LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 69

Search options

  1. Article ; Online: Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications.

    Joshi, Maithili / Joshi, Siddhi / Khambete, Mihir / Degani, Mariam

    Chemical biology & drug design

    2022  Volume 101, Issue 2, Page(s) 453–468

    Abstract: The increasing incidence of Alzheimer's disease (AD) coupled with the lack of therapeutics to address the underlying pathology of the disease has necessitated the need for exploring newer targets. Calcium dysregulation represents a relatively newer ... ...

    Abstract The increasing incidence of Alzheimer's disease (AD) coupled with the lack of therapeutics to address the underlying pathology of the disease has necessitated the need for exploring newer targets. Calcium dysregulation represents a relatively newer target associated with AD. Ca
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Calcium/metabolism ; Calcium Signaling ; Neurons/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; Calcium (SY7Q814VUP) ; Membrane Proteins
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.14175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Tackling SARS-CoV-2: proposed targets and repurposed drugs.

    Joshi, Siddhi / Joshi, Maithili / Degani, Mariam S

    Future medicinal chemistry

    2020  Volume 12, Issue 17, Page(s) 1579–1601

    Abstract: The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities near 371,000 and increasing exponentially, in absence of vaccines and drugs. The pathogenesis of ...

    Abstract The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities near 371,000 and increasing exponentially, in absence of vaccines and drugs. The pathogenesis of SARS-CoV-2 is still being elucidated. Identifying potential targets and repurposing drugs as therapeutic options is the need of the hour. In this review, we focus on potential druggable targets and suitable therapeutics, currently being explored in clinical trials, to treat SARS-CoV-2 infection. A brief understanding of the complex interactions of both viral as well as host targets, and the possible repurposed drug candidates are described with an emphasis on understanding the mechanisms at the molecular level.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/growth & development ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Receptors, Virus/drug effects ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Receptors, Virus
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2020-0147
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Suprabasal Clear Cell Change in Hypopigmented Seborrheic Keratosis.

    Bhargava, Anmol / Gole, Prachi V / Kharkar, Vidya D / Mahajan, Sunanda A / Joshi, Rajiv / Chikhalkar, Siddhi B / Vishwanath, Tejas

    Indian journal of dermatology

    2022  Volume 67, Issue 3, Page(s) 316

    Language English
    Publishing date 2022-11-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_911_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 817: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Diversity and Distribution of

    Shukla, Suraj / Desai, Siddhi / Bagchi, Ashutosh / Singh, Pushpendra / Joshi, Madhvi / Joshi, Chaitanya / Patankar, Jyoti / Maheshwari, Geeti / Rajni, Ekadashi / Shah, Manali / Gajjar, Devarshi

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Klebsiella ... ...

    Abstract Klebsiella pneumoniae
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030449
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Translation and Validation of COST - FACIT (Version 2) Questionnaire into Hindi and Marathi to Assess Financial Toxicity in Indian Cancer Patients.

    Joshi, Amit / Kalra, Devanshi / Menon, Nandini / Gadgil, Durga / Pashilkar, Siddhi / Mokal, Smruti / Prabhash, Kumar / Noronha, Vanita

    South Asian journal of cancer

    2022  Volume 11, Issue 2, Page(s) 97–104

    Abstract: Amit Joshi ...

    Abstract Amit Joshi
    Language English
    Publishing date 2022-04-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X
    ISSN (online) 2278-4306
    ISSN 2278-330X
    DOI 10.1055/s-0041-1741074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Immunohistopathological Study of Papillary Squamotransitional Carcinoma of Uterine Cervix.

    Dhande, Bhagyashree / Khandeparkar, Siddhi Gaurish Sinai / Gogate, Bageshri P / Joshi, Avinash R / Gosavi, Shital Subhash / Mishra, Pooja Vinod

    The Gulf journal of oncology

    2023  Volume 1, Issue 44, Page(s) 16–24

    Abstract: Introduction: Papillary squamotransitional cell carcinoma (PSTCC) arising from the uterine cervix is a distinctive histomorphological subtype of squamous cell carcinoma (SCC) not otherwise specified (NOS) of cervical epithelial tumors.: Aim: The ... ...

    Abstract Introduction: Papillary squamotransitional cell carcinoma (PSTCC) arising from the uterine cervix is a distinctive histomorphological subtype of squamous cell carcinoma (SCC) not otherwise specified (NOS) of cervical epithelial tumors.
    Aim: The present study was undertaken to study the histopathological features and immunoexpression of CK7, CK20, p53 and Ki-67 in PSTCC of the cervix.
    Materials and methods: This study included 43 cases of PSTCC of cervix. A technique of manual tissue array was employed along with IHC staining of entire section in some cases. The expression pattern of CK7, CK 20, p53 and Ki67 in PSTCC was studied and clinico-pathological correlation of various parameters with IHC expression of CK7 and CK20 was observed. Results were subjected to statistical analysis and were considered significant when the p-value was less than 0.05.
    Results: Out of 43 PSTCC cases, there were 38 squamotransitional type and 5 papillary type. Histomorphologically, all the cases studied were having fused papillae with rounded contours and fibrovascular cores with highest number of cases having intermediate cell type morphology (86%). Stromal invasion was seen in 74.4% of cases. Koilocytosis were seen in 39.3% of cases. Thirty-two cases showed CK7 immunopositivity (+) and CK20 immunonegativity (-), nine cases were both CK7 and CK20 - and two cases were CK7- and CK20+. Among them 90.7% cases were p53 positive and all cases were positive for Ki67 immunostaining with highest number of cases showing moderate proliferative activity (74.4%); followed by nine cases showing high (20.93%) and two cases showing low proliferative activity (4.65%).
    Conclusion: The distinct histomorphology and CK7/CK20 immnunoprofile of PSTCC along with Ki67 and p53 could help in arriving at an accurate diagnosis as well predicting its biological behavior.
    MeSH term(s) Female ; Humans ; Cervix Uteri ; Uterine Cervical Neoplasms ; Ki-67 Antigen ; Tumor Suppressor Protein p53 ; Carcinoma, Papillary ; Carcinoma, Squamous Cell
    Chemical Substances Ki-67 Antigen ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-12-10
    Publishing country Kuwait
    Document type Journal Article
    ISSN 2078-2101
    ISSN 2078-2101
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Tackling SARS-CoV-2: proposed targets and repurposed drugs

    Joshi, Siddhi / Joshi, Maithili / Degani, Mariam S

    Future Med Chem

    Abstract: The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities near 371,000 and increasing exponentially, in absence of vaccines and drugs. The pathogenesis of ...

    Abstract The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities near 371,000 and increasing exponentially, in absence of vaccines and drugs. The pathogenesis of SARS-CoV-2 is still being elucidated. Identifying potential targets and repurposing drugs as therapeutic options is the need of the hour. In this review, we focus on potential druggable targets and suitable therapeutics, currently being explored in clinical trials, to treat SARS-CoV-2 infection. A brief understanding of the complex interactions of both viral as well as host targets, and the possible repurposed drug candidates are described with an emphasis on understanding the mechanisms at the molecular level.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610734
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Immunohistochemical study of epidermal growth factor receptor, human epidermal growth factor receptor 2/neu, p53, and Ki67 in oral squamous cell carcinoma.

    Mohanapure, Neelam Sureshrao / Khandeparkar, Siddhi Gaurish Sinai / Saragade, Pradnya B / Gogate, Bageshri P / Joshi, Avinash R / Mehta, Sameera Rajendra

    Journal of oral and maxillofacial pathology : JOMFP

    2022  Volume 26, Issue 1, Page(s) 127–128

    Abstract: Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor occurring in the oral cavity.: Aim: The present study was conducted to evaluate the biomarkers such as epidermal growth factor receptor (EGFR), human epidermal ... ...

    Abstract Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor occurring in the oral cavity.
    Aim: The present study was conducted to evaluate the biomarkers such as epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2/neu), p53 and Ki67 expression in OSCC cases, and its correlation with other well-established clinicopathological parameters.
    Materials and methods: Seventy cases of OSCC cases diagnosed between 2015 and 2019 were included in the study. A technique of manual tissue microarray was employed for the analysis of expression of IHC markers such as EGFR, HER2/neu, p53, and Ki67 in all cases. Results were subjected to the statistical analysis.
    Results: A statistically significant positive association was noted between EGFR expression and tumor grade, tumor stage, and p53 immunoexpression in OSCC cases. Increased EGFR expression was noted insignificantly in OSCC cases with lymph node (LN) metastasis and Ki67 positive cases. Statistically significant positive association was noted between HER2/neu expression and tumor grade and stage of oral SCC cases. Increased HER2/neu expression was noted insignificantly in OSCC cases with LN metastasis, p53 and Ki67 positive OSCC cases. A statistically significant positive association was noted between percent of tumor cells expressing EGFR, HER2/neu, p53 and Ki67, and grade of OSCC.
    Conclusion: This study intends to document prognostic utility of EGFR and HER2/neu expression in OSCC cases in the Indian setting and contribute to the data pool which could aid in formulating individual tailored therapy that includes targeted therapy in oral SCC cases.
    Language English
    Publishing date 2022-03-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.jomfp_310_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Proceedings of the 3rd Indian Cancer Genome Atlas Conference 2022: Biobanking to Omics: Collecting the Global Experience.

    Joshi, Sneha / Mishra, Rupa / Kulkarni, Madhura / Kelkar, Devaki A / Harikrishnan, Keerthi / Vaid, Pooja / V, Gomathi / John, Jisha / Tamhane, Siddhi / Deshpande, Anand / Badve, Sunil / Chintamani / Mehrotra, Ravi / Shashidhara, L S / Kothari, Ashutosh / Koppiker, Chaitanyanand

    JCO global oncology

    2023  Volume 9, Page(s) e2200176

    Abstract: On January 13th and 14th 2022, the Center for Translational Cancer Research organized the virtual third Indian Cancer Genome Atlas (ICGA) Conference 2022 "Biobanking to Omics - Collecting the Global Experience." This conference was planned as the ... ...

    Abstract On January 13th and 14th 2022, the Center for Translational Cancer Research organized the virtual third Indian Cancer Genome Atlas (ICGA) Conference 2022 "Biobanking to Omics - Collecting the Global Experience." This conference was planned as the steppingstone to help ICGA understand the road ahead and the probable roadblocks in its preparatory phase as ICGA begins to streamline the tumor tissue biobanking and multi-omics efforts in the Indian subcontinent. The first day of the conference was dedicated to updates on the current status of ICGA, the future prospect, and the global understanding of multi-omics efforts. The key highlights included two keynote speeches by Dr Wui Jin Koh, Senior Vice President and Chief Medical Office, National Comprehensive Cancer Network, and by Dr Christina Curtis, Associate Professor, Stanford University School of Medicine. The first day ended with an intriguing panel discussion on "ICGA updates and Future Steps." The second day focused on biobanking practices across the globe and several aspects of biobank setup such as infrastructure, maintenance, quality control, patient consent, and lessons learned from established biobanking setups. The talk by Rosita Kammler, Head, Translational Research Coordination, International Breast Cancer Study Group, Switzerland, and Ruhul Amin, Director, Bangladesh Medical Research Council were the key highlights. The second day also ended with an engaging panel discussion on "Tumor tissue biobanking - national and international perspectives." Overall, the conference was well received and had good attendance from national and international students, researchers, and faculty from academia as well as industry.
    MeSH term(s) Humans ; Biological Specimen Banks ; Neoplasms/genetics ; Neoplasms/therapy ; Bangladesh
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.22.00176
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Rare Case of Primary Clear Cell Carcinoma of the Urinary Bladder.

    Kulkarni, Maithili Mandar / Sinai Khandeparkar, Siddhi Gaurish / Joshi, Avinash R / Bhayekar, Pallavi

    Nigerian medical journal : journal of the Nigeria Medical Association

    2019  Volume 60, Issue 1, Page(s) 40–42

    Abstract: Cancers of the urinary bladder account for about 3.2% of all cancers worldwide. Clear cell adenocarcinomas (CCAs) of urinary bladder are rare. CCA must be differentiated from benign condition such as nephrogenic adenoma (NA) as well as malignant ... ...

    Abstract Cancers of the urinary bladder account for about 3.2% of all cancers worldwide. Clear cell adenocarcinomas (CCAs) of urinary bladder are rare. CCA must be differentiated from benign condition such as nephrogenic adenoma (NA) as well as malignant conditions such as urothelial carcinoma with clear cells, metastasis from ovary and kidney, and urinary bladder myomelanocytic tumor. The diagnosis is based on characteristic histopathological and immunohistochemical features. We present a rare case of CCA of urinary bladder with aggressive clinical behavior in a 72-year-old female.
    Language English
    Publishing date 2019-05-28
    Publishing country Nigeria
    Document type Case Reports
    ZDB-ID 424429-1
    ISSN 0300-1652
    ISSN 0300-1652
    DOI 10.4103/nmj.NMJ_8_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top