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  1. Book: ELSEVIER ESSENTIALS Diabetes

    Müller, Ulrich Alfons / Egidi, Günther / Klinge, Andreas / Wolf, Gunter

    das Wichtigste für Ärztinnen und Ärzte aller Fachrichtungen

    (Elsevier Essentials)

    2021  

    Title variant Diabetes
    Author's details Ulrich A. Müller, Günther Egidi, Andreas Klinge, Gunter Wolf (Hrsg.) ; mit Beiträgen von: Prof. Dr. med. Jean-François Chenot [und weiteren]
    Series title Elsevier Essentials
    Keywords Diabetes mellitus
    Subject Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language German
    Size XIV, 141 Seiten, Illustrationen, 27 cm x 21 cm, 442 g
    Edition 1. Auflage
    Publisher Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT020931753
    ISBN 978-3-437-21421-9 ; 3-437-21421-7 ; 9783437173110 ; 3437173111
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 A 700 on loan 0 Vormerkungen

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  2. Book ; Thesis: Analyse von Routinedaten einer Arztpraxis für die Beantwortung versorgunsrelevanter Forschungsfragen

    Müller-Bühl, Konrad / Laux, Gunter

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von Konrad Müller-Bühl ; Doktorvater: Prof. Dr. sc. hum. Gunter Laux
    Language German
    Size II, 71 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021217930
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Migration und Psychose

    Ertel, Ulrich / Lempa, Günter / Müller, Thomas / Münch, Alois / Troje, Elisabeth / Matejek, Norbert

    Forum der psychoanalytischen Psychosentherapie, Band 37

    (Forum der psychoanalytischen Psychosentherapie)

    2023  

    Abstract: Erfahrungen von Flucht und Migration rufen häufig psychische Krisen und Konflikte hervor. Nicht nur aktuelle Fluchtbewegungen werfen die Frage auf, welchen Einfluss biografische Erfahrungen der Migration auf die Entstehung und Aufrechterhaltung ... ...

    Series title Forum der psychoanalytischen Psychosentherapie
    Abstract Erfahrungen von Flucht und Migration rufen häufig psychische Krisen und Konflikte hervor. Nicht nur aktuelle Fluchtbewegungen werfen die Frage auf, welchen Einfluss biografische Erfahrungen der Migration auf die Entstehung und Aufrechterhaltung psychotischer Erkrankungen haben. Zudem stellt sich vielfach die Frage, wie darauf bezogene Krankheitskonzepte und klinische Behandlungsmethoden ausgestaltet und umgesetzt werden können. -- -- Die Autor innen nehmen vor diesem Hintergrund die Konflikt...
    Keywords Beziehungsdynamik ; Falldarstellung ; Flucht ; Geflüchtete ; Identitätskonflikte ; Migration ; PTSD ; Praxis ; Psychoanalyse ; Psychose ; Psychotherapie ; Therapie ; Trauma ; psychodynamische Psychotherapie der Psychosen ; psychotische Erkrankung
    Language German
    Size 174 p.
    Publisher Psychosozial-Verlag
    Document type Book
    Note Hochschulschriften Medizin
    Format 149 x 208 x 15
    ISBN 9783837932072 ; 3837932079
    Database PDA

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  4. Book ; Thesis: Blutdruckregulation bei Kindern und Jugendlichen mit Typ 1 Diabetes mellitus

    Dost, Axel / Beck, James F. / Müller, Ulrich Alfons / Dötsch, Jörg

    2021  

    Abstract: Die Entwicklung eines Diabetes mellitus Typ1 (T1DM) ist mit einem stark erhöhten Risiko für die spätere Entwicklung kardiovaskulärer und mikrovaskulärer Begleiterkrankungen verbunden. Obwohl diese Begleiterkrankungen meist erst im Erwachsenenalter ... ...

    Title variant eins
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Dr. med. Axel Günter Dost
    Abstract Die Entwicklung eines Diabetes mellitus Typ1 (T1DM) ist mit einem stark erhöhten Risiko für die spätere Entwicklung kardiovaskulärer und mikrovaskulärer Begleiterkrankungen verbunden. Obwohl diese Begleiterkrankungen meist erst im Erwachsenenalter klinisch Bedeutung gewinnen, mehren sich Hinweise, dass ihre Entwicklung bereits mit dem Zeitpunkt der Manifestation des T1DM im Kindesalter ihren Anfang nimmt. Als Hauptrisikofaktoren für die Entwicklung der kardiovaskulären und mikrovaskulären Begleiterkrankungen gelten neben der T1DM-assoziierten, chronischen Hyperglykämie vor allem Störungen der Blutdruckregulation, insbesondere die der Form der arteriellen Hypertonie (HTN). So sind Störungen der Regulation des Blutdrucks („Blood pressure“, BP) mit einem höheren Auftreten mikrovaskulärer Komplikationen, wie der diabetischen Nephropathie und Retinopathie vergesellschaftet. Um das Ausmaß und den Krankheitswert von Störungen der Blutdruckregulation bei Kindern und Jugendlichen mit T1DM zu verstehen, wurden ausgesuchte Daten aus dem deutschsprachigen Register für die Verlaufsbeobachtung von Patienten mit Diabetes (DPV-Register) auf mögliche Korrelationen hin betrachtet. Das DPV-Register umfasst inzwischen Dokumentationsdaten von nahezu 90% der an T1DM erkrankten Kinder und Jugendlichen aus Deutschland, Österreich, Luxemburg und Teilen der Schweiz. Im DPV-Register werden die aus heutiger Sicht wesentlichen diabetes-relevanten Daten erfasst. Hierzu gehören: Basisdaten, diabetes-spezifische Parameter, Parameter mit Bezug zu assoziierten Erkrankungen oder Folgeerkrankungen und zusätzliche Medikamente. Diese Daten werden lokal erhoben, dokumentiert und anonymisiert. Die anonymisierten Daten werden zweimal jährlich an das Institut für Epidemiologie und medizinische Biometrie der Universität Ulm versandt und dort zentral auf ihre Qualität hin überprüft.
    Keywords Diabetes mellitus ; Kind ; Blutdruck
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language German ; English
    Size 104 Seiten, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2021
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Habilitationsschrift, enthält Zeitschriftenaufsätze. - Tag der Lehrbefähigung: 14.12.2021
    HBZ-ID HT021365584
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Zivilisationskrankheiten - für eine gesamtwissenschaftliche Prädiktion und Prävention

    Müller, Günter Alwin

    molekulare, phänomenologische, systemische und gestalttheoretische Analyse von Altersdiabetes

    2016  

    Author's details Günter Alwin Müller
    Keywords Zivilisationskrankheit ; Diabetes mellitus Typ 2 ; Ganzheitliches Denken
    Subject Ganzheitliche Denkstrategie ; Vernetztes Denken ; Ganzheit ; Ganzheitlichkeit ; Diabetes mellitus Typ II ; Typ-2-Diabetes ; Nicht insulinabhängiger Diabetes ; Non-insulin dependent diabetes mellitus ; NIDDM ; Altersdiabetes ; Wohlstandskrankheit ; Lifestyle Disease
    Language German
    Size 387 Seiten, Illustrationen
    Publisher PL Academic Research
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book
    HBZ-ID HT019132061
    ISBN 978-3-631-67716-2 ; 3-631-67716-2 ; 9783653072150 ; 9783631693896 ; 9783631693902 ; 3653072158 ; 3631693893 ; 3631693907
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 1124 available for loan (reading room) Lesesaal EG

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  6. Article: Transfer of membrane(s) matter(s)-non-genetic inheritance of (metabolic) phenotypes?

    Müller, Günter A / Müller, Timo D

    Frontiers in molecular biosciences

    2024  Volume 11, Page(s) 1347397

    Abstract: Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs are not only released into extracellular compartments by lipolytic cleavage. In ... ...

    Abstract Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs are not only released into extracellular compartments by lipolytic cleavage. In addition, certain GPI-APs with the glycosylphosphatidylinositol anchor including their fatty acids remaining coupled to the carboxy-terminus of their protein components are also detectable in body fluids, in response to certain stimuli, such as oxidative stress, radicals or high-fat diet. As a consequence, the fatty acid moieties of GPI-APs must be shielded from access of the aqueous environment by incorporation into membranes of extracellular vesicles or into micelle-like complexes together with (lyso)phospholipids and cholesterol. The GPI-APs released from somatic cells and tissues are transferred via those complexes or EVs to somatic as well as pluripotent stem cells with metabolic consequences, such as upregulation of glycogen and lipid synthesis. From these and additional findings, the following hypotheses are developed: i) Transfer of GPI-APs via EVs or micelle-like complexes leads to the induction of new phenotypes in the daughter cells or zygotes, which are presumably not restricted to metabolism. ii) The membrane topographies transferred by the concerted action of GPI-APs and interacting components are replicated by self-organization and self-templation and remain accessible to structural changes by environmental factors. iii) Transfer from mother cells and gametes to their daughter cells and zygotes, respectively, is not restricted to DNA and genes, but also encompasses non-genetic matter, such as GPI-APs and specific membrane constituents. iv) The intergenerational transfer of membrane matter between mammalian organisms is understood as an epigenetic mechanism for phenotypic plasticity, which does not rely on modifications of DNA and histones, but is regarded as molecular mechanism for the inheritance of acquired traits, such as complex metabolic diseases. v) The missing interest in research of non-genetic matter of inheritance, which may be interpreted in the sense of Darwin's "Gemmules" or Galton's "Stirps", should be addressed in future investigations of the philosophy of science and sociology of media.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2024.1347397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Neurometabolismus im anterioren Cingulum und Cerebellum erwachsenen Patienten mit Autismus-Spektrum-Störung

    Müller, Günter Toman

    eine Magnetresonanzspektroskopie-Studie

    2014  

    Author's details von Günter Toman Müller
    Language German
    Size 83 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2015
    HBZ-ID HT018664287
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  8. Book: Migration und Psychose

    Bruns, Georg / Ertel, Ulrich / Lempa, Günter / Müller, Thomas / Münch, Alois / Troje, Elisabeth

    (Forum der psychoanalytischen Psychosentherapie ; Band 37)

    2023  

    Author's details Ulrich Ertel, Günter Lempa, Thomas Müller, Alois Münch, Elisabeth Troje (Hg.) ; mit Beiträgen von Georg Bruns [und weiteren]
    Series title Forum der psychoanalytischen Psychosentherapie ; Band 37
    Collection
    Subject code 150
    Language German
    Size 174 Seiten, 21 cm x 14.8 cm
    Edition Originalausgabe
    Publisher Psychosozial-Verlag
    Publishing place Gießen
    Publishing country Germany
    Document type Book
    HBZ-ID HT030598748
    ISBN 978-3-8379-3207-2 ; 3-8379-3207-9 ; 9783837979992 ; 3837979997
    Database Catalogue ZB MED Medicine, Health

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    2023 A 1101 available for loan (reading room) Lesesaal EG

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  9. Book: Stationäre und ambulante psychoanalytische Behandlung von Psychosen

    Münch, Alois / Ertel, Ulrich / Lempa, Günter / Müller, Thomas / Troje, Elisabeth

    (Forum der psychoanalytischen Psychosentherapie ; 36)

    2021  

    Author's details Ulrich Ertel, Günter Lempa, Thomas Müller, Alois Münch, Elisabeth Troje (Hg.)
    Series title Forum der psychoanalytischen Psychosentherapie ; 36
    Collection
    Keywords Psychoanalytisch orientierte Psychosentherapie ; Psychodynamik der Psychosenbehandlung im stationären und ambulanten Setting ; Mikroprozesse der therapeutischen Interaktion in unterschiedlichen Behandlungsrahmen ; Kritische und hilfreiche Momente in der therapeutischen Interaktion ; Bions Psychosentheorie ; Psychoanalytische Konzepte modifiziert für die Psychosentherapie ; Psychose ; Psychoanalyse ; Ambulante Behandlung ; Stationäre psychiatrische Versorgung
    Subject Stationäre psychiatrische Behandlung ; Ambulante ärztliche Versorgung ; Ambulante Krankenversorgung ; Ambulante Therapie ; Psychoanalytische Therapie ; Geisteskrankheit ; Irrsinn
    Subject code 150
    Language German
    Size 148 Seiten, 21 cm x 14.8 cm
    Publisher Psychosozial-Verlag
    Publishing place Gießen
    Publishing country Germany
    Document type Book
    HBZ-ID HT021132522
    ISBN 978-3-8379-3132-7 ; 3-8379-3132-3
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs.

    Müller, Günter A / Müller, Timo D

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer leaflet of eukaryotic plasma membranes (PMs) only by carboxy-terminal covalently coupled GPI. GPI-APs are known to be released from the surface of donor cells in response ... ...

    Abstract Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer leaflet of eukaryotic plasma membranes (PMs) only by carboxy-terminal covalently coupled GPI. GPI-APs are known to be released from the surface of donor cells in response to insulin and antidiabetic sulfonylureas (SUs) by lipolytic cleavage of the GPI or upon metabolic derangement as full-length GPI-APs with the complete GPI attached. Full-length GPI-APs become removed from extracellular compartments by binding to serum proteins, such as GPI-specific phospholipase D (GPLD1), or insertion into the PMs of acceptor cells. Here, the interplay between the lipolytic release and intercellular transfer of GPI-APs and its potential functional impact was studied using transwell co-culture with human adipocytes as insulin-/SU-responsive donor cells and GPI-deficient erythroleukemia as acceptor cells (ELCs). Measurement of the transfer as the expression of full-length GPI-APs at the ELC PMs by their microfluidic chip-based sensing with GPI-binding α-toxin and GPI-APs antibodies and of the ELC anabolic state as glycogen synthesis upon incubation with insulin, SUs and serum yielded the following results: (i) Loss of GPI-APs from the PM upon termination of their transfer and decline of glycogen synthesis in ELCs, as well as prolongation of the PM expression of transferred GPI-APs upon inhibition of their endocytosis and upregulated glycogen synthesis follow similar time courses. (ii) Insulin and SUs inhibit both GPI-AP transfer and glycogen synthesis upregulation in a concentration-dependent fashion, with the efficacies of the SUs increasing with their blood glucose-lowering activity. (iii) Serum from rats eliminates insulin- and SU-inhibition of both GPI-APs' transfer and glycogen synthesis in a volume-dependent fashion, with the potency increasing with their metabolic derangement. (iv) In rat serum, full-length GPI-APs bind to proteins, among them (inhibited) GPLD1, with the efficacy increasing with the metabolic derangement. (v) GPI-APs are displaced from serum proteins by synthetic phosphoinositolglycans and then transferred to ELCs with accompanying stimulation of glycogen synthesis, each with efficacies increasing with their structural similarity to the GPI glycan core. Thus, both insulin and SUs either block or foster transfer when serum proteins are depleted of or loaded with full-length GPI-APs, respectively, i.e., in the normal or metabolically deranged state. The transfer of the anabolic state from somatic to blood cells over long distance and its "indirect" complex control by insulin, SUs and serum proteins support the (patho)physiological relevance of the intercellular transfer of GPI-APs.
    MeSH term(s) Animals ; Humans ; Rats ; Blood Cells/metabolism ; Glycogen/metabolism ; Glycosylphosphatidylinositols/metabolism ; Insulin/pharmacology ; Sulfonylurea Compounds/pharmacology ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Protein Transport/drug effects ; Hypoglycemic Agents/pharmacology ; Adipocytes/drug effects ; Coculture Techniques
    Chemical Substances Glycogen (9005-79-2) ; Glycosylphosphatidylinositols ; Insulin ; Sulfonylurea Compounds ; Hypoglycemic Agents
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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