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  1. Article: Erratum: Retracted: Phosphotyrosine picked threonine kinase stimulates proliferation of human osteosarcoma cells

    Wang, Zhe-Xiang / Ren, Shao-Chun / Ren, Jing

    Archives of medical science : AMS

    2023  Volume 19, Issue 5, Page(s) 1597

    Abstract: This corrects the article DOI: 10.5114/aoms/115135.]. ...

    Abstract [This corrects the article DOI: 10.5114/aoms/115135.].
    Language English
    Publishing date 2023-09-01
    Publishing country Poland
    Document type Published Erratum
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms/171925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prospects of the potential strategies to improve the efficacy of anti‐PD‐1/PD‐L1 therapy

    Hirohito Yamaguchi / Shao‐Chun Wang / Mien‐Chie Hung

    Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)

    2022  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Capillary action-driven surface-enhanced Raman spectroscopy (SERS) for the identification of phthalocyanine blue in modern paintings based on the BPG spot test.

    Hsueh, Shao-Chun / Wang, Ling-Hsuan / Liao, Yung-Chen / Chiang, Hui-Yu / Lin, Cheng-Huang

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 14, Page(s) 2147–2151

    Abstract: A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported. This method allowed the integration of SERS and the BPG spot test, which are typically employed for ...

    Abstract A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported. This method allowed the integration of SERS and the BPG spot test, which are typically employed for examining pigments on paper or in books. Malachite green oxalate was used as the model material for investigating the extent of enhancement when SERS was applied. The dynamic behavior of the Ag nanoparticles was also studied. When the cotton paper was pre-treated with malachite green oxalate, Ag nanoparticles could be extracted and accumulated on the triangular top, resulting in a dramatic SERS improvement. When malachite green oxalate (at a concentration of 10
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01378b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prospects of the potential strategies to improve the efficacy of anti-PD-1/PD-L1 therapy.

    Yamaguchi, Hirohito / Wang, Shao-Chun / Hung, Mien-Chie

    Clinical and translational medicine

    2022  Volume 12, Issue 5, Page(s) e803

    MeSH term(s) B7-H1 Antigen ; Humans ; Lung Neoplasms ; Programmed Cell Death 1 Receptor
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Natural tannins as anti-SARS-CoV-2 compounds.

    Wang, Shao-Chun / Chou, I-Wen / Hung, Mien-Chie

    International journal of biological sciences

    2022  Volume 18, Issue 12, Page(s) 4669–4676

    Abstract: Tannins are polyphenols enriched in wood, bark, roots, leaves, seeds and fruits of a variety of plants. Over the last two decades, there has been an increasing interest in understanding the biological functions of tannins and their applications as ... ...

    Abstract Tannins are polyphenols enriched in wood, bark, roots, leaves, seeds and fruits of a variety of plants. Over the last two decades, there has been an increasing interest in understanding the biological functions of tannins and their applications as antioxidants, anticancer drugs, and food additives. Since the outbreak of the COVID-19 pandemic, much effort has been devoted to finding an expedient cure. Tannins have been put forward as having possible anti-COVID-19 properties; however, owing to the profuse nature of the structurally diverse derivatives of tannins, the tannin species in the family associated with an indication of anti-COVID-19 have been poorly defined, compounded by frequent terminology misnomers. This article reviews the tannin family in fruits and the current knowledge about the activities of the compounds with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It will aid molecular and cellular biologists in developing natural anti-viral chemicals as means of overcoming the current and future pandemics.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Pandemics ; SARS-CoV-2 ; Tannins/chemistry ; Tannins/pharmacology ; Tannins/therapeutic use
    Chemical Substances Antiviral Agents ; Tannins
    Language English
    Publishing date 2022-07-11
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.74676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: 

    Li, Shi-Gang / Huang, Qiang-Chun / Liu, Shao-Yun / Xiang, Chun-Lei / Wang, Huan-Chong

    PhytoKeys

    2024  Volume 237, Page(s) 191–200

    Abstract: ... ...

    Abstract Isodonxiaoluzhiensis
    Language English
    Publishing date 2024-01-24
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.237.117071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Joint Model Based on Post-Treatment Longitudinal Prognostic Nutritional Index to Predict Survival in Nasopharyngeal Carcinoma.

    Hsiao, Po-Wen / Wang, Yu-Ming / Wu, Shao-Chun / Chen, Wei-Chih / Wu, Ching-Nung / Chiu, Tai-Jan / Yang, Yao-Hsu / Luo, Sheng-Dean

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Background: a low PNI in patients with NPC is linked to poor survival, but prior studies have focused on single-timepoint measurements. Our study aims to employ joint modeling to analyze longitudinal PNI data from each routine visit, exploring its ... ...

    Abstract Background: a low PNI in patients with NPC is linked to poor survival, but prior studies have focused on single-timepoint measurements. Our study aims to employ joint modeling to analyze longitudinal PNI data from each routine visit, exploring its relationship with overall survival.
    Methods: In this retrospective study using data from the Chang Gung Research Database (2007-2019), we enrolled patients with NPC undergoing curative treatment. We analyzed the correlation between patient characteristics, including the PNI, and overall survival. A joint model combining a longitudinal sub-model with a time-to-event sub-model was used to further evaluate the prognostic value of longitudinal PNI.
    Results: A total of 2332 patient were enrolled for the analysis. Separate survival analyses showed that longitudinal PNI was an independent indicator of a reduced mortality risk (adjusted HR 0.813; 95% CI, 0.805 to 0.821). Joint modeling confirmed longitudinal PNI as a consistent predictor of survival (HR 0.864; 95% CI, 0.850 to 0.879). An ROC analysis revealed that a PNI below 38.1 significantly increased the risk of 90-day mortality, with 90.0% sensitivity and 89.6% specificity.
    Conclusions: Longitudinal PNI data independently predicted the overall survival in patients with NPC, significantly forecasting 90-day survival outcomes. We recommend routine PNI assessments during each clinic visit for these patients.
    Language English
    Publishing date 2024-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16051037
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  8. Article ; Online: Validation of a shape-optimized 2-unit cantilevered inlay-retained fiber-reinforced resin-bonded dental prosthesis.

    Chen, Yung-Chung / Fok, Alex / Wang, Shao-Chun / Wang, Jessica Chia-Yi

    The Journal of prosthetic dentistry

    2022  

    Abstract: Statement of problem: Current designs of fiber-reinforced composite (FRC) resin-bonded fixed dental prostheses (RBFDPs) have a limited lifespan, failing mainly through veneer-fiber delamination, debonding, and fracture.: Purpose: The purpose of this ... ...

    Abstract Statement of problem: Current designs of fiber-reinforced composite (FRC) resin-bonded fixed dental prostheses (RBFDPs) have a limited lifespan, failing mainly through veneer-fiber delamination, debonding, and fracture.
    Purpose: The purpose of this in vitro study was to validate a new inlay-retained 2-unit cantilevered RBFDP with an optimized cavity and fiber layout proposed in a previous study by using simulated occlusal loading.
    Material and methods: Two groups of specimens (n=20), 1 with and 1 without glass fibers, were used to test the influence of the cavity design and that of the fiber layout on their load capacity, respectively. The specimens without fibers were directly cut from a resin-ceramic block by using a computer-aided manufacturing system, while those with fibers were manually fabricated with unidirectional glass fibers and composite resin in a silicone mold. The specimens with and without fibers were attached to abutments made of the same resin-ceramic with a cyanoacrylate-based adhesive and a resin-based dental cement, respectively. An increasing compressive load was applied on the mesial fossa of the premolar pontic until failure. Cracking in the specimens during loading was monitored with a 2-channel acoustic emission (AE) system.
    Results: All the specimens without fiber reinforcement debonded from the abutments. Those using the optimized shovel-shaped cavity design had a mean ±standard deviation failure load (50.0 ±17.3 N) that was 193% higher than that of those with the conventional step-box design (17.1 ±6.2 N; P<.001). No significant difference was found between the groups for the mean number of AE events per specimen (step-box: 49 ±34 versus shovel-shaped: 63 ±34; P=.427), the mean amplitude of each event (58.4 ±1.3 dB versus 59.5 ±2.4 dB; P=.299), or the mean time to failure (283.2 ±122.3 seconds versus 297.5 ±66.7 seconds; P=.798). Between the groups of specimens with reinforcing fibers, the mean failure load of the conventional design was approximately half that of the optimized one. Again, no significant difference was found for the mean number of AE events per specimen (conventional: 28 ±18 versus optimized: 52 ±53; P=.248) or the mean amplitude for each AE event (64.9 ±4.2 dB versus 61.7 ±5.2 dB; P=.187). The connectors of 8 fiber-reinforced specimens with the conventional design fractured; the other 2 debonded from the abutments. Half of the shape-optimized fiber-reinforced specimens had fractured abutments, but the cantilevers remained intact, 4 specimens fractured at the connector, and only 1 debonded from its abutment.
    Conclusions: The shape-optimized 2-unit cantilevered FRC RBFDP had a higher load capacity than the conventional design.
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2022.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.145: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Phosphotyrosine picked threonine kinase stimulates proliferation of human osteosarcoma cells

    Wang, Zhe-Xiang / Ren, Shao-Chun / Ren, Jing

    Archives of medical science : AMS

    2021  Volume 18, Issue 3, Page(s) 775–785

    Abstract: Introduction: Osteosarcoma (OS) is the most common primary bone tumor, and the main affected population is adolescents. The survival of OS patients was 10-20% when surgery was used as a single treatment. There is less basic research on OS than other ... ...

    Abstract Introduction: Osteosarcoma (OS) is the most common primary bone tumor, and the main affected population is adolescents. The survival of OS patients was 10-20% when surgery was used as a single treatment. There is less basic research on OS than other tumors, and we need more ways to improve the survival rate. Phosphotyrosine picked threonine kinase (TTK) has been widely reported as an oncogene in multiple types of cancers, and it is also known as a clinical therapeutic target. This study aims to assess TTK expression levels in human OS tissues and its link with the clinical characteristics of OS patients, and to evaluate the potential role in OS development.
    Material and methods: Immunohistochemical (IHC) assays were conducted to detect the expression levels of TTK in a total of 74 OS tissues and the corresponding adjacent tissues. Furthermore, according to the staining intensity of TTK in tumor tissues, patients were divided into TTK high and low expression groups. The possible correlation between TTK expression levels and clinical features were analyzed, and the effects of TTK on OS cell proliferation were detected through colony formation and cell counting kit-8 (CCK8) assays. The effects of TTK on tumor growth were detected using an animal model.
    Results: Phosphotyrosine picked threonine kinase was abnormally highly expressed in human OS tissues. Meanwhile, TTK was significantly correlated with the clinical characteristics such as tumor size (
    Conclusions: We demonstrated the involvement of TTK in the development of OS, and therefore we suggest that TTK should be considered as a promising therapy target for OS.
    Language English
    Publishing date 2021-01-25
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms/115135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Aptamer-guided targeting of the intracellular long-noncoding RNA

    Wang, Yuan-Liang / Chang, Ling-Chu / Chen, Kuen-Bao / Wang, Shao-Chun

    American journal of cancer research

    2021  Volume 11, Issue 3, Page(s) 945–954

    Abstract: Long non-coding RNAs (lncRNAs) are increasingly recognized as promising targets in cancer treatment. However, compared to targeting the ordinary protein-coding genes, suppressing non-coding RNAs expressed in cancer cells has been a more challenging task. ...

    Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as promising targets in cancer treatment. However, compared to targeting the ordinary protein-coding genes, suppressing non-coding RNAs expressed in cancer cells has been a more challenging task. The major hurdles lay on the requirement of a tumor-specific delivery system for the designated inhibitor to suppress the target transcripts within the cellular compartment. EGFR is a cancer driver gene which is frequently associated with the triple-negative phenotype of breast cancer. Prior studies have shown that expression of the tumor-promoting lncRNA
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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