LIVIVO - Search results -

Search results

Result 1 - 10 of total 1316

Search options

Article ; Online: Comments on "Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials".

Luo, Ming-Hao / Wan, Zengyi / Tu, Guo-Wei / Luo, Zhe

2023 Volume 27, Issue 1, Page(s) 348

MeSH term(s)	Humans ; Randomized Controlled Trials as Topic ; Pneumonia/drug therapy ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04619-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5517: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Molecular mechanisms and therapeutic applications of huaier in breast cancer treatment.

Luo, Ke-Fei / Zhou, Lin-Xi / Wu, Zi-Wei / Tian, Yuan / Jiang, Jun / Wang, Ming-Hao

Frontiers in pharmacology

2024 Volume 14, Page(s) 1269096

Abstract: Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although the survival rate and quality of life of patients with breast cancer are improving with the continuous development of medical ... ...

Abstract	Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although the survival rate and quality of life of patients with breast cancer are improving with the continuous development of medical technology, metastasis, recurrence, and drug resistance of breast cancer remain a significant problem. Huaier, a traditional Chinese medicine (TCM) fungus, is a type of Sophora embolism fungus growing on old Sophora stems. The polysaccharides of
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1269096
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Comparison of the efficacy of steroid-free versus classic steroid-containing regimens in primary membranous nephropathy.

Xing, Hui-Lin / Ma, Dong-Hong / Li, Jin / Xu, Qing-Yu / Ji, Li-Ke / Zhu, Qiong-Jie / Luo, Yu-Qing / Guo, Ming-Hao

Frontiers in pharmacology

2024 Volume 15, Page(s) 1286422

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1286422
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Molecular mechanisms and therapeutic applications of huaier in breast cancer treatment

Ke-fei Luo / Lin-xi Zhou / Zi-wei Wu / Yuan Tian / Jun Jiang / Ming-hao Wang

Frontiers in Pharmacology, Vol

2024 Volume 14

Abstract	Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although the survival rate and quality of life of patients with breast cancer are improving with the continuous development of medical technology, metastasis, recurrence, and drug resistance of breast cancer remain a significant problem. Huaier, a traditional Chinese medicine (TCM) fungus, is a type of Sophora embolism fungus growing on old Sophora stems. The polysaccharides of Trametes robiniophila Murr (PS-T) are the main active ingredient of Huaier. There is increasing evidence that Huaier has great potential in breast cancer treatment, and its anti-cancer mechanism may be related to a variety of biological activities, such as the inhibition of cell proliferation, metastasis, tumor angiogenesis, the promotion of cancer cell death, and regulation of tumor-specific immunity. There is growing evidence that Huaier may be effective in the clinical treatment of breast cancer. This review systematically summarizes the basic and clinical studies on the use of Huaier in the treatment of breast cancer, providing useful information to guide the clinical application of Huaier and future clinical studies.
Keywords	huaier ; breast cancer ; cell death ; complementary alternative medicine ; prognosis ; Therapeutics. Pharmacology ; RM1-950
Subject code	610 ; 616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Skin mottling score assesses peripheral tissue hypoperfusion in critically ill patients following cardiac surgery.

Luo, Jing-Chao / Luo, Ming-Hao / Zhang, Yi-Jie / Liu, Wen-Jun / Ma, Guo-Guang / Hou, Jun-Yi / Su, Ying / Hao, Guang-Wei / Tu, Guo-Wei / Luo, Zhe

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 130

Abstract: Background: Skin mottling is a common manifestation of peripheral tissue hypoperfusion, and its severity can be described using the skin mottling score (SMS). This study aims to evaluate the value of the SMS in detecting peripheral tissue hypoperfusion ... ...

Abstract	Background: Skin mottling is a common manifestation of peripheral tissue hypoperfusion, and its severity can be described using the skin mottling score (SMS). This study aims to evaluate the value of the SMS in detecting peripheral tissue hypoperfusion in critically ill patients following cardiac surgery. Methods: Critically ill patients following cardiac surgery with risk factors for tissue hypoperfusion were enrolled (n = 373). Among these overall patients, we further defined a hypotension population (n = 178) and a shock population (n = 51). Hemodynamic and perfusion parameters were recorded. The primary outcome was peripheral hypoperfusion, defined as significant prolonged capillary refill time (CRT, > 3.0 s). The characteristics and hospital mortality of patients with and without skin mottling were compared. The area under receiver operating characteristic curves (AUROC) were used to assess the accuracy of SMS in detecting peripheral hypoperfusion. Besides, the relationships between SMS and conventional hemodynamic and perfusion parameters were investigated, and the factors most associated with the presence of skin mottling were identified. Results: Of the 373-case overall population, 13 (3.5%) patients exhibited skin mottling, with SMS ranging from 1 to 5 (5, 1, 2, 2, and 3 cases, respectively). Patients with mottling had lower mean arterial pressure, higher vasopressor dose, less urine output (UO), higher CRT, lactate levels and hospital mortality (84.6% vs. 12.2%, p < 0.001). The occurrences of skin mottling were higher in hypotension population and shock population, reaching 5.6% and 15.7%, respectively. The AUROC for SMS to identify peripheral hypoperfusion was 0.64, 0.68, and 0.81 in the overall, hypotension, and shock populations, respectively. The optimal SMS threshold was 1, which corresponded to specificities of 98, 97 and 91 and sensitivities of 29, 38 and 67 in the three populations (overall, hypotension and shock). The correlation of UO, lactate, CRT and vasopressor dose with SMS was significant, among them, UO and CRT were identified as two major factors associated with the presence of skin mottling. Conclusion: In critically ill patients following cardiac surgery, SMS is a very specific yet less sensitive parameter for detecting peripheral tissue hypoperfusion.
MeSH term(s)	Humans ; Shock, Septic ; Critical Illness ; Cardiac Surgical Procedures/adverse effects ; Hypotension/diagnosis ; Hypotension/complications ; Lactates
Chemical Substances	Lactates
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02474-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Haste makes waste: staged suppression of autophagic-lysosomal pathway in microglia promotes the efficient clearance of myelin debris.

Qin, Chuan / Chu, Yun-Hui / Zhou, Luo-Qi / Dong, Ming-Hao / Wang, Wei / Tian, Dai-Shi

Autophagy

2023 Volume 19, Issue 6, Page(s) 1896–1898

Abstract: The autophagic-lysosomal pathway of microglia plays a key role in myelin debris removal in white matter damage. As the lipid-rich myelin debris are engulfed by microglia, the cellular autophagic level increases, accompanied by lysosomal dysfunction. ... ...

Abstract	The autophagic-lysosomal pathway of microglia plays a key role in myelin debris removal in white matter damage. As the lipid-rich myelin debris are engulfed by microglia, the cellular autophagic level increases, accompanied by lysosomal dysfunction. However, several issues such as how to regulate this pathway to ensure the effective degradation of myelin debris, and maintain the balance of lipid metabolism are still to be elucidated. Recently, we have demonstrated that the excessive activation of macroautophagy/autophagy leads to lipid overload in lysosomes and lipid droplets accumulation, which could be the initiator of microglial dysfunction and secondary inflammatory white matter damage. Interestingly, staged suppression of autophagic activation in the acute phase of demyelination could benefit microglia allowing them to regain the lipid metabolism balance, and reduce the excessive accumulation of lipids, thus promoting the removal of myelin debris. The neuroprotective effects of microglial autophagy regulation may be related to intracellular linoleic acid (LA) production and PPARG pathway activation.
MeSH term(s)	Myelin Sheath/metabolism ; Microglia/metabolism ; Autophagy/physiology ; Lysosomes/metabolism ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2023.2186097
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6741: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Aerobic exercise improves renal fibrosis in spontaneously hypertensive rats].

Cao, Shu-Yuan / Chang, Qing / Liu, Guo-Chun / Luo, Ming-Hao / Wang, Yang / He, Long-Lin

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2022 Volume 38, Issue 3, Page(s) 212–217

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Fibrosis ; Kidney Diseases ; Male ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Transforming Growth Factor beta
Chemical Substances	Transforming Growth Factor beta
Language	Chinese
Publishing date	2022-08-11
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.6246.2022.042
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Forward modelling and identification of shallow gas in the Bohai Bay seabed

Xiao-Di Yang / Ming-Hao Chun / Xiao-Qiao Luo / Zhi-Guang Yao

Geoenvironmental Disasters, Vol 9, Iss 1, Pp 1-

2022 Volume 10

Abstract: Abstract The accumulation of shallow gas in the seabed reduces the strength of strata or forms a high-pressure air sac, endangering ocean engineering construction. Therefore, it is important to identify the distribution of shallow gas in the seabed ... ...

Abstract	Abstract The accumulation of shallow gas in the seabed reduces the strength of strata or forms a high-pressure air sac, endangering ocean engineering construction. Therefore, it is important to identify the distribution of shallow gas in the seabed within the study area. Shallow gas increases the soil mass porosity and reduces the acoustic wave velocity, causing attenuation by absorbing to high-frequency components in the acoustic waves. Based on the geological drilling data in the area surrounding an oil platform in Bohai Bay, a stratigraphic model was established for forward analysis, and the results suggest the presence of the phase inversion of reflective waves at the interface between shallow gas and strata and sunken events for the lower shallow gas. According to a survey of stratigraphic profiles surrounding the platform, a seismic attribute analysis of acoustic stratigraphic profile data concerning amplitude, instantaneous phase, and instantaneous frequency was carried out, and characteristics such as disordered weak amplitude reflection, phase inversion, sunken events and indicators, including high-frequency loss and shallow gas reflection, were identified. Given that the shallow gas reflection is columnar and ended at the top clay strata of the seabed, the shallow gas was probably produced from deep depths.
Keywords	Seabed shallow gas ; Forward analysis ; Instantaneous phase ; Instantaneous frequency ; Identification of shallow gas ; Disasters and engineering ; TA495 ; Environmental sciences ; GE1-350
Subject code	551 ; 550
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prevalence of depressive tendencies among college students and the influence of attributional styles on depressive tendencies in the post-pandemic era.

Luo, Ming-Ming / Hao, Ming / Li, Xu-Huan / Liao, Jing / Wu, Chun-Mei / Wang, Qi

Frontiers in public health

2024 Volume 12, Page(s) 1326582

Abstract: Introduction: Depression symptoms are prevalent globally, including China, with a notable impact on college students. This study aims to not only estimate the prevalence of depressive tendencies and attributional styles among college students in the ... ...

Abstract	Introduction: Depression symptoms are prevalent globally, including China, with a notable impact on college students. This study aims to not only estimate the prevalence of depressive tendencies and attributional styles among college students in the post-pandemic era but also explore the relationship between the two factors. The findings of this study can provide new insights into early intervention and support services for individuals exhibiting tendencies toward depression. Methods: The survey was administered to college students from various academic backgrounds at a specific university in southern Jiangxi Province by employing two scales to investigate depressive tendencies and attributional styles. Depressive tendency was evaluated using the Patient Health Questionnaire-9 (PHQ-9), while the attributional styles were assessed using the Multidimensional-Multiattributional Causality Scale (MMCS). Univariate analysis and multiple logistic regressions were conducted to identify the related factors of depressive tendency. Results: A relatively high (48.9%) prevalence of depression among college students was found in this study. College students with higher grades (OR = 1.574, 95%CI: 1.369-1.810), profession of medicine and allied health sciences (OR = 1.779, 95%CI: 1.203-2.629), experiencing higher study stress (OR = 2.006, 95%CI: 1.601-2.514), and having poor physical condition (OR = 1.527, 95%CI: 1.247-1.869) were identified as risk factors for depressive tendency. The correlation between higher grades and increased learning pressure, coupled with poorer physical condition, heightens the vulnerability of college students to depression. Moreover, the more they attribute these experiences to achievement effort (OR = 0.897, 95%CI: 0.828-0.972), achievement ability (OR = 0.903, 95% Conclusion: In the group of college students, especially those in higher grades, profession of medicine and allied health sciences or experiencing high learning pressure and poor physical condition, emphasizing the significance of their mental well-being becomes crucial. Offering suitable support and assistance is essential. Additionally, fostering the cultivation of positive attributional and coping strategies by attributing difficulties to controllable factors and instilling a belief in their ability to overcome challenges can help reduce the risk of depression.
MeSH term(s)	Humans ; Depression/epidemiology ; Depression/diagnosis ; Prevalence ; Pandemics ; Students ; Mental Health
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1326582
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ldl-stimulated microglial activation exacerbates ischemic white matter damage.

Zhou, Luo-Qi / Chu, Yun-Hui / Dong, Ming-Hao / Yang, Sheng / Chen, Man / Tang, Yue / Pang, Xiao-Wei / You, Yun-Fan / Wu, Long-Jun / Wang, Wei / Qin, Chuan / Tian, Dai-Shi

Brain, behavior, and immunity

2024 Volume 119, Page(s) 416–430

Abstract: The role of microglia in triggering the blood-brain barrier (BBB) impairment and white matter damage after chronic cerebral hypoperfusion is unclear. Here we demonstrated that the vessel-adjacent microglia were specifically activated by the leakage of ... ...

Abstract	The role of microglia in triggering the blood-brain barrier (BBB) impairment and white matter damage after chronic cerebral hypoperfusion is unclear. Here we demonstrated that the vessel-adjacent microglia were specifically activated by the leakage of plasma low-density lipoprotein (LDL), which led to BBB breakdown and ischemic demyelination. Interestingly, we found that LDL stimulation enhanced microglial phagocytosis, causing excessive engulfment of myelin debris and resulting in an overwhelming lipid burden in microglia. Surprisingly, these lipid-laden microglia exhibited a suppressed profile of inflammatory response and compromised pro-regenerative properties. Microglia-specific knockdown of LDLR or systematic medication lowering circulating LDL-C showed protective effects against ischemic demyelination. Overall, our findings demonstrated that LDL-stimulated vessel-adjacent microglia possess a disease-specific molecular signature, characterized by suppressed regenerative properties, which is associated with the propagation of demyelination during ischemic white matter damage.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2024.04.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito