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Article ; Online: Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface.

Ivanova, O K / Sharapova, T N / Romanova, E A / Yashin, D V / Sashchenko, L P

2023 Volume 508, Issue 1, Page(s) 12–16

Abstract: ... days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also ...

Abstract	To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.
MeSH term(s)	Humans ; Apoptosis ; CD8-Positive T-Lymphocytes ; Cytokines ; Interleukin-2/metabolism ; Lymphocyte Function-Associated Antigen-1/metabolism ; T-Lymphocytes/immunology
Chemical Substances	Cytokines ; Interleukin-2 ; Lymphocyte Function-Associated Antigen-1
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2062390-2
ISSN	1608-3091 ; 1607-6729
ISSN (online)	1608-3091
ISSN	1607-6729
DOI	10.1134/S160767292270003X
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Article ; Online: The Effect of Kerosene Pollution on the Cellulolytic Activity of Albic Retisols and Arenosols (Aridic): A Laboratory Experiment.

Sharapova, A V / Semenkov, I N / Krechetov, P P / Lednev, S A / Koroleva, T V

Eurasian soil science

2022 Volume 55, Issue 2, Page(s) 235–241

Abstract: The results of a laboratory experiment modeling the effect of kerosene contamination on the cellulolytic activity of microbiocenosis of the Albic Retisol (Kaluga oblast, Russia) and Arenosol (Kyzylorda oblast, Republic of Kazakhstan) humus horizons are ... ...

Abstract	The results of a laboratory experiment modeling the effect of kerosene contamination on the cellulolytic activity of microbiocenosis of the Albic Retisol (Kaluga oblast, Russia) and Arenosol (Kyzylorda oblast, Republic of Kazakhstan) humus horizons are described. Cellulolytic activity is assessed according to the rate of weight loss in linen cloth fragments during the incubation for 0-3, 3-7, and 7-13 months. The intensity of cellulolytic activity in the unpolluted Albic Retisol is higher as compared with the Arenosol, which is determined by low acidity and an elevated content of organic matter and nutrients. The soil pollution with kerosene to 10 g/kg causes a reversible change in cellulolytic activity of both Albic Retisol and Arenosol (Aridic). A high load of kerosene (≥25 g/kg) inhibits cellulolytic activity in both soils over 13 months of observation. Supplementary information: The online version contains supplementary material available at 10.1134/S1064229322020119.
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131509-x
ISSN	1556-195X ; 1064-2293
ISSN (online)	1556-195X
ISSN	1064-2293
DOI	10.1134/S1064229322020119
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Article: [Predictive value of

Uskach, T M / Sharapova, Y S / Safiullina, A A / Zinovyeva, E V / Tereshchenko, S N

Terapevticheskii arkhiv

2022 Volume 94, Issue 4, Page(s) 503–510

Abstract: Aim: To study of the features of the clinical course and prognosis in patients with chronic heart failure with low ejection fraction (HFrEF) and atrial fibrillation (AF) depending on the width of the QRS complex.: Materials and methods: We studied ... ...

Abstract	Aim: To study of the features of the clinical course and prognosis in patients with chronic heart failure with low ejection fraction (HFrEF) and atrial fibrillation (AF) depending on the width of the QRS complex. Materials and methods: We studied the case histories of 514 patients (aged 60.213.84 years, 78% men) with HFrEF, hospitalized at the Chazov National Medical Research Center of Cardiology (Moscow) for the period from Jan 1, 2017 to Dec 31, 2018. Patients were divided into 2 groups depending on the duration of the QRS complex. Results: Clinical and statistical retrospective analysis of the medical histories of patients with HFrEF, depending on the QRS duration, showed the predominance of patients with a QRS complex size of less than 130 ms (60.7%). In HFrEF, the expansion of the QRS complex is accompanied by an increase in the rate of readmission in patients with sinus rhythm (p=0.004). In patients with AF, the rehospitalization rate is significantly higher than in sinus rhythm and does not depend on the QRS duration (p=0.001). The incidence of unfavorable outcomes increases in connection with the addition of AF, which is most likely a more significant risk factor than QRS width. Conclusion: These results highlight that patients with AF and a narrow QRS complex have the same poor prognosis as those with a wide QRS complex and require the close attention of cardiologists.
MeSH term(s)	Male ; Humans ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/complications ; Stroke Volume ; Atrial Fibrillation/complications ; Retrospective Studies ; Ventricular Function, Left ; Prognosis ; Chronic Disease
Language	Russian
Publishing date	2022-05-26
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/00403660.2022.04.201459
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Article: The Effect of Kerosene Pollution on the Cellulolytic Activity of Albic Retisols and Arenosols (Aridic): A Laboratory Experiment

Sharapova, A. V. / Semenkov, I. N. / Krechetov, P. P. / Lednev, S. A. / Koroleva, T. V.

Eurasian soil science. 2022 Feb., v. 55, no. 2

2022

Abstract	The results of a laboratory experiment modeling the effect of kerosene contamination on the cellulolytic activity of microbiocenosis of the Albic Retisol (Kaluga oblast, Russia) and Arenosol (Kyzylorda oblast, Republic of Kazakhstan) humus horizons are described. Cellulolytic activity is assessed according to the rate of weight loss in linen cloth fragments during the incubation for 0–3, 3–7, and 7–13 months. The intensity of cellulolytic activity in the unpolluted Albic Retisol is higher as compared with the Arenosol, which is determined by low acidity and an elevated content of organic matter and nutrients. The soil pollution with kerosene to 10 g/kg causes a reversible change in cellulolytic activity of both Albic Retisol and Arenosol (Aridic). A high load of kerosene (≥25 g/kg) inhibits cellulolytic activity in both soils over 13 months of observation.
Keywords	Arenosols ; Russia ; acidity ; humus ; kerosene ; laboratory experimentation ; soil pollution ; weight loss ; Kazakhstan
Language	English
Dates of publication	2022-02
Size	p. 235-241.
Publishing place	Pleiades Publishing
Document type	Article
ZDB-ID	1131509-x
ISSN	1556-195X ; 1064-2293
ISSN (online)	1556-195X
ISSN	1064-2293
DOI	10.1134/S1064229322020119
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Article ; Online: Tag7-Mts1 Complex Activates Chemotaxis of Regulatory T Cells.

Ivanova, O K / Sharapova, T N / Romanova, E A / Sashchenko, L P / Yashin, D V / Georgiev, G P

Doklady. Biochemistry and biophysics

2022 Volume 506, Issue 1, Page(s) 181–184

Abstract: ... regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and ... we demonstrate that regulatory T cells can migrate along the concentration gradient of Tag7-Mts1 complex, and ...

Abstract	One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and investigation of this subpopulation is important for development of new therapeutic approaches. In this study, we demonstrate that regulatory T cells can migrate along the concentration gradient of Tag7-Mts1 complex, and also they produce agents that induce blood cells migration.
MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Chemotaxis ; Cytokines ; Lymphocytes ; Neoplasms
Chemical Substances	Cytokines
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2062390-2
ISSN	1608-3091 ; 1607-6729
ISSN (online)	1608-3091
ISSN	1607-6729
DOI	10.1134/S1607672922050064
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Article: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

Sharapova, T N / Romanova, E A / Sashchenko, L P / Yashin, D V

Acta naturae

2019 Volume 10, Issue 4, Page(s) 115–120

Abstract: The discovery of new chemokines that induce the migration of lymphocytes to the infection site is important for the targeted search for therapeutic agents in immunotherapy. We recently showed that Tag7 (PGLYRP1), an innate immunity protein, forms a ... ...

Abstract	The discovery of new chemokines that induce the migration of lymphocytes to the infection site is important for the targeted search for therapeutic agents in immunotherapy. We recently showed that Tag7 (PGLYRP1), an innate immunity protein, forms a stable complex with the Ca
Language	English
Publishing date	2019-01-01
Publishing country	Russia (Federation)
Document type	Journal Article
ISSN	2075-8251
ISSN	2075-8251
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Article ; Online: Reduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet.

Sharapova, T / Talaty, N / Buck, W R / Fossey, S / Liguori, M J / Van Vleet, T R

Toxicology and applied pharmacology

2021 Volume 415, Page(s) 115439

Abstract: Non-genotoxic carcinogens (NGCs) are known to cause perturbations in DNA methylation, which can be an early event leading to changes in gene expression and the onset of carcinogenicity. Phenobarbital (PB) has been shown to alter liver DNA methylation and ...

Abstract	Non-genotoxic carcinogens (NGCs) are known to cause perturbations in DNA methylation, which can be an early event leading to changes in gene expression and the onset of carcinogenicity. Phenobarbital (PB) has been shown to alter liver DNA methylation and hydroxymethylation patterns in mice in a time dependent manner. The goals of this study were to assess if clofibrate (CFB), a well-studied rodent NGC, would produce epigenetic changes in mice similar to PB, and if a methyl donor supplementation (MDS) would modulate epigenetic and gene expression changes induced by phenobarbital. CByB6F1 mice were treated with 0.5% clofibrate or 0.14% phenobarbital for 7 and 28 days. A subgroup of PB treated and control mice were also fed MDS diet. Liquid Chromatography-Ionization Mass Spectrometry (LC-MS) was used to quantify global liver 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels. Gene expression analysis was conducted using Affymetrix microarrays. A decrease in liver 5hmC but not 5mC levels was observed upon treatment with both CFB and PB with varying time of onset. We observed moderate increases in 5hmC levels in PB-treated mice when exposed to MDS diet and lower expression levels of several phenobarbital induced genes involved in cell proliferation, growth, and invasion, suggesting an early modulating effect of methyl donor supplementation. Overall, epigenetic profiling can aid in identifying early mechanism-based biomarkers of non-genotoxic carcinogenicity and increases the quality of cancer risk assessment for candidate drugs. Global DNA methylation assessment by LC-MS is an informative first step toward understanding the risk of carcinogenicity.
MeSH term(s)	5-Methylcytosine/analogs & derivatives ; 5-Methylcytosine/metabolism ; Animal Feed ; Animal Nutritional Physiological Phenomena ; Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Carcinogens/toxicity ; Clofibrate/toxicity ; DNA Methylation/drug effects ; Dietary Supplements ; Down-Regulation ; Epigenesis, Genetic/drug effects ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Liver/drug effects ; Liver/metabolism ; Male ; Methionine/administration & dosage ; Mice, Transgenic ; Phenobarbital/toxicity ; Time Factors ; Transcriptome
Chemical Substances	Carcinogens ; 5-hydroxymethylcytosine (1123-95-1) ; 5-Methylcytosine (6R795CQT4H) ; Methionine (AE28F7PNPL) ; Clofibrate (HPN91K7FU3) ; Phenobarbital (YQE403BP4D)
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2021.115439
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Article ; Online: Ecological consequences of space rocket accidents in Kazakhstan between 1999 and 2018.

Koroleva, T V / Semenkov, I N / Sharapova, A V / Krechetov, P P / Lednev, S A

Environmental pollution (Barking, Essex : 1987)

2020 Volume 268, Issue Pt A, Page(s) 115711

Abstract: In this paper, we briefly described the ecological consequences of six space rocket accidents launched from the Baikonur Cosmodrome between 1999 and 2018 and focused on an assessment of efficiency of soil remediation following the accidental crash of ... ...

Abstract	In this paper, we briefly described the ecological consequences of six space rocket accidents launched from the Baikonur Cosmodrome between 1999 and 2018 and focused on an assessment of efficiency of soil remediation following the accidental crash of launch vehicle Proton-M on July 2, 2013, which resulted in the severest environmental impact in the modern Russian space industry. On the day after the accident, the content of carcinogenic unsymmetrical dimethylhydrazine and nitrosodimethylamine, as well as nitrate in soils of the crash site exceeded their maximal permissible concentrations by 8900, 6100 and 85 times, respectively. Mitigation measures included soil detoxication by a solution of 10% H
MeSH term(s)	Accidents ; Ecosystem ; Hydrogen Peroxide ; Kazakhstan ; Russia ; Soil ; Soil Pollutants/analysis
Chemical Substances	Soil ; Soil Pollutants ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2020-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2020.115711
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Article: [The analytical review of normative and organizational support of functioning of perinatal service in The Russian Federation in 2000-2020].

Sharapova, O V / Mingazova, E N / Nesterov, A S / Gerasimova, L I / Petrova, I A / Shigabutdinova, T N

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

2021 Volume 29, Issue 4, Page(s) 885–891

Abstract: The formation of code of normative legal documents ensuring activities of perinatal service is one of the most important, basic organizational technologies that determine activities of obstetrics and childhood services, contributing to increasing of ... ...

Abstract	The formation of code of normative legal documents ensuring activities of perinatal service is one of the most important, basic organizational technologies that determine activities of obstetrics and childhood services, contributing to increasing of natality, decreasing of maternal and infant morbidity, and maternal and childhood health care in general. The article presents analysis of formation of normative legal base that regulates functioning of perinatal service in the Russian Federation in 2000-2020. Actually, there is no objective prerequisites for fundamental alterations in the three-level system of medical care of women during pregnancy, labor, postpartum period and newborns. However, the regulatory adjustment of the system, improvement and refinement of models of profile patients' routing, development of medical care of pregnant women, parturient women and puerpera will proceed.
MeSH term(s)	Birth Rate ; Child ; Female ; Humans ; Infant, Newborn ; Obstetrics ; Organizations ; Patient Care ; Pregnancy ; Russia
Language	Russian
Publishing date	2021-09-06
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1483853-9
ISSN	0869-866X
ISSN	0869-866X
DOI	10.32687/0869-866X-2021-29-4-885-891
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Article ; Online: Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.

Sharapova, T N / Romanova, E A / Sashchenko, L P / Yashin, D V

Journal of immunology research

2018 Volume 2018, Page(s) 4501273

Abstract: We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress ... ...

Abstract	We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.
MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; CD3 Complex/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Proliferation ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; HSP70 Heat-Shock Proteins/metabolism ; HeLa Cells ; Humans ; Immunity, Innate ; Interleukin-2/metabolism ; Interleukin-2 Receptor alpha Subunit/metabolism ; Interleukin-7 Receptor alpha Subunit/metabolism ; K562 Cells ; Mice ; Neoplasms, Experimental/immunology ; T-Lymphocyte Subsets/immunology
Chemical Substances	Antigens, Neoplasm ; CD3 Complex ; Cytokines ; HSP70 Heat-Shock Proteins ; Interleukin-2 ; Interleukin-2 Receptor alpha Subunit ; Interleukin-7 Receptor alpha Subunit ; PGLYRP1 protein, human
Language	English
Publishing date	2018-04-11
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2018/4501273
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