibodies after vaccination or infection with Delta and/or Omicron variants. What is Known: • Children were marginally affected by the initial SARS-CoV-2 variants. • The number of infected and hospitalized children increased after the appearance of the Omicron variants. What is New: • Seroprevalence of SARS-CoV-2 in children of Southern Switzerland increased overtime. • Children produced higher levels of neutralizing antibodies after vaccination or infection with Delta and/or Omicron variants in the fourth wave compared to children infected in the first three waves.
Mesh-Begriff(e)	Humans ; Child ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Seroepidemiologic Studies ; Switzerland/epidemiology ; Antibodies, Neutralizing ; Vaccination ; Antibodies, Viral
Chemische Substanzen	Antibodies, Neutralizing ; Antibodies, Viral
Sprache	Englisch
Erscheinungsdatum	2024-01-04
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-05400-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Closing coronavirus spike glycoproteins by structure-guided design.

McCallum, Matthew / Walls, Alexandra C / Corti, Davide / Veesler, David

bioRxiv : the preprint server for biology

2020

Abstract: The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes ... ...

Abstract	The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and host membranes. Although SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of vaccine design, its stability and conformational dynamics are limiting factors for developing countermeasures against this virus. We report here the design of a prefusion SARS-CoV-2 S ectodomain trimer construct covalently stabilized in the closed conformation. Structural and antigenicity analysis showed we successfully shut S in the closed state without otherwise altering its architecture. Finally, we show that this engineering strategy is applicable to other β-coronavirus S glycoproteins and might become an important tool for vaccine design, structural biology, serology and immunology studies.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-06-03
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2020.06.03.129817
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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