LIVIVO - Search results -

Search results

Result 1 - 10 of total 38444

Search options

Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

2023 Volume 9, Page(s) 1038273

Abstract: ... Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE

Chen, Xin-Nong / Ge, Qi-Hui / Zhao, Yi-Xuan / Guo, Xiao-Chen / Zhang, Jun-Ping

Journal of ethnopharmacology

2021 Volume 276, Page(s) 114178

Abstract: Ethnopharmacological relevance: Si-Miao-Yong-An decoction (SMYAD) is a renowned ...

Abstract	Ethnopharmacological relevance: Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was originally recorded in the "Shi Shi Mi Lu", which was edited by medical scientist Chen Shi'duo during the Qing Dynasty. SMYAD has been traditionally used to treat thromboangiitis obliterans. At present, it is mainly used in clinical applications and research of cardiovascular diseases. Aim of the study: To explore the effects of SMYAD on the pathological changes of atherosclerosis (AS) and the differentiation of monocytes, macrophages, and regulatory T (Treg) cells in apolipoprotein E knockout (ApoE Materials and methods: Eight C57BL/6J mice, which were fed with normal diet for 16 weeks, were used as control group. Forty ApoE Results: Compared with the model group, the level of serum TC and LDL-C decreased in the SMYAD group, the pathological changes of aortic sinus decreased, and lipid infiltration of aorta and aortic sinus also decreased. These decreases were accompanied by a significant downregulation of CD36, SRA1, and LOX-1. Furthermore, the proportions of Ly6C Conclusions: SMYAD can improve the pathological changes associated with AS and can inhibit lipid deposition in ApoE
MeSH term(s)	Animals ; Aorta/metabolism ; Aorta/pathology ; Apolipoproteins E/genetics ; CD36 Antigens/metabolism ; Calcium-Binding Proteins/metabolism ; Carrier Proteins/metabolism ; Cell Differentiation/drug effects ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cytokines/blood ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Forkhead Transcription Factors/metabolism ; Lipoproteins, LDL/blood ; Macrophages/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/drug effects ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Receptors, G-Protein-Coupled/metabolism ; Scavenger Receptors, Class E/metabolism ; Spleen/drug effects ; Spleen/metabolism ; T-Lymphocytes, Regulatory/drug effects ; Triglycerides/blood ; Mice
Chemical Substances	Adgre1 protein, mouse ; Apolipoproteins E ; CD36 Antigens ; Calcium-Binding Proteins ; Carrier Proteins ; Cd36 protein, mouse ; Cholesterol, HDL ; Cholesterol, LDL ; Cytokines ; Drugs, Chinese Herbal ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Lipoproteins, LDL ; Olr1 protein, mouse ; Receptors, G-Protein-Coupled ; Scavenger Receptors, Class E ; Triglycerides ; oxidized low density lipoprotein ; si-miao-yong-an decoction ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-05-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114178
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury.

Cui, Wenwen / Xin, Shen / Zhu, Lingjuan / Wang, Mingye / Hao, Yuanyuan / Zhao, Yuqian / Li, Yang / Hou, Yunlong

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 8968464

Abstract: Objective: The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD ...

Abstract	Objective: The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could protect cardiomyocytes from ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods: C57BL/6 mice were used to establish a model of myocardial infarction by I/R injury and treated by SMYAD for 4 weeks. Then, the cardiac functions of mice were evaluated by cardiac magnetic resonance (CMR). Histopathological analysis for the heart remodeling was detected by H&E and Masson staining. The protein expression of collagen I, MMP9, and TNF Results: SMYAD improved cardiac functions such as ventricular volume and ejection fraction of the rats with ischemia/reperfusion injury. Morphological assay indicated that SMYAD reduced the scar size and inhibited fibrosis formation. It was found that SMYAD could regulate collagen I, MMP9, and TNF Conclusion: SMYAD exerted protective effects on ischemia/reperfusion injury in myocardial cells by activating autophagy and inhibiting pyroptosis. This might be the reason why SMYAD protected myocardial tissue and improved cardiac function in mice with ischemia/reperfusion.
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/8968464
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong’an Decoction

Ke-han Sun / Man-fang Yang / Xin-rui Xu / Yang Li / Zhao Gao / Qing-yue Zhang / Hui Li / Shu-qi Wang / Li-xia Lou / Ai-ming Wu / Qiu-shuo Jin / Sheng-xian Wu / Bo Nie

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Simiao Yong’an decoction (SMYAD), a classic traditional Chinese medicine formula, has been used ...

Abstract	Simiao Yong’an decoction (SMYAD), a classic traditional Chinese medicine formula, has been used to treat atherosclerosis (AS) in clinical in China, but its therapeutic mechanism and pharmacodynamic material basis are not clear. In this study, the AS model was caused by a high-fat diet and perivascular carotid collar placement (PCCP), and SMYAD was orally administered to the model and normal mice. A rapid, sensitive, selective, and reliable method using ultrahigh-performance liquid chromatography (UHPLC) system combined with a Q Exactive HF-X mass spectrometer (UHPLC-Q Exactive HF-X MS) was established and validated for the simultaneous determination of seven compounds, including harpagide, chlorogenic acid, swertiamarin, sweroside, angoroside C, liquiritin, and isoliquiritigenin in the plasma of normal and AS mice. The specificity, linearity, precision, accuracy, recovery, and stability of the method were all within the acceptable criteria. The results showed that some pharmacokinetic behaviors of harpagide, chlorogenic acid, and isoliquiritigenin were significantly different among the two groups of mice. The specific parameter changes were harpagide (AUC0–t and AUC0–∞ were 11075.09 ± 2132.38 and 16221.95 ± 5622.42 ng·mL−1·h, respectively; CLz/F was 2.45 ± 0.87 L/h/mg), chlorogenic acid (t1/2 was 21.59 ± 9.16 h; AUC0–∞ was 2637.51 ± 322.54 ng·mL−1·h; CLz/F was 13.49 ± 1.81 L/h/mg) and isoliquiritigenin (AUC0–t and AUC0–∞ were 502.25 ± 165.65 and 653.68 ± 251.34 ng·mL−1·h, respectively; CLz/F was 62.16 ± 23.35 L/h/mg) were altered under the pathological status of AS. These differences might be partly ascribed to the changes in gastrointestinal microbiota, nonspecific drug transporters, and cytochrome P450 activity under the AS state, providing research ideas and experimental basis for pharmacological effects and pharmacodynamic material basis.
Keywords	Other systems of medicine ; RZ201-999
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models.

Liao, Minru / Xie, Qiang / Zhao, Yuqian / Yang, Chengcan / Lin, Congcong / Wang, Guan / Liu, Bo / Zhu, Lingjuan

Pharmacological research

2022 Volume 176, Page(s) 106077

Abstract: ... Notably, Si-Miao-Yong-An decoction (SMYAD) is a traditional Chinese medicine (TCM) used to treat ...

Abstract	Heart failure (HF), the main cause of death in patients with many cardiovascular diseases, has been reported to be closely related to the complicated pathogenesis of autophagy, apoptosis, and inflammation. Notably, Si-Miao-Yong-An decoction (SMYAD) is a traditional Chinese medicine (TCM) used to treat cardiovascular disease; however, the main active components and their relevant mechanisms remain to be discovered. Based on our previous ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) results, we identified angoriside C (AC) and 3,5-dicaffeoylquinic acid (3,5-DiCQA) as the main active components of SMYAD. In vivo results showed that AC and 3,5-DiCQA effectively improved cardiac function, reduced the fibrotic area, and alleviated isoproterenol (ISO)-induced myocarditis in rats. Moreover, AC and 3,5-DiCQA inhibited ISO-induced autophagic cell death by inhibiting the PDE5A/AKT/mTOR/ULK1 pathway and inhibited ISO-induced apoptosis by inhibiting the TLR4/NOX4/BAX pathway. In addition, the autophagy inhibitor 3-MA was shown to reduce ISO-induced apoptosis, indicating that ISO-induced autophagic cell death leads to excess apoptosis. Taken together, the main active components AC and 3,5-DiCQA of SMYAD inhibit the excessive autophagic cell death and apoptosis induced by ISO by inhibiting the PDE5A-AKT and TLR4-NOX4 pathways, thereby reducing myocardial inflammation and improving heart function to alleviate and treat a rat ISO-induced heart failure model and cell heart failure models. More importantly, the main active components of SMYAD will provide new insights into a promising strategy that will promote the discovery of more main active components of SMYAD for therapeutic purposes in the future.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Line ; Cell Survival/drug effects ; Chlorogenic Acid/analogs & derivatives ; Chlorogenic Acid/pharmacology ; Chlorogenic Acid/therapeutic use ; Coumaric Acids/pharmacology ; Coumaric Acids/therapeutic use ; Cyclic Nucleotide Phosphodiesterases, Type 5/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal ; Heart Failure/chemically induced ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/pathology ; Isoproterenol ; Male ; Myoblasts/drug effects ; Myocardium/metabolism ; Myocardium/pathology ; NADPH Oxidase 4/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Trisaccharides/pharmacology ; Trisaccharides/therapeutic use ; Rats
Chemical Substances	Coumaric Acids ; Drugs, Chinese Herbal ; Tlr4 protein, rat ; Toll-Like Receptor 4 ; Trisaccharides ; si-miao-yong-an decoction ; angoroside C (115909-22-3) ; Chlorogenic Acid (318ADP12RI) ; NADPH Oxidase 4 (EC 1.6.3.-) ; Nox4 protein, rat (EC 1.6.3.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35) ; Pde5a protein, rat (EC 3.1.4.35) ; Isoproterenol (L628TT009W) ; 3,5-dicaffeoylquinic acid (ND94C5E75K)
Language	English
Publishing date	2022-01-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106077
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 721: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

Zootaxa

2022 Volume 5115, Issue 4, Page(s) 600

Language	English
Publishing date	2022-03-16
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5115.4.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury

Wenwen Cui / Shen Xin / Lingjuan Zhu / Mingye Wang / Yuanyuan Hao / Yuqian Zhao / Yang Li / Yunlong Hou

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Objective. The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD ...

Abstract	Objective. The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could protect cardiomyocytes from ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods. C57BL/6 mice were used to establish a model of myocardial infarction by I/R injury and treated by SMYAD for 4 weeks. Then, the cardiac functions of mice were evaluated by cardiac magnetic resonance (CMR). Histopathological analysis for the heart remodeling was detected by H&E and Masson staining. The protein expression of collagen I, MMP9, and TNFα was detected by western blot in the heart tissues. H9C2 cells were used to establish the hypoxia/reoxygenation (H/R) model and SMYAD intervention. MTT assays detected the cell viability of myocardial cells. The expression level of IL-1β was evaluated by ELISA. The expression levels of LC3B-II/LC3B-I, p-mTOR, mTOR, NLRP3, procaspase 1, and cleaved-caspase 1 in H9C2 cells were evaluated by Western blot. Results. SMYAD improved cardiac functions such as ventricular volume and ejection fraction of the rats with ischemia/reperfusion injury. Morphological assay indicated that SMYAD reduced the scar size and inhibited fibrosis formation. It was found that SMYAD could regulate collagen I, MMP9, and TNFα protein expression levels in the heart tissues. SMYAD improved the survival rate of H9C2 cardiomyocytes in the H/R injury model. SMYAD elevated the rate of LC3B-II/LC3B-I protein expression, decreased the rate of p-mTOR/mTOR protein expression, and reduced expressions of caspase 1, NLRP3, and IL-1β in H/R cardiomyocytes. Conclusion. SMYAD exerted protective effects on ischemia/reperfusion injury in myocardial cells by activating autophagy and inhibiting pyroptosis. This might be the reason why SMYAD protected myocardial tissue and improved cardiac function in mice with ischemia/reperfusion.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE−/− mice

Chen, Xin-Nong / Ge, Qi-Hui / Zhao, Yi-Xuan / Guo, Xiao-Chen / Zhang, Jun-Ping

Journal of ethnopharmacology. 2021 Aug. 10, v. 276

2021

Abstract: Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was ...

Abstract	Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was originally recorded in the “Shi Shi Mi Lu”, which was edited by medical scientist Chen Shi'duo during the Qing Dynasty. SMYAD has been traditionally used to treat thromboangiitis obliterans. At present, it is mainly used in clinical applications and research of cardiovascular diseases.To explore the effects of SMYAD on the pathological changes of atherosclerosis (AS) and the differentiation of monocytes, macrophages, and regulatory T (Treg) cells in apolipoprotein E knockout (ApoE⁻/⁻) mice.Eight C57BL/6J mice, which were fed with normal diet for 16 weeks, were used as control group. Forty ApoE⁻/⁻ mice were randomly divided into model group, atorvastatin group, SMYAD low-dose (SMYAD-LD) group, SMYAD medium-dose (SMYAD-MD) group, and SMYAD high-dose (SMYAD-HD) group. ApoE⁻/⁻ mice were fed with western diet (WD) for 8 weeks, and the drugs were continuously administered for 8 weeks. The levels of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured by the esterase method. Morphological changes of the aortic sinus in mice were observed by hematoxylin-eosin (HE) staining, the lipid infiltration of the aorta and aortic sinus were observed by oil red O staining, and the spleen index was calculated. The proportion of Ly6Cʰⁱᵍʰ and Ly6Cˡᵒʷ monocyte subsets, macrophages, and their M1 phenotype, as well as Treg cells in spleen were measured by flow cytometry. The expressions of cluster of differentiation 36 (CD36), scavenger receptor A1 (SRA1), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), F4/80, and fork head frame protein 3 (FOXP3) in aortic sinus were assessed by immunohistochemical staining. The serum levels of oxidized low density lipoprotein (ox-LDL), interleukin-1β (IL-1β), IL-18, transforming growth factor-β (TGF-β), and IL-10 were measured by enzyme-linked immunosorbent assays (ELISA).Compared with the model group, the level of serum TC and LDL-C decreased in the SMYAD group, the pathological changes of aortic sinus decreased, and lipid infiltration of aorta and aortic sinus also decreased. These decreases were accompanied by a significant downregulation of CD36, SRA1, and LOX-1. Furthermore, the proportions of Ly6Cʰⁱᵍʰ pro-inflammatory monocyte subsets, macrophages, and their M1 phenotypes in spleen decreased significantly, while the proportion of Treg cells increased. In addition, while the expression of F4/80 decreased, the expression of FOXP3 increased in the aorta sinus. The levels of serum pro-inflammatory factors IL-1β and IL-18 decreased.SMYAD can improve the pathological changes associated with AS and can inhibit lipid deposition in ApoE⁻/⁻ mice induced by WD diet. The likely mechanism is the inhibition of the differentiation and recruitment of monocytes and macrophages, the promotion of the differentiation and recruitment of Treg cells, as well as the reduction of the secretion of pro-inflammatory factors.
Keywords	Western diets ; aorta ; apolipoprotein E ; atherosclerosis ; atorvastatin ; blood serum ; esterases ; flow cytometry ; high density lipoprotein cholesterol ; immunohistochemistry ; interleukin-10 ; interleukin-18 ; low density lipoprotein cholesterol ; macrophages ; monocytes ; oxidation ; phenotype ; scientists ; secretion ; spleen ; traditional medicine ; triacylglycerols
Language	English
Dates of publication	2021-0810
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114178
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.

Zhao, Yuqian / Sun, Dejuan / Chen, Yanmei / Zhan, Kaixuan / Meng, Qu / Zhang, Xue / Zhu, Lingjuan / Yao, Xinsheng

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 130, Page(s) 110522

Abstract: ... which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong ...

Abstract	Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), which is used clinically in cardiovascular diseases has been recently reported to able to resist myocardial fibrosis. The anti-fibrosis effects of SMYAD have been evaluated; however, its intricate mechanisms remain to be clarified. Here, we found that SMYAD treatment reduced the fibrosis injury and collagen fiber deposition that could improve cardiac function in isoprenaline (ISO)-induced fibrosis rat models. Combined with our systematic RNA-seq data of SMYAD treatment, we demonstrated that the remarkable up-regulation or down-regulation of several genes were closely related to the functional enrichment of TGF-β and AMPK pathways that were involved in myocardial fibrosis. Accordingly, we further explored the molecular mechanisms of SMYAD were mainly caused by AMPK activation and thereby suppressing its downstream Akt/mTOR and TGF-β/SMAD3 pathways. Moreover, we showed that the ECM deposition and secretion process were attenuated, suggesting that the fibrosis pathological features are changed. Interestingly, we found the similar AMPK-driven pathways in NIH-3T3 mouse fibroblasts treated with ISO. Taken together, these results demonstrate that SMYAD may be a new candidate agent by regulating AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways for potential therapeutic implications of myocardial fibrosis.
MeSH term(s)	Adrenergic beta-Agonists ; Animals ; Cardiomyopathies/chemically induced ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/prevention & control ; Collagen ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Echocardiography ; Extracellular Matrix/drug effects ; Fibrosis ; Gene Expression/drug effects ; Isoproterenol ; Male ; Mice ; Mitogen-Activated Protein Kinase Kinases/drug effects ; NIH 3T3 Cells ; Oncogene Protein v-akt/drug effects ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Smad3 Protein/drug effects ; TOR Serine-Threonine Kinases/drug effects ; Transforming Growth Factor beta/drug effects
Chemical Substances	Adrenergic beta-Agonists ; Drugs, Chinese Herbal ; Smad3 Protein ; Smad3 protein, rat ; Transforming Growth Factor beta ; si-miao-yong-an decoction ; Collagen (9007-34-5) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, rat (EC 2.7.1.1) ; Oncogene Protein v-akt (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2020-07-28
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110522
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Distribution and fate modeling of 4-nonylphenol, 4-t-octylphenol, and bisphenol A in the Yong River of China.

Cheng, Jun-Rui / Wang, Kan / Yu, Jie / Yu, Zhen-Xun / Yu, Xu-Biao / Zhang, Zhao-Zhao

Chemosphere

2018 Volume 195, Page(s) 594–605

Abstract: ... bisphenol A (BPA) in the water column of the Yong River were investigated and found to be in the range ...

Abstract	In this study, the concentrations of 4-nonylphenol (4-NP), 4-tert-octylphenol (4-t-OP), and bisphenol A (BPA) in the water column of the Yong River were investigated and found to be in the range of 140-3948, 6-828, and 15-1415 ng L
MeSH term(s)	Benzhydryl Compounds/analysis ; China ; Environmental Monitoring/methods ; Phenols/analysis ; Rivers/chemistry ; Waste Water/analysis ; Water Pollutants, Chemical/analysis ; Water Purification ; Water Quality
Chemical Substances	Benzhydryl Compounds ; Phenols ; Waste Water ; Water Pollutants, Chemical ; 4-nonylphenol (I03GBV4WEL) ; 4-tert-octylphenol (IOY9FVU3J3) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2018-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2017.12.085
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2540: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito